KR830009062A - 치환된 3-아미노-시드논-이민의 제조방법 - Google Patents
치환된 3-아미노-시드논-이민의 제조방법 Download PDFInfo
- Publication number
- KR830009062A KR830009062A KR1019820000898A KR820000898A KR830009062A KR 830009062 A KR830009062 A KR 830009062A KR 1019820000898 A KR1019820000898 A KR 1019820000898A KR 820000898 A KR820000898 A KR 820000898A KR 830009062 A KR830009062 A KR 830009062A
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- KR
- South Korea
- Prior art keywords
- carbon atoms
- compound
- radical
- starting material
- acid addition
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pyrane Compounds (AREA)
- Seasonings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 일반식(II)의 화합물을 폐환시켜 일반식(Ia)의 화합물을 제조하고 (이 화합물은 산부가염의 형태로 수득될 수도 있다) 필요한 경우 이 산부 가염으로부터 일반식(I)의 유리 화합물을 분리시키고, 필요한경우 이 유리화합물이나 그 산부가염을 -COR6라디칼을 도입시킬 수 있는 아실화제로 아실화시키고 수득된 화합물을 산부가염으로 전환시킴을 특징으로하여 일반식(I)의 치환된 3-아미노-시드논-이민을 제조하는 방법.상기식에서R2는 수소 또는 -COR4라디칼이고 R3은 메틸, 에틸, 프로필 또는 이소프로필이고 R4는 탄소수 1 내지 3의 알콕시로 치환될수도 있는 탄소수 1내지 4의 지방족 라디칼이거나, 또는 탄소수 5 내지 7의 지환족 라디칼, 탄소수 7내지 14의 비사이클로 알리파틱 라디칼, 탄소수 7내지 16의 트리사이클로 알리파틱 라디칼, 탄소수 1내지 6의 알콕시라디칼, 탄소수 6내지 12의 아릴 옥시라디칼, 탄소수 2내지 7의 알콕시카보닐 라디칼, 탄소수 6내지 12의 아릴 라디칼, 또는 탄소수 6내지 12이고, 1개 내지 3개의 할로겐원자 및/또는 탄소수 1내지 3인 알킬라디칼 1개내지 3개 및/또는 탄소수 1내지 3의 알콕시라디칼 1개 내지 3개 및/또는 1개내지 2개의 니트로그룹에 의해 모노, 디, 트리치환된 아릴 라디칼이다.
- 상기 1에서, 폐환반응을 용매 또는 분산제중에서 0내지 40℃, 특히 0내지 20℃의 온도에서, 수용액의 pH치를 3이하로 떨어뜨릴 수 있는 폐환제를 이용하여 수행함을 특징으로 하는 방법.
- 상기 1 및/또는 2에서, 출발물질이 R3가 메틸 또는 에틸이고 R4가 탄소수 1내지 4의 알킬이고 메톡시메틸, 탄소수 5내지 7의 사이클로알킬, 2,6,6-트리메틸-비사이클로-[3,1,1]-헵틸, 트리사이클로-[3,3,1,1,3,7]데실, 메톡시, 에톡시, 페녹시, 에톡시-카보닐, 페닐, 메틸페닐, 니트로페닐, 클로로페닐인일반식(I)의 화합물을 제조해 낼 수 있는 출발물질임이 특징인 방법.
- 상기 1내지 3중의 하나 또는 여럿에서, R1이 N-메틸-N-(테트라하이드로-3-티에닐-S,S-디옥사이드)-아미노그룹을 뜻함이 특징인 방법.
- 상기 1내지 4중의 하나 또는 여럿에서, R2는 수소, -COR4그룹을 뜻하고 R4는 메틸, 에틸, 사이클로헥실, 페닐, 4-클로로페닐 또는 4-니트로페닐을 뜻함이 특징인 방법.
- 상기 1내지 5중의 하나 또는 여럿에서, 출발물질이 3-(N-메틸-N-(테트라하이드로-3-티에닐-S,S-디옥사이드)-아미노)-시드논-이민 또는 그 산부가염인 일반식(I) 화합물을 제조해 낼수 있는 출발물질임이 특징인 방법.
- 상기 1내지 5중의 하나 또는 여럿에서, 출발물질이 3-(4-에톡시카보닐-피페라진-1-일)-시드논-이민 또는 그 산부가염인일반식(I) 화합물을 제조해 낼수 있는 출발물질임이 특징인 방법.
