DK237979A - Fremgangsmaade til fremstilling af proteiner - Google Patents

Fremgangsmaade til fremstilling af proteiner

Info

Publication number
DK237979A
DK237979A DK237979A DK237979A DK237979A DK 237979 A DK237979 A DK 237979A DK 237979 A DK237979 A DK 237979A DK 237979 A DK237979 A DK 237979A DK 237979 A DK237979 A DK 237979A
Authority
DK
Denmark
Prior art keywords
proteins
procedure
production
cleaved
gene
Prior art date
Application number
DK237979A
Other languages
English (en)
Inventor
W Gilbert
S A Broome
L J Villa-Komaroff
A A Efstratiadis
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25433372&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK237979(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College filed Critical Harvard College
Publication of DK237979A publication Critical patent/DK237979A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/30Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK237979A 1978-06-08 1979-06-07 Fremgangsmaade til fremstilling af proteiner DK237979A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/913,533 US4411994A (en) 1978-06-08 1978-06-08 Protein synthesis

Publications (1)

Publication Number Publication Date
DK237979A true DK237979A (da) 1979-12-09

Family

ID=25433372

Family Applications (1)

Application Number Title Priority Date Filing Date
DK237979A DK237979A (da) 1978-06-08 1979-06-07 Fremgangsmaade til fremstilling af proteiner

Country Status (20)

