KR930702339A - 에폭시숙시남산 유도체 - Google Patents

에폭시숙시남산 유도체

Info

Publication number
KR930702339A
KR930702339A KR1019930700858A KR930700858A KR930702339A KR 930702339 A KR930702339 A KR 930702339A KR 1019930700858 A KR1019930700858 A KR 1019930700858A KR 930700858 A KR930700858 A KR 930700858A KR 930702339 A KR930702339 A KR 930702339A
Authority
KR
South Korea
Prior art keywords
group
succinic acid
acid derivative
epoxy succinic
acid derivatives
Prior art date
Application number
KR1019930700858A
Other languages
English (en)
Other versions
KR0167084B1 (ko
Inventor
미츠오 무라타
시게유끼 수미야
치히로 요꼬오
가츠오 하타야마
Original Assignee
우에하라 아끼라
다이쇼 세이야꾸 가부시끼사이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우에하라 아끼라, 다이쇼 세이야꾸 가부시끼사이샤 filed Critical 우에하라 아끼라
Publication of KR930702339A publication Critical patent/KR930702339A/ko
Application granted granted Critical
Publication of KR0167084B1 publication Critical patent/KR0167084B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

하기 식로 표시되는 에폭시 숙시남산 유도체
(식중, R1은 탄소원자수 1~10의 알킬기, 페닐기 또는 벤질기를 나타내고, R3는 카르복실기의 보호기를 나타낸다.) 그의 약학적으로 허용되는 염, 그의 중간체가 개시되었다. 식 I의 화합물은 근육 붕괴 질환 치료약으로서 유용하다.

Description

에폭시숙시남산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 식
  3. (식중, R1은 탄소원자수 1~10의 알킬기, 페닐기 또는 벤질기를 나타낸다.)로 표시되는 에폭시숙시남산 유도체 및 그의 약학적으로 허용되는 염.
  4. 제1항에 있어서, 식 I 화합물이 N-(L-3-트랜스-n-프로필 카르바모일옥시란-2-카르보닐)-L-이소로이실-L-프롤린인 에폭시숙시남산 유도체.
  5. 제1항에 있어서, 식 I 화합물이 N-(L-3-트랜스-n-펜틸카르바모일옥시란-2-카르보닐)-L-이소로이실-L-프롤린인 에폭시숙시남산 유도체.
  6. 하기 식Ⅱ로 표시되는 에폭시숙시남산 유도체.
  8. (식중, R1은 탄소원자수 1~10의 알킬기, 페닐기 또는 벤질기를 나타내고, R3는 카르복실기의 보호기를 나타낸다).
  9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930700858A 1990-09-29 1991-09-27 에폭시숙시남산 유도체 KR0167084B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2261657A JP2808877B2 (ja) 1990-09-29 1990-09-29 エポキシスクシナム酸誘導体およびその中間体
JP90-261657 1990-09-29
PCT/JP1991/001288 WO1992006090A1 (en) 1990-09-29 1991-09-27 Epoxysuccinamic acid derivative

Publications (2)

Publication Number Publication Date
KR930702339A true KR930702339A (ko) 1993-09-08
KR0167084B1 KR0167084B1 (ko) 1999-01-15

Family

ID=17364955

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700858A KR0167084B1 (ko) 1990-09-29 1991-09-27 에폭시숙시남산 유도체

Country Status (9)

Country Link
US (1) US5281717A (ko)
EP (1) EP0555479B1 (ko)
JP (1) JP2808877B2 (ko)
KR (1) KR0167084B1 (ko)
AT (1) ATE146481T1 (ko)
CA (1) CA2092919C (ko)
DE (1) DE69123757T2 (ko)
ES (1) ES2098370T3 (ko)
WO (1) WO1992006090A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5348970A (en) * 1993-09-22 1994-09-20 Merck & Co., Inc. Antifungal compound and compositions containing the compound
AU8997898A (en) * 1997-09-04 1999-03-22 Nippon Chemiphar Co. Ltd. Epoxysuccinamide derivatives
US6162791A (en) * 1998-03-02 2000-12-19 Apotex Inc. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
US20080227806A1 (en) * 2005-09-28 2008-09-18 American Life Science Pharmaceuticals Novel Drugs for Dementia
US20070238814A1 (en) * 2006-04-10 2007-10-11 Basf Corporation Method of making coating compositions
US8673904B2 (en) 2006-06-13 2014-03-18 The Board Of Trustees Of The Leland Stanford Junior University Epoxide inhibitors of cysteine proteases
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55115878A (en) * 1979-02-27 1980-09-06 Taisho Pharmaceut Co Ltd Epoxysuccinic acid derivative
JPS5772913A (en) * 1980-10-22 1982-05-07 Nippon Chemiphar Co Ltd Remedy for cardiac infraction
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
US5068354A (en) * 1989-05-18 1991-11-26 Taisho Pharmaceutical Co., Ltd. Epoxysuccinic acid derivatives

Also Published As

Publication number Publication date
DE69123757T2 (de) 1997-06-26
CA2092919A1 (en) 1992-03-30
JP2808877B2 (ja) 1998-10-08
ES2098370T3 (es) 1997-05-01
EP0555479A1 (en) 1993-08-18
EP0555479B1 (en) 1996-12-18
JPH04139182A (ja) 1992-05-13
DE69123757D1 (de) 1997-01-30
CA2092919C (en) 2001-08-07
KR0167084B1 (ko) 1999-01-15
EP0555479A4 (ko) 1994-02-09
US5281717A (en) 1994-01-25
ATE146481T1 (de) 1997-01-15
WO1992006090A1 (en) 1992-04-16

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