KR870005954A - 개선된 5-(2,5-디메틸페녹시)-2,2-디메틸펜탄산의 제조 방법 - Google Patents
개선된 5-(2,5-디메틸페녹시)-2,2-디메틸펜탄산의 제조 방법 Download PDFInfo
- Publication number
- KR870005954A KR870005954A KR860010302A KR860010302A KR870005954A KR 870005954 A KR870005954 A KR 870005954A KR 860010302 A KR860010302 A KR 860010302A KR 860010302 A KR860010302 A KR 860010302A KR 870005954 A KR870005954 A KR 870005954A
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- KR
- South Korea
- Prior art keywords
- dimethylphenoxy
- toluene
- lower alkyl
- parts
- preparing
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Luminescent Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- a) 2-메틸프로판산의 저급 알킬 에스테르를 극성 중성 유기 용매내에서 디-(저급 알킬)아민과 반응시켜 일반식(1)의[식중, R은 저급 알킬, M은 알칼리 금속 알칼리 금속 염을 제조한 다음, 약 -20℃ 이상의 온도에서 1-브로모-3-클로로프로판 및 1, 3-디브로모프로판으로부터 선택된 1, 3-디할로프로판과 반응시켜 식중 X가 염소 또는 브롬이고 R이 전술한 바와같은 일반식의X-CH2CH2CH2C(CH3)2COOR중간 생성물을 제조하고 ; b) 상기 중간 생성물을 2, 5-디메틸페놀의 알칼리 금속 염과 반응시켜 상기 2-메틸프로판산의 저급 알킬 에스테르로부터 80% 이상의 수율로 5-(2, 5-디메틸페녹시-2, 2-디메틸펜탄산을 제조하는 단계로 구성되는 5-(2, 5-디메틸페녹시)-2, 2-디메틸펜탄산을 제조하는 방법.
- 제1항에 있어서, 상기 2-메틸프로판산의 저급 알킬 에스테르가 2-메틸프로필 2-메틸프로파노에이트인 방법.
- 제1항에 있어서, 상기 1, 3-디할로프로판이 1-브로모-3-클로로프로판인 방법.
- 제1항에 있어서, 단계 c)를 환류 온도에서 비극성 탄화수소 용매 및 극성 용매의 혼합 용매계에서 행하는 방법.
- 제4항에 있어서, 상기 혼합 용매계가 5부(v/v) 톨루엔/1부(v/v) 디메틸설폭사이드-약 10부(v/v) 톨루엔/1부(v/v) 디메틸설폭사이드로 구성된 것인 방법.
- 제4항에 있어서, 상기 혼합 용매계가 약 7.5부(v/v) 톨루엔/1부(v/v) 디메틸설폭사이드로 구성된 것인 방법.
- a) 2-메틸프로필 2-메틸프로파노에이트를 약 25℃ 이하의 온도에서 리튬 디이소프로필아미드 및 그 다음 1-브로모-3-클로로프로판과 반응시켜 2-메틸프로필 5-클로로-2, 2-디메틸펜타노에이트를 제조하고 b) 계속해서 상기 2-메틸프로필 5-클로로-2, 2-디메틸펜타노에이트를 10부(v/v) 톨루엔/1부(v/v) 디메틸설폭사이드-5부(v/v) 톨루엔/1부(v/v) 혼합물로 구성된 용매내에서 환류시키면서 나트륨 2, 5-디메틸페놀레이트와 반응시키고, 결과의 에스테르를 가수분해시키고, 그런후 혼합물을 산성화시키고 5-(2, 5-디메틸페녹시)-2, 2-디메틸펜탄산을 분리하여 총 수율이 80% 이상인 상기 5-(2, 5-디메틸페녹시)-2, 2-디메틸펜탄산을 얻는 단계로 구성되는 5-(2, 5-디메틸페녹시)-2, 2-디메틸펜탄산을 제조하는 방법.
