KR20130076046A - 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체 - Google Patents

타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체 Download PDF

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Publication number
KR20130076046A
KR20130076046A KR1020110144450A KR20110144450A KR20130076046A KR 20130076046 A KR20130076046 A KR 20130076046A KR 1020110144450 A KR1020110144450 A KR 1020110144450A KR 20110144450 A KR20110144450 A KR 20110144450A KR 20130076046 A KR20130076046 A KR 20130076046A
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KR
South Korea
Prior art keywords
phenyl
disease
pyridin
imidazo
chloro
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KR1020110144450A
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English (en)
Korean (ko)
Inventor
이경익
심재의
김호석
하태희
Original Assignee
한미약품 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Priority to KR1020110144450A priority Critical patent/KR20130076046A/ko
Priority to RU2014131068A priority patent/RU2014131068A/ru
Priority to JP2014550009A priority patent/JP2015503552A/ja
Priority to PCT/KR2012/011570 priority patent/WO2013100631A1/en
Priority to CN201280064532.0A priority patent/CN104024243A/zh
Priority to MX2014007976A priority patent/MX2014007976A/es
Priority to CA2859664A priority patent/CA2859664A1/en
Priority to AU2012363557A priority patent/AU2012363557A1/en
Priority to BR112014016146A priority patent/BR112014016146A8/pt
Priority to EP12861996.2A priority patent/EP2797909A4/en
Priority to US14/368,702 priority patent/US20150299185A1/en
Publication of KR20130076046A publication Critical patent/KR20130076046A/ko
Priority to IL233415A priority patent/IL233415A0/en
Priority to ZA2014/05505A priority patent/ZA201405505B/en
Priority to HK15101096.4A priority patent/HK1200811A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
KR1020110144450A 2011-12-28 2011-12-28 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체 KR20130076046A (ko)

Priority Applications (14)

Application Number Priority Date Filing Date Title
KR1020110144450A KR20130076046A (ko) 2011-12-28 2011-12-28 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
AU2012363557A AU2012363557A1 (en) 2011-12-28 2012-12-27 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor
BR112014016146A BR112014016146A8 (pt) 2011-12-28 2012-12-27 derivados de imidazopiridina como um inibidor de tirosina quinase
PCT/KR2012/011570 WO2013100631A1 (en) 2011-12-28 2012-12-27 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor
CN201280064532.0A CN104024243A (zh) 2011-12-28 2012-12-27 作为酪氨酸激酶抑制剂的新咪唑并吡啶衍生物
MX2014007976A MX2014007976A (es) 2011-12-28 2012-12-27 Derivados de imidazopiridina novedosos como un inhibidor de tirosina cinasa.
CA2859664A CA2859664A1 (en) 2011-12-28 2012-12-27 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor
RU2014131068A RU2014131068A (ru) 2011-12-28 2012-12-27 Новые производные имидазопиридина в качестве ингибиторов тирозинкиназы
JP2014550009A JP2015503552A (ja) 2011-12-28 2012-12-27 チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体
EP12861996.2A EP2797909A4 (en) 2011-12-28 2012-12-27 NOVEL IMIDAZOPYRIDINE DERIVATIVES AS TYROSINE KINASE INHIBITOR
US14/368,702 US20150299185A1 (en) 2011-12-28 2012-12-27 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor
IL233415A IL233415A0 (en) 2011-12-28 2014-06-26 Imidazopyridine derivatives of tyrosine kinase inhibitors, preparations containing them and their uses
ZA2014/05505A ZA201405505B (en) 2011-12-28 2014-07-25 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor
HK15101096.4A HK1200811A1 (en) 2011-12-28 2015-02-02 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020110144450A KR20130076046A (ko) 2011-12-28 2011-12-28 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체

Publications (1)

Publication Number Publication Date
KR20130076046A true KR20130076046A (ko) 2013-07-08

Family

ID=48697977

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020110144450A KR20130076046A (ko) 2011-12-28 2011-12-28 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체

Country Status (14)

Country Link
US (1) US20150299185A1 (ja)
EP (1) EP2797909A4 (ja)
JP (1) JP2015503552A (ja)
KR (1) KR20130076046A (ja)
CN (1) CN104024243A (ja)
AU (1) AU2012363557A1 (ja)
BR (1) BR112014016146A8 (ja)
CA (1) CA2859664A1 (ja)
HK (1) HK1200811A1 (ja)
IL (1) IL233415A0 (ja)
MX (1) MX2014007976A (ja)
RU (1) RU2014131068A (ja)
WO (1) WO2013100631A1 (ja)
ZA (1) ZA201405505B (ja)

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Publication number Priority date Publication date Assignee Title
CN105837572B (zh) * 2015-02-02 2019-04-19 四川大学 N-取代苯基酰胺衍生物及其制备方法和用途
US11008318B2 (en) * 2016-07-11 2021-05-18 Kancera Ab 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity
MA46995A (fr) 2016-12-03 2019-10-09 Acerta Pharma Bv Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase
EP3976612A4 (en) * 2019-05-28 2023-04-26 Mankind Pharma Ltd NEW COMPOUNDS FOR INHIBITION OF JANUS KINASE 1
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy

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IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1017682A4 (en) * 1997-09-26 2000-11-08 Merck & Co Inc NEW ANGIOGENESIS INHIBITORS
US20090170847A1 (en) * 2006-01-23 2009-07-02 Seung Chul Lee Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same
BRPI0707245A2 (pt) * 2006-01-23 2011-04-26 Crystalgenomics Inc derivados de imidazopiridina que inibem a atividade de proteìna quinase, método para a preparação destes e composição farmacêutica contendo os mesmos
EP2560007A1 (en) * 2007-03-28 2013-02-20 Pharmacyclics, Inc. Identification of bruton's tyrosine kinase inhibitors
US20100113520A1 (en) * 2008-11-05 2010-05-06 Principia Biopharma, Inc. Kinase knockdown via electrophilically enhanced inhibitors
CN102482277B (zh) * 2009-05-05 2017-09-19 达纳-法伯癌症研究所有限公司 表皮生长因子受体抑制剂及治疗障碍的方法
KR101483215B1 (ko) * 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
BR112012033253A2 (pt) * 2010-06-23 2016-11-22 Hanmi Science Co Ltd novos derivados de pirimidina fundidos para inibição da atividade de tirosina quinase
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途

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Publication number Publication date
US20150299185A1 (en) 2015-10-22
CA2859664A1 (en) 2013-07-04
BR112014016146A2 (pt) 2017-06-13
BR112014016146A8 (pt) 2017-07-04
JP2015503552A (ja) 2015-02-02
WO2013100631A1 (en) 2013-07-04
AU2012363557A1 (en) 2014-07-17
CN104024243A (zh) 2014-09-03
HK1200811A1 (en) 2015-08-14
MX2014007976A (es) 2014-08-21
EP2797909A1 (en) 2014-11-05
IL233415A0 (en) 2014-08-31
RU2014131068A (ru) 2016-02-20
ZA201405505B (en) 2015-10-28
EP2797909A4 (en) 2015-06-10

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