KR840002372A - 트리펩타이드를 함유한 n-카르복시 알킬플룰린을 제조하는 방법 - Google Patents
트리펩타이드를 함유한 n-카르복시 알킬플룰린을 제조하는 방법 Download PDFInfo
- Publication number
- KR840002372A KR840002372A KR1019820005004A KR820005004A KR840002372A KR 840002372 A KR840002372 A KR 840002372A KR 1019820005004 A KR1019820005004 A KR 1019820005004A KR 820005004 A KR820005004 A KR 820005004A KR 840002372 A KR840002372 A KR 840002372A
- Authority
- KR
- South Korea
- Prior art keywords
- ala
- group
- acid
- proline
- methyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- 229910052731 fluorine Inorganic materials 0.000 title 1
- 239000011737 fluorine Substances 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- -1 carboxy sulfo Chemical group 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 230000004526 pharmaceutical effect Effects 0.000 claims 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 1
- 150000003018 phosphorus compounds Chemical class 0.000 claims 1
- 229960002429 proline Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 구조식인 화합물로 반응시키는 것과 표준 화학반응에 의하여 거기에 존재하는 몇개의 보호기를 제거하는 것, 약제효과를 갖는 트리펩타이드의 염을 임의로 형성하는 것으로 구성된 구조식의 트리펩타이드를 제조하는 방법.여기에서 R은 카르복시 슬포 혹은 포스포노기이고 alk는 에틸리덴이 아닌 1내지 5개의 탄소를 가진 직쇄 또는 가지형 사슬이고, X는 O나 H,H : Y는 H이거나 X가 H,HDLFeO OH : 이고 이들은 X가 H,H이고 Y가 H일때 임의의 결합이다.n은 0내지 3을 포함하는 정수이고, A는 D－나 L－ALa, D－나 L－Phe, D－나 L－β－메틸－β－ALa, D－나 L－페닐－Gly, D－나 L－β－페닐－β－ALa, D－나 L－β－티에닐－Gly, D－나 L－β－ALa, r－아미노부틸산이거나D－나 L－2－아미노부틸산, D－나 L－nor－Val, D－나 L－Leu, 3－아미노－3－메틸부틸산, 2－메틸－ALa나 상기 잔류물의 N－메틸유도체이거나 약제로서 유용한 염이나 상기 화합물의 대용약제 유도체로부터 유도된 아미노산 잔류물이다.R1은 보호된 카르복시, 슬포나 포스포노기이고 R2는 카르북시보호기이고, R2는 상기 정의된 바와같은 부분 A인 아미노기나 N－메틸아미노기이다.
- 카르보디이미드의 존재하에서 반응을 수행하는 청구범위 제1항의 방법.
- 디시클로헥시카르보디이미드의 존재하에서 반응을 수행하는 청구범위 제1항의 방법.
