JPS5519092A - Selected protein producing method - Google Patents
Selected protein producing methodInfo
- Publication number
- JPS5519092A JPS5519092A JP6901879A JP6901879A JPS5519092A JP S5519092 A JPS5519092 A JP S5519092A JP 6901879 A JP6901879 A JP 6901879A JP 6901879 A JP6901879 A JP 6901879A JP S5519092 A JPS5519092 A JP S5519092A
- Authority
- JP
- Japan
- Prior art keywords
- selected protein
- producing method
- protein producing
- cleaved
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/913,533 US4411994A (en) | 1978-06-08 | 1978-06-08 | Protein synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5519092A true JPS5519092A (en) | 1980-02-09 |
JPS6246160B2 JPS6246160B2 (ja) | 1987-09-30 |
Family
ID=25433372
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6901879A Granted JPS5519092A (en) | 1978-06-08 | 1979-06-04 | Selected protein producing method |
JP61066115A Expired - Lifetime JPH0755151B2 (ja) | 1978-06-08 | 1986-03-26 | 選定蛋白質およびそれをコードする組替えdna分子 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP61066115A Expired - Lifetime JPH0755151B2 (ja) | 1978-06-08 | 1986-03-26 | 選定蛋白質およびそれをコードする組替えdna分子 |
Country Status (20)
Country | Link |
---|---|
US (1) | US4411994A (ja) |
EP (1) | EP0006694B2 (ja) |
JP (2) | JPS5519092A (ja) |
AT (1) | ATE5001T1 (ja) |
AU (1) | AU524856B2 (ja) |
BG (1) | BG60444B2 (ja) |
CA (1) | CA1215920A (ja) |
DD (1) | DD148235A5 (ja) |
DE (1) | DE2966291D1 (ja) |
DK (1) | DK237979A (ja) |
ES (1) | ES481362A1 (ja) |
FI (1) | FI791841A (ja) |
GR (1) | GR72953B (ja) |
IE (1) | IE48156B1 (ja) |
IL (1) | IL57491A (ja) |
MX (1) | MX6339E (ja) |
NZ (1) | NZ190524A (ja) |
PT (1) | PT69737A (ja) |
WO (1) | WO1980000030A1 (ja) |
ZA (1) | ZA792486B (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56154999A (en) * | 1980-04-11 | 1981-11-30 | Harvard College | Synthesis of selective aged protein or polypeptide in bacteria matrix |
JPS56166200A (en) * | 1980-02-29 | 1981-12-21 | Univ California | Idiosyncratically cutting linker |
JPS57132895A (en) * | 1980-12-31 | 1982-08-17 | Parubua Irutsuka | Production of rearranged dna molecule and protein |
JPS59132892A (ja) * | 1983-01-12 | 1984-07-31 | カイロン コーポレイション | 真核生物における分泌発現遺伝子 |
JPS59162874A (ja) * | 1983-03-08 | 1984-09-13 | Rikagaku Kenkyusho | 微生物の培養方法 |
JPS59205997A (ja) * | 1983-04-25 | 1984-11-21 | チロン・コ−ポレイシヨン | ヒト−インシユリン様成長因子の製造方法 |
JPS60500701A (ja) * | 1983-03-09 | 1985-05-16 | シタス コ−ポレイシヨン | 変形されたシグナルペプチド |
JPS60501140A (ja) * | 1983-04-22 | 1985-07-25 | アムジエン | 酵母による外因性ポリペプチドの分泌 |
JPS60207596A (ja) * | 1984-03-30 | 1985-10-19 | Mitsubishi Chem Ind Ltd | 蛋白の産生方法 |
JPS6137099A (ja) * | 1984-07-30 | 1986-02-21 | Wakunaga Seiyaku Kk | 蛋白質の製造法 |
JPS61152297A (ja) * | 1984-12-26 | 1986-07-10 | Wakunaga Seiyaku Kk | 蛋白質の製造法 |
JPS61158790A (ja) * | 1984-12-28 | 1986-07-18 | Rikagaku Kenkyusho | 新規プラスミド及びその調製方法並びにそのプラスミドを含有する新規微生物 |
JPS61212288A (ja) * | 1985-03-19 | 1986-09-20 | Agency Of Ind Science & Technol | 蛋白製造法 |
JPS61268183A (ja) * | 1985-05-24 | 1986-11-27 | Wakamoto Pharmaceut Co Ltd | Dna,組換体dnaおよびそれらを含む微生物 |
JPS6229982A (ja) * | 1985-07-30 | 1987-02-07 | Rikagaku Kenkyusho | 新規プラスミド及びそれにより形質転換された新規微生物 |
JPS62122589A (ja) * | 1985-11-25 | 1987-06-03 | Agency Of Ind Science & Technol | Dna塩基配列およびベクタ− |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO80052B (ro) * | 1977-11-08 | 1985-03-30 | Genetech | Procedeu pentru prepararea unui vehicul recombinat de clonare pentru transformarea unei gazde bacteriene pentru a deveni generator de polipeptida heterologa |
