ATE455092T1 - Substituierte tetracyclin-verbindungen zur behandlung von malaria - Google Patents

Substituierte tetracyclin-verbindungen zur behandlung von malaria

Info

Publication number
ATE455092T1
ATE455092T1 AT02723955T AT02723955T ATE455092T1 AT E455092 T1 ATE455092 T1 AT E455092T1 AT 02723955 T AT02723955 T AT 02723955T AT 02723955 T AT02723955 T AT 02723955T AT E455092 T1 ATE455092 T1 AT E455092T1
Authority
AT
Austria
Prior art keywords
malaria
treatment
tetracycline compounds
substituted tetracycline
compounds
Prior art date
Application number
AT02723955T
Other languages
English (en)
Inventor
Michael Draper
Mark Nelson
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Application granted granted Critical
Publication of ATE455092T1 publication Critical patent/ATE455092T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT02723955T 2001-04-24 2002-04-24 Substituierte tetracyclin-verbindungen zur behandlung von malaria ATE455092T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28619301P 2001-04-24 2001-04-24
PCT/US2002/012935 WO2002085303A2 (en) 2001-04-24 2002-04-24 Substituted tetracycline compounds for the treatment of malaria

Publications (1)

Publication Number Publication Date
ATE455092T1 true ATE455092T1 (de) 2010-01-15

Family

ID=23097495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02723955T ATE455092T1 (de) 2001-04-24 2002-04-24 Substituierte tetracyclin-verbindungen zur behandlung von malaria

Country Status (9)

Country Link
US (1) US20040092490A1 (de)
EP (2) EP2186793A1 (de)
JP (4) JP2004529927A (de)
AT (1) ATE455092T1 (de)
AU (2) AU2002254714C1 (de)
CA (1) CA2444899C (de)
DE (1) DE60235083D1 (de)
ES (1) ES2338994T3 (de)
WO (1) WO2002085303A2 (de)

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US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1263442A1 (de) * 2000-01-24 2002-12-11 Trustees Of Tufts College Tetracycline verbindungen zur behandlung von mit cryptosporidium parvum gebundenen krankheiten
JP2004505012A (ja) * 2000-03-31 2004-02-19 トラスティーズ・オブ・タフツ・カレッジ ７−および９−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
EP1286954B1 (de) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituierte kondensierte ring-tetrazyclin- verbindungen
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
MXPA03000055A (es) 2000-07-07 2003-07-14 Tufts College Compuestos de monociclina sustituidos en posicion 9..
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
JP2005506291A (ja) * 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ， インク． ７，９−置換テトラサイクリン化合物
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1381372A2 (de) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituierte tetracyclin-verbindungen als synergistische antimykotische mittel
US20040092490A1 (en) * 2001-04-24 2004-05-13 Michael Draper Substituted tetracycline compounds for the treatment of malaria
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
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AU2003287218C1 (en) * 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
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EP2332904A3 (de) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivate von Tetracyclin-Verbindungen
AU2012202559B2 (en) * 2004-05-21 2014-07-17 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
KR101171408B1 (ko) * 2004-05-21 2012-08-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
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EP2479169B1 (de) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthese eines Enon-Zwischenprodukts
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
SI2109602T1 (sl) * 2006-12-21 2014-06-30 Paratek Pharmaceuticals, Inc. Derivati tetraciklina za zdravljenje bakterijskih, virusnih in parazitskih infekcij
RU2483072C2 (ru) 2007-11-29 2013-05-27 Актелион Фармасьютиклз Лтд Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12
MX2011001367A (es) 2008-08-08 2011-06-28 Tetraphase Pharmaceuticals Inc Compuestos de tetraciclina sustituidos con fluor en c7.
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
ES2627772T3 (es) 2009-05-08 2017-07-31 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
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CN105001112B (zh) * 2015-06-30 2017-02-01 浦城正大生化有限公司 水溶性金霉素琥珀酸单酯盐及其制备方法
CN117903083A (zh) 2016-10-19 2024-04-19 四相制药公司 艾若威四环素的结晶形式
PT3649109T (pt) * 2017-07-04 2021-09-10 Sanofi Sa Compostos de etinilo, a sua preparação e a sua utilização terapêutica para o tratamento de malária

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Also Published As

Publication number Publication date
JP2013151540A (ja) 2013-08-08
AU2002254714B2 (en) 2008-09-11
DE60235083D1 (de) 2010-03-04
CA2444899C (en) 2011-06-21
CA2444899A1 (en) 2002-10-31
EP2186793A1 (de) 2010-05-19
WO2002085303A2 (en) 2002-10-31
JP2009221219A (ja) 2009-10-01
ES2338994T3 (es) 2010-05-14
EP1399414A4 (de) 2006-03-22
US20040092490A1 (en) 2004-05-13
AU2002254714B8 (en) 2008-10-02
AU2002254714C1 (en) 2010-01-07
WO2002085303A3 (en) 2003-05-15
AU2008255241B2 (en) 2012-06-28
EP1399414A2 (de) 2004-03-24
EP1399414B1 (de) 2010-01-13
JP2013010806A (ja) 2013-01-17
JP2004529927A (ja) 2004-09-30
AU2008255241A1 (en) 2009-01-08

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