- 제7항에 있어서, 상기 용매가 약 7.5부(v/v) 톨루엔/1부(v/v) 디메틸설폭사이드의 혼합물로 구성된것인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/806,312 US4665226A (en) | 1985-12-09 | 1985-12-09 | Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid |
US806,312 | 1985-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870005954A true KR870005954A (ko) | 1987-07-08 |
Family
ID=25193782
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR860010302A KR870005954A (ko) | 1985-12-09 | 1986-12-03 | 개선된 5-(2,5-디메틸페녹시)-2,2-디메틸펜탄산의 제조 방법 |
KR1019860010302Q KR950003120B1 (ko) | 1985-12-09 | 1987-12-03 | 개선된 5-(2,5-디메틸페녹시)-2,2-디메틸펜탄산의 제조 방법 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860010302Q KR950003120B1 (ko) | 1985-12-09 | 1987-12-03 | 개선된 5-(2,5-디메틸페녹시)-2,2-디메틸펜탄산의 제조 방법 |
Country Status (22)
Country | Link |
---|---|
US (1) | US4665226A (ko) |
EP (1) | EP0226161B1 (ko) |
JP (1) | JP2506094B2 (ko) |
KR (2) | KR870005954A (ko) |
CN (1) | CN1012896B (ko) |
AT (1) | ATE47832T1 (ko) |
AU (1) | AU590358B2 (ko) |
CA (1) | CA1267155A (ko) |
DE (1) | DE3666805D1 (ko) |
DK (1) | DK174496B1 (ko) |
ES (1) | ES2011245B3 (ko) |
FI (1) | FI85974C (ko) |
GR (1) | GR3000216T3 (ko) |
HK (1) | HK112193A (ko) |
HU (1) | HU195635B (ko) |
IE (1) | IE59499B1 (ko) |
IL (1) | IL80885A (ko) |
IN (1) | IN166169B (ko) |
NO (1) | NO164293C (ko) |
PH (1) | PH24273A (ko) |
PT (1) | PT83888B (ko) |
ZA (1) | ZA868893B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5235097A (en) * | 1990-05-11 | 1993-08-10 | Egis Gyogyszergyar | Process for the preparation of 2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid, intermediates for preparing this compound and process for preparing the intermediates |
HU205891B (en) * | 1990-05-11 | 1992-07-28 | Gyogyszerkutato Intezet | Process for producing 2,2-dimethyl-5-/2,5-dimethyl-phenoxy/-pentanoic acid |
US5041640A (en) * | 1990-09-20 | 1991-08-20 | Warner-Lambert Company | Process for mono-, di-, trisubstituted acetic acids |
BE1007058A3 (fr) * | 1992-06-16 | 1995-03-07 | Omnichem Sa | Un procede nouveau pour la preparation de l'acide 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoique. |
IT1265087B1 (it) * | 1993-05-20 | 1996-10-30 | Recordati Chem Pharm | Processo per la preparazione di gemfibrozil |
US5412112A (en) * | 1994-06-14 | 1995-05-02 | Industrial Technology Research Institute | Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids |
US5530145A (en) * | 1994-06-14 | 1996-06-25 | Syn-Tech Chem & Pharm Co., Ltd. | Anticholesteremic compounds |
US20050261493A1 (en) * | 2002-08-08 | 2005-11-24 | Mark Fulston | Methods for the isolation and purification of ansamitocins |
CN101440032B (zh) * | 2008-11-13 | 2012-05-23 | 浙江大学 | 一种吉非罗齐的多晶型及其制备方法 |
WO2020212955A1 (en) * | 2019-04-18 | 2020-10-22 | Hikal Limited | Process for the preparation of a key intermediate of gemfibrozil |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3674836A (en) * | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
US3759986A (en) * | 1970-03-30 | 1973-09-18 | Parke Davis & Co | Esters of 2,2-dimethyl-5-(aryloxy)-1-pentanols |
US3707566A (en) * | 1970-03-30 | 1972-12-26 | Parke Davis & Co | Aryloxypentane compounds |
GB1422679A (en) * | 1972-11-16 | 1976-01-28 | Funai Pharmaceutical Ind Ltd | Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same |
GB2025942A (en) * | 1978-05-31 | 1980-01-30 | Sori Soc Rech Ind | Phenoxyalkylcarboxylic acids |
DK305884A (da) * | 1983-06-24 | 1984-12-25 | Yamanouchi Pharma Co Ltd | Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
-
1985
- 1985-12-09 US US06/806,312 patent/US4665226A/en not_active Expired - Lifetime
-
1986
- 1986-11-18 IN IN1005/DEL/86A patent/IN166169B/en unknown
- 1986-11-19 IE IE306086A patent/IE59499B1/en not_active IP Right Cessation
- 1986-11-24 ZA ZA868893A patent/ZA868893B/xx unknown
- 1986-11-24 AU AU65606/86A patent/AU590358B2/en not_active Ceased
- 1986-11-25 CA CA000523753A patent/CA1267155A/en not_active Expired - Fee Related
- 1986-12-01 FI FI864900A patent/FI85974C/fi not_active IP Right Cessation
- 1986-12-03 KR KR860010302A patent/KR870005954A/ko not_active IP Right Cessation
- 1986-12-05 PH PH34561A patent/PH24273A/en unknown
- 1986-12-05 IL IL80885A patent/IL80885A/xx unknown
- 1986-12-08 HU HU865104A patent/HU195635B/hu not_active IP Right Cessation
- 1986-12-08 AT AT86117076T patent/ATE47832T1/de not_active IP Right Cessation
- 1986-12-08 EP EP86117076A patent/EP0226161B1/en not_active Expired
- 1986-12-08 NO NO864933A patent/NO164293C/no unknown
- 1986-12-08 DK DK198605882A patent/DK174496B1/da not_active IP Right Cessation
- 1986-12-08 ES ES86117076T patent/ES2011245B3/es not_active Expired - Lifetime
- 1986-12-08 JP JP61290642A patent/JP2506094B2/ja not_active Expired - Fee Related
- 1986-12-08 DE DE8686117076T patent/DE3666805D1/de not_active Expired
- 1986-12-09 CN CN86108472A patent/CN1012896B/zh not_active Expired
- 1986-12-09 PT PT83888A patent/PT83888B/pt not_active IP Right Cessation
-
1987
- 1987-12-03 KR KR1019860010302Q patent/KR950003120B1/ko active
-
1989
- 1989-11-15 GR GR89400242T patent/GR3000216T3/el unknown
-
1993
- 1993-10-21 HK HK1121/93A patent/HK112193A/xx not_active IP Right Cessation
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