JPS6259081B2 - - Google Patents
Info
- Publication number
- JPS6259081B2 JPS6259081B2 JP53034026A JP3402678A JPS6259081B2 JP S6259081 B2 JPS6259081 B2 JP S6259081B2 JP 53034026 A JP53034026 A JP 53034026A JP 3402678 A JP3402678 A JP 3402678A JP S6259081 B2 JPS6259081 B2 JP S6259081B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- fungicidal
- formulation
- formulation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 claims description 55
- 239000000203 mixture Substances 0.000 claims description 29
- 230000000855 fungicidal effect Effects 0.000 claims description 25
- 238000009472 formulation Methods 0.000 claims description 22
- 239000004480 active ingredient Substances 0.000 claims description 13
- 239000000417 fungicide Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- 239000000460 chlorine Substances 0.000 claims description 7
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 7
- 208000031888 Mycoses Diseases 0.000 claims description 6
- 241000219094 Vitaceae Species 0.000 claims description 6
- 239000000969 carrier Substances 0.000 claims description 6
- 235000021021 grapes Nutrition 0.000 claims description 6
- 206010017533 Fungal infection Diseases 0.000 claims description 5
- 229910052731 fluorine Chemical group 0.000 claims description 5
- 239000011737 fluorine Chemical group 0.000 claims description 5
- 231100001184 nonphytotoxic Toxicity 0.000 claims description 5
- -1 pyrimidine compound Chemical class 0.000 claims description 5
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- HKIOYBQGHSTUDB-UHFFFAOYSA-N folpet Chemical compound C1=CC=C2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C2=C1 HKIOYBQGHSTUDB-UHFFFAOYSA-N 0.000 claims description 3
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 241000233679 Peronosporaceae Species 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 238000005507 spraying Methods 0.000 claims 2
- TWFZGCMQGLPBSX-UHFFFAOYSA-N carbendazim Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 19
- 201000010099 disease Diseases 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 238000012360 testing method Methods 0.000 description 11
- 230000002195 synergetic effect Effects 0.000 description 9
- 241000209140 Triticum Species 0.000 description 8
- 235000021307 Triticum Nutrition 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 7
- 229920001817 Agar Polymers 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000008272 agar Substances 0.000 description 6
- 239000006013 carbendazim Substances 0.000 description 6
- MGDOJPNDRJNJBK-UHFFFAOYSA-N ethylaluminum Chemical compound [Al].C[CH2] MGDOJPNDRJNJBK-UHFFFAOYSA-N 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- NHOWDZOIZKMVAI-UHFFFAOYSA-N (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol Chemical compound C=1N=CN=CC=1C(C=1C(=CC=CC=1)Cl)(O)C1=CC=C(Cl)C=C1 NHOWDZOIZKMVAI-UHFFFAOYSA-N 0.000 description 5
- 239000007900 aqueous suspension Substances 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- WURBVZBTWMNKQT-UHFFFAOYSA-N 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one Chemical compound C1=NC=NN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 WURBVZBTWMNKQT-UHFFFAOYSA-N 0.000 description 4
- LRAJHPGSGBRUJN-OMIVUECESA-N cefepime hydrochloride Chemical compound O.Cl.[Cl-].S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 LRAJHPGSGBRUJN-OMIVUECESA-N 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000221785 Erysiphales Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000005909 Kieselgur Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920000847 nonoxynol Polymers 0.000 description 3
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical class CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 239000004563 wettable powder Substances 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 239000005789 Folpet Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920001732 Lignosulfonate Polymers 0.000 description 2
- 239000005802 Mancozeb Substances 0.000 description 2
- 241001123569 Puccinia recondita Species 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000002577 cryoprotective agent Substances 0.000 description 2
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 229910052901 montmorillonite Inorganic materials 0.000 description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 239000001965 potato dextrose agar Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WPRAXAOJIODQJR-UHFFFAOYSA-N 1-(3,4-dimethylphenyl)ethanone Chemical compound CC(=O)C1=CC=C(C)C(C)=C1 WPRAXAOJIODQJR-UHFFFAOYSA-N 0.000 description 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- UGDWWCJKEUBONY-UHFFFAOYSA-N 6-chloro-6-methylcyclohexa-1,3-dien-1-ol Chemical compound CC1(Cl)CC=CC=C1O UGDWWCJKEUBONY-UHFFFAOYSA-N 0.000 description 1
