KR850004757A - 치환 트란스-1, 2-디아미노싸이클로헥실 아미드 화합물의 제법 - Google Patents

치환 트란스-1, 2-디아미노싸이클로헥실 아미드 화합물의 제법 Download PDF

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KR850004757A
KR850004757A KR1019840007723A KR840007723A KR850004757A KR 850004757 A KR850004757 A KR 850004757A KR 1019840007723 A KR1019840007723 A KR 1019840007723A KR 840007723 A KR840007723 A KR 840007723A KR 850004757 A KR850004757 A KR 850004757A
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hydrogen
alkyl
preparation
amide compound
substituted trans
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KR1019840007723A
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KR880002532B1 (ko
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크리스토퍼 호웰 데이비드
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에드워드 에프.엘스라져
워너-램버트 컴페니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

치환 트란스-1,2-디아미노싸이클로헥실 아미드 화합물의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식(2)의 화합물을 다음 일반식(3)의 카복실산 또는 산의 카복실 유도체와 반응시키는 것으로 구성된 일반식(Ⅰ)의 화합물을 제조하는 방법.
    식중,
    R1은 메틸이고, R2는 수소이고, C1-6알킬 -CH2CH＝CR3R4(R3및 R4는 각각 수소 또는 메틸)이거나, R1및 R2는 환을 형성하여 같이 질소원자를 포함하는 다음과 같은 형태이다.
    n은 0-6의 정수이고, X는 산소, 황 또는 -CHR5(R5는 수소 C1-6알킬, 아릴)또는 NR6(R6는 수소이거나 C1-6알킬)이며,
    Y는 수소, 불소, 염소, C1-6알킬 또는 아릴, Z는 산소, 황, -CH2-, 또는 NR7(R7은 수소, C1-6알킬이거나 X가 CHR5일 경우, R7은 직접 X에 연결된다)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007723A 1983-12-06 1984-12-06 치환 트란스-1, 2-디아미노싸이클로헥실 아미드 화합물 및 이의 제조방법 KR880002532B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55873183A 1983-12-06 1983-12-06
US558,731 1983-12-06
US558731 1983-12-06
US06/669,922 US4656182A (en) 1983-12-06 1984-11-13 Substituted trans-1,2-diaminocyclohexyl amide compounds
US669922 1984-11-13
US669,922 1984-11-13

Publications (2)

Publication Number Publication Date
KR850004757A true KR850004757A (ko) 1985-07-27
KR880002532B1 KR880002532B1 (ko) 1988-11-28

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KR1019840007723A KR880002532B1 (ko) 1983-12-06 1984-12-06 치환 트란스-1, 2-디아미노싸이클로헥실 아미드 화합물 및 이의 제조방법

Country Status (17)

Country Link
US (1) US4656182A (ko)
EP (1) EP0147085B1 (ko)
KR (1) KR880002532B1 (ko)
AU (1) AU565236B2 (ko)
CA (1) CA1234808A (ko)
DE (1) DE3481614D1 (ko)
DK (1) DK576184A (ko)
ES (1) ES538243A0 (ko)
FI (1) FI80031C (ko)
GR (1) GR81174B (ko)
HU (1) HU200162B (ko)
IE (1) IE57673B1 (ko)
IL (1) IL73632A (ko)
NO (1) NO165838C (ko)
NZ (1) NZ210440A (ko)
OA (1) OA07885A (ko)
PH (1) PH21740A (ko)

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US4656182A (en) 1987-04-07
FI80031C (fi) 1990-04-10
NO844853L (no) 1985-06-07
HU200162B (en) 1990-04-28
AU565236B2 (en) 1987-09-10
IL73632A0 (en) 1985-02-28
PH21740A (en) 1988-02-10
NZ210440A (en) 1989-01-06
FI80031B (fi) 1989-12-29
NO165838C (no) 1991-04-17
ES8602599A1 (es) 1985-12-01
IE843037L (en) 1985-06-06
GR81174B (en) 1985-04-05
HUT36777A (en) 1985-10-28
IL73632A (en) 1988-01-31
AU3608084A (en) 1985-06-13
IE57673B1 (en) 1993-02-24
EP0147085B1 (en) 1990-03-14
FI844751L (fi) 1985-06-07
EP0147085A3 (en) 1987-02-04
DK576184D0 (da) 1984-12-04
NO165838B (no) 1991-01-07
DK576184A (da) 1985-06-07
CA1234808A (en) 1988-04-05
EP0147085A2 (en) 1985-07-03
ES538243A0 (es) 1985-12-01
DE3481614D1 (de) 1990-04-19
FI844751A0 (fi) 1984-12-03
OA07885A (en) 1986-11-20
KR880002532B1 (ko) 1988-11-28

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