KR870002085A - 아졸릴- 사이클로프로필- 에탄올 유도체의 제조방법 - Google Patents

아졸릴- 사이클로프로필- 에탄올 유도체의 제조방법 Download PDF

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KR870002085A
KR870002085A KR1019860007170A KR860007170A KR870002085A KR 870002085 A KR870002085 A KR 870002085A KR 1019860007170 A KR1019860007170 A KR 1019860007170A KR 860007170 A KR860007170 A KR 860007170A KR 870002085 A KR870002085 A KR 870002085A
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formula
compound
fluorine
unsubstituted
chlorine
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KR1019860007170A
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샤페르 볼프강
라에테르 볼프강
디트마르 발테르
자흐제 부르하르트
하르쯔 페테르
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베른하르트 벡크, 하인리히 벡커
훽스트 아크티엔 게젤샤프트
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Publication of KR870002085A publication Critical patent/KR870002085A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

아졸릴-사이클로프로필-에탄올 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. a) 일반식(II)의 화합물을 일반식(III)의 황일리드와 반응시켜 일반식(IV)의 화합물을 생성시킨 후, 일반식(IV)의 화합물을 일반식(V)의 화합물과 반응시키고 생성된 일반식(I)의 화합물을 유리염기 또는 산부가염 또는 생리학적으로 가수분해 가능하며 허용 가능한 유도체 형태로 분리시키거나, b) 일반식(II)의 화합물을 일반식(III)을 황일리드와 반응시켜 일반식(IV)의 화합물을 생성시킨 후, 이 일반식(IV)의 화합물을 분리시키지 않은채 반응 혼합물에 일반식(V)의 화합물을 가함으로써, 일반식(IV)의 화합물을 일반식(I)의 화합물로 전환시키고, 생성된 일반식(I)의 화합물을 유리염기 또는 산부가염 또는 생리학적으로 가수분해 가능하며 허용 가능한 유도체 형태로 분리시키거나, c) 일반식(VI)의 화합물을 일반식(IIIa)의 황 일리드 2당량과 반응시켜 일반식(IV)의 화합물을 생성시킨 후, 이 일반식(IV)의 화합물을 분리시키지 않은채 반응 혼합물에 일반식(V)의 화합물을 가함으로써, 일반식(Ⅵ)의 화합물을 일반식(I)의 화합물로 전환시키고, 생성된 일반식(I)의 화합물을 유리염기 또는 산부가염 또는 생리학적으로 가수분해 가능하며 허용가능한 유도체 형태로 분리시키거나, d) 일반식(VI)의 화합물을 일반식(IIIa)의 황일리드 1당량과 반응시켜 일반식(II)의 화합물을 생성시킨 후 이 일반식(II) 화합물을 반리시키지 않은채 일반식(IIIb)의 황 일리드 1당량과 반응시켜 일반식(IV)의 화합물을 생성시킨후, 이 일반식(IV)의 화합물을 분리시키지 않은채 반응 혼합물에 일반식(V)의 화합물을 가함 으로써, 일반식(IV)의 화합물을 일반식(I)의 화합물로 전환시키고, 생성된 일반식(I)의 화합물을 유리염기 또는 산부가염 또는 생리학적으로 가수분해 가능하며 허용가능한 유도체 형태로 분리시킴을 특징으로 하여 일반식(I)의 화합물 및 이의 약제학적으로 허용되는 염과 에스테르 및 이의 입체 이성체를 제조하는 방법.
    상기 식에서, A는 CH 또는 N을 나타내고, R1및 R2는 같거나 다르며, 각각 페닐, 비페닐, 펜옥시페닐, 벤질페닐, 벤질옥시페닐, 나프틸, 티에닐, 푸릴 또는 피리딜을 나타내며, 여기에서 환은 비치환되거나, 불소, 염소, 브롬, 요오드, 1 내지 9개의 불소 또는 염소원자로 치환되거나 비치환된 직쇄 또는 측쇄(C1-C8)-알킬, (C3-C6)-사이클로알킬, (C3-C6)-사이클로알킬-(C1-C4)-알킬, (C1-C8)-알콕시, (C1-C8)-알킬티오 또는 니트로 중에서 선택된 같거나 다른 1 내지 3개의 치환체로 치환되고, Z는 0 또는 1을 나타내며, M은 수소, 트리메틸실릴 그룹 또는1가 금속을 나타낸다.
  2. 제1항에 있어서, R1및 R2가 같거나 다르며, 각각 비치환된 비페닐, 펜옥시페닐, 벤질페닐, 벤질옥시페닐, 나프틸, 티에닐, 푸릴 또는 피리딜이거나, 불소, 염소, 브롬, (C1-C4)-알킬, 트리플루오로메틸, (C1-C4)-알콕시, (C1-C4)-알킬티오 또는 니트로 중에서 선택된 1 또는 2개의 치환체로 치환되거나 비치환된 페닐그룹을 나타내는 일반식(I)의 화합물을 제조하는 방법.
  3. 제1항 또는 제2항에 있어서, R1및 R2가 비치환되거나 불소, 염소, 브롬 및 트리플루오로메틸 그룹중에서 선택된 1 또는 2개의 치환체로 치환된 페닐그룹을 나타내는 방법.
  4. 제1 내지 제3항중 어느 한 항에 있어서, R1및 R2의 치환체가 각각 불소 또는 염소를 나타내는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860007170A 1985-08-29 1986-08-28 아졸릴- 사이클로프로필- 에탄올 유도체의 제조방법 KR870002085A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3530799.4 1985-08-29
DE19853530799 DE3530799A1 (de) 1985-08-29 1985-08-29 Azolyl-cyclopropyl-ethanol-derivate, verfahren zu ihrer herstellung und ihre verwendung