- 241001444080 Aphanomyces euteiches Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000221300 Puccinia Species 0.000 description 1
- 241000233639 Pythium Species 0.000 description 1
- 241000918584 Pythium ultimum Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229920002323 Silicone foam Polymers 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- CRPOUZQWHJYTMS-UHFFFAOYSA-N dialuminum;magnesium;disilicate Chemical compound [Mg+2].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] CRPOUZQWHJYTMS-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000010801 foot rot Diseases 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 235000019357 lignosulphonate Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000013514 silicone foam Substances 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- HQCFDOOSGDZRII-UHFFFAOYSA-M sodium;tridecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOS([O-])(=O)=O HQCFDOOSGDZRII-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明は化学薬品の新規な組合せによつて栽培
植物の黴感染を治療する方法に関し、またその新
規な組合せを含む殺黴用配合物を提供する。
従つて本発明の一態様に従えば第1の殺黴活性
成分として式:
The present invention relates to a method of treating fungal infections in cultivated plants by a novel combination of chemicals, and provides fungicidal formulations comprising the novel combination. Therefore, according to one aspect of the invention, the first fungicidal active ingredient has the formula:
【式】又は[Formula] or
【式】
(ただし式中Xは塩素又はフツ素である)をもつ
トリアジン又はピリミジン化合物、第2の殺黴活
性成分として式:A triazine or pyrimidine compound having the formula: where X is chlorine or fluorine, as the second fungicidal active ingredient:
【式】 又は【formula】 or
【式】
をもつベンツイミダゾール又はアルミニウム塩を
一種又はそれ以上の不活性な非植物毒性担体と組
合せたものからなる殺黴用配合物が提供される。
上述の諸化合物はすべて既知の化合物であり、
文献中に明瞭に定義された方法によつて製造され
うる。上述の配合物中に定められた活性成分の組
合せは新規であり、裁培植物の黴感染を制御し又
はこれに抵抗するのに意外なほど有効であること
が見出された。式(a)又は(b)の化合物と式(b)
の化合物との組合せはブドウのウドンコカビ感染
の制御に特に有用であり、一方式(a)又は(b)の
化合物と式(a)の化合物との組合せは粉様ウドン
コカビ(powdery mildew)、根腐れ(foot rot)
及びその他の熟成期に穀物に影響する葉又は穂の
病気のような穀物の病気の治療に特に価値あるこ
とが見出された。
従つて本発明の第2の態様に従えば植物、特に
穀物及びブドウの黴感染を治療する方法が提供さ
れるが、その方法はそれらの植物に対し上述の殺
黴用配合物の殺黴上有効な量を施用することから
なる。上述の方法においてその配合物は好適には
発芽(crop emergence)以後で収穫が行われる
までの任意の時期に葉を施すことによつて与えら
れ、その施用の量と頻度とは黴による病気の激し
さ、又は予想される激しさによつて決められる。
しかしながら治療の回数を減少(例えばブドウの
ウドンコ病感染の制御には2〜3週毎に僅か1
回)させても効果を保ちうること、従つて労賃を
著しく減少しうることが本発明の特徴的一態様で
あり、上述の組合せを使用することによつて得ら
れる特別な利点である。
ブドウの病気治療への使用に好適なピリミジン
は式(b)においてXが塩素であるが、Xがフツ素
である式(b)の化合物は穀物の黴感染に関連した
使用に好適である。
被処理植物に対し本発明の配合物の各成分を
別々に連続して施し得るし、同時にでも施しうる
が、同時施用の方が本発明によれば好適である。
式(a)の化合物の施用量は好適には10〜500g/
ヘクタールで、式(b)の化合物の施用量はブドウ
の病気治療に当り好適には、10〜100g/ヘクタ
ール、最も好適には10〜30g/ヘクタールである
が、式(a)又は(b)の化合物の施用量は好適には
100〜3000g/ヘクタールである。従つて本発明
の組合せにおける式の化合物と式の化合物と
の比は重量で5:1〜1:300の範囲内にある。
好適には式(a)化合物と式(a)化合物との比は
2:1〜1:25にあつて20〜200g/ヘクタール
の式(a)化合物が施用され、式(b)化合物と式
(a)化合物との比は1:1〜1:25であつて20〜
100g/ヘクタールの式(b)化合物が施用され、
100〜500g/ヘクタールの式(a)化合物が使用さ
れうる。好適には式(a)化合物と式(b)化合物と
の比は1:5〜1:100であり、やはり20〜200
g/ヘクタールの式(a)化合物が使用され、式
(b)化合物と式(b)化合物との比は1:10〜1:
100の範囲内にあつて20〜100g/ヘクタールの式
(b)化合物が使用され、1000〜2000g/ヘクター
ルの式(b)化合物が使用される。
式(b)化合物、即ちエチル亜リン酸アルミニウ
ム塩(AEP)は好適には更に別の殺黴剤、例え
ばマンコゼブ〔mancozeb〕(商標名)或はホルペ
ツト〔folpet〕(商標名)、即ち2−〔(トリクロル
メチル)−チオ〕−1H−イソインドール−1・3
(2H)−ジオンと組合せて使用される〔Phytiarie
Phytopharmacie 1(1977)参照〕。別の殺黴剤
と組合せて使用する場合にはAEPとその殺黴剤
との重量比は3:1〜1:2の範囲内にあろう。
製造、貯蔵及び輸送を簡単にするために式化
合物と式化合物との組合せは通常の場合に上述
の施用比が容易に達成されうるために必要な程度
に水で希釈されることを目的として濃縮物状に製
造されるであろう。この濃縮配合物は0.5〜90重
量%、好適には5〜90重量%の活性諸成分を一種
又はそれ以上の不活性非植物毒性担体と組合せて
含有しうる。この配合物は通常は湿潤性粉末又は
ダスト、或は水性サスペンシヨンの形であろう
が、AEPの水性サスペンシヨンは水性媒中の
AEPの半減期が比較的短い(約100日)ことにも
とづき不安定になり易いことに留意すべきであ
る。この濃縮配合物は使用前に水で適正に希釈さ
れるように企図されている。この水性分散体の形
成はこの目的に適当な慣用噴霧タンク中で行われ
うる。
湿潤性粉末又はダストはこの活性成分、一種又
はそれ以上の不活性担体及び適宜な界面活性剤の
緊密な混合物である。この不活性担体はアタプル
ガイト粘土〔attapulgite clays〕、モンモリロナ
イト粘土〔montmorillonite clays〕、ケイ藻土、
カオリン、雲母、タルク及び精製ケイ酸塩から選
ばれうる。有効な界面活性剤はスルホン酸化リグ
ニン、ナフタリンスルホン酸塩、及び縮合ナフタ
リンスルホン酸塩、アルキルコハク酸塩、アルキ
ルベンゼンスルホン酸塩、アルキル硫酸塩及び非
イオン性界面活性剤例えばフエノールのエチレン
オキシド付加物の中から見出されうる。本発明の
範囲内にある湿潤性粉末の例は次の組成を持つも
のである。
湿潤性粉末
重量%
式の化合物 0.25〜10
式の化合物 10〜80
界面活性剤(単数又は複数) 0〜10
分散剤 0〜10
抗ケーキング剤 0〜10
不活性担体(単数又は複数) 100となるまで添加
水性サスペンシヨン及び溶液は水又は適正な溶
剤中に懸濁又は溶解された活性諸成分と、それぞ
れ、所望の界面活性剤、増粘剤、抗凍結剤又は防
腐剤とからなる。適正な界面活性剤は湿潤性粉末
と関連させて上述されたものから選ばれうる。増
粘剤は使用される場合には通常適正なセルロース
物質及び天然ガムから選ばれるがグリコール類は
一般に抗凍結剤が必要とされる場合に使用され
る。防腐剤は広い範囲の諸物質例えば種々のパラ
ベン抗菌剤、フエノール、o−クロルクレゾー
ル、フエニル水銀硝酸塩及びホルムアルデヒドか
ら選ばれうる。本発明の範囲内にある水性サスペ
ンシヨンの典型例は次の通りである:
水性サスペンシヨン(流動性)
重量%
式の化合物 0.1〜8
式(a)の化合物 20〜52
界面活性剤 0〜15
増粘剤 0〜3
抗凍結剤 0〜20
防腐剤 0〜1
起泡抑止剤 0〜0.5
