JPS55147257A - Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component - Google Patents

Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component

Info

Publication number
JPS55147257A
JPS55147257A JP5423979A JP5423979A JPS55147257A JP S55147257 A JPS55147257 A JP S55147257A JP 5423979 A JP5423979 A JP 5423979A JP 5423979 A JP5423979 A JP 5423979A JP S55147257 A JPS55147257 A JP S55147257A
Authority
JP
Japan
Prior art keywords
lower alkyl
pyroglutamic acid
formula
benzoyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5423979A
Other languages
Japanese (ja)
Inventor
Masaaki Toda
Katsuhiro Imaki
Shigeru Sakuyama
Tadanori Okada
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP5423979A priority Critical patent/JPS55147257A/en
Priority to FR8009787A priority patent/FR2455585A1/en
Priority to GB8014359A priority patent/GB2051781B/en
Priority to DE19803016960 priority patent/DE3016960A1/en
Priority to IT8048579A priority patent/IT8048579A0/en
Publication of JPS55147257A publication Critical patent/JPS55147257A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:Pyroglutamic acid derivatives of formula I (R1 is H, lower alkanoyl, or benzoyl; R2 is H or lower alkyl; R is H or lower alkyl), or nontoxic salts of the above acid wherein R is H.
EXAMPLE: (2S)-1-[3-Acetylthio-2-(RS)-methylpropanoyl]pyroglutamic acid t-butyl ester.
USE: Remedy for hypertension. Inhibits angiotensin-converting enzymes.
PROCESS: A compound of formula I (wherein R1 is lower alkanoyl or benzoyl; R is lower alkyl) is obtained by the reaction of a compound of formula II (M is alkali metal; R3 is lower alkyl) and a reactive derivative (e.g. acid chloride, p-nitrophenyl ester) of a compound of formula III (R4 is lower alkanoyl or benzoyl) in an inert organic solvent (e.g. methylene chloride, benzene, etc.), followed by the hydrolysis under basic or acidic conditions if necessary.
COPYRIGHT: (C)1980,JPO&Japio
JP5423979A 1979-05-04 1979-05-04 Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component Pending JPS55147257A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP5423979A JPS55147257A (en) 1979-05-04 1979-05-04 Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component
FR8009787A FR2455585A1 (en) 1979-05-04 1980-04-30 OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION
GB8014359A GB2051781B (en) 1979-05-04 1980-05-01 Oxoamino acid derivatives
DE19803016960 DE3016960A1 (en) 1979-05-04 1980-05-02 OXOAMINOAID DERIVATIVES AND THEIR NON-TOXIC SALTS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IT8048579A IT8048579A0 (en) 1979-05-04 1980-05-05 OXOAMINO ACIDS DERIVATIVES PROCEDURE FOR PRODUCING THEM AND COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5423979A JPS55147257A (en) 1979-05-04 1979-05-04 Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component

Publications (1)

Publication Number Publication Date
JPS55147257A true JPS55147257A (en) 1980-11-17

Family

ID=12964985

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5423979A Pending JPS55147257A (en) 1979-05-04 1979-05-04 Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component

Country Status (1)

Country Link
JP (1) JPS55147257A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568361A (en) * 1979-06-25 1981-01-28 Squibb & Sons Inc Pyroglutamic acid derivative and analogue
JPS56133261A (en) * 1980-03-21 1981-10-19 Squibb & Sons Inc Mercaptoacyl derivative of keto-substituted proline and pipecolic acid, manufacture and use
JPS58131968A (en) * 1981-09-09 1983-08-06 Chugai Pharmaceut Co Ltd Thiol ester compound
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568361A (en) * 1979-06-25 1981-01-28 Squibb & Sons Inc Pyroglutamic acid derivative and analogue
JPS56133261A (en) * 1980-03-21 1981-10-19 Squibb & Sons Inc Mercaptoacyl derivative of keto-substituted proline and pipecolic acid, manufacture and use
JPH0140827B2 (en) * 1980-03-21 1989-08-31 Squibb & Sons Inc
JPS58131968A (en) * 1981-09-09 1983-08-06 Chugai Pharmaceut Co Ltd Thiol ester compound
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor

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