KR850007586A - 피롤리돈 유도체의 제조방법 - Google Patents

피롤리돈 유도체의 제조방법 Download PDF

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Publication number
KR850007586A
KR850007586A KR1019850002148A KR850002148A KR850007586A KR 850007586 A KR850007586 A KR 850007586A KR 1019850002148 A KR1019850002148 A KR 1019850002148A KR 850002148 A KR850002148 A KR 850002148A KR 850007586 A KR850007586 A KR 850007586A
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South Korea
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formula
compound
alkyl
process according
gamma
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KR1019850002148A
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KR920000047B1 (ko
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파이페르(외 1) 위고
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암브로기오 세콘디
아이. 에스. 에프. 에스. 퍼. 에이
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Publication of KR850007586A publication Critical patent/KR850007586A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

피롤리돈 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 구조식(2)화합물의 수산기를 염기 조건에서는 안정하고 산성 조건하에서는 제거될 수 있는 보호기로 보호하여 하기 구조식(3)화합물을 산출시키고 알카리 금속으로부터 생성된 강한 친핵성 염기의 존재에서 그 구조식(3)화합물을 고리화하여 하기 구조식(4)화합물을 산출시켜 산성 조건하에 보호기(Prot기)를 제거하며, 필요에 따라 Y가 OR인 생성물을 식 HNR1R2의 아민과 반응시키는 것을 특징으로 하는 하기 구조식(1)화합물의 제조방법.
    상기식들에서, Y는 NR1R2또는 OR이고 R1과 R2는 같거나 상이한 것으로 수소 또는 C1-3알킬이며 R은 C1-3알킬이며 X는 클로로 또는 브로모이며 Prot는 염기조건에서는 안정하며 산성조건에서는 제거될 수 있는 수산-보호기이다.
  2. 제1항에 있어서, 강 염기가 소듐 하이드라이드 또는 포타슘 t-부톡시드인 것을 특징으로 하는 제조방법.
  3. 제1항에 또는 2항에 있어서 Prot가 테트라하이드로피리닐 또는 α-에톡시에틸인 것을 특징으로 하는 제조방법.
  4. 제1항 내지 3항의 어느 한항에 있어서 구조식 (1),(2),(3),(4)의 모든 화합물에서 Y가 NR1R2이고 R1과 R2는 둘다 수소인 것을 특징으로 하는 제조방법.
  5. 제1항 내지 3항의 어느 한항에 있어서 구조식 (1),(2),(3),(4)의 모든 화합물에서 Y가 -OC2H5인 것을 특징으로 하는 제조방법.
  6. 제1항 내지 3항의 어느 한항에 있어서 하기 구조식(6)화합물을 환원시켜 구조식(2)화합물이 제조되는 것을 특징으로 하는 제조방법.
    여기에서 Y는 NR1R2또는 OR이고 R1과 R2는 같거나 서로 다른 것으로 수소 또는 C1-3알킬이며 R은 C1-3알킬이다.
  7. 제6항에 있어서, 구조식(6)화합물이 감마-브로모아세토아세틸브로마이드 또는 감마-클로로아세토아세틸 클로라이드를 하기 구조식(7)의 글리신 유도체와 반응시켜 제조되는 것을 특징으로 하는 제조방법.
    NH2CH2COY (7)
    여기에서 Y는 NR1R2또는 OR이고 R1각 R2는 수소 또는 C1-3알킬이며 R은 C1-3알킬이다.
  8. 제7항에 있어서, 감마-브로모아세토아세틸 브로마이드 또는 감마-클로로아세토 아세틸 클로라이드가 디케텐을 브롬 또는 염소와 반응시켜 제조되는 것을 특징으로 하는 제조방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850002148A 1984-04-02 1985-03-30 피롤리돈 유도체의 제조방법 KR920000047B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT20358/84A IT1173768B (it) 1984-04-02 1984-04-02 Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti
IT20358 1984-04-02
IT20358/84 1984-04-02

Publications (2)

Publication Number Publication Date
KR850007586A true KR850007586A (ko) 1985-12-07
KR920000047B1 KR920000047B1 (ko) 1992-01-06

Family

ID=11166012

Family Applications (1)

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KR1019850002148A KR920000047B1 (ko) 1984-04-02 1985-03-30 피롤리돈 유도체의 제조방법