水 100となるまで添加
上述の一般例は当業熟練者のために本発明にお
いて有用な濃縮組成物の型を適正に示している筈
であるが、以下の非限定的な諸例は本発明の配合
物の態様を更に例示するのに役立つであろう。こ
れらの諸例において“CCPM”という語はXが塩
素である式(b)の化合物を表わし、一方、そのX
がフツ素である類似化合物は“CFPM”という文
字で示される。同様に式(a)の化合物は記号
“CTDB”で示され、式(a)の化合物は“MBC”
式(b)の化合物は“AEP”で示される。
例 1〜8
下記の湿潤性粉末類を製造した:
(1)
重量%
CCPM 0.5
AEP 50.0
ジオクチルスルホコハク酸ナトリウム 2.0
エトキシ化ノニルフエノール 2.0
リグニンスルホン酸ナトリウム 3.0
シリカ 6.0
カオリン粘土 100.0となるまで添加
(2)
重量%
CFPM 1.0
AEP 50.0
ラウリル硫酸ナトリウム 3.0
スルホン酸リグニン 2.0
ケイ藻土 100.0となるまで添加
(3)
重量%
CTDB 0.5
AEP 37.5
アルキルエーテル硫酸ナトリウム 5.0
亜硫酸塩廃液粉末(Sulfite lye powder) 3.0
シリカ 4.0
タルク 100.0となるまで添加
(4)
重量%
CCPM 5.0
MBC 50.0
ジオクチルスルホコハク酸ナトリウム 4.0
リグニンスルホン酸ナトリウム 1.5
沈殿シリカ 2.5
アタプルガイト 100.0となるまで添加
(5)
重量%
CFPM 3.0
MBC 45.0
アルキルナフタリンスルホン酸ナトリウム 8.0
ケイ藻土 6.0
モンモリロナイト 100.0となるまで添加
(6)
重量%
CTDB 12.0
MBC 60.0
縮合ナフタリンススルホン酸類ナトリウム塩
5.0
トリデシル硫酸ナトリウム 2.0
シリカ 5.0
カオリン 100.0となるまで添加
(7)
重量%
CCPM 1.0
AEP 30.0
ホルペツト(Folpet) 15.0
ラウリル硫酸ナトリウム 2.5
リグニンスルホン酸ナトリウム 4.0
沈殿シリカ 8.0
カオリン 100.0となるまで添加
(8)
重量%
CTDB 2.0
AEP 40.0
マンコゼブ(Mancozeb) 20.0
エトキシ化ノニルフエノール 2.0
ジオクチルスルホコハク酸ナトリウム 2.0
リグニンスルホン酸トリウム 3.0
水和ケイアルミン酸ナトリウム 7.5
タルク 100.0となるまで添加
各例において、活性諸成分と記載の賦形剤とを
慣用混合装置内で注意深く配合した。その配合物
を次に流体エネルギーミル中で1〜10ミクロンの
範囲になるまで更に〓ね、最後にその混合物を再
び混ぜ合わせ、包装に先立つて脱気した。
例 9〜11
次の水性サスペンシヨン類を製造した:
(9)
重量%
CFPM 4.0
MBC 40.0
ポリオキシエチレンポリオキシプロピレンブロ
ツク共重合体 2.0
キサンタンゴム(Xanthan gum) 0.4
シリコン系起泡抑止剤 0.1
水 100.0となるまで添加
(10)
重量%
CTDB 2.5
MBC 50.0
ラウリル硫酸ナトリウム 3.0
ベントナイト 3.0
エチレングリコール 5.0
ホルムアルデヒド 0.2
水 100.0となるまで添加
(11)
重量%
CCPM 5.0
MBC 40.0
エトキシ化ノニルフエノール 4.0
ヒドロキシメチルセルロース 2.0
シリコン系起泡抑止剤 0.15
プロピレングリコール 6.0
水 100.0となるまで添加
両活性成分は適正な慣用法によつて細かくさ
れ、界面活性剤系、防腐剤及び一部の増粘剤を含
む水中に分散された。両活性成分の粒径を液体混
〓(liquid milling)によつて更に細かくし、残
部の増粘剤を加え、水和させ、生成物を水で所定
容積となるまで希釈した。
試験例 1
本発明に従う殺黴剤フエナリモール
〔fenarimol(式(b)においてXが塩素である化合
物の商標名)〕及びカルベンダジム
〔carbendazim(式(a)のカルベンダジムの商標
名)〕の組合せによる配合物を試験した結果下記
の通りの相乗効果を奏することが認められた。
フエナリモールの10及び20ppm並びにカルベ
ンダジムの100ppmを含有する水性噴射剤をまず
調製した。これらを単独で及び組合せて小麦(植
物体)に対して試験した。殺黴処理後の小麦を乾
燥した後にこれに対してサビ病菌(rust
fungus)であるプクシニアレコンジタ(puccinia
recondita)の夏胞子を接種してから恒温室内に
48時間放置した。恒温保持時間終了時に該小麦を
温室内に置いて病状を進展させた。未処理対象小
麦との比較により病害抑制率の値を計測した。A fungicidal formulation is provided comprising a benzimidazole or aluminum salt having the formula in combination with one or more inert, non-phytotoxic carriers. All of the above-mentioned compounds are known compounds,
It can be produced by methods well defined in the literature. The combination of active ingredients defined in the above-mentioned formulations is novel and has been found to be surprisingly effective in controlling or resisting fungal infections in cultivated plants. Compounds of formula (a) or (b) and formula (b)
The combination of a compound of formula (a) or (b) with a compound of formula (a) is particularly useful for controlling powdery mildew infections of grapes, whereas the combination of a compound of formula (a) or (b) with a compound of formula (a) is particularly useful for controlling powdery mildew, root rot, and (foot rot)
It has been found to be particularly valuable in the treatment of cereal diseases such as leaf or panicle diseases and other diseases affecting the grain during ripening. According to a second aspect of the invention there is thus provided a method for treating fungal infections of plants, particularly cereals and grapes, which method comprises administering to those plants a fungicidal formulation as described above. It consists of applying an effective amount. In the method described above, the formulation is preferably applied by application to the leaves at any time after crop emergence until harvest, the amount and frequency of application being such that the amount and frequency of application is determined to prevent the fungal disease. Determined by intensity or expected intensity.
However, reducing the number of treatments (e.g. as little as 1 treatment every 2-3 weeks to control powdery mildew infections in grapes)
It is a characteristic aspect of the present invention that the effect can be maintained even after repeated use, and that labor costs can therefore be significantly reduced, and are a particular advantage obtained by using the above-mentioned combination. Pyrimidines suitable for use in the treatment of grape diseases are those of formula (b) in which X is chlorine, whereas compounds of formula (b) in which X is fluorine are suitable for use in connection with fungal infections of grain. Although each component of the formulation according to the invention can be applied to the plants to be treated separately in succession or even simultaneously, simultaneous application is preferred according to the invention.
