KR100563906B1 - 첩부식 제제 - Google Patents
첩부식 제제 Download PDFInfo
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- KR100563906B1 KR100563906B1 KR1020007010217A KR20007010217A KR100563906B1 KR 100563906 B1 KR100563906 B1 KR 100563906B1 KR 1020007010217 A KR1020007010217 A KR 1020007010217A KR 20007010217 A KR20007010217 A KR 20007010217A KR 100563906 B1 KR100563906 B1 KR 100563906B1
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- hydrochloride
- acid
- organic acid
- patch preparation
- average particle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
- 염기성약물염 및 분체평균입자경이 0.1∼100㎛인 유기산염을 함유하는 조성물을 열융해 또는 용매에 용해시켜 얻어지는 점착층을 가지는 첩부제제에 있어서, 유기산염이 지방족카르본산염, 방향족카르본산염, 알킬술폰산염, 알킬술폰산 유도체의 수용성 무기염류 및 콜산유도체의 수용성 무기염류로 구성되는 군으로부터 선택되는 1종 또는 2종 이상인 첩부식제제
- 제 1항에 있어서, 염기성 약물염은 염산플루라제팜, 염산릴마제폰, 타르타르산부톨파놀, 시트르산페리속살, 염산메탄페타민, 염산메틸페니데이트, 염산클로르프로마진, 염산이미프라민, 염산리도카인, 염산프로카인, 염산옥시부티닌, 염산티자니진, 염산에펠리존, 메실산플리디놀, 염화카르프로늄, 브롬화네오스틱민, 염산트리헥시페니딜, 염산아망타진, 푸말산크레마스틴, 탄닌산디펜히드라민, 염산트로부테롤, 염산프로카테롤, 염산이소프레날린, 염산도파민, 염산디르티아젬, 염산페라파밀, 시트르산니카메타이트, 염산트라졸린, 염산프루날리진, 염산니카르디핀, 염산프로프라노롤, 염산아르프레노롤, 푸말산케토티펜, 염산아제라스틴, 메실산베타히스틴, 염산디페니돌, 황산모르핀, 시트르산펜타닐로부터 선택되는 1종 또는 2종 이상인 첩부식제제
- 제 1항에 있어서, 유기산염의 분체평균입자경이 0.1∼10㎛인 첩부식제제
- 제 1항에 있어서, 유기산염 0.01∼15중량%를 함유하는 첩부식제제
- 제 1항에 있어서, 염기성약물 0.1∼20중량% 함유하는 첩부식제제
- 제 1항에 있어서, 유기산염이 아세트산염인 것을 특징으로 하는 첩부식제제
- 제 6항에 있어서, 유기산염이 아세트산나트륨인 것을 특징으로 하는 첩부식제제
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10-122758 | 1998-04-17 | ||
JP12275898A JP4205778B2 (ja) | 1998-04-17 | 1998-04-17 | 貼付製剤 |
Publications (2)
Publication Number | Publication Date |
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KR20010074446A KR20010074446A (ko) | 2001-08-04 |
KR100563906B1 true KR100563906B1 (ko) | 2006-03-24 |
Family
ID=14843895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020007010217A KR100563906B1 (ko) | 1998-04-17 | 1999-04-08 | 첩부식 제제 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20070184097A1 (ko) |
EP (1) | EP1074251A4 (ko) |
JP (1) | JP4205778B2 (ko) |
KR (1) | KR100563906B1 (ko) |
CN (1) | CN1189163C (ko) |
AU (1) | AU759374B2 (ko) |
CA (1) | CA2328949A1 (ko) |
WO (1) | WO1999053906A1 (ko) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100674108B1 (ko) * | 1999-04-13 | 2007-01-26 | 히사미쓰 세이야꾸 가부시키가이샤 | 경피흡수형 제제 |
EP1221315A4 (en) * | 1999-10-13 | 2007-12-12 | Senju Pharma Co | ADHESIVE OPHTHALMIC PREPARATIONS FOR PERCUTANEOUS SPREADING |
WO2002038139A1 (fr) * | 2000-11-07 | 2002-05-16 | Hisamitsu Pharmaceutical Co., Inc. | Preparation pharmaceutique du type a absorption percutanee |
DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
JP4199485B2 (ja) | 2002-06-07 | 2008-12-17 | 久光製薬株式会社 | 貼付剤 |
JP4354678B2 (ja) * | 2002-08-28 | 2009-10-28 | 久光製薬株式会社 | 貼付剤 |
JP2004224701A (ja) * | 2003-01-17 | 2004-08-12 | Yuutoku Yakuhin Kogyo Kk | 外用貼付剤 |
JP5512910B2 (ja) * | 2003-04-10 | 2014-06-04 | テイカ製薬株式会社 | ツロブテロール含有経皮吸収製剤およびこれを使用する貼付剤 |
JP4617069B2 (ja) * | 2003-06-16 | 2011-01-19 | コスメディ製薬株式会社 | 貼付剤 |
WO2004112770A1 (ja) * | 2003-06-20 | 2004-12-29 | Teikoku Seiyaku Co., Ltd. | ツロブテロール含有貼付剤 |
JP4468669B2 (ja) * | 2003-09-22 | 2010-05-26 | 久光製薬株式会社 | 低刺激性貼付剤 |
CA2562731A1 (en) * | 2004-04-13 | 2005-11-03 | Alza Corporation | Apparatus and method for transdermal delivery of fentanyl-based agents |
JP5075334B2 (ja) * | 2004-11-22 | 2012-11-21 | 久光製薬株式会社 | 薬物含有貼付剤 |
ATE413166T1 (de) * | 2004-11-22 | 2008-11-15 | Hisamitsu Pharmaceutical Co | Transdermales pflaster enthaltend einen schmelzpunktsenkenden hilfsstoff |
US20090012181A1 (en) * | 2005-01-31 | 2009-01-08 | Satoshi Amano | Patch |
