KR860004039A - 9-클로로-1,5-벤조티아제핀 유도체의 제조방법 - Google Patents
9-클로로-1,5-벤조티아제핀 유도체의 제조방법 Download PDFInfo
- Publication number
- KR860004039A KR860004039A KR1019850008578A KR850008578A KR860004039A KR 860004039 A KR860004039 A KR 860004039A KR 1019850008578 A KR1019850008578 A KR 1019850008578A KR 850008578 A KR850008578 A KR 850008578A KR 860004039 A KR860004039 A KR 860004039A
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- KR
- South Korea
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- sup
- acid addition
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 일반식(II)의 화합물 또는 이의 염을 하기 일반식(III)의 화합물 또는 이의 염과 축합시키고, 필요시 생성물을 약학적으로 허용되는 이의 산 부가염으로 전환시킴을 특징으로 하여 하기 일반식(I)의 1,5-벤조티아제핀 유도체 또는 약학적으로 허용되는 이의 산 부가염을 제조하는 방법.상기식에서, R1은 수소, 또는 저급 알킬노일이고, R2및 R3는 각각 저급 알킬이며, X는 할로겐이다.
- 제1항에 있어서, R1이 수소 또는 탄소수 2 내지 5의 알카노일이고, R2및 R2가 각각 탄소수 1 내지 4의 알킬인 방법.
- 제2항에 있어서, R1이 수소 또는 아세틸이고, R2및 R3가 메틸인 방법.
- 제1항, 제2항 또는 제3항에 있어서, 일반식(I)화합물이 시스 이성체인 방법.
- 제1항, 제2항 또는 제3항에 있어서, 일반식(I)화합물이 (+)-시스 이성체인 방법.
- 제5항에 있어서, 일반식(I) 화합물의 (+)-시스 이성체가(+)-시스-2-(4-메톡시페닐)-3-하이드록시-5-[2-(디메틸아미노)에틸]-9-클로로-2,3-디하이드로-1,5-벤조티아제핀-4(5H)-온 또는 이의 약학적으로 허용되는 산 부가염인 방법.
- 제5항에 있어서, 일반식(I) 화합물의 (+)-시스 이성체가 (+)-시스-2-(4-메톡시페닐)-3-아세톡시-5-[2-(디메틸아미노)에틸]-9-클로로-2,3-디하이드로-1,5-벤조티아제핀-4(5H)-온 또는 이의 약학적으로 허용되는 산 부가염인 방법.
- 하기 일반식(I-a)의 화합물 또는 이의 염을 하기 일반식(IV)의 저급 알카노산 또는 이의 반응성 유도체로 아실화시키고, 필요시 생성물을 이의 약학적으로 허용되는 산 부가염으로 전환시킴을 특징으로 하여 일반식(I-b)의 1,5-벤조티아제핀 유도체를 제조하는 방법.상기 식에서, R2, R3및 R4는 각각 저급 알킬이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08429102A GB2167063A (en) | 1984-11-17 | 1984-11-17 | 6 or 9-chloro-1, 5-benzothiazepine derivatives |
GB8429102 | 1984-11-17 | ||
CN85101892A CN85101892B (zh) | 1984-11-17 | 1985-04-01 | 制备新型的1,5-苯并硫杂吖庚因衍生物的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860004039A true KR860004039A (ko) | 1986-06-16 |
KR890003600B1 KR890003600B1 (ko) | 1989-09-27 |
Family
ID=25741514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850008578A KR890003600B1 (ko) | 1984-11-17 | 1985-11-16 | 9-클로로-1,5-벤조티아제핀 유도체의 제조방법 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4665068A (ko) |
EP (1) | EP0182273B1 (ko) |
JP (1) | JPS61122281A (ko) |
KR (1) | KR890003600B1 (ko) |
CN (2) | CN85101892B (ko) |
AT (1) | ATE40997T1 (ko) |
AU (1) | AU578755B2 (ko) |
BG (2) | BG44709A3 (ko) |
CA (1) | CA1226281A (ko) |
DD (2) | DD249271A5 (ko) |
DE (1) | DE3568428D1 (ko) |
DK (1) | DK171821B1 (ko) |
ES (2) | ES8704914A1 (ko) |
GB (1) | GB2167063A (ko) |
HU (1) | HU193834B (ko) |
NO (1) | NO163488C (ko) |
PH (1) | PH23328A (ko) |
PT (1) | PT81504B (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0256888B1 (en) * | 1986-08-20 | 1991-07-03 | McNeilab, Inc. | Benzothiazepine vasodilators having aralkyl substitution |
IE61939B1 (en) * | 1987-07-31 | 1994-11-30 | Tanabe Seiyaku Co | Naphthothiazepine derivatives and a process for preparing the same |
JPS6450872A (en) * | 1987-08-21 | 1989-02-27 | Tanabe Seiyaku Co | Production of 1,5-benzothiazepine derivative |
JPH01128974A (ja) * | 1987-11-13 | 1989-05-22 | Tanabe Seiyaku Co Ltd | 1,5−ベンゾチアゼピン誘導体の製法 |
FR2630107B1 (fr) * | 1988-04-19 | 1990-06-08 | Synthelabo | Procede de preparation du (+) - (2s,3s) (amino-2 phenyl)thio)-3 hydroxy-2 (methoxy-4 phenyl)-3 propionate de methyle |
US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
