JPS55147257A - Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component - Google Patents
Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective componentInfo
- Publication number
- JPS55147257A JPS55147257A JP5423979A JP5423979A JPS55147257A JP S55147257 A JPS55147257 A JP S55147257A JP 5423979 A JP5423979 A JP 5423979A JP 5423979 A JP5423979 A JP 5423979A JP S55147257 A JPS55147257 A JP S55147257A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- pyroglutamic acid
- formula
- benzoyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
Abstract
NEW MATERIAL:Pyroglutamic acid derivatives of formula I (R1 is H, lower alkanoyl, or benzoyl; R2 is H or lower alkyl; R is H or lower alkyl), or nontoxic salts of the above acid wherein R is H.
EXAMPLE: (2S)-1-[3-Acetylthio-2-(RS)-methylpropanoyl]pyroglutamic acid t-butyl ester.
USE: Remedy for hypertension. Inhibits angiotensin-converting enzymes.
PROCESS: A compound of formula I (wherein R1 is lower alkanoyl or benzoyl; R is lower alkyl) is obtained by the reaction of a compound of formula II (M is alkali metal; R3 is lower alkyl) and a reactive derivative (e.g. acid chloride, p-nitrophenyl ester) of a compound of formula III (R4 is lower alkanoyl or benzoyl) in an inert organic solvent (e.g. methylene chloride, benzene, etc.), followed by the hydrolysis under basic or acidic conditions if necessary.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5423979A JPS55147257A (en) | 1979-05-04 | 1979-05-04 | Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component |
FR8009787A FR2455585A1 (en) | 1979-05-04 | 1980-04-30 | OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION |
GB8014359A GB2051781B (en) | 1979-05-04 | 1980-05-01 | Oxoamino acid derivatives |
DE19803016960 DE3016960A1 (en) | 1979-05-04 | 1980-05-02 | OXOAMINOAID DERIVATIVES AND THEIR NON-TOXIC SALTS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
IT8048579A IT8048579A0 (en) | 1979-05-04 | 1980-05-05 | OXOAMINO ACIDS DERIVATIVES PROCEDURE FOR PRODUCING THEM AND COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5423979A JPS55147257A (en) | 1979-05-04 | 1979-05-04 | Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55147257A true JPS55147257A (en) | 1980-11-17 |
Family
ID=12964985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5423979A Pending JPS55147257A (en) | 1979-05-04 | 1979-05-04 | Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55147257A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS568361A (en) * | 1979-06-25 | 1981-01-28 | Squibb & Sons Inc | Pyroglutamic acid derivative and analogue |
JPS56133261A (en) * | 1980-03-21 | 1981-10-19 | Squibb & Sons Inc | Mercaptoacyl derivative of keto-substituted proline and pipecolic acid, manufacture and use |
JPS58131968A (en) * | 1981-09-09 | 1983-08-06 | Chugai Pharmaceut Co Ltd | Thiol ester compound |
EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
-
1979
- 1979-05-04 JP JP5423979A patent/JPS55147257A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS568361A (en) * | 1979-06-25 | 1981-01-28 | Squibb & Sons Inc | Pyroglutamic acid derivative and analogue |
JPS56133261A (en) * | 1980-03-21 | 1981-10-19 | Squibb & Sons Inc | Mercaptoacyl derivative of keto-substituted proline and pipecolic acid, manufacture and use |
JPH0140827B2 (en) * | 1980-03-21 | 1989-08-31 | Squibb & Sons Inc | |
JPS58131968A (en) * | 1981-09-09 | 1983-08-06 | Chugai Pharmaceut Co Ltd | Thiol ester compound |
EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
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