The application rate of the compound of formula (a) is preferably between 10 and 500 g/
per hectare, the application rate of the compound of formula (b) is preferably between 10 and 100 g/ha, most preferably between 10 and 30 g/ha for treating diseases of grapes, but not with formula (a) or (b). The application rate of the compound is preferably
100-3000g/ha. The ratio of compounds of formula to compounds of formula in the combinations of the invention is therefore in the range from 5:1 to 1:300 by weight.
Preferably the ratio of the compound of formula (a) to the compound of formula (a) is between 2:1 and 1:25, so that between 20 and 200 g/ha of the compound of formula (a) are applied, and the compound of formula (b) and the compound of formula
(a) The ratio with the compound is 1:1 to 1:25 and 20 to
100g/ha of compound of formula (b) is applied;
100 to 500 g/ha of a compound of formula (a) may be used. Preferably the ratio of compounds of formula (a) to compounds of formula (b) is between 1:5 and 1:100, again between 20 and 200.
g/ha of formula (a) compound is used and formula
The ratio of the compound (b) to the compound of formula (b) is 1:10 to 1:
Formula of 20-100g/ha within the range of 100
(b) compound is used, 1000-2000 g/ha of formula (b) compound is used. The compound of formula (b), namely ethyl aluminum phosphite (AEP), is preferably further combined with another fungicide, such as mancozeb (trade name) or folpet (trade name), namely 2- [(Trichloromethyl)-thio]-1H-isoindole-1,3
Used in combination with (2H)-dione [Phytiarie
Phytopharmacie 1 (1977)]. When used in combination with another fungicide, the weight ratio of AEP to that fungicide will be in the range of 3:1 to 1:2. For ease of manufacture, storage and transport, the combination of formula compounds and formula compounds is usually concentrated with the aim of being diluted with water to the extent necessary so that the application ratios mentioned above can be easily achieved. It will be manufactured in physical form. The concentrated formulations may contain from 0.5 to 90% by weight, preferably from 5 to 90%, of the active ingredients in combination with one or more inert, non-phytotoxic carriers. This formulation will normally be in the form of a wettable powder or dust, or an aqueous suspension;
It should be noted that AEP is susceptible to instability due to its relatively short half-life (approximately 100 days). This concentrated formulation is intended to be properly diluted with water before use. Formation of this aqueous dispersion can be carried out in a conventional spray tank suitable for this purpose. Wettable powders or dusts are an intimate mixture of the active ingredient, one or more inert carriers and suitable surfactants. The inert carriers are attapulgite clays, montmorillonite clays, diatomaceous earth,
It may be selected from kaolin, mica, talc and refined silicates. Effective surfactants include sulfonated lignin, naphthalene sulfonates, and condensed naphthalene sulfonates, alkyl succinates, alkylbenzene sulfonates, alkyl sulfates, and nonionic surfactants such as ethylene oxide adducts of phenols. can be found from An example of a wettable powder within the scope of the invention is one having the following composition. Wettable powder wt% compound of formula 0.25-10 compound of formula 10-80 surfactant(s) 0-10 dispersant 0-10 anti-caking agent 0-10 inert carrier(s) 100 Aqueous suspensions and solutions consist of the active ingredients suspended or dissolved in water or a suitable solvent, and the desired surfactants, thickeners, cryoprotectants or preservatives, respectively. Suitable surfactants may be selected from those mentioned above in connection with wettable powders. Thickeners, if used, are usually selected from suitable cellulosic materials and natural gums, while glycols are generally used when cryoprotectants are required. Preservatives may be selected from a wide variety of substances, such as various paraben antimicrobials, phenols, o-chlorcresol, phenylmercury nitrate, and formaldehyde. Typical examples of aqueous suspensions within the scope of the present invention are: Aqueous Suspension (Flowability) Weight % Compound of Formula 0.1-8 Compound of Formula (a) 20-52 Surfactant 0-15 Thickener 0-3 Anti-freeze agent 0-20 Preservative 0-1 Foam suppressant 0-0.5 Water Added to 100% The above general examples will help those skilled in the art to prepare concentrated compositions useful in the present invention. The following non-limiting examples will serve to further illustrate embodiments of the formulations of the present invention. In these examples, the term "CCPM" refers to a compound of formula (b) where X is chlorine, whereas
Similar compounds where is fluorine are designated by the letters "CFPM". Similarly, the compound of formula (a) is denoted by the symbol “CTDB” and the compound of formula (a) is denoted by “MBC”.
Compounds of formula (b) are designated "AEP". Examples 1-8 The following wettable powders were prepared: (1) Weight % CCPM 0.5 AEP 50.0 Sodium dioctyl sulfosuccinate 2.0 Ethoxylated nonylphenol 2.0 Sodium lignin sulfonate 3.0 Silica 6.0 Kaolin clay Added to 100.0 (2) Weight% CFPM 1.0 AEP 50.0 Sodium lauryl sulfate 3.0 Sulfonic acid lignin 2.0 Diatomaceous earth Added until 100.0 (3) Weight% CTDB 0.5 AEP 37.5 Sodium alkyl ether sulfate 5.0 Sulfite lye powder 3.0 Silica 4.0 Talc 100.0 Added until (4) weight% CCPM 5.0 MBC 50.0 Sodium dioctyl sulfosuccinate 4.0 Sodium ligninsulfonate 1.5 Precipitated silica 2.5 Attapulgite Added until 100.0 (5) weight% CFPM 3.0 MBC 45.0 Sodium alkylnaphthalene sulfonate 8.0 Diatomaceous earth 6.0 Montmorillonite Added until 100.0 (6) % by weight CTDB 12.0 MBC 60.0 Condensed naphthalene sulfonic acids sodium salt
5.0 Sodium tridecyl sulfate 2.0 Silica 5.0 Kaolin Added until 100.0 (7) % by weight CCPM 1.0 AEP 30.0 Folpet 15.0 Sodium lauryl sulfate 2.5 Sodium ligninsulfonate 4.0 Precipitated silica 8.0 Kaolin Added until 100.0 (8) % by weight CTDB 2.0 AEP 40.0 Mancozeb 20.0 Ethoxylated nonylphenol 2.0 Sodium dioctylsulfosuccinate 2.0 Thorium ligninsulfonate 3.0 Hydrated sodium silicate 7.5 Talc Added to 100.0 In each case, the active ingredients and excipients as indicated were carefully blended in a conventional mixing apparatus. The formulation was then further milled in a fluid energy mill to a range of 1-10 microns, and finally the mixture was recombined and degassed prior to packaging. Examples 9-11 The following aqueous suspensions were prepared: (9) % by weight CFPM 4.0 MBC 40.0 Polyoxyethylene polyoxypropylene block copolymer 2.0 Xanthan gum 0.4 Silicone foam inhibitor 0.1 Water 100.0 CTDB 2.5 MBC 50.0 Sodium lauryl sulfate 3.0 Bentonite 3.0 Ethylene glycol 5.0 Formaldehyde 0.2 Water Added until 100.0 (11) Weight % CCPM 5.0 MBC 40.0 Ethoxylated nonylphenol 4.0 Hydroxymethylcellulose 2.0 Silicon-based Foam suppressant 0.15 Propylene Glycol 6.0 Water Added to 100.0 Both active ingredients were comminuted by good conventional methods and dispersed in water containing a surfactant system, preservatives and some thickening agents. The particle size of both active ingredients was further reduced by liquid milling, the remaining thickener was added and hydrated, and the product was diluted to volume with water. Test Example 1 Combination of the fungicide according to the present invention fenarimol (trade name of a compound in which X is chlorine in formula (b)) and carbendazim (trade name of carbendazim of formula (a)) As a result of testing the formulation, it was found that the following synergistic effects were exhibited. Aqueous propellants containing 10 and 20 ppm of fenarimol and 100 ppm of carbendazim were first prepared. These were tested alone and in combination on wheat (plants). After drying the wheat after fungicidal treatment, it is treated with rust bacteria.