FR2637285B1 (fr) * | 1988-10-03 | 1991-04-12 | Synthelabo | Procede de preparation de derives de l'acide propionique et produits obtenus |
IT1230057B (it) * | 1989-04-13 | 1991-09-27 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine |
US5057513A (en) * | 1989-05-25 | 1991-10-15 | Fujisawa Pharmaceutical Co., Ltd. | Spiro-thiazepine derivatives useful as paf antagonists |
US5001236A (en) * | 1989-11-22 | 1991-03-19 | Marion Laboratories, Inc. | Benzothiazepines |
IT1240651B (it) * | 1990-05-17 | 1993-12-17 | Zambon Spa | Processo per la risoluzione di derivati glicidici |
IT1302261B1 (it) | 1998-09-24 | 2000-09-05 | Zambon Spa | Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB287079A (en) * | 1927-03-14 | 1929-02-07 | Ass Telephone & Telegraph Co | Improvements in or relating to telephone systems |
US3075967A (en) * | 1961-06-12 | 1963-01-29 | Olin Mathieson | Benzothiazines |
US3341519A (en) * | 1965-04-28 | 1967-09-12 | Squibb & Sons Inc | Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins |
GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
KR870000906B1 (ko) * | 1982-09-16 | 1987-05-06 | 더 뱁콕 앤드 윌콕스 캄패니 | 과립 제조 기구용 제어장치 |
US4567175A (en) * | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
IT1206505B (it) * | 1983-07-22 | 1989-04-27 | Schiapparelli Farma | Nuovi derivati benzotiazepinonici, metodo per la loro preparazione e composizioni farmaceutiche che licontengono. |
US4585768A (en) * | 1984-04-10 | 1986-04-29 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and processes for preparing the same |
-
1984
- 1984-11-17 GB GB08429102A patent/GB2167063A/en not_active Withdrawn
-
1985
- 1985-04-01 CN CN85101892A patent/CN85101892B/zh not_active Expired
- 1985-10-31 US US06/793,628 patent/US4665068A/en not_active Expired - Fee Related
- 1985-11-04 AU AU49331/85A patent/AU578755B2/en not_active Ceased
- 1985-11-12 PH PH33051A patent/PH23328A/en unknown
- 1985-11-13 CN CN85108458A patent/CN85108458B/zh not_active Expired
- 1985-11-13 AT AT85114422T patent/ATE40997T1/de active
- 1985-11-13 EP EP85114422A patent/EP0182273B1/en not_active Expired
- 1985-11-13 DE DE8585114422T patent/DE3568428D1/de not_active Expired
- 1985-11-14 ES ES548898A patent/ES8704914A1/es not_active Expired
- 1985-11-15 BG BG8572382A patent/BG44709A3/xx unknown
- 1985-11-15 DD DD85294053A patent/DD249271A5/de not_active IP Right Cessation
- 1985-11-15 DK DK530685A patent/DK171821B1/da not_active IP Right Cessation
- 1985-11-15 DD DD85282915A patent/DD239202A5/de not_active IP Right Cessation
- 1985-11-15 JP JP60257448A patent/JPS61122281A/ja active Granted
- 1985-11-15 NO NO854565A patent/NO163488C/no unknown
- 1985-11-15 PT PT81504A patent/PT81504B/pt not_active IP Right Cessation
- 1985-11-15 HU HU854366A patent/HU193834B/hu not_active IP Right Cessation
- 1985-11-15 BG BG8778445A patent/BG44379A3/xx unknown
- 1985-11-16 KR KR1019850008578A patent/KR890003600B1/ko not_active IP Right Cessation
- 1985-11-18 CA CA000495576A patent/CA1226281A/en not_active Expired
-
1986
- 1986-09-22 ES ES557079A patent/ES8707723A1/es not_active Expired
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Legal Events
Date | Code | Title | Description |
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A201 | Request for examination | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19970827 Year of fee payment: 9 |
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LAPS | Lapse due to unpaid annual fee |