US6268122B1 (en) | 1978-12-22 | 2001-07-31 | Biogen, Inc. | Recombinant DNA molecules and their method of production |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
GR70279B (ja) * | 1979-09-12 | 1982-09-03 | Univ California | |
DE3001928A1 (de) * | 1980-01-19 | 1981-08-06 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus |
US6455275B1 (en) | 1980-02-25 | 2002-09-24 | The Trustees Of Columbia University In The City Of New York | DNA construct for producing proteinaceous materials in eucaryotic cells |
AU545912B2 (en) * | 1980-03-10 | 1985-08-08 | Cetus Corporation | Cloned heterologous jive products in bacillies |
US4711843A (en) * | 1980-12-31 | 1987-12-08 | Cetus Corporation | Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis |
ATE56471T1 (de) | 1980-04-03 | 1990-09-15 | Biogen Inc | Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon. |
US6610830B1 (en) | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
NZ198445A (en) * | 1980-09-25 | 1984-05-31 | Genentech Inc | Production of human fibroblast interferon by recombinant dna technology |
US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
GR76959B (ja) * | 1981-01-02 | 1984-09-04 | Univ New York State Res Found | |
NZ199391A (en) * | 1981-01-02 | 1985-12-13 | Genentech Inc | Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin |
US4663285A (en) * | 1981-01-06 | 1987-05-05 | The Public Health Laboratory Service Board | Chimeric plasmids |
ZA824218B (en) * | 1981-06-29 | 1983-04-27 | Cetus Corp | Plasmid for producing human insulin |
JPS5869897A (ja) * | 1981-10-20 | 1983-04-26 | Gakuzo Tamura | Dna遺伝子 |
EP0078154A3 (en) * | 1981-10-28 | 1985-01-09 | The Regents Of The University Of California | Plasmids and cells for heterologous expression of metallothioneins and processes for producing and using the metallothionein |
US4532207A (en) * | 1982-03-19 | 1985-07-30 | G. D. Searle & Co. | Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase |
US4863855A (en) * | 1982-05-14 | 1989-09-05 | The Research Foundation Of State University Of New York | Novel cloning vehicles for polypeptide expression in microbial hosts |
JPS592689A (ja) * | 1982-06-04 | 1984-01-09 | Handai Biseibutsubiyou Kenkyukai | 強力な遺伝子発現能を有する新規レプリコンの作成法 |
US4595658A (en) * | 1982-09-13 | 1986-06-17 | The Rockefeller University | Method for facilitating externalization of proteins synthesized in bacteria |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
US4962055A (en) * | 1983-03-08 | 1990-10-09 | Rikagaku Kenkyusho | Plasmid, method for construction of the same, microorganisms carrying the plasmid and method for cultivation of the microorganism |
DK138984A (da) * | 1983-03-08 | 1984-09-09 | Rikagaku Kenkyusho | Plasmid, fremgangsmaade til fremstilling heraf, mikroorganismer indeholdende samme samt fremgangsmaade til dyrkning af mikroorganismen |
US4820642A (en) * | 1983-04-04 | 1989-04-11 | The Regents Of The University Of California | Amplified expression vector |
US7198919B1 (en) | 1983-04-25 | 2007-04-03 | Genentech, Inc. | Use of alpha factor sequences in yeast expression systems |
US4663280A (en) * | 1983-05-19 | 1987-05-05 | Public Health Research Institute Of The City Of New York | Expression and secretion vectors and method of constructing vectors |
