KR910000638A - 피롤카르복시산 유도체 - Google Patents

피롤카르복시산 유도체 Download PDF

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Publication number
KR910000638A
KR910000638A KR1019890008697A KR890008697A KR910000638A KR 910000638 A KR910000638 A KR 910000638A KR 1019890008697 A KR1019890008697 A KR 1019890008697A KR 890008697 A KR890008697 A KR 890008697A KR 910000638 A KR910000638 A KR 910000638A
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KR
South Korea
Prior art keywords
carbon atoms
group
pharmaceutically acceptable
alkyl group
hydrogen atom
Prior art date
Application number
KR1019890008697A
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English (en)
Inventor
마사오 타니구찌
코헤이 우메즈
다다시 시라사까
신야 이노우에
테쯔로 신푸꾸
마사유끼 미쯔까
마유미 히라타
Original Assignee
미쓰비시 가세이 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 미쓰비시 가세이 가부시끼가이샤 filed Critical 미쓰비시 가세이 가부시끼가이샤
Publication of KR910000638A publication Critical patent/KR910000638A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

내용 없음

Description

피롤카르복시산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(Ⅰ)으로 표시되는 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염:
    상기식에서, R1은 수소원자, 5내지 25개 탄소원자를 갖는 알킬기 또는 5내지 25개탄소원자를 갖는 알켄일기이고, R2는 수소원자, 페닐기 또는 임의로 치환된 1내지10개 탄소원자를 갖는 알킬기이며, 또 R3은 수소원자, 5내지 25개 탄소원자를 갖는 알킬기 또는 5내지 25개 탄소원자를 갖는 알켄일기임.
  2. 제1항에 있어서, R2가 할로겐 원자 히드록시기, 아미노기, 1내지 5개 탄소원자를 갖는 알킬아미노기, 2내지 10탄소원자를 갖는 디알킬아미노기, 카르바모일기, 1내지 5개 탄소원자를 갖는 알킬카르보닐아미노기, 1내지 5개 탄소원자를 갖는 알킬티오기, 메르캅토기, 1내지 5개 탄소원자를 갖는 알킬 카르보닐옥시기 또는 아미노카르보닐옥시기에 의해 치환된 알킬기인 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염.
  3. 제1항에 있어서, R1이 10내지 16개 탄소 원자를 갖는 알킬기 또는 10내지 16개 탄소원자를 갖는 알켄일기인 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염.
  4. 제1항 또는 제2항에 있어서, R2가 수소원자, 페닐기 또는 임의로 치환된 1내지 4개 탄소원자를 갖는 직쇄 또는 측쇄 알킬기인 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염.
  5. 제1항에 있어서, R3이 수소원자인 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염.
  6. 제1항에 있어서, R3이 10내지 16개 탄소원자를 갖는 알킬기 또는 10내지 16개 탄소원자를 갖는 알켄일기인 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염.
  7. 하기 일반식(Ⅰ)으로 표시되는 치료유효량의 피롤카르복시산 유도체 또는 약제학적으로 허용되는 그의 염을 약제학적으로 허용되는 담체 또는 희석제와 함께 포함하는, 과지방혈증 및/또는 동맥 경하증을 치료하기 위한 약제 조성물.
    상기식에서, R1은 수소원자, 5내지 25개 탄소원자를 갖는 알킬기 또는 5내지 25개 탄소원자를 갖는 알켄일기이고, R3는 수소원자, 페닐기 또는 임의로 치환된 1내지 10개 탄소원자를 갖는 알킬기이며, 또 R3은 수소원자, 5내지 25개 탄소원자를 갖는 알킬기 또는 5내지 2개 탄소원자를 갖는 알켄일기임.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890008697A 1988-06-23 1989-06-23 피롤카르복시산 유도체 KR910000638A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15568988 1988-06-23
JP155689/88 1988-06-23
JP32446988 1988-12-22
JP324469/88 1988-12-22
JP88512/89 1989-04-07
JP8851289 1989-04-07

Publications (1)

Publication Number Publication Date
KR910000638A true KR910000638A (ko) 1991-01-29

Family

ID=27305835

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890008697A KR910000638A (ko) 1988-06-23 1989-06-23 피롤카르복시산 유도체

Country Status (3)

Country Link
US (1) USRE35096E (ko)
JP (1) JPH06104658B2 (ko)
KR (1) KR910000638A (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100460414B1 (ko) * 1995-11-02 2005-01-26 다이이찌 산토리 파마 가부시키가이샤 1-치환피롤-3-카르복실산유도체의제조방법
JPH09183765A (ja) 1995-11-02 1997-07-15 Suntory Ltd １位置換ピロール−３−カルボン酸誘導体の製造法
NZ520640A (en) * 2000-02-15 2005-04-29 Upjohn Co Pyrrole substituted 2-indolinone protein kinase inhibitors
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2003031438A1 (en) 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors
PL2513053T3 (pl) 2009-12-18 2018-03-30 Ogeda Sa Pochodne kwasu pirolidyno-karboksylowego jako agoniści receptora 43 sprzężonego z białkiem G (GPR43), kompozycja farmaceutyczna i sposoby do zastosowania w leczeniu zaburzeń metabolicznych
EP3610872A1 (en) 2013-11-27 2020-02-19 Epics Therapeutics Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500713A (en) * 1946-11-13 1950-03-14 American Cyanamid Co Monoalkamine esters of pyrrole-3-carboxylic acids
US2479971A (en) * 1946-11-13 1949-08-23 American Cyanamid Co Monoalkamine esters of pyrrole-3-carboxylic acids
US2479972A (en) * 1946-11-14 1949-08-23 American Cyanamid Co Monoalkamine esters of pyrrole-5-carboxylic acids
GB1592996A (en) * 1977-10-10 1981-07-15 Rolland Sa A Acylated pyrrole carboxylic acids and derivatives thereof
US4382143A (en) * 1979-07-23 1983-05-03 American Cyanamid Company Hypolipidemic and antiatherosclerotic novel (monosubstituted-amino)heteroaryl carboxylic acids and analogs
JPS5885861A (ja) * 1981-11-18 1983-05-23 Nippon Soda Co Ltd ２，３−ジ置換ピロ−ル類の製造方法
JPS6144815A (ja) * 1984-08-10 1986-03-04 Kitasato Inst:The 血小板凝集阻害剤
US4560700A (en) * 1985-02-08 1985-12-24 Merrell Dow Pharmaceuticals Inc. Pyrrole-3-carboxylate cardiotonic agents
US4824958A (en) * 1986-06-13 1989-04-25 Warner-Lambert Company Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides
CA2032421A1 (en) * 1989-12-20 1991-06-21 Mitsubishi Chemical Corporation Pyrrolealdehyde derivative

Also Published As

Publication number Publication date
JPH0347165A (ja) 1991-02-28
JPH06104658B2 (ja) 1994-12-21
USRE35096E (en) 1995-11-21

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