- 상기 1내지 5중의 하나 또는 여럿에서, 출발물질이 3-(N-메틸-N-(테트라하이드로-3-티에닐-S,S-디옥사이드)-아미노)-N6-니트로벤조일-시드논-이민 또는 그 산부가염인 일반식(I) 화합물을 제조해 낼수 있는 출발물질임이 특징인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019880007345A KR880001429B1 (ko) | 1981-03-02 | 1988-06-17 | 치환된 3-아미노-시드논-이민의 제조방법 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813107933 DE3107933A1 (de) | 1981-03-02 | 1981-03-02 | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3107933 | 1981-03-02 | ||
DE3107933.4 | 1981-03-02 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880007345A Division KR880001429B1 (ko) | 1981-03-02 | 1988-06-17 | 치환된 3-아미노-시드논-이민의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830009062A true KR830009062A (ko) | 1983-12-17 |
KR880001428B1 KR880001428B1 (ko) | 1988-08-08 |
Family
ID=6126174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8200898A KR880001428B1 (ko) | 1981-03-02 | 1982-03-02 | 치환된 3-아미노-시드논-이민의 제조방법 |
Country Status (23)
Country | Link |
---|---|
US (2) | US4436743A (ko) |
EP (1) | EP0059356B1 (ko) |
JP (1) | JPS57158768A (ko) |
KR (1) | KR880001428B1 (ko) |
AT (1) | ATE13055T1 (ko) |
AU (1) | AU545292B2 (ko) |
CA (1) | CA1192905A (ko) |
CS (1) | CS224645B2 (ko) |
DD (1) | DD208617A5 (ko) |
DE (2) | DE3107933A1 (ko) |
DK (1) | DK149852C (ko) |
ES (1) | ES510015A0 (ko) |
FI (1) | FI820518L (ko) |
HU (1) | HU190683B (ko) |
IL (1) | IL65141A (ko) |
NO (1) | NO820476L (ko) |
NZ (1) | NZ199862A (ko) |
PH (1) | PH18696A (ko) |
PL (1) | PL136818B1 (ko) |
PT (1) | PT74507B (ko) |
RO (1) | RO84816B (ko) |
SU (1) | SU1097197A3 (ko) |
ZA (1) | ZA821327B (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なn−アシルシドノンイミン誘導体およびその製法 |
US4517179A (en) * | 1983-04-29 | 1985-05-14 | Pennwalt Corporation | Rapid dissolving, uniform drug compositions and their preparation |
DK243084A (da) * | 1983-05-26 | 1984-11-27 | Takeda Chemical Industries Ltd | Perkutane farmaceutiske praeparater til udvortes brug |
DE3526068A1 (de) * | 1985-07-20 | 1987-01-22 | Cassella Ag | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische praeparate |
DE3702083A1 (de) * | 1987-01-24 | 1988-08-04 | Cassella Ag | Allylmercaptoacetyl-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3732174A1 (de) * | 1987-09-24 | 1989-04-06 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
US5221680A (en) * | 1988-01-14 | 1993-06-22 | Cassella Aktiengesellschaft | Substituted 3-aminosydnonimines |
FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
US5120732A (en) * | 1988-06-14 | 1992-06-09 | Cassella Aktiengesellschaft | Substituted 3-aminosyndone imines, a process for their preparation and their use |
DE4025604A1 (de) * | 1990-08-13 | 1992-02-20 | Cassella Ag | 3-dicyclohexylamino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE4028679A1 (de) * | 1990-09-10 | 1992-03-19 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE4031373A1 (de) * | 1990-10-04 | 1992-04-09 | Cassella Ag | 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
WO1997017334A1 (fr) * | 1995-11-06 | 1997-05-15 | Chugai Seiyaku Kabushiki Kaisha | Derives d'imine de sydnone |
FR2758459B1 (fr) | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
US6531158B1 (en) | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1695897C3 (de) | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US3833580A (en) | 1966-08-09 | 1974-09-03 | Boehringer Sohn Ingelheim | 3-morpholino-n6-cyclohexylcarbonyl sydnonimine |