GB8314362D0 (en) * | 1983-05-24 | 1983-06-29 | Celltech Ltd | Polypeptide and protein products |
IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
FR2549855B1 (fr) * | 1983-07-29 | 1987-03-27 | Grp Genie Genetique | Sequence nucleotidique codant pour le peptide signal de la toxine diphterique, vecteur contenant cette sequence nucleotidique, leur application a la transformation de micro-organismes et compositions peptidiques obtenues |
US4695542A (en) | 1983-10-04 | 1987-09-22 | Dnax Research Institute Of Molecular And Cellular Biology, Inc. | cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity |
KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
PH23920A (en) * | 1983-12-20 | 1990-01-23 | Cetus Corp | Glucoamylase cdna |
IT1185503B (it) * | 1984-01-11 | 1987-11-12 | Univ New York | Cloni di odna di eritropietina umana |
US4859465A (en) * | 1984-04-20 | 1989-08-22 | The Regents Of The University Of California | Vaccine capable of eliciting multivalent antibodies |
DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
US6022950A (en) * | 1984-06-07 | 2000-02-08 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US5668255A (en) * | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
US4801537A (en) * | 1984-06-08 | 1989-01-31 | Genex Corporation | Vector for expression of polypeptides in bacilli |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
JPH062074B2 (ja) * | 1984-07-27 | 1994-01-12 | 國男 山根 | オリゴペプチドの製法 |
EP0170266B1 (en) * | 1984-07-30 | 1993-03-24 | Wakunaga Seiyaku Kabushiki Kaisha | Process for producing protein, and vector, recombinant dna and transformant used therefor |
US5691181A (en) * | 1984-08-21 | 1997-11-25 | Celltech Limited | DNA encoding lipase from human gastric mucosal tissue |
US5272254A (en) * | 1984-10-02 | 1993-12-21 | Biogen Inc. | Production of streptavidin-like polypeptides |
JP2624470B2 (ja) * | 1984-10-02 | 1997-06-25 | バイオジェン インコーポレイテッド | ストレプトアビジン様ポリペプチドの製造 |
US4963495A (en) * | 1984-10-05 | 1990-10-16 | Genentech, Inc. | Secretion of heterologous proteins |
US5190874A (en) * | 1984-12-28 | 1993-03-02 | Rikagaku Kenkyusho | Method for producing penicillinase and xylanase |
US4774180A (en) * | 1986-02-26 | 1988-09-27 | Massachusetts Institute Of Technology | Construction and application of polyproteins |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
USH2055H1 (en) | 1985-09-20 | 2002-12-03 | Zymogenetics, Inc. | Expression of tissue-type plasminogen activator in bacteria |
EP0240550A4 (en) * | 1985-09-26 | 1989-09-19 | Genetics Inst | LUNG SURFACE ACTIVE PROTEINS. |
EP0238645A1 (en) * | 1985-10-03 | 1987-09-30 | Biotechnology Research Partners, Ltd. | Novel lipoprotein-based drug-delivery systems |
GB8529014D0 (en) * | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
CA1339757C (en) * | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
US5084384A (en) * | 1987-04-23 | 1992-01-28 | Monsanto Company | Secretion of insulin-like growth factor-I |
US5426036A (en) * | 1987-05-05 | 1995-06-20 | Hoechst Aktiengesellschaft | Processes for the preparation of foreign proteins in streptomycetes |
US5066792A (en) * | 1987-09-04 | 1991-11-19 | Board Of Regents University Of Texas | Gene probe for detection of specific human leukemias |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP0763543A2 (en) | 1988-09-02 | 1997-03-19 | The Rockefeller University | A method for preparing an inflammatory cytokine (MIP-2) and diagnostic and therapeutic applications for the cytokine or its antibody |