Country Link
US (1) US4411994A (da)
EP (1) EP0006694B2 (da)
JP (2) JPS5519092A (da)
AT (1) ATE5001T1 (da)
AU (1) AU524856B2 (da)
BG (1) BG60444B2 (da)
CA (1) CA1215920A (da)
DD (1) DD148235A5 (da)
DE (1) DE2966291D1 (da)
DK (1) DK237979A (da)
ES (1) ES481362A1 (da)
FI (1) FI791841A (da)
GR (1) GR72953B (da)
IE (1) IE48156B1 (da)
IL (1) IL57491A (da)
MX (1) MX6339E (da)
NZ (1) NZ190524A (da)
PT (1) PT69737A (da)
WO (1) WO1980000030A1 (da)
ZA (1) ZA792486B (da)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO80052B (ro) * 1977-11-08 1985-03-30 Genetech Procedeu pentru prepararea unui vehicul recombinat de clonare pentru transformarea unei gazde bacteriene pentru a deveni generator de polipeptida heterologa
US6268122B1 (en) 1978-12-22 2001-07-31 Biogen, Inc. Recombinant DNA molecules and their method of production
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
GR70279B (da) * 1979-09-12 1982-09-03 Univ California
DE3001928A1 (de) * 1980-01-19 1981-08-06 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US6455275B1 (en) 1980-02-25 2002-09-24 The Trustees Of Columbia University In The City Of New York DNA construct for producing proteinaceous materials in eucaryotic cells
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
AU545912B2 (en) * 1980-03-10 1985-08-08 Cetus Corporation Cloned heterologous jive products in bacillies
US4711843A (en) * 1980-12-31 1987-12-08 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
ATE56471T1 (de) 1980-04-03 1990-09-15 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
NZ198445A (en) * 1980-09-25 1984-05-31 Genentech Inc Production of human fibroblast interferon by recombinant dna technology
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
GR76959B (da) * 1981-01-02 1984-09-04 Univ New York State Res Found
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4663285A (en) * 1981-01-06 1987-05-05 The Public Health Laboratory Service Board Chimeric plasmids
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
JPS5869897A (ja) * 1981-10-20 1983-04-26 Gakuzo Tamura Dna遺伝子
EP0078154A3 (en) * 1981-10-28 1985-01-09 The Regents Of The University Of California Plasmids and cells for heterologous expression of metallothioneins and processes for producing and using the metallothionein
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4863855A (en) * 1982-05-14 1989-09-05 The Research Foundation Of State University Of New York Novel cloning vehicles for polypeptide expression in microbial hosts
JPS592689A (ja) * 1982-06-04 1984-01-09 Handai Biseibutsubiyou Kenkyukai 強力な遺伝子発現能を有する新規レプリコンの作成法
US4595658A (en) * 1982-09-13 1986-06-17 The Rockefeller University Method for facilitating externalization of proteins synthesized in bacteria
EP0116201B1 (en) * 1983-01-12 1992-04-22 Chiron Corporation Secretory expression in eukaryotes
SE8300693L (sv) * 1983-02-09 1984-08-10 Sven Lofdahl Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
US4962055A (en) * 1983-03-08 1990-10-09 Rikagaku Kenkyusho Plasmid, method for construction of the same, microorganisms carrying the plasmid and method for cultivation of the microorganism
DK138984A (da) * 1983-03-08 1984-09-09 Rikagaku Kenkyusho Plasmid, fremgangsmaade til fremstilling heraf, mikroorganismer indeholdende samme samt fremgangsmaade til dyrkning af mikroorganismen
JPS59162874A (ja) * 1983-03-08 1984-09-13 Rikagaku Kenkyusho 微生物の培養方法
US4711844A (en) * 1983-03-09 1987-12-08 Cetus Corporation Modified signal peptides
US4820642A (en) * 1983-04-04 1989-04-11 The Regents Of The University Of California Amplified expression vector
JPS60501140A (ja) * 1983-04-22 1985-07-25 アムジエン 酵母による外因性ポリペプチドの分泌
ATE220101T1 (de) * 1983-04-25 2002-07-15 Chiron Corp Hybrid-dns-synthesis von reifen insulinähnlichen wachstumsfaktoren
US7198919B1 (en) 1983-04-25 2007-04-03 Genentech, Inc. Use of alpha factor sequences in yeast expression systems
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
IL71991A (en) 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
FR2549855B1 (fr) * 1983-07-29 1987-03-27 Grp Genie Genetique Sequence nucleotidique codant pour le peptide signal de la toxine diphterique, vecteur contenant cette sequence nucleotidique, leur application a la transformation de micro-organismes et compositions peptidiques obtenues
JPH0646946B2 (ja) * 1984-03-30 1994-06-22 三菱化成株式会社 蛋白の産生方法
US4695542A (en) 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
PH23920A (en) * 1983-12-20 1990-01-23 Cetus Corp Glucoamylase cdna
IT1185503B (it) * 1984-01-11 1987-11-12 Univ New York Cloni di odna di eritropietina umana
US4859465A (en) * 1984-04-20 1989-08-22 The Regents Of The University Of California Vaccine capable of eliciting multivalent antibodies
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US6022950A (en) * 1984-06-07 2000-02-08 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
US5668255A (en) * 1984-06-07 1997-09-16 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
US4801537A (en) * 1984-06-08 1989-01-31 Genex Corporation Vector for expression of polypeptides in bacilli
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPH062074B2 (ja) * 1984-07-27 1994-01-12 國男 山根 オリゴペプチドの製法
JP2524695B2 (ja) * 1984-12-26 1996-08-14 湧永製薬株式会社 蛋白質の製造法
JP2524693B2 (ja) * 1984-07-30 1996-08-14 湧永製薬株式会社 蛋白質の製造法
EP0170266B1 (en) * 1984-07-30 1993-03-24 Wakunaga Seiyaku Kabushiki Kaisha Process for producing protein, and vector, recombinant dna and transformant used therefor
US5691181A (en) * 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
