SG10201913599RA - 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) - Google Patents

9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)

Info

Publication number
SG10201913599RA
SG10201913599RA SG10201913599RA SG10201913599RA SG10201913599RA SG 10201913599R A SG10201913599R A SG 10201913599RA SG 10201913599R A SG10201913599R A SG 10201913599RA SG 10201913599R A SG10201913599R A SG 10201913599RA SG 10201913599R A SG10201913599R A SG 10201913599RA
Authority
SG
Singapore
Prior art keywords
cabp
bacterial pneumonia
minocycline compounds
acquired bacterial
treating community
Prior art date
Application number
SG10201913599RA
Inventor
Evangelos L Tzanis
Paul Mcgovern
Amy Manley
Lynne Garrity-Ryan
S Ken Tanaka
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Publication of SG10201913599RA publication Critical patent/SG10201913599RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG10201913599RA 2016-11-01 2017-10-31 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) SG10201913599RA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662416010P 2016-11-01 2016-11-01
US201662422843P 2016-11-16 2016-11-16
US201762480516P 2017-04-02 2017-04-02
US201762500611P 2017-05-03 2017-05-03
US201762514415P 2017-06-02 2017-06-02

Publications (1)

Publication Number Publication Date
SG10201913599RA true SG10201913599RA (en) 2020-02-27

Family

ID=62076212

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913599RA SG10201913599RA (en) 2016-11-01 2017-10-31 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
SG11201903846TA SG11201903846TA (en) 2016-11-01 2017-10-31 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201903846TA SG11201903846TA (en) 2016-11-01 2017-10-31 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)

Country Status (13)

Country Link
US (3) US10383884B2 (en)
EP (1) EP3534908A4 (en)
JP (2) JP2019532976A (en)
CN (1) CN110087655A (en)
AU (1) AU2017353588B2 (en)
BR (1) BR112019008897A2 (en)
CA (1) CA3042514A1 (en)
MX (2) MX2019005070A (en)
PH (1) PH12019500960A1 (en)
RU (1) RU2019113715A (en)
SG (2) SG10201913599RA (en)
TW (1) TW201821082A (en)
WO (1) WO2018085216A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201913599RA (en) * 2016-11-01 2020-02-27 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
US20200126094A1 (en) * 2018-10-19 2020-04-23 BioIDC, Inc. Medical research fraud detection system and software
PT117254B (en) 2021-05-26 2024-04-18 Hovione Farm S A METHOD FOR SYNTHESIS OF 9-AMINOMETHYL TETRACYCLINE COMPOUNDS

