JPS57123140A - Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component - Google Patents
Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active componentInfo
- Publication number
- JPS57123140A JPS57123140A JP56008696A JP869681A JPS57123140A JP S57123140 A JPS57123140 A JP S57123140A JP 56008696 A JP56008696 A JP 56008696A JP 869681 A JP869681 A JP 869681A JP S57123140 A JPS57123140 A JP S57123140A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- carboxylic acid
- remedy
- active component
- acid amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The compound of formula (A is organic amine).
EXAMPLE: ML-236B carboxylic acid t-octylamine salt.
USE: Remedy for hyperlipemia. It is superior in effect of inhibiting the cholesterol synthesis in the liver to known ML-236B derivatives.
PROCESS: The compound of formula can be prepared by saponifying ML-236B with a caustic alkali,dissolving the resultant ML-236B carboxylic acid alkali metal salt in an aqueous solvent (pref. hydrous acetone), adding 1W1.2 times mole of a mineral acid salt of the objective amine, and reacting at 5W10°C and 7W8.5pH.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56008696A JPS57123140A (en) | 1981-01-23 | 1981-01-23 | Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56008696A JPS57123140A (en) | 1981-01-23 | 1981-01-23 | Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57123140A true JPS57123140A (en) | 1982-07-31 |
Family
ID=11700078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56008696A Pending JPS57123140A (en) | 1981-01-23 | 1981-01-23 | Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57123140A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989008094A1 (en) * | 1988-02-29 | 1989-09-08 | Tobishi Yakuhin Kogyo Kabushiki Kaisha | Novel derivatives of physiologically active substance ml-236b and process for their preparation |
US6838566B2 (en) | 1998-09-18 | 2005-01-04 | Lek Pharmaceuticals D.D. | Salts of HMG-CoA reductase inhibitors |
JP2011512366A (en) * | 2008-02-20 | 2011-04-21 | グノーシス・エツセ・ピー・アー | Folate, their composition and use |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50155690A (en) * | 1974-06-07 | 1975-12-16 | ||
JPS5356314A (en) * | 1976-11-02 | 1978-05-22 | Sankyo Co Ltd | Remedies for hyperlipemia containing ml-236b metal salt as main component |
JPS5428828A (en) * | 1977-08-08 | 1979-03-03 | Sankyo Co Ltd | Remedy for hyperlipemia mainly composed of ml-236b carboxylic acid amino acid salt |
-
1981
- 1981-01-23 JP JP56008696A patent/JPS57123140A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50155690A (en) * | 1974-06-07 | 1975-12-16 | ||
JPS5356314A (en) * | 1976-11-02 | 1978-05-22 | Sankyo Co Ltd | Remedies for hyperlipemia containing ml-236b metal salt as main component |
JPS5428828A (en) * | 1977-08-08 | 1979-03-03 | Sankyo Co Ltd | Remedy for hyperlipemia mainly composed of ml-236b carboxylic acid amino acid salt |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989008094A1 (en) * | 1988-02-29 | 1989-09-08 | Tobishi Yakuhin Kogyo Kabushiki Kaisha | Novel derivatives of physiologically active substance ml-236b and process for their preparation |
US6838566B2 (en) | 1998-09-18 | 2005-01-04 | Lek Pharmaceuticals D.D. | Salts of HMG-CoA reductase inhibitors |
JP2011512366A (en) * | 2008-02-20 | 2011-04-21 | グノーシス・エツセ・ピー・アー | Folate, their composition and use |
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