LT3257564T - Perkrovos ir eliuentinė chromatografija - Google Patents

Perkrovos ir eliuentinė chromatografija

Info

Publication number
LT3257564T
LT3257564T LTEP17157670.5T LT17157670T LT3257564T LT 3257564 T LT3257564 T LT 3257564T LT 17157670 T LT17157670 T LT 17157670T LT 3257564 T LT3257564 T LT 3257564T
Authority
LT
Lithuania
Prior art keywords
overload
elute chromatography
elute
chromatography
Prior art date
Application number
LTEP17157670.5T
Other languages
English (en)
Inventor
Deepa NADARAJAH
Amit Mehta
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48192803&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3257564(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of LT3257564T publication Critical patent/LT3257564T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/42Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424Elution mode
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847Multimodal interactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
LTEP17157670.5T 2011-11-02 2012-11-02 Perkrovos ir eliuentinė chromatografija LT3257564T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161554898P 2011-11-02 2011-11-02

Publications (1)

Publication Number Publication Date
LT3257564T true LT3257564T (lt) 2019-04-10

Family

ID=48192803

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP17157670.5T LT3257564T (lt) 2011-11-02 2012-11-02 Perkrovos ir eliuentinė chromatografija

Country Status (25)

Country Link
US (3) US20140301977A1 (lt)
EP (3) EP3257564B2 (lt)
JP (4) JP6356607B2 (lt)
KR (1) KR20140091721A (lt)
CN (2) CN104023804B (lt)
AU (1) AU2012323995B2 (lt)
BR (1) BR112014010406A2 (lt)
CA (1) CA2854330A1 (lt)
DK (2) DK2773438T4 (lt)
ES (2) ES2637423T5 (lt)
HK (1) HK1201489A1 (lt)
HR (1) HRP20190485T1 (lt)
HU (2) HUE035685T2 (lt)
IL (1) IL232146A0 (lt)
LT (1) LT3257564T (lt)
MX (1) MX2014005330A (lt)
PL (2) PL3257564T3 (lt)
PT (1) PT3257564T (lt)
RS (1) RS58472B1 (lt)
RU (1) RU2014121884A (lt)
SG (1) SG11201402019TA (lt)
SI (2) SI3257564T1 (lt)
TR (1) TR201903707T4 (lt)
WO (1) WO2013067301A1 (lt)
ZA (1) ZA201402932B (lt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201803960SA (en) 2010-07-30 2018-07-30 Emd Millipore Corp Chromatography media and method
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CN104023804B (zh) 2011-11-02 2017-05-24 弗·哈夫曼-拉罗切有限公司 超载和洗脱层析
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9249182B2 (en) * 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CN104884147A (zh) * 2012-10-24 2015-09-02 建新公司 使用mes和mops作为流动相改性剂从多峰树脂洗脱生物分子
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3079808B1 (en) 2013-12-12 2020-05-27 EMD Millipore Corporation Method of separating monomeric protein from protein agregates with a porous membrane comprising a co-polymer of benzyl acrylamide and acrylamide
US11219690B2 (en) * 2013-12-13 2022-01-11 Novo Nordisk Healthcare Ag Method for thioether conjugation of proteins
KR20150083689A (ko) * 2014-01-10 2015-07-20 삼성전자주식회사 항 c-Met 항체 정제 방법
CN106103465B (zh) 2014-03-10 2021-01-08 吉瑞工厂 使用预清洗步骤的免疫球蛋白纯化
US10252258B2 (en) * 2014-03-24 2019-04-09 Nitto Boseki Co., Ltd. Method for separating and concentrating target substance using novel cationic graft polymer
US10280195B2 (en) * 2014-05-28 2019-05-07 Agency For Science, Technology And Research Virus reduction method
JP2017519838A (ja) 2014-06-25 2017-07-20 ジェイエイチエル バイオテック インコーポレイテッド タンパク質の精製のための方法及び試薬
CN104208719B (zh) * 2014-09-24 2017-05-03 北京天广实生物技术股份有限公司 一种抗体偶联药物的阳离子交换层析纯化方法
EP3230299A1 (en) * 2014-12-08 2017-10-18 EMD Millipore Corporation Mixed bed ion exchange adsorber
WO2016144824A1 (en) * 2015-03-06 2016-09-15 Genentech, Inc. Ultrapurified dsba and dsbc and methods of making and using the same
CN106290591B (zh) * 2015-05-14 2019-07-26 上海医药工业研究院 一种庆大霉素C1a的检测方法
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
WO2017032610A1 (en) * 2015-08-21 2017-03-02 F. Hoffmann-La Roche Ag Affinity chromatography purification with low conductivity wash buffer
KR102617148B1 (ko) * 2016-08-15 2023-12-26 제넨테크, 인크. 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법
GB201702856D0 (en) * 2017-02-22 2017-04-05 Ge Healthcare Bio Sciences Ab Method in continuous chromatography
CN111527202B (zh) * 2017-11-08 2024-03-29 蓝天免疫疗法有限责任公司 So3色谱在病毒纯化方法中的应用
EP3818150A1 (en) * 2018-07-04 2021-05-12 ProBioGen AG Method for purifying an enveloped virus
US20210396725A1 (en) * 2018-12-21 2021-12-23 3M Innovative Properties Company Method for Testing a Chromatography Device Used for Ion Exchange
WO2020172658A1 (en) 2019-02-24 2020-08-27 Bristol-Myers Squibb Company Methods of isolating a protein
TW202112799A (zh) 2019-06-05 2021-04-01 美商建南德克公司 過載層析管柱之再生方法
CN111351876A (zh) * 2020-04-01 2020-06-30 上海中科新生命生物科技有限公司 一种抗体药中宿主细胞蛋白半绝对定量检测方法
US11379651B1 (en) * 2020-07-06 2022-07-05 Turtl Surf & Immerse Limited Methods and systems for interactive content creation