FR2648713B1 (fr) * | 1989-06-26 | 1994-06-10 | Commissariat Energie Atomique | Proteines hybrides entre une enzyme extracytoplasmique et une autre proteine, leur procede de preparation, ainsi que leur application comme agent de diagnostic |
US7413537B2 (en) * | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
US5578464A (en) * | 1989-10-31 | 1996-11-26 | Schering Corporation | E. coli secretory strains |
US5595900A (en) * | 1990-02-14 | 1997-01-21 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
AU8740491A (en) * | 1990-09-28 | 1992-04-28 | Protein Engineering Corporation | Proteinaceous anti-dental plaque agents |
AU1545692A (en) * | 1991-03-01 | 1992-10-06 | Protein Engineering Corporation | Process for the development of binding mini-proteins |
EP1281770B1 (en) | 1993-03-10 | 2010-03-03 | GlaxoSmithKline LLC | Human brain phosphodiesterase and screening method |
US5691180A (en) * | 1994-06-09 | 1997-11-25 | The Regents Of The University Of Michigan | DNA sequence encoding N-acetyl-galactosamine-transferase |
US5807732A (en) * | 1995-02-28 | 1998-09-15 | Lowe; John B. | GDP-L-fucose: β-D-galactoside 2-α-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person |
US5770420A (en) * | 1995-09-08 | 1998-06-23 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53137215A (en) * | 1977-05-06 | 1978-11-30 | Harima Refractories Co Ltd | Reparing material of blast oven gate by spray method |
JPS54163600A (en) * | 1977-11-08 | 1979-12-26 | Genentech Inc | Microbiological polypeptide expression method and means |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082613A (en) * | 1976-04-23 | 1978-04-04 | The Regents Of The University Of Minnesota | Process for the production of insulin by genetically transformed fungal cells |
JPS54145289A (en) * | 1977-11-08 | 1979-11-13 | Genentech Inc | Improving method of microbiological polypeptide displaying method and means |
-
1978
- 1978-06-08 US US05/913,533 patent/US4411994A/en not_active Expired - Lifetime
-
1979
- 1979-05-02 ZA ZA792486A patent/ZA792486B/xx unknown
- 1979-05-22 NZ NZ190524A patent/NZ190524A/xx unknown
- 1979-05-24 GR GR59168A patent/GR72953B/el unknown
- 1979-06-04 EP EP79301054A patent/EP0006694B2/en not_active Expired - Lifetime
- 1979-06-04 JP JP6901879A patent/JPS5519092A/ja active Granted
- 1979-06-04 AT AT79301054T patent/ATE5001T1/de active
- 1979-06-04 DE DE7979301054T patent/DE2966291D1/de not_active Expired
- 1979-06-05 AU AU47752/79A patent/AU524856B2/en not_active Ceased
- 1979-06-06 DD DD79213428A patent/DD148235A5/de unknown
- 1979-06-06 IL IL57491A patent/IL57491A/xx unknown
- 1979-06-06 PT PT69737A patent/PT69737A/pt unknown
- 1979-06-07 WO PCT/US1979/000399 patent/WO1980000030A1/en unknown
- 1979-06-07 MX MX798053U patent/MX6339E/es unknown
- 1979-06-07 ES ES481362A patent/ES481362A1/es not_active Expired
- 1979-06-07 DK DK237979A patent/DK237979A/da not_active Application Discontinuation
- 1979-06-08 FI FI791841A patent/FI791841A/fi not_active Application Discontinuation
- 1979-06-08 CA CA000329373A patent/CA1215920A/en not_active Expired
- 1979-08-08 IE IE1115/79A patent/IE48156B1/en unknown
-
1986
- 1986-03-26 JP JP61066115A patent/JPH0755151B2/ja not_active Expired - Lifetime
-
1994