JPS61268183A (ja) * 1985-05-24 1986-11-27 Wakamoto Pharmaceut Co Ltd Dna,組換体dnaおよびそれらを含む微生物
US5272254A (en) * 1984-10-02 1993-12-21 Biogen Inc. Production of streptavidin-like polypeptides
JP2624470B2 (ja) * 1984-10-02 1997-06-25 バイオジェン インコーポレイテッド ストレプトアビジン様ポリペプチドの製造
US4963495A (en) * 1984-10-05 1990-10-16 Genentech, Inc. Secretion of heterologous proteins
JPH0817702B2 (ja) * 1984-12-28 1996-02-28 理化学研究所 新規プラスミド及びその調製方法並びにそのプラスミドを含有する新規微生物
US5190874A (en) * 1984-12-28 1993-03-02 Rikagaku Kenkyusho Method for producing penicillinase and xylanase
US4774180A (en) * 1986-02-26 1988-09-27 Massachusetts Institute Of Technology Construction and application of polyproteins
JP2500311B2 (ja) * 1985-03-19 1996-05-29 工業技術院長 蛋白製造法
JP2620852B2 (ja) * 1985-07-30 1997-06-18 理化学研究所 新規プラスミド及びそれにより形質転換された新規微生物
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
USH2055H1 (en) 1985-09-20 2002-12-03 Zymogenetics, Inc. Expression of tissue-type plasminogen activator in bacteria
EP0240550A4 (en) * 1985-09-26 1989-09-19 Genetics Inst LUNG SURFACE ACTIVE PROTEINS.
EP0238645A1 (en) * 1985-10-03 1987-09-30 Biotechnology Research Partners, Ltd. Novel lipoprotein-based drug-delivery systems
JPH0669377B2 (ja) * 1985-11-25 1994-09-07 工業技術院長 Dna塩基配列およびベクタ−
GB8529014D0 (en) * 1985-11-25 1986-01-02 Biogen Nv Enhanced secretion of heterologous proteins
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US5084384A (en) * 1987-04-23 1992-01-28 Monsanto Company Secretion of insulin-like growth factor-I
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
US5066792A (en) * 1987-09-04 1991-11-19 Board Of Regents University Of Texas Gene probe for detection of specific human leukemias
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0763543A2 (en) 1988-09-02 1997-03-19 The Rockefeller University A method for preparing an inflammatory cytokine (MIP-2) and diagnostic and therapeutic applications for the cytokine or its antibody
FR2648713B1 (fr) * 1989-06-26 1994-06-10 Commissariat Energie Atomique Proteines hybrides entre une enzyme extracytoplasmique et une autre proteine, leur procede de preparation, ainsi que leur application comme agent de diagnostic
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
US5578464A (en) * 1989-10-31 1996-11-26 Schering Corporation E. coli secretory strains
US5595900A (en) * 1990-02-14 1997-01-21 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
AU1545692A (en) * 1991-03-01 1992-10-06 Protein Engineering Corporation Process for the development of binding mini-proteins
EP1281770B1 (en) 1993-03-10 2010-03-03 GlaxoSmithKline LLC Human brain phosphodiesterase and screening method
US5691180A (en) * 1994-06-09 1997-11-25 The Regents Of The University Of Michigan DNA sequence encoding N-acetyl-galactosamine-transferase
US5807732A (en) * 1995-02-28 1998-09-15 Lowe; John B. GDP-L-fucose: β-D-galactoside 2-α-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person
US5770420A (en) * 1995-09-08 1998-06-23 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
US6087128A (en) * 1998-02-12 2000-07-11 Ndsu Research Foundation DNA encoding an avian E. coli iss
AU1223600A (en) 1998-10-28 2000-05-15 Genentech Inc. Process
JP4629664B2 (ja) * 2003-04-29 2011-02-09 ジェネンコー・インターナショナル・インク 新規なバチルス029celセルラーゼ
EP1618182B1 (en) 2003-04-30 2013-07-10 Genencor International, Inc. NOVEL BACILLUS mHKcel CELLULASE
CA2523722A1 (en) * 2003-04-30 2004-11-18 Genencor International, Inc. Novel bacillus bagcel cellulase
US7511005B2 (en) * 2003-05-12 2009-03-31 Danisco Us Inc., Genencor Division Lipolytic enzyme elip
US20100129862A1 (en) * 2003-05-12 2010-05-27 Jones Brian E Novel lipolytic Enzyme lip1
EP1625208A4 (en) * 2003-05-12 2006-10-18 Genencor Int NEW LIPOLYTIC ENZYME LIP2
AU2021260878A1 (en) 2020-04-20 2022-11-17 Vestaron Corporation Proteolytically stable U1-agatoxin-Ta1b variant polypeptides for pest control
TW202205956A (zh) 2020-05-01 2022-02-16 美商韋斯塔隆公司 殺蟲組合
IL301655A (en) 2020-09-28 2023-05-01 Vestaron Corp MU-Digotoxin-DC1A variant polypeptides for pest control
WO2022212863A1 (en) 2021-04-01 2022-10-06 Vestaron Corporation Liposome formulations for pesticide delivery and methods for producing and using the same
CA3215602A1 (en) 2021-04-01 2022-10-06 Vestaron Corporation Av3 mutant polypeptides for pest control
CA3238619A1 (en) 2021-11-29 2023-06-01 Michael Gerber Pharmaceutical compositions for the treatment of visceral pain
WO2023192924A1 (en) 2022-03-30 2023-10-05 Vestaron Corporation Combinations of av3 mutant polypeptides and bt toxins for pest control
TW202413392A (zh) 2022-05-18 2024-04-01 美商韋斯塔隆公司 殺蟲actx肽變異體
WO2023245100A1 (en) 2022-06-17 2023-12-21 Vestaron Corporation Antimicrobial ncr13 variant peptides
WO2023245169A1 (en) 2022-06-17 2023-12-21 Vestaron Corporation Antimicrobial peptide combinations
WO2023245128A1 (en) 2022-06-17 2023-12-21 Vestaron Corporation Antimicrobial peptide
WO2024026406A2 (en) 2022-07-29 2024-02-01 Vestaron Corporation Next Generation ACTX Peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082613A (en) * 1976-04-23 1978-04-04 The Regents Of The University Of Minnesota Process for the production of insulin by genetically transformed fungal cells
JPS53137215A (en) * 1977-05-06 1978-11-30 Harima Refractories Co Ltd Reparing material of blast oven gate by spray method
JPS54145289A (en) * 1977-11-08 1979-11-13 Genentech Inc Improving method of microbiological polypeptide displaying method and means
EP0001929B1 (en) * 1977-11-08 1989-04-19 Genentech, Inc. Plasmid for transforming bacterial host to render it capable of polypeptide expression

