KR900007827A - 심장보호 작용을 갖는 토코페롤 유사체 - Google Patents
심장보호 작용을 갖는 토코페롤 유사체 Download PDFInfo
- Publication number
- KR900007827A KR900007827A KR1019890016464A KR890016464A KR900007827A KR 900007827 A KR900007827 A KR 900007827A KR 1019890016464 A KR1019890016464 A KR 1019890016464A KR 890016464 A KR890016464 A KR 890016464A KR 900007827 A KR900007827 A KR 900007827A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- methyl groups
- general formula
- groups
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (22)
- 하기 일반식의 화합물, 그의 (R) 및 (S)거울상이성질체, 및 그의 라세미체 혼합물 및 제약학상 허용되는 그의 염.[상기 식중, Q는 NR1R2또는 NR1R2R3·X이고, X는 할라이드 또는 OS(0)2R4(R4는 H, C1-6알킬, 알릴 또는 아릴킬이고, R1,R2및 R3는 각각 독립적으로 C1-6저급 알킬이고, R5는 H 또는 C1-6알킬이고, R6은 H 또는 -C(0)R이고, 여기서 R는 H 또는 C1-6알킬이고R7은 H 또는 C1-6알킬이고 R8은 H 또는 C1-6알킬이고, n은 1 내지 6의 정수].
- 제1항에 있어서,상기 Q가 NR1R2R3·X인 화합물.
- 제2항에 있어서,상기 R5R7및 R8이 메틸기인 화합물.
- 제2항에 있어서, 상기 R1R2및 R3가 메틸기인 화합물.
- 제2항에 있어서, 상기 X가 클로로, 브로모 또는 p-톨루엔술포닐인 화합물.
- 제2항에 있어서, 상기 R6가 H인 화합물.
- 제2항에 있어서, 상기 R6가 R(CO)-인 화합물.
- 제2항에 있어서, 상기 n이 2인 화합물.
- 제8항에 있어서, 상기 R1,R2,R3,R5,R7및 R8인 메틸기인 화합물.
- 제9항에 있어서, 상기 R6가 H인 화합물.
- 제10항에 있어서, 상기 X가 클로로, 브로모 또는 p-톨루엔술포닐인 화합물.
- 제9항에 있어서, 상기 R6가 R(CO)-인 화합물.
- 제12항에 있어서, 상기 X가 클로로, 브로모 또는 p-톨루엔술포닐인 화합물.
- 제1항에 있어서, 상기 Q가 NR1R2인 화합물.
- 제14항에 있어서, 상기 R5, R7및 R8이 메틸기인 화합물.
- 제14항에 있어서, 상기 R1및 R2가 메틸기인 화합물.
- 제14항에 있어서, 상기 R6가 H인 화합물.
- 제14항에 있어서, 상기 R6가 R(CO)-인 화합물.
- 제14항에 있어서, 상기 R6가 R(CO)-인 화합물.
- 제19항에 있어서, 상기 R1,R2,R5,R7및 R8이 메틸기이고, R6가 H-인 화합물.
- 제19항에 있어서, 상기 R1,R2,R5,R7및 R8이 메틸기이고 R6가 R(CO)-인 화합물.
- (a) 하기 일반식의 화합물을 일반식 R3X의 화합물과 함께 아민화시키고,(b) 하기 일반식의 화합물을 일반식 HNR1R2또는 NR1R2R3의 디알킬아미노 또는 트리알킬아민과 함께 아민화시키는것으로 되는 하기 일반식 화합물의 제조 방법.[상기 식중, Q는 NR1R2또는 NR1R2R3·X이고, R5,R7및 R8은 H이거나 또는 C1-6알킬기이고, R1,R2및 R3는 C1-6알킬기이고, X는 할라이드 또는 OS(O)2R4(R4는 H, C1-6알킬, 아릴 또는 아랄킬임)이고, R6는 H, R-(CO) (R은 H 또는 C1-9알킬임)이고 n은 1 내지 6의 정수].※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88402853A EP0369082A1 (en) | 1988-11-14 | 1988-11-14 | Cardioprotective tocopherol analogs |
EP88402853.1 | 1988-11-14 | ||
US402854.9 | 1988-11-14 | ||
US402853.1 | 1988-11-14 | ||
EP88402854.9 | 1988-11-14 | ||
EP88402854A EP0369083A1 (en) | 1988-11-14 | 1988-11-14 | Cardioprotective tocopherol analogs |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900007827A true KR900007827A (ko) | 1990-06-02 |
KR0160112B1 KR0160112B1 (ko) | 1998-12-01 |
Family
ID=26118102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890016464A KR0160112B1 (ko) | 1988-11-14 | 1989-11-13 | 심장보호 작용을 갖는 토코페롤 유사체 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0369874B1 (ko) |
JP (1) | JP3066901B2 (ko) |
KR (1) | KR0160112B1 (ko) |
CN (1) | CN1033972C (ko) |
AR (1) | AR246962A1 (ko) |
AT (1) | ATE118771T1 (ko) |
AU (1) | AU620660B2 (ko) |
CA (1) | CA2002649C (ko) |
DE (1) | DE68921298T2 (ko) |
DK (1) | DK568189A (ko) |
ES (1) | ES2071674T3 (ko) |
FI (1) | FI91404C (ko) |
HU (2) | HU204807B (ko) |
IE (1) | IE65584B1 (ko) |
IL (1) | IL92291A (ko) |
NO (1) | NO173334C (ko) |
NZ (1) | NZ231367A (ko) |
PT (1) | PT92299B (ko) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2676056B1 (fr) * | 1991-05-03 | 1993-07-16 | Adir | Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5135945A (en) * | 1991-06-05 | 1992-08-04 | Merrell Dow Pharmaceuticals Inc. | Cholesterol-lowering tocopherol analogs |
