KR860003259A - 벤젠-융합 복소환 화합물의 제조방법 - Google Patents
벤젠-융합 복소환 화합물의 제조방법 Download PDFInfo
- Publication number
- KR860003259A KR860003259A KR1019850007824A KR850007824A KR860003259A KR 860003259 A KR860003259 A KR 860003259A KR 1019850007824 A KR1019850007824 A KR 1019850007824A KR 850007824 A KR850007824 A KR 850007824A KR 860003259 A KR860003259 A KR 860003259A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- salt
- carboxy
- group
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- -1 nitro, amino, hydroxy Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식(Ⅱ)의 화합물 또는 그 염을 구조식(Ⅲ)의 화합물 또는 그 염과 반응시켜서 구조식(1)의 화합물 또는 그 염을 제조하거나; 구조식(Ia)의 화합물 또는 그 염을 -R4 a기 도입제와 반응시켜서 구조식 (Ib)의 화합물 또는 그 염을 제조하거나; 구조식 (Ic)의 화합물 또는 그 염을 환원시켜서 구조식(Id)의 화합물 또는 그 염을 제조하거나; 구조식(Ie)의 화합물 또는 그 염으로부터 카복시보호기를 제거하여 구조식(If)의 화합물 또는 그 염을 제조하거나; 일반식(Ig)의 화합물 또는 그 염으로부터 카복시 보호기를 제거하여 구조시(Ih)의 화합물 또는 그 염을 제조하거나, 구조식(Ii)의 화합물 또는 그 염을 아실화제와 반응시켜 구조식(Ij)의 화합물 또는 그 염을 제조함을 특징으로 하는 구조식(I) 화합물을 제조하는 방법.상기 식에서, R1은 할로겐, 니트로, 아미노, 하이드록시, 저급알킬, 카복시나 보호딘 카복시로 치환된 저급알콕시, 아미노 잔기에 저급알킬을 가지거나 갖지 않은 아실아미노, 또는 할로겐을 가지거나 갖지 않은 아릴옥시이며; R1 d는 니트로이며; R1 b는 아미노이며; R1 c는 보호된 카복시로 치환된 저급알콕시이며; R1 d는 카복시로 치환된 저급알콕시이며; R2는 수소 또는 할로겐이며; X는 -O- 또는이며, 여기에서 R3는 수소 또는 저급알킬 또는 아실이며; A는 다음 구조식의 기여기에서 R4는 수소, 저급알케닐, 저급알킬이며, 이들 기는 하이드록시, 아실, 저급알콕시, 디(저급)알킬아미노, 카복시 보호딘 카복시 또는 아릴로 이루어진 그룹에서 선택된 적당한 치환기를 가질 수도 있다; 이거나 또는 R1은 수소 또는 저급알콕시이고, R2는 수소이며, X는여기에서는 저급알카노 일기이다, 이며 A는 다음 구조식의 기이며;는 아실이며; A1은 다음식구조의 기여기에서,는 저급알케닐, 저급알키닐 또는 알킬이며, 이들 기는 하이드록시, 아실, 저급알콕시, 디(저급)알킬아미노, 카복시, 보호된 카복시 및 아릴로 그룹에서 선택된 적당한 치환체(들)을 가질 수도 있다. A2는 다음 구조식의 기여기에서,는 보호된 카복시로 치환된 알킬, A3는 다음 구조식의 기여기에서,는 카복시로 치환된 알킬이며, B는 하이드록시 또는 구조식의 기, 여기에서 R5와 R6는 각각 저급알킬이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8427124 | 1984-10-26 | ||
| GB848427124A GB8427124D0 (en) | 1984-10-26 | 1984-10-26 | Benzene-fused heterocyclic compound |
| GB8513399 | 1985-05-28 | ||
| GB858513399A GB8513399D0 (en) | 1985-05-28 | 1985-05-28 | Heterocyclic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860003259A true KR860003259A (ko) | 1986-05-21 |
Family
ID=26288380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850007824A KR860003259A (ko) | 1984-10-26 | 1985-10-23 | 벤젠-융합 복소환 화합물의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4675324A (ko) |
| EP (1) | EP0180352B1 (ko) |
| JP (1) | JPH0649702B2 (ko) |
| KR (1) | KR860003259A (ko) |
| CN (1) | CN85108618A (ko) |
| AT (1) | ATE89825T1 (ko) |
| AU (1) | AU4855185A (ko) |
| DE (1) | DE3587362T2 (ko) |
| DK (1) | DK493185A (ko) |
| ES (2) | ES8702139A1 (ko) |
| FI (1) | FI853757L (ko) |
| GR (1) | GR852593B (ko) |
| HU (1) | HUT40124A (ko) |
| NO (1) | NO854275L (ko) |
| PH (1) | PH21213A (ko) |
| SU (1) | SU1375137A3 (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839368A (en) * | 1986-05-02 | 1989-06-13 | Mochida Pharmaceutical Co., Ltd. | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives |
| US4816467A (en) * | 1987-01-09 | 1989-03-28 | Farmitalia Carlo Erba S.R.L | Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use |
| WO1988007994A1 (en) * | 1987-04-09 | 1988-10-20 | E.I. Du Pont De Nemours And Company | Insecticidal substituted indazoles |
| JP2602037B2 (ja) * | 1987-10-31 | 1997-04-23 | 持田製薬株式会社 | １−アシル−２，３−ジヒドロ−４（１ｈ）−キノリノン−４−オキシム誘導体、その製法およびそれらを主成分とする利尿、降圧、抗浮腫および腹水除去用医薬組成物 |
| US5192768A (en) * | 1990-09-14 | 1993-03-09 | Kyowa Hakko Kogyo Co., Ltd. | Pyrazoloquinoline derivatives |