puccinia recondita (puccinia fungus)
recondita) and then placed in a thermostatic chamber.
It was left for 48 hours. At the end of the constant temperature period, the wheat was placed in a greenhouse to allow the disease to develop. The disease suppression rate was measured by comparison with untreated target wheat.
【表】
(注)* 未処理対照における罹病率
殺黴剤の単独使用時に得られた観測値から周知
のコルビイ式〔Colby equation(Weeds15、20
−22(1967)〕の適用により配合組成物の理論的
病害抑制率(計算値)(E)を計算し得る。
該コルビイ式は下記の通りに表わされる:
E=X+Y−XY/100
但し式中Eは効果に関する期待値%、Xは化合
物Xによる病害抑制率%、Yは化合物Yによる病
害抑制率%である。X及びYの配合による効果が
上式から計算されたE値よりも大であればXとY
との併用による相乗効果が得られたと考えられ
る。
第1表において観測値は理論的計算値(E)よりも
大である事実により相乗効果が得られたと結論さ
れる。
なお、本発明で得られた試験結果における病害
抑制率%の観測値からコルビイ式による効果期待
値(計算値)を算出する手順について詳記すると
以下の通りである。計算例として第1表の数値に
ついてコルビイ式における化合物Xをフエナリモ
ールとし、化合物Yをカルベンダジムとし、これ
らについてX値(即ちフエナリモール単独の場合
の観測値)、Y値(即ちカルベンダジム単独の場
合の観測値)を挙げ、これらからX+Y値、XY
値、XY/100値及びE値(即ちX+Y−XY/
100)を計算すると下表の通りとなる。[Table] (Note) * Morbidity rate in untreated control The well-known Colby equation (Weeds 15, 20
-22 (1967)], the theoretical disease inhibition rate (calculated value) (E) of the blended composition can be calculated. The Colby equation is expressed as follows: E = X + Y - XY / 100 where E is the expected value % of the effect, X is the disease suppression rate by compound X, and Y is the disease suppression rate by compound Y. . If the effect of the combination of X and Y is greater than the E value calculated from the above formula, then
It is thought that a synergistic effect was obtained when used in combination with It is concluded that a synergistic effect was obtained due to the fact that the observed value in Table 1 is larger than the theoretically calculated value (E). The detailed procedure for calculating the expected effect value (calculated value) using the Colby equation from the observed value of disease suppression rate % in the test results obtained in the present invention is as follows. As a calculation example, for the values in Table 1, compound X in the Colby formula is fenarimol, compound Y is carbendazim, and for these, the observed values), and from these, calculate the X+Y value, XY
value, XY/100 value and E value (i.e. X+Y-XY/
100) is calculated as shown in the table below.
【表】
即ちX(10ppm)+Y(100ppm)の時に得ら
れた観測値(77%)は対応するE値(71%)より
大きく、X(20ppm)+Y(100ppm)の時に得
られた観測値(82%)は対応するE値(76%)よ
り大きいことが結論された。
試験例 2
本発明に従う殺黴剤トリアジメフオン
(triadimefon(式(a)の化合物の商標名)〕及び
カルベンダジム〔式(a)の化合物の商標名〕の組
合せによる配合物を試験した結果下記の通りの相
乗効果を奏することが認められた。
トリアジメフオンの10及び20ppm並びにカル
ベンダジムの200ppmを含有する水性噴射剤をま
ず調製した。これらを単独で、及び組合せて小麦
(植物体)に対して試験した。殺黴処理後の小麦
を乾燥した後にこれに対してサビ病菌プクシニア
レコンジタの夏胞子を接種してから恒温室内に
48時間放置した。恒温保持時間終了時に該小麦を
温室内に置いて病状を進展させた。未処理対照小
麦との比較により病害抑制率の値を計測した。[Table] In other words, the observed value (77%) obtained when X (10 ppm) + Y (100 ppm) is larger than the corresponding E value (71%), and the observed value obtained when X (20 ppm) + Y (100 ppm) (82%) was concluded to be greater than the corresponding E value (76%). Test Example 2 A combination of the fungicide triadimefon (trade name of the compound of formula (a)) and carbendazim (trade name of the compound of formula (a)) according to the present invention was tested and the results were as follows: Aqueous propellants containing 10 and 20 ppm of triadimefone and 200 ppm of carbendazim were first prepared. These were tested alone and in combination against wheat (plants). After drying the wheat after fungicidal treatment, it is inoculated with summer spores of the rust fungus Puccinia recondita and then placed in a thermostatic chamber.
It was left for 48 hours. At the end of the constant temperature period, the wheat was placed in a greenhouse to allow the disease to develop. Disease control rate values were determined by comparison with untreated control wheat.
