JPS57123140A - Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component - Google Patents

Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component

Info

Publication number
JPS57123140A
JPS57123140A JP56008696A JP869681A JPS57123140A JP S57123140 A JPS57123140 A JP S57123140A JP 56008696 A JP56008696 A JP 56008696A JP 869681 A JP869681 A JP 869681A JP S57123140 A JPS57123140 A JP S57123140A
Authority
JP
Japan
Prior art keywords
salt
carboxylic acid
remedy
active component
acid amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56008696A
Other languages
Japanese (ja)
Inventor
Kunio Nakano
Sueo Shiozawa
Seiji Tachibana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP56008696A priority Critical patent/JPS57123140A/en
Publication of JPS57123140A publication Critical patent/JPS57123140A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formula (A is organic amine).
EXAMPLE: ML-236B carboxylic acid t-octylamine salt.
USE: Remedy for hyperlipemia. It is superior in effect of inhibiting the cholesterol synthesis in the liver to known ML-236B derivatives.
PROCESS: The compound of formula can be prepared by saponifying ML-236B with a caustic alkali,dissolving the resultant ML-236B carboxylic acid alkali metal salt in an aqueous solvent (pref. hydrous acetone), adding 1W1.2 times mole of a mineral acid salt of the objective amine, and reacting at 5W10°C and 7W8.5pH.
COPYRIGHT: (C)1982,JPO&Japio
JP56008696A 1981-01-23 1981-01-23 Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component Pending JPS57123140A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56008696A JPS57123140A (en) 1981-01-23 1981-01-23 Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56008696A JPS57123140A (en) 1981-01-23 1981-01-23 Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component

Publications (1)

Publication Number Publication Date
JPS57123140A true JPS57123140A (en) 1982-07-31

Family

ID=11700078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56008696A Pending JPS57123140A (en) 1981-01-23 1981-01-23 Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component

Country Status (1)

Country Link
JP (1) JPS57123140A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008094A1 (en) * 1988-02-29 1989-09-08 Tobishi Yakuhin Kogyo Kabushiki Kaisha Novel derivatives of physiologically active substance ml-236b and process for their preparation
US6838566B2 (en) 1998-09-18 2005-01-04 Lek Pharmaceuticals D.D. Salts of HMG-CoA reductase inhibitors
JP2011512366A (en) * 2008-02-20 2011-04-21 グノーシス・エツセ・ピー・アー Folate, their composition and use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50155690A (en) * 1974-06-07 1975-12-16
JPS5356314A (en) * 1976-11-02 1978-05-22 Sankyo Co Ltd Remedies for hyperlipemia containing ml-236b metal salt as main component
JPS5428828A (en) * 1977-08-08 1979-03-03 Sankyo Co Ltd Remedy for hyperlipemia mainly composed of ml-236b carboxylic acid amino acid salt

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50155690A (en) * 1974-06-07 1975-12-16
JPS5356314A (en) * 1976-11-02 1978-05-22 Sankyo Co Ltd Remedies for hyperlipemia containing ml-236b metal salt as main component
JPS5428828A (en) * 1977-08-08 1979-03-03 Sankyo Co Ltd Remedy for hyperlipemia mainly composed of ml-236b carboxylic acid amino acid salt

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008094A1 (en) * 1988-02-29 1989-09-08 Tobishi Yakuhin Kogyo Kabushiki Kaisha Novel derivatives of physiologically active substance ml-236b and process for their preparation
US6838566B2 (en) 1998-09-18 2005-01-04 Lek Pharmaceuticals D.D. Salts of HMG-CoA reductase inhibitors
JP2011512366A (en) * 2008-02-20 2011-04-21 グノーシス・エツセ・ピー・アー Folate, their composition and use

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