| ATE239710T1 (de) | 1994-06-15 | 2003-05-15 | Otsuka Pharma Co Ltd | Benzoheterocyclische derivate verwendbar als vasopressin- oder oxytocin-modulatoren |
| US5865170A (en) * | 1997-07-23 | 1999-02-02 | Moles; Randall C. | Customizable mouthpiece for scuba-divers |
| WO2004048378A1 (en) * | 2002-11-22 | 2004-06-10 | Active Biotech Ab | Pyrazoloquinolines with immunomodulating activity |
| AU2004270161A1 (en) * | 2003-08-28 | 2005-03-17 | Nicox S.A. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
| JP2008531579A (ja) * | 2005-02-24 | 2008-08-14 | ニトロメッド インコーポレーティッド | 酸化窒素増強利尿化合物、組成物および使用方法 |
| TWI405571B (zh) | 2006-12-29 | 2013-08-21 | Abbott Gmbh & Co Kg | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2009079A1 (ko) * | 1968-05-22 | 1970-01-30 | Sandoz Sa | |
| US3624102A (en) * | 1969-05-21 | 1971-11-30 | Warner Lambert Co | Substituted benzopyranopyrazoles |
| CY1357A (en) * | 1979-06-21 | 1987-08-07 | Ciba Geigy Ag | Pyrazolo-quinolines, processes for their production, pharmaceutical compositions containing them and their therapeutical use |
| US4524146A (en) * | 1982-12-08 | 1985-06-18 | Ciba-Geigy Corporation | Certain -2-heterocycle substituted pyrazoloquinolines |
-
1985
- 1985-09-24 PH PH32840A patent/PH21213A/en unknown
- 1985-09-26 US US06/780,582 patent/US4675324A/en not_active Expired - Fee Related
- 1985-09-30 FI FI853757A patent/FI853757L/fi not_active Application Discontinuation
- 1985-10-08 DE DE8585307200T patent/DE3587362T2/de not_active Expired - Fee Related
- 1985-10-08 AT AT85307200T patent/ATE89825T1/de not_active IP Right Cessation
- 1985-10-08 EP EP85307200A patent/EP0180352B1/en not_active Expired - Lifetime
- 1985-10-14 AU AU48551/85A patent/AU4855185A/en not_active Abandoned
- 1985-10-23 KR KR1019850007824A patent/KR860003259A/ko not_active Application Discontinuation
- 1985-10-24 JP JP60239205A patent/JPH0649702B2/ja not_active Expired - Lifetime
- 1985-10-25 DK DK493185A patent/DK493185A/da not_active Application Discontinuation
- 1985-10-25 SU SU853967801A patent/SU1375137A3/ru active
- 1985-10-25 NO NO854275A patent/NO854275L/no unknown
- 1985-10-25 ES ES548205A patent/ES8702139A1/es not_active Expired
- 1985-10-25 HU HU854120A patent/HUT40124A/hu unknown
- 1985-10-25 CN CN198585108618A patent/CN85108618A/zh active Pending
- 1985-10-29 GR GR852593A patent/GR852593B/el unknown
-
1986
- 1986-09-01 ES ES557041A patent/ES8801266A1/es not_active Expired
-
1987
- 1987-04-24 US US07/042,299 patent/US4767780A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4855185A (en) | 1986-05-01 |
| DK493185A (da) | 1986-04-27 |
| ES548205A0 (es) | 1986-12-16 |
| PH21213A (en) | 1987-08-21 |
| CN85108618A (zh) | 1986-08-27 |
| FI853757A0 (fi) | 1985-09-30 |
| ATE89825T1 (de) | 1993-06-15 |
| EP0180352B1 (en) | 1993-05-26 |
| EP0180352A2 (en) | 1986-05-07 |
| US4767780A (en) | 1988-08-30 |
| EP0180352A3 (en) | 1988-03-30 |
| ES557041A0 (es) | 1987-12-16 |
| JPH0649702B2 (ja) | 1994-06-29 |
| ES8801266A1 (es) | 1987-12-16 |
| NO854275L (no) | 1986-04-28 |
| ES8702139A1 (es) | 1986-12-16 |
| GR852593B (ko) | 1985-12-24 |
| DE3587362T2 (de) | 1993-09-09 |
| SU1375137A3 (ru) | 1988-02-15 |
| DK493185D0 (da) | 1985-10-25 |
| HUT40124A (en) | 1986-11-28 |
| JPS61112076A (ja) | 1986-05-30 |
| FI853757L (fi) | 1986-04-27 |
| US4675324A (en) | 1987-06-23 |
| DE3587362D1 (de) | 1993-07-01 |
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