【表】
(注)* 未処理対照における罹病率
殺黴剤の単独使用時に得られた観測値からコル
ビイ式の適用により配合組成物の理論的病害抑制
率(E)を計算した。第2表において観測値は理論的
計算値(E)よりも大である事実により相乗効果が得
られたと結論される。
試験例 3
本発明に従う殺黴剤フエナリモール〔式(b)〕
及びエチル亜リン酸アルミニウム〔式(b)の化合
物〕の組合せによる配合物を試験した結果下記の
通りの相乗効果を奏することが認められた。
フエナリモールの10及び20ppm並びにエチル
亜リン酸アルミニウムの100ppmを含有するポテ
トデキストロース寒天をまず調製した。これらの
調製物の試料及び適宜の配合物試料を15×100mm
ペトリ皿中へ注入して固化させた。
黴すなわちピシウムカルチマム(pythium
ultimum)の成育菌糸体を含む6mmの寒天プラグ
を該ペトリ皿の中央部で寒天表面に対し菌糸体含
有表面を上にして接種した。このペトリ皿を26℃
に恒温保持した。
殺黴剤含有寒天表面上に成育した菌糸体の放射
状の成育状態を対照と比較して計測した。[Table] (Note) * Morbidity rate in untreated control The theoretical disease inhibition rate (E) of the combination composition was calculated by applying the Colby equation from the observed values obtained when the fungicide was used alone. It is concluded that a synergistic effect was obtained due to the fact that the observed value in Table 2 is larger than the theoretically calculated value (E). Test Example 3 Fungicide according to the present invention Fenarimol [Formula (b)]
As a result of testing a combination of ethyl aluminum phosphite and ethyl aluminum phosphite (compound of formula (b)), it was found that the following synergistic effect was exhibited. Potato dextrose agar containing 10 and 20 ppm of fenarimol and 100 ppm of ethyl aluminum phosphite was first prepared. Samples of these preparations and appropriate formulation samples were placed in a 15 x 100 mm
It was poured into a Petri dish and allowed to solidify. Mold or Pythium cultimum
A 6 mm agar plug containing growing mycelium of M. ultimum was inoculated in the center of the Petri dish with the mycelium-containing surface facing up against the agar surface. This Petri dish was heated to 26°C.
The temperature was maintained at constant temperature. The radial growth state of the mycelia grown on the surface of the fungicide-containing agar was measured in comparison with the control.
【表】
殺黴剤の単独使用時に得られた観測値からコル
ビイ式の適用により配合組成物の理論的病害抑制
率(E)を計算した。第3表において観測値は理論的
計算値(E)よりも大である事実により相乗効果が得
られたと結論される。
試験例 4
本発明に従う殺黴剤トリアジメフオン〔式
(a)〕及びエチル亜リン酸アルミニウム〔式(b)〕
の組合せによる配合物を試験した結果下記の通り
の相乗効果を奏することが認められた。
トリアジメフオンの1及び2ppm並びにエチル
亜リン酸アルミニウムの100ppmを含有するポテ
トデキストロース寒天をまず調製した。これらの
調製物の試料及び適宜の配合物試料を15×100mm
ペトリ皿中へ注入して固化させた。
黴すなわちアフアノミセス ユテイケス
(Aphanomyces euteiches)の成育菌糸体を含む
6mmの寒天プラグを該ペトリ皿の中央部で寒天表
面に対し菌糸体含有表面を上にして接種した。こ
のペトリ皿を26℃に恒温保持した。
殺黴剤含有寒天表面上に成育した菌糸体の放射
状の成育状態を対照と比較して計測した。[Table] The theoretical disease inhibition rate (E) of the combination composition was calculated by applying the Colby equation from the observed values obtained when the fungicide was used alone. In Table 3, it is concluded that a synergistic effect was obtained due to the fact that the observed value is larger than the theoretically calculated value (E). Test Example 4 The fungicide triadimefone according to the present invention [formula
(a)] and ethyl aluminum phosphite [formula (b)]
As a result of testing a combination of the following, it was found that the following synergistic effects were achieved. Potato dextrose agar containing 1 and 2 ppm of triadimefone and 100 ppm of ethyl aluminum phosphite was first prepared. Samples of these preparations and appropriate formulation samples were placed in a 15 x 100 mm
It was poured into a Petri dish and allowed to solidify. A 6 mm agar plug containing a growing mycelium of the mold, Aphanomyces euteiches, was inoculated onto the agar surface in the center of the Petri dish with the mycelium-containing surface facing up. This Petri dish was kept constant at 26°C. The radial growth state of the mycelia grown on the surface of the fungicide-containing agar was measured in comparison with the control.
【表】
殺黴剤の単独使用時に得られた観測値からコル
ビイ式の適用による配合組成物の理論的病害抑制
率(E)を計算した。第4表において観測値は理論的
計算値(E)よりも大である事実により相乗効果が得
られたと結論される。
被検菌としてピシウム ウルチマムを使用して
更に前記の操作を行うことにより試験した結果は
下記の通りであつた。[Table] The theoretical disease inhibition rate (E) of the combination composition was calculated by applying the Colby equation from the observed values obtained when the fungicide was used alone. It is concluded that a synergistic effect was obtained due to the fact that the observed value in Table 4 is larger than the theoretically calculated value (E). Using Pythium ultimum as a test bacterium, the above procedure was further performed to obtain the following test results.
【表】
第5表の結果もまた該被検菌に対して相乗効果
を奏することを示したものである。[Table] The results in Table 5 also show that the compound has a synergistic effect against the test bacteria.
