KR880701723A - 세팔로스코린 유도체의 신규한 제조방법 - Google Patents
세팔로스코린 유도체의 신규한 제조방법Info
- Publication number
- KR880701723A KR880701723A KR1019880700628A KR880700628A KR880701723A KR 880701723 A KR880701723 A KR 880701723A KR 1019880700628 A KR1019880700628 A KR 1019880700628A KR 880700628 A KR880700628 A KR 880700628A KR 880701723 A KR880701723 A KR 880701723A
- Authority
- KR
- South Korea
- Prior art keywords
- ceftazidime
- pentahydrate
- dihydrochloride
- acetone
- ethanol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 수성 염산을 사용하여 구조식(Ia)의 화합물 또는 이의 산부가염의 에스테르 그룹을 분해시키고, 이렇게 하여 생성된 세프타지딤을, 염기를 가하여 5수화물로서 반응 혼합물로부터 직접 결정화시키거나, 아세톤 및/또는 에탄올, 또는 다른 수-혼화성 반-용매(anti-Solvent)를 가하여 먼저 세프타지딤의 디하이드로 클로라이드를 분리시킨 다음, 이를 공지방법에 따라 5수화물로 전환시킴을 특징으로 하여, 구조식(III)의 세프타지딤의 5수화물을 제조하는 신규한 방법.
- 제1항에 있어서, 수성 염산의 농도가 20 내지 40중량%임을 특징으로 하는 방법.
- 제1항 또는 2항에 있어서, 에스테르 분해를 -15 내지 +35℃에서 수행함을 특징으로 하는 방법.
- 제1항 내지 3항중의 어느 한 항에 있어서, 세프타지딤의 5수화물을, 세프타지딤 디하이드로클로라이드의 중간 분리없이 반응 용액으로부터 직접 결정화시킴을 특징으로 하는 방법.
- 제1항 내지 제3항중의 어느 한 항에 있어서,아세톤 및/또는 에탄올을 가하여 반응 혼합물로부터 세프타지딤의 디하이드로크롤라이드를 결정화시키고 이를 공지방법에 따라 세프타지딤 디하이드로클로라이드를 결정화시키고 이를 공지방법에 따라 세프타지딤 5수화물로 전환시킴을 특징으로 하는 방법.
- 수성 염산을 사용하여, 제1항에 기술된 구조식(Ia)의 화합물 또는 이의 산부가염의 에스테르 그룹을 분해시키고 생성된 디하이드로클로라이드를 아세톤 및/또는 에탄올 또는 다른 수-혼화성 반-용매를 가하여 결정화시킴을 특징으로 하여, 세프타지딤의 디하이드로클로라이드를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATA2657/86 | 1986-10-07 | ||
AT0265786A AT387390B (de) | 1986-10-07 | 1986-10-07 | Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy |
PCT/EP1987/000574 WO1988002752A1 (en) | 1986-10-07 | 1987-10-06 | New process for producing cephalosporine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880701723A true KR880701723A (ko) | 1988-11-04 |
KR950010597B1 KR950010597B1 (ko) | 1995-09-20 |
Family
ID=3538212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880700628A KR950010597B1 (ko) | 1986-10-07 | 1987-10-06 | 세팔로스포린 유도체의 신규한 제조방법 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0267427B1 (ko) |
JP (2) | JP2507505B2 (ko) |
KR (1) | KR950010597B1 (ko) |
AT (2) | AT387390B (ko) |
DE (1) | DE3777537D1 (ko) |
ES (1) | ES2033277T3 (ko) |
GR (1) | GR3004109T3 (ko) |
HK (1) | HK68295A (ko) |
WO (1) | WO1988002752A1 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106317081B (zh) * | 2016-08-22 | 2018-08-31 | 山东罗欣药业集团恒欣药业有限公司 | 一种抗感染药物头孢他啶晶体化合物及其药物组合物 |
CN106432280A (zh) * | 2016-09-23 | 2017-02-22 | 临沂草之美医药科技有限公司 | 一种治疗外科手术感染的药物头孢他啶晶体化合物 |
CN106397458A (zh) * | 2016-09-23 | 2017-02-15 | 临沂草之美医药科技有限公司 | 一种治疗外科手术感染的药物头孢他啶晶体化合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4329453A (en) * | 1979-10-02 | 1982-05-11 | Glaxo Group Limited | Cephalosporin antibiotic |
US4537959A (en) * | 1984-03-26 | 1985-08-27 | Eli Lilly And Company | Crystalline cephalosporin antibiotic salt |
US4616080A (en) * | 1984-07-02 | 1986-10-07 | Eli Lilly And Company | Simplified process of forming crystalline ceftazidime pentahydrate |
ATE60607T1 (de) * | 1984-11-08 | 1991-02-15 | Lilly Co Eli | Verfahren zur herstellung von kristallinischem ceftazidime-pentahydrat. |
-
1986
- 1986-10-07 AT AT0265786A patent/AT387390B/de not_active IP Right Cessation
-
1987
- 1987-10-06 KR KR1019880700628A patent/KR950010597B1/ko not_active IP Right Cessation
- 1987-10-06 ES ES198787114592T patent/ES2033277T3/es not_active Expired - Lifetime
- 1987-10-06 JP JP62506626A patent/JP2507505B2/ja not_active Expired - Lifetime
- 1987-10-06 EP EP87114592A patent/EP0267427B1/de not_active Expired - Lifetime
- 1987-10-06 WO PCT/EP1987/000574 patent/WO1988002752A1/de unknown
- 1987-10-06 AT AT87114592T patent/ATE73809T1/de not_active IP Right Cessation
- 1987-10-06 DE DE8787114592T patent/DE3777537D1/de not_active Expired - Lifetime
-
1992
- 1992-03-19 GR GR920400466T patent/GR3004109T3/el unknown
-
1995
- 1995-05-04 HK HK68295A patent/HK68295A/xx not_active IP Right Cessation
- 1995-11-07 JP JP7288491A patent/JP2594780B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3777537D1 (de) | 1992-04-23 |
JP2507505B2 (ja) | 1996-06-12 |
JPH08283272A (ja) | 1996-10-29 |
WO1988002752A1 (en) | 1988-04-21 |
ATE73809T1 (de) | 1992-04-15 |
JP2594780B2 (ja) | 1997-03-26 |
KR950010597B1 (ko) | 1995-09-20 |
HK68295A (en) | 1995-05-12 |
ATA265786A (de) | 1988-06-15 |
EP0267427B1 (de) | 1992-03-18 |
ES2033277T3 (es) | 1993-03-16 |
EP0267427A1 (de) | 1988-05-18 |
GR3004109T3 (ko) | 1993-03-31 |
JPH01500906A (ja) | 1989-03-30 |
AT387390B (de) | 1989-01-10 |
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