KR850004386A - 유효 화합물 방출 조성체 제조방법 - Google Patents

유효 화합물 방출 조성체 제조방법 Download PDF

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Publication number
KR850004386A
KR850004386A KR1019840008334A KR840008334A KR850004386A KR 850004386 A KR850004386 A KR 850004386A KR 1019840008334 A KR1019840008334 A KR 1019840008334A KR 840008334 A KR840008334 A KR 840008334A KR 850004386 A KR850004386 A KR 850004386A
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South Korea
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weight
resin
process according
effective compound
layer
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KR1019840008334A
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English (en)
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본 비테라 미클로스
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에리히 데브리쯔, 요아힘 그렘
바이엘 악티엔 게젤샤프트
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Application filed by 에리히 데브리쯔, 요아힘 그렘, 바이엘 악티엔 게젤샤프트 filed Critical 에리히 데브리쯔, 요아힘 그렘
Publication of KR850004386A publication Critical patent/KR850004386A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Control Of Eletrric Generators (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • External Artificial Organs (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)

Abstract

내용 없음

Description

유효 화합물 방출 조성체 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 치료 조성체 제조용 장치의 개략도임. 제2도는 본 발명완성 제품의 단면 도식임.

Claims (10)

  1. 유효 화합물에 본질적으로 침투되지 않는 피복층, 유효 화합물 축적층 및 필요에 따라 박리시킬 수 있고, 유효 화합물에 본질적으로 침투되지 않는 피복층으로 되는 치료조성체의 제조방법에 있어서, 유리 전이온도 20℃인 고무상과 같은 주로 무정형인 올레핀계 공중합체를 임의로 디엔고무 또는 스티렌/디엔고무와 혼합해서 그 자체로 또는 폴리이소부틸렌의 중합체 성분 50중량%이하와 혼합시킨 혼합물로 되는 중합체 성분, 1이상의 비말동반제 및 1이상의 수지를 용매중에 용해시키고, 유효화합물로서 중합체 성분의 혼합물의 중량에 기초해서 소염제 2―15중량%, 비말동반제 및 수지를 또한 용매중에 용해시키고, 이용액들을 혼합해서 얻은 혼합용액을 유효화합물에 본질적으로 침투되지 않ㄴ느 필름피복층에 고르게 사용하고, 인발시켜 필름을 형성시키고, 피복시킨 필름(회복층)을 처음에 실온에서 건조시킨 다음 50℃이하에서 건조시키고, 필요에 따라 건조시킨 필름(피복층)의 피복층에, 유효화합물에 본질적으로 침투되지 않고 박리시킬 수 있는 보호층을 제공함을 특징으로 하는 치료 조성제의 제조방법.
  2. 제1항에 있어서, 하기 일반식(Ⅰ) 및 (또는) 일반식(Ⅱ)의 소염제가 유효 화합물로 사용되는 방법:
    상기식에서, R1―R5는 같거나 서로 다를 수 있는 수소, 할로겐, 서급알킬 또는 치환알킬이고, X는 N 또는 CH이고, Y는 수소, 금속이온, 알킬 또는 치환알킬이고, R은 수소, 저급 알킬 또는 치환알킬이고, Ar은 아릴, 헤테로아릴, 치환아릴 또는 치환헤테로 알릴이고, n+m은 정수로서 0,1 또는 2이고, p는 0 또는 1임. 단 n,m 및 p가 0인 경우에 Ar는 아릴 또는 헤테로아릴을 나타내지 않는다.
  3. 제1항에 있어서, 하기 일반식의 혼합물이 유효 화합물로 사용되는 방법.
  4. 제1,2및 3항에 있어서, 유효 화합물 축적층 제조에 있어서, 중합체 성분 30―60중량%, 비말동반제 30―60중량% 및 점착성을 개선시키는 수지 2―20중량%를 사용하고, 이 3성분의 합량이 100%인 방법.
  5. 제 1,2,3, 및 4항에 있어서, 중합체 성분으로서 디올레핀과더 공중합시킬 수 있고, 20℃이하의 유리전이 온도를 가지며, 그 자체로 또는 α―올레핀류와 랜덤하게 또는 블록형태로 또한 공중합시킬 수 있는 공지의 디엔고무의 중합체 총량 95중량%이하와 혼합시킨 적어도 1이상의 C12―C18―α―올레핀 또는 시클로올레핀으로 되고 주로 무정형인 공중합체를 사용하는 방법.
  6. 제1,2,3,4 및 5항에 있어서, 중합체 성분으로 에틸렌 및 (또는) 프로필렌과 C4―C18―α―올레핀류로 되는 주로 무정형인 공중합체가 사용되는 방법.
  7. 제1,2,3,4,5 및 6항에 있어서, 사용된 디엔 고무가 1,3―디엔류에 기초한 것인 방법.
  8. 제1,2,3,4,5,6 및 7항에 있어서, EPDM 고무가 디엔류와 공중합된 α―올레핀 공중합체로 사용되는 방법.
  9. 제1,2,3,4,5,7,8항에 있어서, 유효 화합물 축적층에 사용된 필름(피복층)이 흡장성이 굴요성재 또는 비굴요성재로 되는 방법.
  10. 제1,2,3,4,5,6,7,8 및 9항에 있어서, 폴리테르펜 수지 또는 로진의 변형 글리세롤에 스테르가 유효 화합물 축적용 수지로 사용되고, 오일류, 지방산 에스테르류, 트리글리세리드류, 알코올류 및 (또는) 지방산류가 유효 화합물 축적층용 비말동반 제로서 사용되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840008334A 1983-12-28 1984-12-26 유효 화합물 방출 조성체 제조방법 KR850004386A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3347277,7 1983-12-28
DE19833347277 DE3347277A1 (de) 1983-12-28 1983-12-28 Wirkstoffabgabesysteme