WO2006093139A1 (ja) | 2005-02-28 | 2006-09-08 | Hisamitsu Pharmaceutical Co., Inc. | 経皮吸収製剤 |
US20110189261A1 (en) * | 2008-03-03 | 2011-08-04 | Hisamitsu Pharmaceutical Co., Inc. | Transdermally absorbable preparation |
US20090297590A1 (en) * | 2008-05-30 | 2009-12-03 | Masahiro Yamaji | Ketotifen transdermal drug delivery systems and methods for treating ophthalmic disease |
JP4856125B2 (ja) * | 2008-06-27 | 2012-01-18 | 祐徳薬品工業株式会社 | 安定化されたフェンタニルまたはその塩含有組成物及びこれを用いた医薬製剤並びにフェンタニルまたはその塩の安定化方法 |
CN102076340B (zh) * | 2008-06-27 | 2013-01-23 | 祐德药品工业株式会社 | 含芬太尼或其盐的经皮吸收型贴剂 |
JP5698837B2 (ja) | 2011-04-18 | 2015-04-08 | 久光製薬株式会社 | 貼付剤の製造方法及び貼付剤 |
WO2013081014A1 (ja) * | 2011-11-28 | 2013-06-06 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
KR102013478B1 (ko) | 2012-07-26 | 2019-08-22 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 |
US10493156B2 (en) | 2012-07-26 | 2019-12-03 | Hisamitsu Pharmaceutical Co., Inc. | Patch and method for producing the same |
JP5949285B2 (ja) * | 2012-07-31 | 2016-07-06 | ライオン株式会社 | 貼付剤 |
EP2907515B1 (en) * | 2012-10-11 | 2019-01-02 | Hisamitsu Pharmaceutical Co., Inc. | Skin patch |
JP5270035B1 (ja) | 2012-12-06 | 2013-08-21 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
JP5307931B1 (ja) * | 2012-12-27 | 2013-10-02 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
JP5415645B1 (ja) | 2013-06-28 | 2014-02-12 | 久光製薬株式会社 | 貼付剤の製造方法、貼付剤及び包装体 |
JP2016153391A (ja) * | 2015-02-16 | 2016-08-25 | 日本合成化学工業株式会社 | 無水酢酸ナトリウム結晶 |
JP6931179B2 (ja) * | 2015-05-18 | 2021-09-01 | 三菱ケミカル株式会社 | 無水酢酸ナトリウム結晶の製造方法及び無水酢酸ナトリウム結晶 |
CN109922796B (zh) | 2016-06-23 | 2023-04-07 | 考里安有限责任公司 | 具有亲水和疏水域的粘合剂基质和治疗剂 |
US10300025B2 (en) * | 2016-07-27 | 2019-05-28 | Corium, Inc. | Donepezil transdermal delivery system |
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EP0788792A1 (en) * | 1994-11-29 | 1997-08-13 | Hisamitsu Pharmaceutical Co., Inc. | Matrix type patch preparation |
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JP3002493B2 (ja) * | 1990-03-12 | 2000-01-24 | 積水化学工業株式会社 | 経皮吸収製剤 |
US5629019A (en) * | 1992-02-27 | 1997-05-13 | Alza Corporation | Formulations with hydrophobic permeation enhancers |
JP3836566B2 (ja) * | 1996-05-13 | 2006-10-25 | 久光製薬株式会社 | フェンタニル含有経皮投与テープ製剤 |
JP3615620B2 (ja) * | 1996-06-13 | 2005-02-02 | 積水化学工業株式会社 | 貼付剤 |
-
1998
- 1998-04-17 JP JP12275898A patent/JP4205778B2/ja not_active Expired - Lifetime
-
1999
- 1999-04-08 WO PCT/JP1999/001868 patent/WO1999053906A1/ja active IP Right Grant
- 1999-04-08 AU AU31666/99A patent/AU759374B2/en not_active Expired
- 1999-04-08 CA CA002328949A patent/CA2328949A1/en not_active Abandoned
- 1999-04-08 CN CNB998051209A patent/CN1189163C/zh not_active Expired - Lifetime
- 1999-04-08 KR KR1020007010217A patent/KR100563906B1/ko not_active IP Right Cessation
- 1999-04-08 EP EP99913584A patent/EP1074251A4/en not_active Withdrawn
-
2007
- 2007-03-20 US US11/725,929 patent/US20070184097A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0788792A1 (en) * | 1994-11-29 | 1997-08-13 | Hisamitsu Pharmaceutical Co., Inc. | Matrix type patch preparation |
Also Published As
Publication number | Publication date |
---|---|
AU3166699A (en) | 1999-11-08 |
WO1999053906A1 (fr) | 1999-10-28 |
EP1074251A4 (en) | 2007-06-27 |
JPH11302161A (ja) | 1999-11-02 |
KR20010074446A (ko) | 2001-08-04 |
CN1297349A (zh) | 2001-05-30 |
JP4205778B2 (ja) | 2009-01-07 |
US20070184097A1 (en) | 2007-08-09 |
EP1074251A1 (en) | 2001-02-07 |
CN1189163C (zh) | 2005-02-16 |
AU759374B2 (en) | 2003-04-10 |
CA2328949A1 (en) | 1999-10-28 |
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