Claims (1)
トリアジン又はピリミジン化合物、及び第2の殺
黴活性成分として次式: 【式】 又は【式】 をもつベンツイミダゾール又はアルミニウム塩を
一種又はそれ以上の不活性な非植物毒性担体と組
合せてなることを特徴とする殺黴用配合物。 2 0.5〜90重量%の活性成分(複数)からな
り、その残部が一種又はそれ以上の不活性な非植
物毒性担体(単数又は複数)からなる特許請求の
範囲第1項に記載の殺黴用配合物。 3 式(b)の化合物においてXが塩素である特許
請求の範囲第1又は2項に記載の殺黴用配合物。 4 式(b)の化合物と更に2−〔(トリクロルメチ
ル)−チオ〕−1H−イソインドール−1・3
(2H)−ジオンとからなり、その(b)化合物とそ
のジオンとの重量比が3:1〜1:1である特許
請求の範囲第1〜3項の何れかに記載の殺黴用配
合物。 5 式()の化合物と式()の化合物とを一
種又はそれ以上の不活性な非植物毒性担体と混合
することからなる特許請求の範囲第1〜4項の何
れかに記載の殺黴用配合物の製造法。 6 特許請求の範囲第1項及び第3〜5項の何れ
かに記載の配合物、又は水で希釈された特許請求
の範囲第4項に記載の配合物で黴に感染した植物
を処理することからなる植物における黴の感染を
治療又は予防する方法。 7 Xが塩素である式(b)のピリミジンと式(b)
のアルミニウム塩とからなる特許請求の範囲第1
又は2項に記載の配合物の水性分散体を柔毛ウド
ンコ病(downy mildew)のブドウに対して噴霧
することからなるブドウの柔毛ウドンコ病を治療
又は予防するための特許請求の範囲第6項に記載
の方法。 8 黴に感染した穀物にXがフツ素である式(b)
のピリミジンと式(a)のベンツイミダゾールとか
らなる特許請求の範囲第1項に記載の配合物の水
性分散体を黴に感染した穀物に対し噴霧すること
からなる穀物における黴の感染を治療又は予防す
るための特許請求の範囲第6項に記載の方法。[Claims] 1. A triazine or pyrimidine compound having the formula: [Formula] or [Formula] (wherein X is chlorine or fluorine) as a first fungicidal active ingredient, and a second fungicidal active ingredient. A fungicidal formulation characterized in that it comprises as active ingredient a benzimidazole or an aluminum salt having the formula: [Formula] or [Formula] in combination with one or more inert, non-phytotoxic carriers. 2. The fungicidal agent according to claim 1, consisting of 0.5 to 90% by weight of active ingredient(s), with the remainder consisting of one or more inert, non-phytotoxic carrier(s). compound. 3. The fungicidal formulation according to claim 1 or 2, wherein in the compound of formula (b), X is chlorine. 4 Compound of formula (b) and further 2-[(trichloromethyl)-thio]-1H-isoindole-1.3
(2H)-dione, and the weight ratio of the (b) compound to the dione is 3:1 to 1:1, the fungicidal formulation according to any one of claims 1 to 3. thing. 5. The fungicidal method according to any one of claims 1 to 4, which comprises mixing the compound of formula () and the compound of formula () with one or more inert, non-phytotoxic carriers. Method of manufacturing the formulation. 6. Treating plants infected with mold with the formulation according to any one of claims 1 and 3 to 5, or the formulation according to claim 4 diluted with water. A method for treating or preventing fungal infection in plants, comprising: 7 Pyrimidine of formula (b) where X is chlorine and formula (b)
Claim 1 consisting of an aluminum salt of
Claim 6 for treating or preventing downy mildew of grapes, comprising spraying an aqueous dispersion of the formulation according to claim 2 on grapes with downy mildew. The method described in section. 8 Equation (b) where X is fluorine in grain infected with mold
a pyrimidine of formula (a) and a benzimidazole of formula (a), comprising spraying onto the mold-infected grain an aqueous dispersion of a formulation according to claim 1 comprising A method according to claim 6 for preventing.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB12972/77A GB1596380A (en) | 1977-03-28 | 1977-03-28 | Fungicidal combinations |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS53121932A JPS53121932A (en) | 1978-10-24 |
JPS6259081B2 true JPS6259081B2 (en) | 1987-12-09 |
Family
ID=10014480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3402678A Granted JPS53121932A (en) | 1977-03-28 | 1978-03-24 | Antifungal composition |
Country Status (34)
Country | Link |
---|---|
JP (1) | JPS53121932A (en) |
AR (2) | AR227124A1 (en) |
AT (1) | AT362195B (en) |
AU (1) | AU515204B2 (en) |
BE (1) | BE865215A (en) |
BG (4) | BG30167A4 (en) |
BR (1) | BR7801746A (en) |
CA (1) | CA1108046A (en) |
CH (1) | CH629363A5 (en) |
CS (4) | CS198292B2 (en) |
DD (1) | DD135031A5 (en) |
DE (2) | DE2858350C2 (en) |
DK (1) | DK149442C (en) |
ES (1) | ES468098A1 (en) |
FR (4) | FR2390096A1 (en) |
GB (1) | GB1596380A (en) |
GR (1) | GR64791B (en) |
HU (2) | HU179506B (en) |
IE (1) | IE46690B1 (en) |
IL (1) | IL54318A (en) |
IN (1) | IN147690B (en) |
IT (1) | IT1105157B (en) |
LU (1) | LU79285A1 (en) |
MX (1) | MX5640E (en) |
NL (1) | NL7803064A (en) |
NO (4) | NO147260C (en) |
NZ (1) | NZ186757A (en) |
PL (4) | PL112622B1 (en) |
PT (1) | PT67801A (en) |
RO (4) | RO78273A (en) |
SE (5) | SE447783B (en) |
SU (1) | SU1409119A3 (en) |
TR (1) | TR20072A (en) |
ZA (1) | ZA781700B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01167287U (en) * | 1988-05-16 | 1989-11-24 | ||
JPH0274094U (en) * | 1988-11-28 | 1990-06-06 | ||
JPH071190Y2 (en) * | 1989-03-01 | 1995-01-18 | 狭山精密工業株式会社 | Spiral control mechanism in pachinko ball lifting device |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2560510C2 (en) * | 1975-11-26 | 1989-02-16 | Bayer Ag, 5090 Leverkusen, De | |
IT1143721B (en) * | 1977-12-01 | 1986-10-22 | Sipcam Spa | FUNGICIDAL COMPOSITION FOR THE FIGHT AGAINST PLANT DISEASES |
DE2846038A1 (en) * | 1978-10-23 | 1980-05-08 | Basf Ag | 1,2,4-TRIAZOLE DERIVATIVES, THEIR PRODUCTION AND USE |
DE3208142A1 (en) * | 1982-03-06 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | FUNGICIDAL AGENT |
FR2524261A1 (en) * | 1982-04-01 | 1983-10-07 | Rhone Poulenc Agrochimie | FENARIMOL FUNGICIDE POWDER COMPOSITION |
GB8629360D0 (en) * | 1986-12-09 | 1987-01-21 | Sandoz Ltd | Fungicides |
DE3818903A1 (en) * | 1988-06-03 | 1989-12-14 | Stama Maschinenfabrik Gmbh | DRILLING AND MILLING PLANT |
NZ260462A (en) * | 1994-05-05 | 1996-04-26 | Horticulture & Food Res Inst | Tree treatment and composition comprising phosphorous acid, a bioprecursor or a salt thereof and a triazole |