EP0535283A1 (en) * | 1991-10-02 | 1993-04-07 | Merrell Dow Pharmaceuticals Inc. | Cardioprotective tocopherol analogs |
DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
CA2082004A1 (en) * | 1991-11-20 | 1993-05-21 | David Laffan | Substituted pentaalkylchromans |
EP0550292A1 (en) * | 1992-01-02 | 1993-07-07 | Merrell Dow Pharmaceuticals Inc. | Tissue protective tocopherol analogs |
US5510373A (en) * | 1992-04-06 | 1996-04-23 | Merrell Pharmaceuticals Inc. | Cardioprotective agents |
US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
DE69306559T2 (de) * | 1992-04-06 | 1997-04-10 | Merrell Pharmaceuticals Inc. (N.D.Ges.D. Staates Delaware), Cincinnati, Ohio | Neue kardioprotektive wirkstoffe |
US5545660A (en) * | 1992-04-07 | 1996-08-13 | Merrell Pharmaceuticals Inc. | Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans |
IT1256264B (it) * | 1992-12-31 | 1995-11-29 | Lifegroup Spa | N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione |
US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5684039A (en) * | 1995-07-25 | 1997-11-04 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5670667A (en) * | 1995-07-25 | 1997-09-23 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5663194A (en) * | 1995-07-25 | 1997-09-02 | Mewshaw; Richard E. | Chroman-2-ylmethylamino derivatives |
CN100334080C (zh) * | 2005-06-01 | 2007-08-29 | 华东理工大学 | 苯并二氢吡喃碳糖苷衍生物 |
CN111269208A (zh) * | 2020-04-09 | 2020-06-12 | 通化师范学院 | 一种Trolox醇酯类衍生物及其制备方法和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4321270A (en) * | 1981-01-29 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Substituted chromans |
-
1989
- 1989-11-09 CA CA002002649A patent/CA2002649C/en not_active Expired - Lifetime
- 1989-11-10 AR AR89315417A patent/AR246962A1/es active
- 1989-11-13 NZ NZ231367A patent/NZ231367A/xx unknown
- 1989-11-13 IE IE364089A patent/IE65584B1/en not_active IP Right Cessation
- 1989-11-13 PT PT92299A patent/PT92299B/pt not_active IP Right Cessation
- 1989-11-13 IL IL9229189A patent/IL92291A/en not_active IP Right Cessation
- 1989-11-13 KR KR1019890016464A patent/KR0160112B1/ko not_active IP Right Cessation
- 1989-11-13 FI FI895393A patent/FI91404C/fi not_active IP Right Cessation
- 1989-11-13 DK DK568189A patent/DK568189A/da not_active Application Discontinuation
- 1989-11-13 HU HU895879A patent/HU204807B/hu not_active IP Right Cessation
- 1989-11-13 NO NO894521A patent/NO173334C/no not_active IP Right Cessation
- 1989-11-14 DE DE68921298T patent/DE68921298T2/de not_active Expired - Lifetime
- 1989-11-14 AU AU44682/89A patent/AU620660B2/en not_active Ceased
- 1989-11-14 CN CN89109257A patent/CN1033972C/zh not_active Expired - Fee Related
- 1989-11-14 AT AT89403125T patent/ATE118771T1/de not_active IP Right Cessation
- 1989-11-14 ES ES89403125T patent/ES2071674T3/es not_active Expired - Lifetime
- 1989-11-14 JP JP1294094A patent/JP3066901B2/ja not_active Expired - Lifetime
- 1989-11-14 EP EP89403125A patent/EP0369874B1/en not_active Expired - Lifetime
-
1995
- 1995-06-16 HU HU95P/P00237P patent/HU211877A9/hu unknown
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