Publications (1)

Publication Number Publication Date
KR850004386A true KR850004386A (ko) 1985-07-15

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ID=6218283

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840008334A KR850004386A (ko) 1983-12-28 1984-12-26 유효 화합물 방출 조성체 제조방법

Country Status (18)

Country Link
US (1) US4661104A (ko)
EP (1) EP0150426B1 (ko)
JP (1) JPS60158110A (ko)
KR (1) KR850004386A (ko)
AT (1) ATE57838T1 (ko)
AU (1) AU569355B2 (ko)
CA (1) CA1240924A (ko)
DE (2) DE3347277A1 (ko)
DK (1) DK626484A (ko)
ES (1) ES8605157A1 (ko)
FI (1) FI845133L (ko)
GR (1) GR82618B (ko)
HU (1) HU193074B (ko)
IL (1) IL73936A (ko)
NO (1) NO162216B (ko)
NZ (1) NZ210689A (ko)
PT (1) PT79763B (ko)
ZA (1) ZA8410059B (ko)

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US4954344A (en) * 1981-06-29 1990-09-04 Alza Corporation Method for treating nocturnal angina
DE3344691A1 (de) * 1983-12-10 1985-06-20 Bayer Ag, 5090 Leverkusen Wirkstoffabgasesysteme
DE3587616D1 (de) * 1984-12-22 1993-11-11 Sanol Arznei Schwarz Gmbh Wirkstoffpflaster.
JP2572763B2 (ja) * 1987-04-02 1997-01-16 帝國製薬株式会社 エトフェナマ−ト含有貼付薬
US5051261A (en) * 1987-11-24 1991-09-24 Fmc Corporation Method for preparing a solid sustained release form of a functionally active composition
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
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US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
EP0431519B1 (en) * 1989-12-04 1994-06-15 G.D. Searle & Co. System for transdermal albuterol administration
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
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US5580573A (en) * 1991-02-01 1996-12-03 E. R. Squibb And Sons, Inc. Temperature activated controlled release
US5294438A (en) * 1991-02-05 1994-03-15 Minnesota Mining And Manufacturing Company Lubricating and moisturizing shaving preparations
EP0607434B1 (en) * 1991-08-30 1999-01-27 Hisamitsu Pharmaceutical Co., Inc. Anti-inflammatory analgesic plaster
US5264219A (en) * 1992-08-07 1993-11-23 Minnesota Mining And Manufacturing Company Transdermal drug delivery backing
JPH08504146A (ja) * 1992-12-09 1996-05-07 パステラ，アンソニー・フランシス 円板状表面スキマーを備えた船舶
DE19834025A1 (de) * 1998-07-28 2000-02-03 Aventis Res & Tech Gmbh & Co Mikrokapseln hergestellt aus Cycloolefinpolymeren oder Cycloolefincopolymeren und deren Verwendung zur kontrollierten Wirkstoffabgabe
DE19940238A1 (de) 1999-08-25 2001-03-01 Lohmann Therapie Syst Lts Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten
DE10003767A1 (de) 2000-01-28 2001-10-04 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
CN101080219B (zh) * 2004-12-15 2010-11-17 帝国制药株式会社 含依托芬那酯的外用贴剂
MY148823A (en) * 2007-01-11 2013-06-14 Drossapharm Ag Medically active plaster

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Also Published As

Publication number Publication date
US4661104A (en) 1987-04-28
NZ210689A (en) 1988-08-30
NO845001L (no) 1985-07-01
ATE57838T1 (de) 1990-11-15
NO162216B (no) 1989-08-21
CA1240924A (en) 1988-08-23
EP0150426B1 (de) 1990-10-31
IL73936A (en) 1988-09-30
DE3483525D1 (de) 1990-12-06
ZA8410059B (en) 1985-08-28
ES8605157A1 (es) 1986-03-16
EP0150426A3 (en) 1986-01-15
PT79763A (en) 1985-01-01
HUT36705A (en) 1985-10-28
AU3664884A (en) 1985-07-04
PT79763B (en) 1986-10-21
AU569355B2 (en) 1988-01-28
DK626484A (da) 1985-06-29
GR82618B (en) 1985-05-02
JPS60158110A (ja) 1985-08-19
ES538862A0 (es) 1986-03-16
EP0150426A2 (de) 1985-08-07
IL73936A0 (en) 1985-03-31
HU193074B (en) 1987-08-28
FI845133A0 (fi) 1984-12-27
DE3347277A1 (de) 1985-07-11
DK626484D0 (da) 1984-12-21
FI845133L (fi) 1985-06-29

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