KR910018024A - 경피흡수성 에페리손 또는 톨페리손 제제 - Google Patents
경피흡수성 에페리손 또는 톨페리손 제제 Download PDFInfo
- Publication number
- KR910018024A KR910018024A KR1019910006675A KR910006675A KR910018024A KR 910018024 A KR910018024 A KR 910018024A KR 1019910006675 A KR1019910006675 A KR 1019910006675A KR 910006675 A KR910006675 A KR 910006675A KR 910018024 A KR910018024 A KR 910018024A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- salt
- salts
- polyvinylpyrrolidone
- base
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예와 비교실시 예에서 테입의 에페리손 염산염의 경피흡수율을 나타내는 그라프. 제2도는 실시예와 비교실시 예에서 테입의 에페리손 염산염의 용출 속도를 나타내는 그라프, 제3도는 실시예와 비교실시 예에서 테입의 톨페리손 염산염의 경피흡수율을 나타내는 그라프.
Claims (5)
- 에페리손, 그의 염, 톨페리손 또는 그의 염의 약리학적 유효량, 물에 의해 팽창하는 교차결합된 폴리비닐피롤리돈 및 기제로 구성되는 것을 특징으로 하는 경피투여되는 약학적 조성물.
- 제1항에 있어서, 에페리손, 그의 염 , 톨페리손 또는 그의 염을 0.05 내지 30중량%, 물에 의해 팽창하는 교차결합 될 폴리비닐피롤리돈을 0.5 내지 20중량% 그리고 기제를 포함하는 것을 특징으로 하는 약학적 조성물.
- 제1항에 있어서, 상기 폴리비닐피롤리돈이 N-비닐-2-피롤리돈과 N-비닐-2-피롤리돈의 0.1 내지 20중량%의 다관능성 단량체와의 공중합체인 것을 특징으로 하는 약학적 조성물.
- 제1항에 있어서, 에페리손, 그의 염, 톨페리손 또는 그의 염 0.05 내지 30중량%, 물에의해 팽창하는 교차결합된 폴리비닐 피롤리돈 0.5 내지 20중량%, 기제 및 10중량%까지의 경피흡수 증진제를 포함하는 것을 특징으로 하는 약학적 조성물.
- 제1항에 있어서, 에페리손, 그의 염, 톨페리손 및 그의 염은 각각의 포화용해도 이상 함유되고, 기제에 미세결정상으로 분산되어 있는 것을 특징으로 하는 약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11279290 | 1990-04-27 | ||
JP2-112.792 | 1990-04-27 | ||
JP2-112792 | 1990-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910018024A true KR910018024A (ko) | 1991-11-30 |
KR930007407B1 KR930007407B1 (ko) | 1993-08-10 |
Family
ID=14595632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910006675A KR930007407B1 (ko) | 1990-04-27 | 1991-04-25 | 경피흡수성 에페리손 또는 톨페리손 제제 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0454089B1 (ko) |
JP (1) | JP3170304B2 (ko) |
KR (1) | KR930007407B1 (ko) |
CN (1) | CN1049817C (ko) |
AT (1) | ATE109980T1 (ko) |
CA (1) | CA2041330C (ko) |
DE (1) | DE69103459T2 (ko) |
DK (1) | DK0454089T3 (ko) |
ES (1) | ES2058977T3 (ko) |
MY (1) | MY115126A (ko) |
PT (1) | PT97505B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252334A (en) * | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
JPH06247846A (ja) * | 1993-02-22 | 1994-09-06 | Toko Yakuhin Kogyo Kk | 塩酸リトドリンの経皮吸収製剤用組成物 |
AU7396294A (en) † | 1993-06-25 | 1995-01-24 | Alza Corporation | Incorporating poly-n-vinyl amide in a transdermal system |
CN1188189C (zh) * | 1995-06-07 | 2005-02-09 | 奥瑟-麦内尔制药公司 | 基质层含有17-脱乙酰基诺孕酯的经皮贴片及基质的用途 |
AT409083B (de) * | 1999-04-01 | 2002-05-27 | Sanochemia Pharmazeutika Ag | Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung |
JP5209433B2 (ja) * | 2007-10-19 | 2013-06-12 | 日東電工株式会社 | 貼付製剤 |
US20100266670A1 (en) * | 2007-12-10 | 2010-10-21 | Akira Yamamoto | Transdermally absorptive preparation |
JP5631854B2 (ja) * | 2010-12-13 | 2014-11-26 | 久光製薬株式会社 | 医薬組成物および貼付剤 |
KR20140118410A (ko) * | 2013-03-29 | 2014-10-08 | 초당약품공업 주식회사 | 저장 및 pH 안정성이 개선된 에페리손 의약 조성물 |
US10300025B2 (en) * | 2016-07-27 | 2019-05-28 | Corium, Inc. | Donepezil transdermal delivery system |
WO2020086046A2 (en) * | 2018-10-26 | 2020-04-30 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Topical compositions comprising tolperisone and flurbiprofen combination |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL61721A (en) * | 1980-12-16 | 1984-03-30 | Blank Izhak | Nitroglycerin preparations |
AU563054B2 (en) * | 1984-10-24 | 1987-06-25 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Percutaneous tape of isdn |
JPH0720866B2 (ja) * | 1987-05-15 | 1995-03-08 | 三生製薬株式会社 | エペリゾン又はトルペリゾン或いはそれらの塩類含有経皮適用製剤 |
-
1991
- 1991-04-10 MY MYPI91000596A patent/MY115126A/en unknown
- 1991-04-23 JP JP09189691A patent/JP3170304B2/ja not_active Expired - Fee Related
- 1991-04-24 AT AT91106600T patent/ATE109980T1/de not_active IP Right Cessation
- 1991-04-24 ES ES91106600T patent/ES2058977T3/es not_active Expired - Lifetime
- 1991-04-24 EP EP91106600A patent/EP0454089B1/en not_active Expired - Lifetime
- 1991-04-24 DE DE69103459T patent/DE69103459T2/de not_active Expired - Fee Related
- 1991-04-24 DK DK91106600.9T patent/DK0454089T3/da active
- 1991-04-25 KR KR1019910006675A patent/KR930007407B1/ko not_active IP Right Cessation
- 1991-04-26 CN CN91102645A patent/CN1049817C/zh not_active Expired - Fee Related
- 1991-04-26 CA CA002041330A patent/CA2041330C/en not_active Expired - Fee Related
- 1991-04-26 PT PT97505A patent/PT97505B/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2041330C (en) | 1996-05-28 |
JPH04217919A (ja) | 1992-08-07 |
EP0454089A1 (en) | 1991-10-30 |
PT97505B (pt) | 1998-08-31 |
CN1056055A (zh) | 1991-11-13 |
KR930007407B1 (ko) | 1993-08-10 |
CN1049817C (zh) | 2000-03-01 |
MY115126A (en) | 2003-04-30 |
JP3170304B2 (ja) | 2001-05-28 |
ES2058977T3 (es) | 1994-11-01 |
DE69103459D1 (de) | 1994-09-22 |
PT97505A (pt) | 1992-01-31 |
EP0454089B1 (en) | 1994-08-17 |
DK0454089T3 (da) | 1994-09-19 |
DE69103459T2 (de) | 1995-01-19 |
CA2041330A1 (en) | 1991-10-28 |
ATE109980T1 (de) | 1994-09-15 |
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