SI2773438T2 - Izpiralna kromatografija s preobremenitvijo - Google Patents
Izpiralna kromatografija s preobremenitvijoInfo
- Publication number
- SI2773438T2 SI2773438T2 SI201231031T SI201231031T SI2773438T2 SI 2773438 T2 SI2773438 T2 SI 2773438T2 SI 201231031 T SI201231031 T SI 201231031T SI 201231031 T SI201231031 T SI 201231031T SI 2773438 T2 SI2773438 T2 SI 2773438T2
- Authority
- SI
- Slovenia
- Prior art keywords
- overload
- elute chromatography
- elute
- chromatography
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161554898P | 2011-11-02 | 2011-11-02 | |
PCT/US2012/063242 WO2013067301A1 (en) | 2011-11-02 | 2012-11-02 | Overload and elute chromatography |
EP12845437.8A EP2773438B2 (en) | 2011-11-02 | 2012-11-02 | Overload and elute chromatography |
Publications (2)
Publication Number | Publication Date |
---|---|
SI2773438T1 SI2773438T1 (sl) | 2017-10-30 |
SI2773438T2 true SI2773438T2 (sl) | 2022-05-31 |
Family
ID=48192803
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201231562T SI3257564T1 (sl) | 2011-11-02 | 2012-11-02 | Izpiralna kromatografija s preobremenitvijo |
SI201231031T SI2773438T2 (sl) | 2011-11-02 | 2012-11-02 | Izpiralna kromatografija s preobremenitvijo |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201231562T SI3257564T1 (sl) | 2011-11-02 | 2012-11-02 | Izpiralna kromatografija s preobremenitvijo |
Country Status (25)
Country | Link |
---|---|
US (3) | US20140301977A1 (sl) |
EP (3) | EP2773438B2 (sl) |
JP (4) | JP6356607B2 (sl) |
KR (1) | KR20140091721A (sl) |
CN (2) | CN107163101B (sl) |
AU (1) | AU2012323995B2 (sl) |
BR (1) | BR112014010406A2 (sl) |
CA (1) | CA2854330A1 (sl) |
DK (2) | DK3257564T3 (sl) |
ES (2) | ES2637423T5 (sl) |
HK (1) | HK1201489A1 (sl) |
HR (1) | HRP20190485T1 (sl) |
HU (2) | HUE035685T2 (sl) |
IL (1) | IL232146A0 (sl) |
LT (1) | LT3257564T (sl) |
MX (1) | MX2014005330A (sl) |
PL (2) | PL2773438T5 (sl) |
PT (1) | PT3257564T (sl) |
RS (1) | RS58472B1 (sl) |
RU (1) | RU2014121884A (sl) |
SG (1) | SG11201402019TA (sl) |
SI (2) | SI3257564T1 (sl) |
TR (1) | TR201903707T4 (sl) |
WO (1) | WO2013067301A1 (sl) |
ZA (1) | ZA201402932B (sl) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101619865B1 (ko) | 2010-07-30 | 2016-05-11 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
CN107163101B (zh) | 2011-11-02 | 2021-08-17 | 弗·哈夫曼-拉罗切有限公司 | 超载和洗脱层析 |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9249182B2 (en) * | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US20150275195A1 (en) | 2012-10-24 | 2015-10-01 | Genzyme Corporation | Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers |
SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
KR101891522B1 (ko) | 2013-12-12 | 2018-08-24 | 이엠디 밀리포어 코포레이션 | 아크릴아미드 함유 필터를 사용한 단백질 분리 |
ES2869309T3 (es) * | 2013-12-13 | 2021-10-25 | Novo Nordisk Healthcare Ag | Método para la conjugación de proteínas con tioéter |
KR20150083689A (ko) * | 2014-01-10 | 2015-07-20 | 삼성전자주식회사 | 항 c-Met 항체 정제 방법 |
HUE048782T2 (hu) | 2014-03-10 | 2020-08-28 | Richter Gedeon Nyrt | Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával |
JP6583635B2 (ja) * | 2014-03-24 | 2019-10-02 | 日東紡績株式会社 | 新規カチオン性グラフト重合体を用いた標的物分離濃縮方法 |
JP2017519734A (ja) * | 2014-05-28 | 2017-07-20 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | ウイルスの減少方法 |
WO2015200645A1 (en) | 2014-06-25 | 2015-12-30 | Jhl Biotech, Inc. | Methods and reagents for purification of proteins |
CN104208719B (zh) * | 2014-09-24 | 2017-05-03 | 北京天广实生物技术股份有限公司 | 一种抗体偶联药物的阳离子交换层析纯化方法 |
WO2016093926A1 (en) | 2014-12-08 | 2016-06-16 | Emd Millipore Corporation | Mixed bed ion exchange adsorber |
KR20170122216A (ko) * | 2015-03-06 | 2017-11-03 | 제넨테크, 인크. | 초순수화 dsba 및 dsbc와 이를 제조하고 사용하는 방법 |
CN106290591B (zh) * | 2015-05-14 | 2019-07-26 | 上海医药工业研究院 | 一种庆大霉素C1a的检测方法 |
GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
JP7084301B2 (ja) * | 2015-08-21 | 2022-06-14 | エフ.ホフマン-ラ ロシュ アーゲー | 低伝導率洗浄緩衝液を用いたアフィニティークロマトグラフィー精製方法 |
SG11201901228QA (en) * | 2016-08-15 | 2019-03-28 | Genentech Inc | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
GB201702856D0 (en) * | 2017-02-22 | 2017-04-05 | Ge Healthcare Bio Sciences Ab | Method in continuous chromatography |
CN111527202B (zh) * | 2017-11-08 | 2024-03-29 | 蓝天免疫疗法有限责任公司 | So3色谱在病毒纯化方法中的应用 |
US20220267738A1 (en) * | 2018-07-04 | 2022-08-25 | Probiogen Ag | Method For Purifying An Enveloped Virus |
US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
TW202112799A (zh) | 2019-06-05 | 2021-04-01 | 美商建南德克公司 | 過載層析管柱之再生方法 |
CN111351876A (zh) * | 2020-04-01 | 2020-06-30 | 上海中科新生命生物科技有限公司 | 一种抗体药中宿主细胞蛋白半绝对定量检测方法 |
US11379651B1 (en) * | 2020-07-06 | 2022-07-05 | Turtl Surf & Immerse Limited | Methods and systems for interactive content creation |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
DE69029036T2 (de) | 1989-06-29 | 1997-05-22 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
KR0149181B1 (ko) | 1990-06-29 | 1998-08-17 | 데이비드 알, 맥지 | 형질전환된 미생물에 의한 멜라닌의 제조방법 |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
CA2102511A1 (en) | 1991-05-14 | 1992-11-15 | Paul J. Higgins | Heteroconjugate antibodies for treatment of hiv infection |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
EP1997894B1 (en) | 1992-02-06 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Biosynthetic binding protein for cancer marker |
DE69333082T2 (de) | 1992-02-11 | 2004-05-06 | Cell Genesys, Inc., Foster City | Erzielen von homozygotem durch zielgerichtete genetische ereignisse |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
AU668423B2 (en) | 1992-08-17 | 1996-05-02 | Genentech Inc. | Bispecific immunoadhesins |
WO1994011026A2 (en) | 1992-11-13 | 1994-05-26 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
CA2106612C (en) * | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
DE69732129T2 (de) * | 1996-09-13 | 2005-12-08 | Transkaryotic Therapies, Inc., Cambridge | THERAPIE FÜR alpha GALACTOSIDASE A INSUFFIZIENZ |
SI1900751T1 (sl) * | 1996-11-27 | 2010-03-31 | Genentech Inc | Afinitetno čiščenje polipeptida na proteinskemA matriksu |