BE788052A (fr) * | 1971-08-26 | 1973-02-26 | Science Union & Cie Societe Fr | Nouveaux derives de la sydnone imine |
US3833589A (en) * | 1972-07-31 | 1974-09-03 | Sandoz Ag | Substituted sydnonimine nitrate esters |
DE2930736A1 (de) * | 1979-07-28 | 1981-02-12 | Cassella Ag | Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
JPS5832870A (ja) * | 1981-08-24 | 1983-02-25 | Hiroyoshi Hidaka | 新規なシドノンイミン誘導体及びその製法 |
JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なn−アシルシドノンイミン誘導体およびその製法 |
-
1981
- 1981-03-02 DE DE19813107933 patent/DE3107933A1/de not_active Withdrawn
-
1982
- 1982-02-15 DE DE8282101091T patent/DE3263342D1/de not_active Expired
- 1982-02-15 AT AT82101091T patent/ATE13055T1/de not_active IP Right Cessation
- 1982-02-15 EP EP82101091A patent/EP0059356B1/de not_active Expired
- 1982-02-16 FI FI820518A patent/FI820518L/fi not_active Application Discontinuation
- 1982-02-16 DK DK67682A patent/DK149852C/da not_active IP Right Cessation
- 1982-02-16 NO NO820476A patent/NO820476L/no unknown
- 1982-02-19 US US06/350,366 patent/US4436743A/en not_active Expired - Fee Related
- 1982-02-26 RO RO106750A patent/RO84816B/ro unknown
- 1982-02-26 CA CA000397186A patent/CA1192905A/en not_active Expired
- 1982-02-26 DD DD82237741A patent/DD208617A5/de unknown
- 1982-03-01 HU HU82616A patent/HU190683B/hu unknown
- 1982-03-01 AU AU80966/82A patent/AU545292B2/en not_active Ceased
- 1982-03-01 ES ES510015A patent/ES510015A0/es active Granted
- 1982-03-01 ZA ZA821327A patent/ZA821327B/xx unknown
- 1982-03-01 NZ NZ199862A patent/NZ199862A/en unknown
- 1982-03-01 PH PH26931A patent/PH18696A/en unknown
- 1982-03-01 JP JP57030669A patent/JPS57158768A/ja active Pending
- 1982-03-01 IL IL65141A patent/IL65141A/xx unknown
- 1982-03-01 SU SU823398796A patent/SU1097197A3/ru active
- 1982-03-01 PL PL1982235274A patent/PL136818B1/pl unknown
- 1982-03-01 PT PT74507A patent/PT74507B/pt unknown
- 1982-03-02 CS CS821412A patent/CS224645B2/cs unknown
- 1982-03-02 KR KR8200898A patent/KR880001428B1/ko active
-
1983
- 1983-05-06 US US06/477,146 patent/US4551454A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PH18696A (en) | 1985-09-05 |
RO84816A (ro) | 1984-08-17 |
HU190683B (en) | 1986-10-28 |
ES8303404A1 (es) | 1983-02-01 |
DE3263342D1 (en) | 1985-06-05 |
CS224645B2 (en) | 1984-01-16 |
DE3107933A1 (de) | 1982-09-16 |
RO84816B (ro) | 1984-09-30 |
DD208617A5 (de) | 1984-04-04 |
ES510015A0 (es) | 1983-02-01 |
EP0059356B1 (de) | 1985-05-02 |
NZ199862A (en) | 1985-04-30 |
IL65141A0 (en) | 1982-05-31 |
KR880001428B1 (ko) | 1988-08-08 |
US4436743A (en) | 1984-03-13 |
FI820518L (fi) | 1982-09-03 |
DK149852B (da) | 1986-10-13 |
PT74507A (de) | 1982-04-01 |
DK149852C (da) | 1987-06-01 |
NO820476L (no) | 1982-09-03 |
AU545292B2 (en) | 1985-07-11 |
ATE13055T1 (de) | 1985-05-15 |
AU8096682A (en) | 1982-09-16 |
US4551454A (en) | 1985-11-05 |
PL136818B1 (en) | 1986-03-31 |
CA1192905A (en) | 1985-09-03 |
PT74507B (de) | 1983-11-08 |
ZA821327B (en) | 1983-01-26 |
IL65141A (en) | 1984-10-31 |
DK67682A (da) | 1982-09-03 |
EP0059356A1 (de) | 1982-09-08 |
JPS57158768A (en) | 1982-09-30 |
SU1097197A3 (ru) | 1984-06-07 |
PL235274A1 (ko) | 1982-10-25 |
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