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KR870002085A true KR870002085A (ko) 1987-03-30

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KR1019860007170A KR870002085A (ko) 1985-08-29 1986-08-28 아졸릴- 사이클로프로필- 에탄올 유도체의 제조방법

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Country Link
EP (1) EP0212605A3 (ko)
JP (1) JPS6251670A (ko)
KR (1) KR870002085A (ko)
AU (1) AU6203086A (ko)
DE (1) DE3530799A1 (ko)
DK (1) DK409886A (ko)
ES (1) ES2001270A6 (ko)
FI (1) FI863480A (ko)
GR (1) GR862211B (ko)
HU (1) HU197315B (ko)
IL (1) IL79853A0 (ko)
PT (1) PT83271B (ko)
ZA (1) ZA866529B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100384362B1 (ko) * 2001-04-26 2003-05-22 주식회사 코오롱 경편용 해도형 극세 가연 가공사 및 그의 제조방법
KR100546461B1 (ko) * 1998-03-27 2006-05-25 주식회사 코오롱 신축성이 우수한 인공피혁.

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3608792A1 (de) * 1986-03-15 1987-09-24 Hoechst Ag 1,1-disubstituierte cyclopropanderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3784787T2 (de) * 1986-06-23 1994-01-20 Du Pont Merck Pharma Fungizide Karbinole.
DE3644616A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazolderivate, verfahren zur herstellung und deren verwendung
DE3704359A1 (de) * 1987-02-12 1988-08-25 Basf Ag Azolhalbaminal-derivate und ihre verwendung als nitrifikationsinhibitoren
FI97382C (fi) * 1988-03-04 1996-12-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi
DE3909862A1 (de) * 1989-03-25 1990-09-27 Basf Ag Azolylethylcyclopropane, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschutzmittel
US5250383A (en) * 1990-02-23 1993-10-05 Fuji Photo Film Co., Ltd. Process for forming multilayer coating
FR2690441A1 (fr) * 1992-04-08 1993-10-29 Rhone Poulenc Agrochimie Nouveaux dérivés triazole et imidazole fongicides.
CN102639508A (zh) 2009-12-08 2012-08-15 株式会社吴羽 唑衍生物及其制造方法、该衍生物的中间体化合物及其制造方法、以及含有该衍生物的农业园艺试剂和工业材料保护剂
US9253983B2 (en) 2011-05-31 2016-02-09 Kureha Corporation Triazole compound and use thereof
EP2719281A4 (en) 2011-06-07 2014-11-19 Kureha Corp CHEMICAL AGENT FOR AGRICULTURE OR HORTICULTURE, COMPOSITION FOR CONTROLLING PLANT DISEASES, METHOD FOR CONTROLLING PLANT DISEASES AND PLANT DISEASE PRODUCT

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042303A1 (de) * 1979-11-13 1981-08-27 Sandoz-Patent-GmbH, 7850 Lörrach Organische verbindungen, deren herstellung und verwendung
DE3337937A1 (de) * 1982-10-28 1984-05-03 Sandoz-Patent-GmbH, 7850 Lörrach Neue azolderivate
DE3342693A1 (de) * 1983-11-25 1985-06-05 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von ss-hydroxy-ethyl-(1,2,4-triazol)- derivaten

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100546461B1 (ko) * 1998-03-27 2006-05-25 주식회사 코오롱 신축성이 우수한 인공피혁.
KR100384362B1 (ko) * 2001-04-26 2003-05-22 주식회사 코오롱 경편용 해도형 극세 가연 가공사 및 그의 제조방법

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JPS6251670A (ja) 1987-03-06
AU6203086A (en) 1987-03-05
ES2001270A6 (es) 1988-05-01
DK409886D0 (da) 1986-08-28
EP0212605A2 (de) 1987-03-04
ZA866529B (en) 1987-04-29
DE3530799A1 (de) 1987-03-05
HUT43573A (en) 1987-11-30
FI863480A (fi) 1987-03-01
IL79853A0 (en) 1986-11-30
FI863480A0 (fi) 1986-08-27
GR862211B (en) 1986-12-23
EP0212605A3 (de) 1987-08-26
PT83271B (de) 1988-10-03
DK409886A (da) 1987-03-01
HU197315B (en) 1989-03-28
PT83271A (de) 1986-09-01

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