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (en) 1966-05-31 1967-12-01
DE1767891C3 (en) 1968-06-28 1980-10-30 Pfizer Process for the preparation of aqueous medicinal solutions for parenteral, peroral and local use containing a tetracycline derivative
NL158172B (en) 1972-09-18 1978-10-16 Farmaceutici Italia PROCESS FOR PREPARING TETRACYCLINE DERIVATIVES WITH A 7-PLACE SUBSTITUENT.
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (en) 1974-09-06 1976-03-18 Merck Patent Gmbh TETRACYCLIC COMPOUNDS AND PROCEDURES FOR THEIR PRODUCTION
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US5589470A (en) 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4806529A (en) 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806372A (en) 1985-02-15 1989-02-21 Georgia Oil & Gas Co., Inc. Nitrite-free-curing of bacon and product thereof
US6756365B2 (en) 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
AU2466099A (en) 1998-01-23 1999-08-09 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
US6256365B1 (en) 1999-08-16 2001-07-03 Analogic Corporation Apparatus and method for reconstruction of images in a computed tomography system using oblique slices
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
DE60027465T2 (en) 1999-09-14 2007-02-01 The Trustees Of Tufts College, Medford PROCESS FOR PREPARING SUBSTITUTED TETRACYCLINES BY MEANS OF TRANSITION-BASED CHEMISTRY
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
JP2003523963A (en) 2000-01-24 2003-08-12 トラスティーズ・オブ・タフツ・カレッジ Tetracycline compounds for the treatment of Cryptosporidium parvum-related diseases
BR0109725A (en) 2000-03-31 2003-02-04 Tufts College Substituted tetracycline compound, method for treating a tetracycline-responsive state in a mammal, pharmaceutical composition, method for synthesizing a 7- or 9-substituted tetracycline compound, and reactive intermediate
AU2001259701A1 (en) 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
DE60144375D1 (en) 2000-07-07 2011-05-19 Trustees Of Tufts College Medford 7-, 8-, and 9-SUBSTITUTED TETRACYCLIN COMPOUNDS
WO2002004406A2 (en) 2000-07-07 2002-01-17 Trustees Of Tufts College 9-substituted minocycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
HUP0301163A3 (en) 2000-07-07 2008-08-28 Tufts College 7-substituted tetracycline dervatives, pharmaceutical compositions containing them and their use
US20050143353A1 (en) 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
CZ20032780A3 (en) 2001-03-13 2004-01-14 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072031A2 (en) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
CA2457234A1 (en) 2001-03-14 2002-09-19 Mark L. Nelson Substituted tetracycline compounds as antifungal agents
US8088820B2 (en) 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060194773A1 (en) 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003005971A2 (en) 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
AU2002323688A1 (en) 2001-09-10 2003-03-24 Paratek Pharmaceuticals, Inc. Computational method for determining oral bioavailability
EP2322501B1 (en) 2002-01-08 2015-08-05 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
KR101093842B1 (en) 2002-03-08 2011-12-13 파라테크 파마슈티컬스, 인크. Amino-Methyl Substituted Tetracycline Compounds
CN1653037A (en) 2002-03-21 2005-08-10 帕拉特克药品公司 Substituted tetracycline compounds
KR101089429B1 (en) 2002-07-12 2011-12-07 파라테크 파마슈티컬스, 인크. 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
JP4686189B2 (en) 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Methods of using substituted tetracycline compounds to modulate RNA
WO2004091513A2 (en) 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EA201001081A1 (en) 2003-07-09 2011-02-28 Пэрэтек Фамэсьютикэлс, Инк. TETRACYCLINE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF TETRACYCLINE-SENSITIVE CONDITION IN THE SUBJECT
US20060287283A1 (en) 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP1716101A1 (en) 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
JP2008518035A (en) 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド Substituted tetracycline compounds
EP1848685A1 (en) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AU2006272698B2 (en) 2005-07-21 2012-11-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
EP1991236A2 (en) 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
US20080118979A1 (en) 2006-05-15 2008-05-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
LT2120963T (en) 2006-12-21 2019-01-10 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
CA2673466C (en) 2006-12-21 2016-06-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
AU2008239606A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
AU2008246119A1 (en) 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EA201070233A1 (en) 2007-07-06 2010-08-30 Паратек Фармасьютикалс, Инк. METHODS OF SYNTHESIS OF SUBSTITUTED COMPOUNDS OF TETRACYCLINE (OPTIONS)
WO2009111064A2 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (en) 2008-03-28 2018-04-16 Paratek Pharm Innc Oral tablet formulation of tetracycline compound
WO2009128913A1 (en) 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
TWI585071B (en) 2008-05-23 2017-06-01 派洛泰克藥物股份有限公司 Tosylate salts and polymorphs of a tetracycline compound
ES2430254T3 (en) 2008-08-08 2013-11-19 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds substituted with c7-fluoro
CA2980727C (en) * 2015-03-24 2023-09-19 Paratek Pharmaceuticals, Inc. Minocycline compounds for biodefense
EP3432891A4 (en) * 2016-03-24 2019-10-30 Paratek Pharmaceuticals, Inc. Methods for treating and preventing c. difficile infection
MX2018013271A (en) 2016-05-02 2019-03-28 Paratek Pharm Innc 9-aminomethyl minocycline compounds and methods of use thereof in urinary tract infection (uti) treatment.
TW202206081A (en) 2016-08-03 2022-02-16 美商派瑞泰Spv2有限公司 9-aminomethyl minocycline compounds and uses thereof
SG10201913599RA (en) * 2016-11-01 2020-02-27 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)

Also Published As

Publication number Publication date
JP2019532976A (en) 2019-11-14
MX2019005070A (en) 2019-09-23
US10835542B2 (en) 2020-11-17
US20180153908A1 (en) 2018-06-07
EP3534908A1 (en) 2019-09-11
BR112019008897A2 (en) 2019-08-13
CN110087655A (en) 2019-08-02
RU2019113715A (en) 2020-12-03
WO2018085216A8 (en) 2018-06-21
SG11201903846TA (en) 2019-05-30
US10383884B2 (en) 2019-08-20
CA3042514A1 (en) 2018-05-11
US20200009162A1 (en) 2020-01-09
AU2017353588A1 (en) 2019-06-20
JP2023058513A (en) 2023-04-25
WO2018085216A1 (en) 2018-05-11
MX2023004966A (en) 2023-05-24
US20210052609A1 (en) 2021-02-25
PH12019500960A1 (en) 2019-08-19
EP3534908A4 (en) 2020-05-27
RU2019113715A3 (en) 2020-12-07
TW201821082A (en) 2018-06-16
AU2017353588B2 (en) 2022-07-14

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