- 1994-02-11 BG BG98458A patent/BG60444B2/bg unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53137215A (en) * | 1977-05-06 | 1978-11-30 | Harima Refractories Co Ltd | Reparing material of blast oven gate by spray method |
JPS54163600A (en) * | 1977-11-08 | 1979-12-26 | Genentech Inc | Microbiological polypeptide expression method and means |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56166200A (en) * | 1980-02-29 | 1981-12-21 | Univ California | Idiosyncratically cutting linker |
JPH0669375B2 (ja) * | 1980-02-29 | 1994-09-07 | ザ・レジエンツ・オブ・ザ・ユニバ−シイテイ・オブ・カリフオルニア | 特異的切断リンカ− |
JPS56154999A (en) * | 1980-04-11 | 1981-11-30 | Harvard College | Synthesis of selective aged protein or polypeptide in bacteria matrix |
JPS57132895A (en) * | 1980-12-31 | 1982-08-17 | Parubua Irutsuka | Production of rearranged dna molecule and protein |
JPH03206889A (ja) * | 1980-12-31 | 1991-09-10 | Ilkka Palva | 組み換えdna分子 |
JPH0372893A (ja) * | 1983-01-12 | 1991-03-28 | Chiron Corp | 酵母による組換ポリペプチドの製造方法 |
JPS59132892A (ja) * | 1983-01-12 | 1984-07-31 | カイロン コーポレイション | 真核生物における分泌発現遺伝子 |
JPS59162874A (ja) * | 1983-03-08 | 1984-09-13 | Rikagaku Kenkyusho | 微生物の培養方法 |
JPH0355105B2 (ja) * | 1983-03-08 | 1991-08-22 | ||
JPS60500701A (ja) * | 1983-03-09 | 1985-05-16 | シタス コ−ポレイシヨン | 変形されたシグナルペプチド |
JPS60501140A (ja) * | 1983-04-22 | 1985-07-25 | アムジエン | 酵母による外因性ポリペプチドの分泌 |
JPH07143886A (ja) * | 1983-04-25 | 1995-06-06 | Chiron Corp | ヒト−インシュリン様成長因子をコードする遺伝子系 |
JPS59205997A (ja) * | 1983-04-25 | 1984-11-21 | チロン・コ−ポレイシヨン | ヒト−インシユリン様成長因子の製造方法 |
JPS60207596A (ja) * | 1984-03-30 | 1985-10-19 | Mitsubishi Chem Ind Ltd | 蛋白の産生方法 |
JPS6137099A (ja) * | 1984-07-30 | 1986-02-21 | Wakunaga Seiyaku Kk | 蛋白質の製造法 |
JP2524693B2 (ja) * | 1984-07-30 | 1996-08-14 | 湧永製薬株式会社 | 蛋白質の製造法 |
JPS61152297A (ja) * | 1984-12-26 | 1986-07-10 | Wakunaga Seiyaku Kk | 蛋白質の製造法 |
JP2524695B2 (ja) * | 1984-12-26 | 1996-08-14 | 湧永製薬株式会社 | 蛋白質の製造法 |
JPS61158790A (ja) * | 1984-12-28 | 1986-07-18 | Rikagaku Kenkyusho | 新規プラスミド及びその調製方法並びにそのプラスミドを含有する新規微生物 |
JPH0817702B2 (ja) * | 1984-12-28 | 1996-02-28 | 理化学研究所 | 新規プラスミド及びその調製方法並びにそのプラスミドを含有する新規微生物 |
JPS61212288A (ja) * | 1985-03-19 | 1986-09-20 | Agency Of Ind Science & Technol | 蛋白製造法 |
JPS61268183A (ja) * | 1985-05-24 | 1986-11-27 | Wakamoto Pharmaceut Co Ltd | Dna,組換体dnaおよびそれらを含む微生物 |
JPS6229982A (ja) * | 1985-07-30 | 1987-02-07 | Rikagaku Kenkyusho | 新規プラスミド及びそれにより形質転換された新規微生物 |
JPS62122589A (ja) * | 1985-11-25 | 1987-06-03 | Agency Of Ind Science & Technol | Dna塩基配列およびベクタ− |
Also Published As
Publication number | Publication date |
---|---|
AU524856B2 (en) | 1982-10-07 |
MX6339E (es) | 1985-04-23 |
WO1980000030A1 (en) | 1980-01-10 |
IE791115L (en) | 1979-12-08 |
IL57491A (en) | 1983-09-30 |
EP0006694A3 (en) | 1980-01-23 |
EP0006694B2 (en) | 1992-01-22 |
EP0006694B1 (en) | 1983-10-12 |
DE2966291D1 (en) | 1983-11-17 |
BG60444B2 (bg) | 1995-03-31 |
DD148235A5 (de) | 1981-05-13 |
CA1215920A (en) | 1986-12-30 |
JPS6246160B2 (ja) | 1987-09-30 |
AU4775279A (en) | 1979-12-13 |
EP0006694A2 (en) | 1980-01-09 |
NZ190524A (en) | 1982-09-14 |
ZA792486B (en) | 1981-01-28 |
US4411994A (en) | 1983-10-25 |
JPS61227598A (ja) | 1986-10-09 |
PT69737A (en) | 1979-07-01 |
ATE5001T1 (de) | 1983-10-15 |
IE48156B1 (en) | 1984-10-17 |
DK237979A (da) | 1979-12-09 |
JPH0755151B2 (ja) | 1995-06-14 |
FI791841A (fi) | 1979-12-09 |
GR72953B (ja) | 1984-01-18 |
IL57491A0 (en) | 1979-10-31 |
ES481362A1 (es) | 1980-03-01 |
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