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
ATE204902T1 (de) 1990-06-29 2001-09-15 Large Scale Biology Corp Melaninproduktion durch transformierte mikroorganismen
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
EP0625200B1 (en) 1992-02-06 2005-05-11 Chiron Corporation Biosynthetic binding protein for cancer marker
ATE244763T1 (de) 1992-02-11 2003-07-15 Cell Genesys Inc Erzielen von homozygotem durch zielgerichtete genetische ereignisse
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
EP0656064B1 (en) 1992-08-17 1997-03-05 Genentech, Inc. Bispecific immunoadhesins
DK0669836T3 (da) 1992-11-13 1996-10-14 Idec Pharma Corp Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
RU2179034C2 (ru) * 1996-09-13 2002-02-10 Транскариотик Терапиз, Инк. ЛЕЧЕНИЕ В СЛУЧАЕ ДЕФИЦИТА α-ГАЛАКТОЗИДАЗЫ А
ES2335365T3 (es) * 1996-11-27 2010-03-25 Genentech, Inc. Purificacion por afinidad de polipeptido en una matriz de proteina a.
CN103641885A (zh) * 1998-05-06 2014-03-19 基因技术股份有限公司 用离子交换层析纯化蛋白质
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US8372954B2 (en) 2000-12-22 2013-02-12 National Research Council Of Canada Phage display libraries of human VH fragments
CN1500095B (zh) * 2001-02-01 2010-06-16 比奥根艾迪克Ma公司 神经胚活素的多聚体偶联物及其应用方法
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
US20070261962A1 (en) * 2002-04-02 2007-11-15 Ryszard Gajek Separation Systems with Charge Mosaic Membrane
CN1705505B (zh) * 2002-10-18 2010-04-28 旭化成医疗株式会社 亲水微孔膜
AU2004220325B2 (en) 2003-06-30 2011-05-12 Domantis Limited Polypeptides
CN101052654A (zh) 2004-08-19 2007-10-10 健泰科生物技术公司 具有改变的效应子功能的多肽变体
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
US8067182B2 (en) 2005-03-11 2011-11-29 Wyeth Llc Method of weak partitioning chromatography
GB2439875B (en) * 2005-04-22 2010-10-20 Waters Investments Ltd Apparatus and methods for mass spectrometric directed purification of biopolymers
EA017733B1 (ru) * 2006-08-28 2013-02-28 Арес Трейдинг С.А. СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ
MY157846A (en) * 2006-08-28 2016-07-29 Ares Trading Sa Process for the purification of fc-containing proteins
BRPI0812288A2 (pt) 2007-06-01 2014-11-25 Hoffmann La Roche Purificação de imunoglobulina.
DE102009005479A1 (de) * 2009-01-21 2010-07-22 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren für die Stofftrennung
JP5614936B2 (ja) * 2009-02-19 2014-10-29 旭化成ケミカルズ株式会社 アニオン交換基が固定された多孔膜を用いた核酸の精製方法
JP5791602B2 (ja) * 2009-08-07 2015-10-07 イー・エム・デイー・ミリポア・コーポレイシヨン 試料中の1つ以上の不純物から標的タンパク質を精製するための方法
WO2011035282A1 (en) * 2009-09-21 2011-03-24 Ge Healthcare Bio-Sciences Ab Dual capture separation
CN102094034A (zh) * 2009-12-09 2011-06-15 泰州新生源生物医药有限公司 一种重组人Fc融合长效干扰素的纯化工艺
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
JP2014503495A (ja) * 2010-11-15 2014-02-13 バイオジェン アイデック インコーポレイテッド 過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮
CN104023804B (zh) 2011-11-02 2017-05-24 弗·哈夫曼-拉罗切有限公司 超载和洗脱层析