FR2732191B1 (en) * | 1995-03-30 | 2000-12-29 | Rhone Poulenc Agrochimie | ANTIFUNGAL TREATMENT OF BANANA TREES |
GB0811079D0 (en) * | 2008-06-17 | 2008-07-23 | Syngenta Participations Ag | Herbicide formulation |
CN103583541B (en) * | 2012-08-17 | 2015-11-11 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing Fenarimol |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1569940A (en) * | 1967-04-27 | 1969-06-06 | ||
FR2140205B1 (en) | 1971-06-04 | 1977-12-23 | Oreal | |
US3912752A (en) * | 1972-01-11 | 1975-10-14 | Bayer Ag | 1-Substituted-1,2,4-triazoles |
US3869456A (en) * | 1972-03-13 | 1975-03-04 | Lilly Co Eli | Synthesis of 5-pyrimidinecarbinols |
US3868244A (en) | 1972-03-13 | 1975-02-25 | Lilly Co Eli | Plant growth regulation |
DE2303757A1 (en) * | 1973-01-26 | 1974-08-15 | Hoechst Ag | Fungicidal wettable powders contg. benzimidazole carbamates - mixed with powdered carrier, penetrating agent, but without emulsifying agents |
DE2354467C3 (en) * | 1973-10-31 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Fungicidal dispersions based on benzimidazole methyl carbamate |
DE2456627C2 (en) * | 1973-12-14 | 1984-05-10 | PEPRO - Société pour le Développement et la Vente de Spécialités Chimiques, Lyon | Fungicidal agents based on phosphonic acid esters |
FR2254276B1 (en) * | 1973-12-14 | 1977-03-04 | Philagro Sa | |
FR2279331A1 (en) * | 1974-07-24 | 1976-02-20 | Hoechst Ag | Fungicidal wettable powders contg. benzimidazole carbamates - mixed with powdered carrier, penetrating agent, but without emulsifying agents |
DE2560510C2 (en) * | 1975-11-26 | 1989-02-16 | Bayer Ag, 5090 Leverkusen, De |
-
1977
- 1977-03-28 GB GB12972/77A patent/GB1596380A/en not_active Expired
-
1978
- 1978-03-15 IT IT48444/78A patent/IT1105157B/en active
- 1978-03-20 CA CA299,331A patent/CA1108046A/en not_active Expired
- 1978-03-20 IN IN295/CAL/78A patent/IN147690B/en unknown
- 1978-03-20 PT PT67801A patent/PT67801A/en unknown
- 1978-03-20 SE SE7803184A patent/SE447783B/en not_active IP Right Cessation
- 1978-03-20 FR FR7807978A patent/FR2390096A1/en active Granted
- 1978-03-20 MX MX786944U patent/MX5640E/en unknown
- 1978-03-21 CH CH306178A patent/CH629363A5/en not_active IP Right Cessation
- 1978-03-21 RO RO7899323A patent/RO78273A/en unknown
- 1978-03-21 DE DE2858350A patent/DE2858350C2/de not_active Expired
- 1978-03-21 IL IL54318A patent/IL54318A/en unknown
- 1978-03-21 AR AR271494A patent/AR227124A1/en active
- 1978-03-21 GR GR55758A patent/GR64791B/en unknown
- 1978-03-21 RO RO7899324A patent/RO78274A/en unknown
- 1978-03-21 DK DK127978A patent/DK149442C/en not_active IP Right Cessation
- 1978-03-21 DE DE2812287A patent/DE2812287C2/en not_active Expired
- 1978-03-21 RO RO7899325A patent/RO78260A/en unknown
- 1978-03-21 RO RO7893574A patent/RO73042A/en unknown
- 1978-03-21 ES ES468098A patent/ES468098A1/en not_active Expired
- 1978-03-21 BR BR7801746A patent/BR7801746A/en unknown
- 1978-03-22 NO NO781040A patent/NO147260C/en unknown
- 1978-03-22 BG BG7841508A patent/BG30167A4/en unknown
- 1978-03-22 NL NL7803064A patent/NL7803064A/en not_active Application Discontinuation
- 1978-03-22 LU LU79285A patent/LU79285A1/en unknown
- 1978-03-22 NZ NZ186757A patent/NZ186757A/en unknown
- 1978-03-22 BG BG7839128A patent/BG29863A3/en unknown
- 1978-03-22 AT AT203678A patent/AT362195B/en not_active IP Right Cessation
- 1978-03-22 BG BG7841507A patent/BG30166A4/en unknown
- 1978-03-22 BG BG7841506A patent/BG30165A4/en unknown
- 1978-03-22 DD DD78204345A patent/DD135031A5/en unknown
- 1978-03-22 AU AU34430/78A patent/AU515204B2/en not_active Expired
- 1978-03-22 BE BE6046404A patent/BE865215A/en not_active IP Right Cessation
- 1978-03-23 TR TR20072A patent/TR20072A/en unknown
- 1978-03-23 ZA ZA00781700A patent/ZA781700B/en unknown
- 1978-03-23 HU HU78LI322A patent/HU179506B/en unknown
- 1978-03-23 IE IE588/78A patent/IE46690B1/en unknown
- 1978-03-23 HU HU812978A patent/HU188701B/en unknown
- 1978-03-24 CS CS789185A patent/CS198292B2/en unknown
- 1978-03-24 PL PL1978216611A patent/PL112622B1/en unknown
- 1978-03-24 JP JP3402678A patent/JPS53121932A/en active Granted
- 1978-03-24 CS CS789183A patent/CS198290B2/en unknown
- 1978-03-24 SU SU782594402A patent/SU1409119A3/en active
- 1978-03-24 PL PL1978216612A patent/PL112286B1/en unknown
- 1978-03-24 PL PL1978205555A patent/PL108903B1/en unknown
- 1978-03-24 CS CS789184A patent/CS198291B2/en unknown
- 1978-03-24 PL PL1978216610A patent/PL112146B1/en unknown
- 1978-03-24 CS CS781922A patent/CS198289B2/en unknown
- 1978-09-08 FR FR7825893A patent/FR2390097A1/en active Granted
- 1978-09-08 FR FR7825894A patent/FR2390098A1/en active Granted
- 1978-09-08 FR FR7825895A patent/FR2390099B1/fr not_active Expired
-
1981
- 1981-02-02 AR AR284171A patent/AR225793A1/en active
-
1982
- 1982-05-07 NO NO821513A patent/NO148241C/en unknown
- 1982-05-07 NO NO821512A patent/NO148622C/en unknown
- 1982-05-07 NO NO821514A patent/NO148621C/en unknown
-
1983
- 1983-03-23 SE SE8301606A patent/SE454398B/en not_active IP Right Cessation
-
1986
- 1986-05-30 SE SE8602470A patent/SE8602470D0/en not_active Application Discontinuation
-
1987
- 1987-08-19 SE SE8703223A patent/SE8703223L/en not_active Application Discontinuation
- 1987-08-19 SE SE8703224A patent/SE8703224D0/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01167287U (en) * | 1988-05-16 | 1989-11-24 | ||
JPH0274094U (en) * | 1988-11-28 | 1990-06-06 | ||
JPH071190Y2 (en) * | 1989-03-01 | 1995-01-18 | 狭山精密工業株式会社 | Spiral control mechanism in pachinko ball lifting device |
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