JP4469933B2 (ja) * | 1998-05-06 | 2010-06-02 | ジェネンテック, インコーポレイテッド | イオン交換クロマトグラフィによるタンパク質精製 |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US8372954B2 (en) | 2000-12-22 | 2013-02-12 | National Research Council Of Canada | Phage display libraries of human VH fragments |
UA100967C2 (ru) * | 2001-02-01 | 2013-02-25 | Байоджен Айдек Ма Інк. | Конъюгаты нейбластина с полимерами и способы их применения |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
US20070261962A1 (en) * | 2002-04-02 | 2007-11-15 | Ryszard Gajek | Separation Systems with Charge Mosaic Membrane |
AU2003301399B2 (en) * | 2002-10-18 | 2006-07-06 | Asahi Kasei Medical Co., Ltd. | Microporous hydrophilic membrane |
SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
JP2008510466A (ja) | 2004-08-19 | 2008-04-10 | ジェネンテック・インコーポレーテッド | エフェクター機能が変更しているポリペプチド変異体 |
NZ580115A (en) | 2004-09-23 | 2010-10-29 | Genentech Inc | Cysteine engineered antibody light chains and conjugates |
ES2797480T3 (es) * | 2005-03-11 | 2020-12-02 | Wyeth Llc | Un procedimiento de cromatografía de reparto débil |
JP2008537153A (ja) | 2005-04-22 | 2008-09-11 | ウオーターズ・インベストメンツ・リミテツド | 生体高分子の質量分析管理された精製のための装置および方法 |
AU2007291282B2 (en) * | 2006-08-28 | 2011-10-20 | Ares Trading S.A. | Process for the purification of Fc-fusion proteins |
NZ574626A (en) * | 2006-08-28 | 2011-12-22 | Ares Trading Sa | Process for removing free Fc-moieties from fluids comprising Fc-containing proteins using ion exchange chromatography |
AU2008256411B2 (en) | 2007-06-01 | 2013-08-22 | F. Hoffmann-La Roche Ag | Immunoglobulin purification |
DE102009005479A1 (de) * | 2009-01-21 | 2010-07-22 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren für die Stofftrennung |
JP5614936B2 (ja) * | 2009-02-19 | 2014-10-29 | 旭化成ケミカルズ株式会社 | アニオン交換基が固定された多孔膜を用いた核酸の精製方法 |
CN102574911B (zh) * | 2009-08-07 | 2017-06-06 | Emd密理博公司 | 从样品的一或多种杂质中纯化靶蛋白的方法 |
WO2011035282A1 (en) * | 2009-09-21 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Dual capture separation |
CN102094034A (zh) * | 2009-12-09 | 2011-06-15 | 泰州新生源生物医药有限公司 | 一种重组人Fc融合长效干扰素的纯化工艺 |
WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
AU2011329053A1 (en) * | 2010-11-15 | 2013-06-06 | Biogen Inc. | Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography |
CN107163101B (zh) | 2011-11-02 | 2021-08-17 | 弗·哈夫曼-拉罗切有限公司 | 超载和洗脱层析 |
-
2012
- 2012-11-02 CN CN201710173196.8A patent/CN107163101B/zh active Active
- 2012-11-02 JP JP2014540118A patent/JP6356607B2/ja active Active
- 2012-11-02 HU HUE12845437A patent/HUE035685T2/en unknown
- 2012-11-02 LT LTEP17157670.5T patent/LT3257564T/lt unknown
- 2012-11-02 PL PL12845437T patent/PL2773438T5/pl unknown
- 2012-11-02 ES ES12845437T patent/ES2637423T5/es active Active
- 2012-11-02 EP EP12845437.8A patent/EP2773438B2/en active Active
- 2012-11-02 DK DK17157670.5T patent/DK3257564T3/en active
- 2012-11-02 CN CN201280065729.6A patent/CN104023804B/zh active Active
- 2012-11-02 PT PT17157670T patent/PT3257564T/pt unknown
- 2012-11-02 RS RS20190358A patent/RS58472B1/sr unknown