Country Status (20)

Country Link
US (2) US4629797A (ko)
EP (1) EP0156655B1 (ko)
JP (1) JPH0610191B2 (ko)
KR (1) KR920000047B1 (ko)
AR (1) AR240917A1 (ko)
AT (1) ATE38832T1 (ko)
AU (1) AU568274B2 (ko)
CA (1) CA1241334A (ko)
DE (1) DE3566403D1 (ko)
DK (1) DK145485A (ko)
ES (4) ES8700655A1 (ko)
FI (1) FI82035C (ko)
GR (1) GR850819B (ko)
HU (1) HU193749B (ko)
IL (2) IL74779A (ko)
IT (1) IT1173768B (ko)
NO (1) NO165676C (ko)
NZ (1) NZ211705A (ko)
PT (1) PT80202B (ko)
ZA (1) ZA852263B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
EP0223328B1 (en) 1985-07-26 1992-01-29 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
CH680293A5 (ko) * 1990-06-26 1992-07-31 Lonza Ag
KR100498268B1 (ko) * 1997-12-09 2005-11-01 주식회사 엘지생활건강 피롤리돈계 양쪽성 계면활성제
US8904443B2 (en) * 2005-09-07 2014-12-02 Sony Corporation System and method for improving home network GUI response time and presentation
CN101704778B (zh) * 2009-09-30 2012-10-17 厦门市华兴化工有限公司 一种制备4-羟基吡咯烷酮-2-乙酰胺的方法
CN102603601B (zh) * 2011-01-21 2013-12-25 重庆润泽医药有限公司 (s)-奥拉西坦的制备方法
CN102603598B (zh) * 2011-01-21 2014-07-16 重庆润泽医药有限公司 （s）-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法
CN102432516B (zh) * 2011-12-14 2013-10-09 山东阿如拉药物研究开发有限公司 奥拉西坦的精制方法
CN102627596B (zh) * 2012-03-16 2016-01-27 天津景寅医药生物技术发展有限公司 一种4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法
US9069141B2 (en) 2012-12-10 2015-06-30 Baker Hughes Incorporated Fiber optic termination arrangement and method of making the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici

Also Published As

Publication number Publication date
HU193749B (en) 1987-11-30
CA1241334A (en) 1988-08-30
FI851244A0 (fi) 1985-03-28
IT1173768B (it) 1987-06-24
ES8800136A1 (es) 1987-11-01
ES555009A0 (es) 1987-11-01
JPS60231651A (ja) 1985-11-18
DE3566403D1 (en) 1988-12-29
DK145485A (da) 1985-10-03
ES8706601A1 (es) 1987-07-01
ES8706613A1 (es) 1987-07-01
EP0156655A3 (en) 1986-02-05
ATE38832T1 (de) 1988-12-15
ES541811A0 (es) 1986-10-16
NO165676C (no) 1991-03-20
CA1255326C (ko) 1989-06-06
US4788300A (en) 1988-11-29
PT80202A (en) 1985-05-01
AR240917A1 (es) 1991-03-27
ES555011A0 (es) 1987-07-01
IL74779A (en) 1990-11-05
AR240917A2 (es) 1991-03-27
FI82035B (fi) 1990-09-28
US4629797A (en) 1986-12-16
AU4070485A (en) 1985-10-10
NZ211705A (en) 1990-07-26
JPH0610191B2 (ja) 1994-02-09
PT80202B (pt) 1987-06-17
ZA852263B (en) 1985-11-27
KR920000047B1 (ko) 1992-01-06
DK145485D0 (da) 1985-04-01
NO165676B (no) 1990-12-10
FI82035C (fi) 1991-01-10
AU568274B2 (en) 1987-12-17
EP0156655A2 (en) 1985-10-02
EP0156655B1 (en) 1988-11-23
NO851330L (no) 1985-10-03
FI851244L (fi) 1985-10-03
IT8420358A0 (it) 1984-04-02
ES555010A0 (es) 1987-07-01
ES8700655A1 (es) 1986-10-16
IL84951A (en) 1990-11-05
IL74779A0 (en) 1985-07-31
HUT38310A (en) 1986-05-28
GR850819B (ko) 1985-11-25

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