KR910009259A - 천식 또는 특정 피부 질환의 치료를 위한 피리미돈 유도체 및 동족체 - Google Patents

천식 또는 특정 피부 질환의 치료를 위한 피리미돈 유도체 및 동족체 Download PDF

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Publication number
KR910009259A
KR910009259A KR1019900018241A KR900018241A KR910009259A KR 910009259 A KR910009259 A KR 910009259A KR 1019900018241 A KR1019900018241 A KR 1019900018241A KR 900018241 A KR900018241 A KR 900018241A KR 910009259 A KR910009259 A KR 910009259A
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South Korea
Prior art keywords
pharmaceutical composition
asthma
compound
treatment
skin diseases
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KR1019900018241A
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English (en)
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KR930001832B1 (ko
Inventor
비. 쳉 존
Original Assignee
알렌 제이. 스피겔
화이자 인코포레이티드
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Publication of KR910009259A publication Critical patent/KR910009259A/ko
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Publication of KR930001832B1 publication Critical patent/KR930001832B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

천식 또는 특정 피부 질환의 치료를 위한 피리미돈 유도체 및 동족체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 천식 또는 기도 또는 피부염증을 경감시키는 양의 하기 일반식(1)의 광학적 활성 또는 라세미 화합물 또는 X가 NH인 경우 그의 약제학적으로 허용가능한 산부가염과 약제학적으로 허용가능한 담체를 포함하는, 사람의 천식 또는 염증성 기도 또는 피부 질환의 치료를 위한 약제학적 조성물 :
    상기식에서, R1은 탄소수 7 내지 11의 폴리사이클로알킬 그룹이고; R2는 메틸 또는 에틸이며; X는 0 또는 NH이고; Y는
    또는이며;
    R3은 수소, (C1-C3)알킬, (C2-C3)알케닐, 벤질 또는 펜에틸이고; R4는 수소, (C1-C3)알킬 또는 (C2-C3)알카노일이다.
  2. 제1항에 있어서, R2가 메틸이고, X가 0인 약제학적 조성물.
  3. 제2항에 있어서, Y가
    인 약제학적 조성물.
  4. 제3항에 있어서, R1이 바이시클로[2.2.1]헵트-2-일인 약제학적 조성물.
  5. 제4항에 있어서, R1이 엑소-바이시클로[2.2.1]헵트-2-일인 약제학적 조성물.
  6. 제5항에 있어서, 화합물이 라세미 형태인 약제학적 조성물.
  7. 제5항에 있어서, 화합물이 광학적으로 활성인 약제학적 조성물.
  8. 만성 천식을 치료하기 위한 제1항 또는 제5항의 약제학적 조성물.
  9. 건선을 치료하기 위한 제1항 또는 제5항의 약제학적 조성물.
  10. 아토피성 피부염을 치료하기 위한 제1항 또는 제5항의 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900018241A 1989-11-13 1990-11-12 천식 또는 특정 피부 질환의 치료를 위한 피리미돈 유도체 및 동족체 KR930001832B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1989/005221 WO1991007177A1 (en) 1989-11-13 1989-11-13 Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
US05221 1989-11-13
US89/05221 1989-11-13

Publications (2)

Publication Number Publication Date
KR910009259A true KR910009259A (ko) 1991-06-28
KR930001832B1 KR930001832B1 (ko) 1993-03-15

Family

ID=22215372

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900018241A KR930001832B1 (ko) 1989-11-13 1990-11-12 천식 또는 특정 피부 질환의 치료를 위한 피리미돈 유도체 및 동족체

Country Status (17)

Country Link
US (1) US5342842A (ko)
EP (1) EP0428313B1 (ko)
JP (2) JPH0662412B2 (ko)
KR (1) KR930001832B1 (ko)
AT (1) ATE101040T1 (ko)
AU (1) AU627631B2 (ko)
CA (1) CA2029704C (ko)
DE (1) DE69006452T2 (ko)
DK (1) DK0428313T3 (ko)
HU (1) HU212311B (ko)
IE (1) IE63472B1 (ko)
IL (1) IL96260A (ko)
MY (1) MY111474A (ko)
NZ (1) NZ236038A (ko)
PT (1) PT95854B (ko)
WO (2) WO1991007177A1 (ko)
ZA (1) ZA909043B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5814651A (en) * 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
PL309257A1 (en) * 1992-12-02 1995-10-02 Pfizer Pirocatechin doethers as selective inhibitors of ped iv
US5482944A (en) * 1993-07-13 1996-01-09 Pfizer Inc. Pyrimidones and imidazolinones for treatment of shock
JP2818820B2 (ja) * 1993-11-26 1998-10-30 ファイザー・インク． 抗炎症剤としての３−アリール−２−イソオキサゾリン類
US5502072A (en) * 1993-11-26 1996-03-26 Pfizer Inc. Substituted oxindoles
DK0749428T3 (da) * 1994-03-09 1998-11-16 Pfizer Isooxazolinforbindelser som inhibitorer af TNF-frigivelse
JPH09505081A (ja) * 1994-03-09 1997-05-20 ファイザー・インコーポレーテッド ５−リポキシゲナーゼ阻害物質としてのイソキサゾリン化合物
US5563143A (en) * 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
US6265402B1 (en) 1996-08-27 2001-07-24 Nikken Chemicals Co., Ltd. Use of 2-phenylmorpholin-5-one derivatives
CA2402384A1 (en) * 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2401446A1 (de) * 1973-01-16 1974-07-25 Voorhees Pharmazeutische zubereitungen zur linderung von hautproliferationserkrankungen
SU888821A3 (ru) * 1976-12-03 1981-12-07 Шеринг Аг (Инофирма) Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов
DE3315797A1 (de) * 1983-04-30 1984-10-31 Beiersdorf Ag, 2000 Hamburg Substituierte phenyl-2-(1h)-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8416140D0 (en) * 1984-06-25 1984-08-01 Fujisawa Pharmaceutical Co Pyrimidinone derivatives
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant

Also Published As

Publication number Publication date
PT95854B (pt) 1997-11-28
MY111474A (en) 2000-06-30
HU9201575D0 (en) 1993-04-28
IE904058A1 (en) 1991-05-22
IL96260A (en) 1995-11-27
ZA909043B (en) 1992-06-24
US5342842A (en) 1994-08-30
NZ236038A (en) 1997-03-24
JP2514163B2 (ja) 1996-07-10
AU627631B2 (en) 1992-08-27
PT95854A (pt) 1991-09-13
HU212311B (en) 1996-05-28
AU6653690A (en) 1991-08-01
CA2029704C (en) 1995-02-07
JPH0748255A (ja) 1995-02-21
EP0428313A3 (en) 1991-11-06
IL96260A0 (en) 1991-08-16
JPH03209322A (ja) 1991-09-12
CA2029704A1 (en) 1991-05-14
EP0428313B1 (en) 1994-02-02
KR930001832B1 (ko) 1993-03-15
IE63472B1 (en) 1995-04-19
DE69006452T2 (de) 1994-05-11
JPH0662412B2 (ja) 1994-08-17
DE69006452D1 (de) 1994-03-17
ATE101040T1 (de) 1994-02-15
WO1991007177A1 (en) 1991-05-30
HUT70052A (en) 1995-09-28
EP0428313A2 (en) 1991-05-22
WO1991007178A1 (en) 1991-05-30
DK0428313T3 (da) 1994-03-07

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