- 2012-11-02 ES ES17157670T patent/ES2717536T3/es active Active
- 2012-11-02 MX MX2014005330A patent/MX2014005330A/es unknown
- 2012-11-02 WO PCT/US2012/063242 patent/WO2013067301A1/en active Application Filing
- 2012-11-02 HU HUE17157670A patent/HUE043755T2/hu unknown
- 2012-11-02 SI SI201231562T patent/SI3257564T1/sl unknown
- 2012-11-02 KR KR1020147014357A patent/KR20140091721A/ko not_active Application Discontinuation
- 2012-11-02 SI SI201231031T patent/SI2773438T2/sl unknown
- 2012-11-02 CA CA2854330A patent/CA2854330A1/en not_active Abandoned
- 2012-11-02 PL PL17157670T patent/PL3257564T3/pl unknown
- 2012-11-02 DK DK12845437.8T patent/DK2773438T4/da active
- 2012-11-02 AU AU2012323995A patent/AU2012323995B2/en active Active
- 2012-11-02 TR TR2019/03707T patent/TR201903707T4/tr unknown
- 2012-11-02 RU RU2014121884/10A patent/RU2014121884A/ru not_active Application Discontinuation
- 2012-11-02 SG SG11201402019TA patent/SG11201402019TA/en unknown
- 2012-11-02 US US14/355,818 patent/US20140301977A1/en not_active Abandoned
- 2012-11-02 BR BR112014010406A patent/BR112014010406A2/pt not_active Application Discontinuation
- 2012-11-02 EP EP17157670.5A patent/EP3257564B1/en active Active
- 2012-11-02 EP EP18206718.1A patent/EP3527274A1/en active Pending
-
2014
- 2014-04-22 IL IL232146A patent/IL232146A0/en unknown
- 2014-04-23 ZA ZA2014/02932A patent/ZA201402932B/en unknown
-
2015
- 2015-03-02 HK HK15102085.5A patent/HK1201489A1/xx unknown
-
2018
- 2018-04-18 US US15/956,635 patent/US20190023768A1/en not_active Abandoned
- 2018-06-14 JP JP2018113263A patent/JP2018184405A/ja active Pending
-
2019
- 2019-03-11 HR HRP20190485TT patent/HRP20190485T1/hr unknown
- 2019-11-20 JP JP2019209674A patent/JP6979442B2/ja active Active
-
2020
- 2020-10-20 US US17/075,238 patent/US20210206836A1/en active Pending
-
2021
- 2021-11-15 JP JP2021185350A patent/JP7203928B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20190485T1 (hr) | Kromatografija preopterećenja i elucijska kromatografija | |
HUS2100012I1 (hu) | 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók | |
HK1211258A1 (en) | Chromatographic materials | |
HK1205041A1 (en) | Chromatography columns | |
EP2831096A4 (en) | AFFINITY CHROMATOGRAPHY MATRIX | |
HK1214938A1 (zh) | 分析輔件 | |
EP2780789A4 (en) | CHROMATOGRAPHIC CONFIGURATION INTERFACE | |
GB201020148D0 (en) | Chromatography column | |
PL2691770T3 (pl) | Prekoncentrator | |
EP2590722A4 (en) | TIMING PROCEDURE | |
GB201111775D0 (en) | Compounds and uses thereof | |
GB2478652B (en) | Chromatography assembly | |
AU346758S (en) | Chromatography column | |
GB201020146D0 (en) | Chromatography column | |
EP2803993A4 (en) | AUTOMATIC SAMPLER | |
GB201118317D0 (en) | Intrathermic and interthermic extractive thermiats | |
AU346759S (en) | Chromatography system | |
LT3689878T (lt) | 4-imidazopiridazin-1-il-benzamidai ir 4-imidazotriazin-1-il-benzamidai kaip btk inhibitoriai | |
GB201121726D0 (en) | Compounds and uses thereof | |
GB201121551D0 (en) | Compounds and uses thereof |