Also Published As

Publication number Publication date
JP6979442B2 (ja) 2021-12-15
DK2773438T4 (da) 2022-01-03
TR201903707T4 (tr) 2019-04-22
PL3257564T3 (pl) 2019-06-28
JP6356607B2 (ja) 2018-07-11
EP3527274A1 (en) 2019-08-21
PL2773438T3 (pl) 2017-11-30
CN104023804B (zh) 2017-05-24
JP2018184405A (ja) 2018-11-22
HRP20190485T1 (hr) 2019-04-19
ES2637423T3 (es) 2017-10-13
EP2773438B2 (en) 2021-10-20
AU2012323995A1 (en) 2013-05-16
CN107163101A (zh) 2017-09-15
ES2637423T5 (es) 2022-03-17
HUE043755T2 (hu) 2019-09-30
RU2014121884A (ru) 2015-12-10
CN107163101B (zh) 2021-08-17
IL232146A0 (en) 2014-05-28
JP2020059718A (ja) 2020-04-16
CN104023804A (zh) 2014-09-03
JP7203928B2 (ja) 2023-01-13
EP2773438B1 (en) 2017-06-14
US20140301977A1 (en) 2014-10-09
US20190023768A1 (en) 2019-01-24
EP2773438A4 (en) 2015-06-03
ZA201402932B (en) 2016-08-31
EP2773438A1 (en) 2014-09-10
AU2012323995B2 (en) 2016-06-09
BR112014010406A2 (pt) 2017-04-25
EP3257564B1 (en) 2019-01-23
SI3257564T1 (sl) 2019-04-30
SG11201402019TA (en) 2014-09-26
ES2717536T3 (es) 2019-06-21
SI2773438T1 (sl) 2017-10-30
DK2773438T3 (en) 2017-08-21
MX2014005330A (es) 2014-09-08
EP3257564B2 (en) 2024-05-29
NZ624317A (en) 2016-06-24
US20210206836A1 (en) 2021-07-08
EP3257564A1 (en) 2017-12-20
WO2013067301A1 (en) 2013-05-10
HK1201489A1 (en) 2015-09-04
CA2854330A1 (en) 2013-05-10
PT3257564T (pt) 2019-03-22
KR20140091721A (ko) 2014-07-22
PL2773438T5 (pl) 2022-01-17
SI2773438T2 (sl) 2022-05-31
JP2014532718A (ja) 2014-12-08
RS58472B1 (sr) 2019-04-30
DK3257564T3 (en) 2019-04-15
HUE035685T2 (en) 2018-05-28
JP2022033774A (ja) 2022-03-02

Similar Documents

Publication Publication Date Title
HRP20190485T1 (hr) Kromatografija preopterećenja i elucijska kromatografija
HUS2100012I1 (hu) 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók
HK1211258A1 (en) Chromatographic materials
HK1205041A1 (en) Chromatography columns
HK1214938A1 (zh) 分析輔件
EP2831096A4 (en) AFFINITY CHROMATOGRAPHY MATRIX
EP2780789A4 (en) CHROMATOGRAPHIC CONFIGURATION INTERFACE
GB201020148D0 (en) Chromatography column
PL2691770T3 (pl) Prekoncentrator
EP2590722A4 (en) TIMING PROCEDURE
GB201111775D0 (en) Compounds and uses thereof
GB2478652B (en) Chromatography assembly
AU346758S (en) Chromatography column
GB201020146D0 (en) Chromatography column
EP2803993A4 (en) AUTOMATIC SAMPLER
GB201118317D0 (en) Intrathermic and interthermic extractive thermiats
AU346759S (en) Chromatography system
LT3689878T (lt) 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk inhibitoriai
GB201121726D0 (en) Compounds and uses thereof
GB201121551D0 (en) Compounds and uses thereof