- 벤질 에스테르 염산으로서의 β－알라닐－L－프롤린을 N－카르보메톡시메틸－L－프롤린 염산과 반응시켜 N－카르복시메틸－L－프롤릴－β－알라닐－L－프롤린을 생성하는 청구범위 제1항의 공정.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31872181A | 1981-11-06 | 1981-11-06 | |
| US318721 | 1981-11-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840002372A true KR840002372A (ko) | 1984-06-25 |
| KR880002594B1 KR880002594B1 (ko) | 1988-12-03 |
Family
ID=23239338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8205004A KR880002594B1 (ko) | 1981-11-06 | 1982-11-05 | 트리펲타이드를 함유한 n-카르복시알킬프롤린을 제조하는 방법 |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0080283B1 (ko) |
| JP (1) | JPS5890537A (ko) |
| KR (1) | KR880002594B1 (ko) |
| AT (1) | ATE17736T1 (ko) |
| AU (1) | AU562011B2 (ko) |
| CA (1) | CA1247085A (ko) |
| CS (1) | CS235030B2 (ko) |
| DD (1) | DD206553A5 (ko) |
| DE (1) | DE3268884D1 (ko) |
| DK (1) | DK480682A (ko) |
| ES (1) | ES8401447A1 (ko) |
| FI (1) | FI75175C (ko) |
| GR (1) | GR77368B (ko) |
| HU (1) | HU187808B (ko) |
| IE (1) | IE53982B1 (ko) |
| IL (1) | IL67070A (ko) |
| NO (1) | NO160081C (ko) |
| NZ (1) | NZ202232A (ko) |
| PH (1) | PH18708A (ko) |
| PL (1) | PL136098B1 (ko) |
| PT (1) | PT75769B (ko) |
| RO (1) | RO84706B (ko) |
| YU (1) | YU245582A (ko) |
| ZA (1) | ZA827816B (ko) |
| ZW (1) | ZW23282A1 (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040013679A (ko) * | 2002-08-08 | 2004-02-14 | 현대산업개발 주식회사 | 실내 공기 상태 표시장치 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE174343T1 (de) * | 1991-02-27 | 1998-12-15 | Lacer Sa | Antihypertensive n-(alpha-substituiertes pyridyl)-carbonyldipeptide |
| JP3068200B2 (ja) | 1995-06-06 | 2000-07-24 | ファイザー・インコーポレーテッド | グリコーゲンホスホリラーゼ阻害剤としての置換ｎ−（インドール−２−カルボニル−）アミドおよび誘導体 |
| MY114711A (en) | 1995-06-06 | 2002-12-31 | Pfizer | Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents |
| CA2224062C (en) * | 1995-06-06 | 2001-09-04 | Pfizer Limited | Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors |
| US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
-
1982
- 1982-10-20 NZ NZ202232A patent/NZ202232A/en unknown
- 1982-10-26 IL IL67070A patent/IL67070A/xx unknown
- 1982-10-26 ZA ZA827816A patent/ZA827816B/xx unknown
- 1982-10-27 PH PH28047A patent/PH18708A/en unknown
- 1982-10-27 ZW ZW232/82A patent/ZW23282A1/xx unknown
- 1982-10-29 PT PT75769A patent/PT75769B/pt unknown
- 1982-10-29 DK DK480682A patent/DK480682A/da not_active Application Discontinuation
- 1982-11-02 YU YU02455/82A patent/YU245582A/xx unknown
- 1982-11-03 RO RO108968A patent/RO84706B/ro unknown
- 1982-11-04 AU AU90173/82A patent/AU562011B2/en not_active Ceased
- 1982-11-04 GR GR69726A patent/GR77368B/el unknown
- 1982-11-05 NO NO823693A patent/NO160081C/no unknown
- 1982-11-05 DE DE8282305879T patent/DE3268884D1/de not_active Expired
- 1982-11-05 CS CS827906A patent/CS235030B2/cs unknown
- 1982-11-05 HU HU823574A patent/HU187808B/hu unknown
- 1982-11-05 CA CA000414962A patent/CA1247085A/en not_active Expired
- 1982-11-05 JP JP57195195A patent/JPS5890537A/ja active Pending
- 1982-11-05 ES ES517144A patent/ES8401447A1/es not_active Expired
- 1982-11-05 DD DD82244613A patent/DD206553A5/de unknown
- 1982-11-05 AT AT82305879T patent/ATE17736T1/de not_active IP Right Cessation
- 1982-11-05 IE IE2647/82A patent/IE53982B1/en unknown
- 1982-11-05 EP EP82305879A patent/EP0080283B1/en not_active Expired
- 1982-11-05 KR KR8205004A patent/KR880002594B1/ko active
- 1982-11-05 FI FI823798A patent/FI75175C/fi not_active IP Right Cessation
- 1982-11-06 PL PL1982238893A patent/PL136098B1/pl unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040013679A (ko) * | 2002-08-08 | 2004-02-14 | 현대산업개발 주식회사 | 실내 공기 상태 표시장치 |
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