Also Published As

Publication number Publication date
AU524856B2 (en) 1982-10-07
MX6339E (es) 1985-04-23
WO1980000030A1 (en) 1980-01-10
IE791115L (en) 1979-12-08
IL57491A (en) 1983-09-30
EP0006694A3 (en) 1980-01-23
EP0006694B2 (en) 1992-01-22
EP0006694B1 (en) 1983-10-12
DE2966291D1 (en) 1983-11-17
BG60444B2 (bg) 1995-03-31
DD148235A5 (de) 1981-05-13
CA1215920A (en) 1986-12-30
JPS6246160B2 (da) 1987-09-30
JPS5519092A (en) 1980-02-09
AU4775279A (en) 1979-12-13
EP0006694A2 (en) 1980-01-09
NZ190524A (en) 1982-09-14
ZA792486B (en) 1981-01-28
US4411994A (en) 1983-10-25
JPS61227598A (ja) 1986-10-09
PT69737A (en) 1979-07-01
ATE5001T1 (de) 1983-10-15
IE48156B1 (en) 1984-10-17
JPH0755151B2 (ja) 1995-06-14
FI791841A (fi) 1979-12-09
GR72953B (da) 1984-01-18
IL57491A0 (en) 1979-10-31
ES481362A1 (es) 1980-03-01

Similar Documents

Publication Publication Date Title
DK237979A (da) Fremgangsmaade til fremstilling af proteiner
ATE192500T1 (de) Rekombinante viren vektoren zur expression in muskelzellen
SE8107812L (sv) Rekombinerade dna-molekyler och forfaranden for framstellning av proteiner
ES2046177T3 (es) Construccion de una proteina enlazante a igg para facilitar el tratamiento aguas abajo utilizando ingenieria de proteinas.
EP0722461A4 (en) EXPRESSION OF FUSION POLYPEPTIDES TRANSPORTED OUT OF CYTOPLASM WITHOUT HEAD SEQUENCE
BR7908410A (pt) Meio para deteccao de anticorpos de vhb no soro do sangue,e processo para deteccao da presenca da infeccao por virus da hepatite b em seres humanos
DE3684892D1 (de) Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens.
ES8705467A1 (es) Un procedimiento para producir la proteina apoacuorina
ES2056817T5 (es) Transformacion de trichoderma.
BR8102164A (pt) Processo para sintetizar, dentro de um hospedeiro bacteriano e secretar, atraves da membrana do hospedeiro, uma proteina ou polipeptideo slecionada, bem como veiculo de clonagem e hospedeiro transformado como ultimo
DE69131580D1 (de) GDF-1 und UOG1 Proteine
ATE263836T1 (de) Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
HUP0002472A2 (hu) Izolált dendritikus sejtmembrán-fehérje gének
JPS6420095A (en) Polypeptide having anti-blood coagulating action
KR870004139A (ko) 인체 λ-인터페론의 생물학적 활성 유도체를 제조하는 방법
DE3881023D1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
KR880014107A (ko) 안지오게닌의 유전공학적 제조방법
DK0939769T3 (da) Vertebrat-Smoothened-proteiner
ATE43139T1 (de) Klonierungs- und expressionsvektoren fuer gammainterferon, transformierte bakterien und verfahren zur herstellung von gamma-interferon.
DK551786D0 (da) Rekombinant-dna-sekvens, der koder for aminosyresekvenser i et toksin, expressionssystem omfattende samme og vaertsceller transformeret hermed
ES2059340T3 (es) Un metodo de preparacion de proteinas.
EP0688224A4 (en) MUTANT PROTEIN, METHODS AND MATERIALS USED FOR ITS MANUFACTURE AND USE
PT742829E (pt) Expressao de proteinas heterologas em bacterias atenuadas utilizando os promotores htra

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment