JPH11513047A - ヒアルロン酸の微細粒子中に封入された薬物の徐放性組成物 - Google Patents
ヒアルロン酸の微細粒子中に封入された薬物の徐放性組成物Info
- Publication number
- JPH11513047A JPH11513047A JP10541488A JP54148898A JPH11513047A JP H11513047 A JPH11513047 A JP H11513047A JP 10541488 A JP10541488 A JP 10541488A JP 54148898 A JP54148898 A JP 54148898A JP H11513047 A JPH11513047 A JP H11513047A
- Authority
- JP
- Japan
- Prior art keywords
- fine particles
- oil
- composition
- hyaluronic acid
- growth hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ヒアルロン酸またはその無機塩の微細粒子および前記微細粒子中に封入さ れたタンパク質またはペプチド薬物を含む徐放性薬物組成物であって、前記微細 粒子の平均粒径が0.1ないし40μm範囲である組成物。 2.安定剤をさらに含む請求項1に記載の組成物。 3.前記微細粒子の平均粒径が1ないし10μmである請求項1に記載の組成 物。 4.前記薬物が、ヒト成長ホルモン、ウシ成長ホルモン、ブタ成長ホルモン、 成長ホルモン放出ホルモン、成長ホルモン放出ペプチド、顆粒球−コロニー刺激 因子、顆粒球マクロファージ−コロニー刺激因子、マクロファージ−コロニー刺 激因子、エリスロポエチン、骨格形態発生タンパク質、インターフェロン、イン スリン、アトリオペプチン−III、モノクロナール抗体、腫瘍壊死因子、マクロ ファージ活性化因子、インターロイキン、腫瘍変性因子、インスリン−類似成長 因子、表皮成長因子、組織プラスミノゲンアクチベーターおよびウロキナーゼか らなる群から選ばれることを特徴とする請求項1に記載の組成物。 5.前記ヒアルロン酸の無機塩が、ヒアルロン酸のナトリウム、カリウム、リ チウム、カルシウム、アンモニウム、マグネシウム、亜鉛、銅およびコバルトの 塩からなる群から選ばれることを特徴とする請求項1に記載の組成物。 6.前記安定剤が、多糖類、タンパク質、アミノ酸、脂質、脂肪酸、ポリエチ レングリコール、無機塩、界面活性剤およびこれらの混合物からなる群から選ば れることを特徴とする請求項2に記載の組成物。 7.請求項1の徐放性組成物を注射剤用媒体に分散した注射剤。 8.分散剤または防腐剤をさらに含む請求項7に記載の注射剤。 9.前記注射剤用媒体が、緩衝水溶液、エタノール、プロピレングリコール、 ポリエチレングリコール、植物油、ミネラル油、スクアレン、たら肝油、モノ− 、ジ−、およびトリ−グリセリド、およびこれらの混合物からなる群から選ばれ ることを特徴とする請求項7に記載の注射剤。 10.前記植物油が、トウモロコシ油、オリーブ油、大豆油、紅花油、綿実油 、 落花生油、胡麻油、ココナツ油、ヒマシ油およびこれらの混合物からなる群から 選ばれることを特徴とする請求項9に記載の注射剤。 11.請求項1の徐放性組成物を含むエアロゾル製剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970012046A KR100236771B1 (ko) | 1997-04-01 | 1997-04-01 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
KR1997/12046 | 1997-04-01 | ||
PCT/KR1998/000062 WO1998043664A1 (en) | 1997-04-01 | 1998-03-26 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11513047A true JPH11513047A (ja) | 1999-11-09 |
JP3445283B2 JP3445283B2 (ja) | 2003-09-08 |
Family
ID=19501732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54148898A Expired - Lifetime JP3445283B2 (ja) | 1997-04-01 | 1998-03-26 | ヒアルロン酸の微細粒子中に封入された薬物の徐放性組成物 |
Country Status (26)
Country | Link |
---|---|
US (3) | US20080063727A1 (ja) |
EP (1) | EP0918535B1 (ja) |
JP (1) | JP3445283B2 (ja) |
KR (1) | KR100236771B1 (ja) |
CN (1) | CN1132625C (ja) |
AR (1) | AR011208A1 (ja) |
AT (1) | ATE285245T1 (ja) |
AU (1) | AU721929B2 (ja) |
BG (1) | BG64642B1 (ja) |
BR (1) | BR9804802B1 (ja) |
CA (1) | CA2256596C (ja) |
DE (1) | DE69828252T2 (ja) |
DK (1) | DK0918535T3 (ja) |
ES (1) | ES2232939T3 (ja) |
HK (1) | HK1020885A1 (ja) |
HU (1) | HUP0000737A3 (ja) |
ID (1) | ID20584A (ja) |
IL (1) | IL127220A (ja) |
MY (1) | MY132812A (ja) |
NZ (1) | NZ333019A (ja) |
PL (1) | PL195223B1 (ja) |
PT (1) | PT918535E (ja) |
TR (1) | TR199802500T1 (ja) |
TW (1) | TW514532B (ja) |
WO (1) | WO1998043664A1 (ja) |
ZA (1) | ZA982533B (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003525232A (ja) * | 2000-02-29 | 2003-08-26 | クワッドラント・ヘルスケア・(ユーケイ)・リミテッド | 肺送達のための治療用組成物 |
WO2005054301A1 (ja) * | 2003-11-14 | 2005-06-16 | Chugai Seiyaku Kabushiki Kaisha | 架橋多糖微粒子およびその製造方法 |
JP2009521486A (ja) * | 2005-12-23 | 2009-06-04 | アルタス ファーマシューティカルズ インコーポレイテッド | ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法 |
JP2014517030A (ja) * | 2011-06-14 | 2014-07-17 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | メラノコルチンリセプターリガンドを有効成分として含有する持続放出性組成物 |
JP2014196347A (ja) * | 2008-05-20 | 2014-10-16 | サントル ナスィオナル ド ラ ルシェルシュ スィアンティフィク(セ.エン.エル.エス.) | ペプチドを含むナノ粒子、それを含むベクター、ならびに前記ナノ粒子および前記ベクターの薬学的使用 |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
JP4234803B2 (ja) * | 1997-10-27 | 2009-03-04 | 久光製薬株式会社 | 薬物放出速度が制御された医薬組成物 |
AU3055099A (en) | 1998-05-20 | 1999-12-06 | Charna Chemicals Ltd. | A pharmaceutical formulation for nasal administration |
EP1091730A1 (de) * | 1998-06-29 | 2001-04-18 | White Spot AG | Verwendung von wachstumsfaktoren zur arzneimittelherstellung |
ATE376824T1 (de) | 1999-01-13 | 2007-11-15 | Alchemia Oncology Pty Ltd | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln |
EP2481401A1 (en) | 1999-01-18 | 2012-08-01 | LG Life Sciences, Ltd. | Lipophilic microparticles containing a protein drug or antigen and formulation comprising same |
SE9904121D0 (sv) | 1999-11-15 | 1999-11-15 | Gustaf Jederstroem | Hydrophobe biomolecular structure |
US7785625B2 (en) | 2000-01-14 | 2010-08-31 | Lg Life Sciences, Limited | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
CN1406140A (zh) | 2000-02-28 | 2003-03-26 | 吉倪塞思公司 | 纳米胶囊包封***与方法 |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
JP4931282B2 (ja) * | 2000-10-02 | 2012-05-16 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
US8637077B2 (en) | 2000-12-28 | 2014-01-28 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
WO2002085399A1 (en) * | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Peptide-containing preparations |
WO2003018062A1 (en) * | 2001-08-27 | 2003-03-06 | Meditech Research Limited | Improved therapeutic protocols |
GB0129489D0 (en) * | 2001-12-10 | 2002-01-30 | Quadrant Healthcare Uk Ltd | Sustained-release compositions |
WO2005116130A1 (en) * | 2004-05-27 | 2005-12-08 | Novozymes Biopolymer A/S | A fast dissolving dried hyaluronic acid product |
JP5060131B2 (ja) | 2004-09-07 | 2012-10-31 | 中外製薬株式会社 | 水溶性ヒアルロン酸修飾物の製造方法 |
MY139088A (en) * | 2005-02-21 | 2009-08-28 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
US8017152B2 (en) | 2005-05-27 | 2011-09-13 | Stratosphere Pharma Ab | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
CN103784960A (zh) * | 2005-07-27 | 2014-05-14 | 阿尔卡米亚肿瘤学股份有限公司 | 使用乙酰透明质酸的治疗方案 |
US8319625B2 (en) * | 2005-09-01 | 2012-11-27 | Simplexgrinnell Lp | Fire alarm textual notification related application |
CN101287475B (zh) * | 2005-09-07 | 2012-11-14 | 阿尔卡米亚肿瘤学股份有限公司 | 包含透明质酸和治疗抗体的治疗组合物以及制药用途 |
KR100939983B1 (ko) | 2006-10-31 | 2010-02-03 | 주식회사 엘지생명과학 | 히아루론산-소수성 폴리 아미노산 공중합체 |
EP2423233B1 (en) | 2009-04-22 | 2015-03-11 | Alteogen, Inc | In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasing in vivo half-life using same |
SI2512450T1 (en) | 2009-12-15 | 2018-05-31 | Ascendis Pharma Endocrinology Division A/S | A dry growth hormone composition transiently bound to a polymeric carrier |
US9399019B2 (en) | 2012-05-09 | 2016-07-26 | Evonik Corporation | Polymorph compositions, methods of making, and uses thereof |
US9902753B2 (en) | 2012-06-05 | 2018-02-27 | Cj Healthcare Corporation | Method of purifying a long-acting human growth hormone |
WO2015018461A1 (fr) | 2013-08-09 | 2015-02-12 | Genbiotech | Compositions therapeutiques comprenant d'acide hyaluronique |
CA2959660A1 (en) | 2014-09-03 | 2016-03-10 | Genesegues, Inc. | Therapeutic nanoparticles and related compositions, methods, and systems |
PT3220892T (pt) | 2014-11-21 | 2021-11-05 | Ascendis Pharma Endocrinology Div A/S | Formas de dosagem de hormona do crescimento de longa ação |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6391325A (ja) * | 1986-10-07 | 1988-04-22 | Chugai Pharmaceut Co Ltd | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
JPH02213A (ja) * | 1987-10-19 | 1990-01-05 | Taiho Yakuhin Kogyo Kk | 生理活性ペプチド持続製剤 |
JPH03215430A (ja) * | 1990-01-19 | 1991-09-20 | Kita Kiyoshi | 関節腔抗凝固剤 |
JPH04282322A (ja) * | 1991-03-08 | 1992-10-07 | Denki Kagaku Kogyo Kk | 生物活性ペプチド製剤 |
JPH04283510A (ja) * | 1990-11-22 | 1992-10-08 | Vectorpharma Internatl Spa | 薬物学的活性物質の調節的放出のために適した粒状医薬組成物及び上記組成物の製法 |
JPH0565231A (ja) * | 1991-03-12 | 1993-03-19 | Takeda Chem Ind Ltd | エリスロポエチンの持続性製剤 |
JPH0597694A (ja) * | 1991-03-08 | 1993-04-20 | Denki Kagaku Kogyo Kk | 生理活性ペプチド製剤 |
JPH05186362A (ja) * | 1991-07-10 | 1993-07-27 | Takeda Chem Ind Ltd | 水溶性組成物 |
JPH05186364A (ja) * | 1991-08-01 | 1993-07-27 | Takeda Chem Ind Ltd | 水溶性組成物 |
JPH08198772A (ja) * | 1994-11-25 | 1996-08-06 | Kirin Brewery Co Ltd | 顆粒球コロニー刺激因子含有粉末経鼻投与製剤 |
JPH09309843A (ja) * | 1996-05-21 | 1997-12-02 | Shiseido Co Ltd | ヒアルロン酸含有経肺投与用製剤 |
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-
1997
- 1997-04-01 KR KR1019970012046A patent/KR100236771B1/ko not_active IP Right Cessation
-
1998
- 1998-03-25 ZA ZA982533A patent/ZA982533B/xx unknown
- 1998-03-25 MY MYPI98001281A patent/MY132812A/en unknown
- 1998-03-26 IL IL12722098A patent/IL127220A/en not_active IP Right Cessation
- 1998-03-26 ES ES98911246T patent/ES2232939T3/es not_active Expired - Lifetime
- 1998-03-26 AT AT98911246T patent/ATE285245T1/de active
- 1998-03-26 TR TR1998/02500T patent/TR199802500T1/xx unknown
- 1998-03-26 NZ NZ333019A patent/NZ333019A/xx not_active IP Right Cessation
- 1998-03-26 AU AU65241/98A patent/AU721929B2/en not_active Expired
- 1998-03-26 HU HU0000737A patent/HUP0000737A3/hu unknown
- 1998-03-26 CA CA002256596A patent/CA2256596C/en not_active Expired - Lifetime
- 1998-03-26 PL PL98330230A patent/PL195223B1/pl not_active IP Right Cessation
- 1998-03-26 DK DK98911246T patent/DK0918535T3/da active
- 1998-03-26 WO PCT/KR1998/000062 patent/WO1998043664A1/en active IP Right Grant
- 1998-03-26 EP EP98911246A patent/EP0918535B1/en not_active Revoked
- 1998-03-26 JP JP54148898A patent/JP3445283B2/ja not_active Expired - Lifetime
- 1998-03-26 ID IDW980121D patent/ID20584A/id unknown
- 1998-03-26 DE DE69828252T patent/DE69828252T2/de not_active Revoked
- 1998-03-26 CN CN988004003A patent/CN1132625C/zh not_active Expired - Lifetime
- 1998-03-26 BR BRPI9804802-3A patent/BR9804802B1/pt not_active IP Right Cessation
- 1998-03-26 PT PT98911246T patent/PT918535E/pt unknown
- 1998-03-30 TW TW087104742A patent/TW514532B/zh not_active IP Right Cessation
- 1998-04-01 AR ARP980101469A patent/AR011208A1/es active IP Right Grant
- 1998-11-30 BG BG102969A patent/BG64642B1/bg unknown
-
1999
- 1999-12-30 HK HK99106197A patent/HK1020885A1/xx not_active IP Right Cessation
-
2007
- 2007-10-31 US US11/979,148 patent/US20080063727A1/en not_active Abandoned
-
2010
- 2010-09-29 US US12/893,203 patent/US20110020458A1/en not_active Abandoned
-
2013
- 2013-02-20 US US13/771,722 patent/US20130230598A1/en not_active Abandoned
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6391325A (ja) * | 1986-10-07 | 1988-04-22 | Chugai Pharmaceut Co Ltd | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
JPH02213A (ja) * | 1987-10-19 | 1990-01-05 | Taiho Yakuhin Kogyo Kk | 生理活性ペプチド持続製剤 |
JPH03215430A (ja) * | 1990-01-19 | 1991-09-20 | Kita Kiyoshi | 関節腔抗凝固剤 |
JPH04283510A (ja) * | 1990-11-22 | 1992-10-08 | Vectorpharma Internatl Spa | 薬物学的活性物質の調節的放出のために適した粒状医薬組成物及び上記組成物の製法 |
JPH04282322A (ja) * | 1991-03-08 | 1992-10-07 | Denki Kagaku Kogyo Kk | 生物活性ペプチド製剤 |
JPH0597694A (ja) * | 1991-03-08 | 1993-04-20 | Denki Kagaku Kogyo Kk | 生理活性ペプチド製剤 |
JPH0565231A (ja) * | 1991-03-12 | 1993-03-19 | Takeda Chem Ind Ltd | エリスロポエチンの持続性製剤 |
JPH05186362A (ja) * | 1991-07-10 | 1993-07-27 | Takeda Chem Ind Ltd | 水溶性組成物 |
JPH05186364A (ja) * | 1991-08-01 | 1993-07-27 | Takeda Chem Ind Ltd | 水溶性組成物 |
JPH08198772A (ja) * | 1994-11-25 | 1996-08-06 | Kirin Brewery Co Ltd | 顆粒球コロニー刺激因子含有粉末経鼻投与製剤 |
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