JPH10505231A - B細胞リンパ腫細胞および白血病細胞に特異的な免疫結合体およびヒト化抗体 - Google Patents
B細胞リンパ腫細胞および白血病細胞に特異的な免疫結合体およびヒト化抗体Info
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- JPH10505231A JPH10505231A JP8507371A JP50737196A JPH10505231A JP H10505231 A JPH10505231 A JP H10505231A JP 8507371 A JP8507371 A JP 8507371A JP 50737196 A JP50737196 A JP 50737196A JP H10505231 A JPH10505231 A JP H10505231A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.LL2モノクローナル抗体(mAb)の軽鎖可変(VK)領域のアミノ酸 配列をコードするDNA配列を含む、第4図A(配列識別番号1)の分離された ポリヌクレオチド。 2.LL2 mAbの重鎖可変(VH)領域のアミノ酸配列をコードするDN A配列を含む、第4図B(配列識別番号3)の分離されたポリヌクレオチド。 3.hLL2 VKドメインのアミノ酸配列をコードするDNA配列を含む、 第5図A(配列識別番号5)の分離されたポリヌクレオチド。 4.hLL2 VHドメインのアミノ酸配列をコードするDNA配列を含む、 第5図B(配列識別番号7)の分離されたポリヌクレオチド。 5.請求項1乃至4のいずれか1つに記載のポリヌクレオチドによりコードさ れるタンパク質。 6.アミノ酸配列(配列識別番号2の残基24〜40) KSSQSVLYSANHKNYLA を含む、LL2 mAbのVK領域の相補性決定領域1(CDR1)分離ポリペ プチド。 7.アミノ酸配列(配列識別番号2の残基56〜62) WASTRES を含む、LL2 mAbのVK領域の分離CDR2ポリペプチド。 8.アミノ酸配列(配列識別番号2の残基95〜103) HQYLSSWTF を含む、LL2 mAbのVK領域の分離CDR3ポリペプチド。 9.アミノ酸配列(配列識別番号4の残基31〜35) SYWLH を含む、LL2 mAbのVH領域の分離CDR2ポリペプチド。 10.アミノ酸配列(配列識別番号4の残基50〜66) YINPRNDYTEYNQNFKD を含む、LL2 mAbのVH領域の分離CDR2ポリペプチド。 11.アミノ酸配列(配列識別番号4の残基99〜105) RDITTFY を含む、LL2 mAbのVH領域の分離CDR3ポリペプチド。 12.VKpBRプラスミドに挿入された請求項1に記載のポリヌクレオチド。 13.VHpBSプラスミドに挿入された請求項2に記載のポリヌクレオチド。 14.さらにIgプロモーターおよびシグナルペプチド配列を含む、請求項1 2または13に記載のプラスミド。 15.LL2pKhと呼ばれる哺乳類発現ベクターに組み込まれ、前記ベクターがさ らにIgプロモーター、シグナルペプチドDNA配列、ヒトκ定常領域のゲノム 配列、Igエンハンサー、κエンハンサー、およびマーカー遺伝子を含む、請求 項1または3に記載のポリヌクレオチド。 16.LL2pK1gと呼ばれる哺乳類発現ベクターに組み込まれ、前記ベクターが さらにIgプロモーター、シグナルペプチドDNA配列、ヒトIgG1定常領域 のゲノム配列、Igエンハンサーおよびマーカー遺伝子を含む、請求項2または 4に記載のポリヌクレオチド。 17.ヒトκ定常領域およびヒトIgG1定常領域に連結された請求項1また は2のmLL2 mAbの軽鎖および重鎖を含む、請求項3または4のcLL2 mAb。 18.hLL2 mAbが親mLL2抗体のB細胞腫細胞および白血球細胞タ ゲッティング特性および細胞インターナリゼーション特性を実質的に保持してい るような、ヒトκ定常領域ドメインおよびヒトIgG1定常領域ドメインにそれ ぞれ連結された第1A図および第1B図のヒトVK領域およびヒトVH領域のフ レームワーク配列にそれぞれ連結された請求項6乃至10のいずれかのmLL2 mAbの軽鎖相補性決定領域および重鎖相補性決定領域を含む、hLL2 m Ab。 19.診断用試薬または治療用試薬に共有結合したcLL2抗体またはhLL 2抗体またはそれらのフラグメントを含む結合体。 20.前記診断用試薬が標識を含むことを特徴とする、請求項19に記載の結 合体。 21.前記治療用試薬が細胞障害剤を含むことを特徴とする、請求項19に記 載の結合体。 22.前記抗体またはそのフラグメントの炭水化物部分によって前記試薬が前 記抗体またはそのフラグメントに結合していることを特徴とする、請求項19に 記載の結合体。 23.被験者のB細胞リンパ腫または白血病を治療する方法において、製薬上 許容できる媒体で調合された請求項21に記載の結合体の治療上有効な量を前記 被験者に投与するステップを含む方法。 24.被験者のB細胞リンパ腫細胞または白血病細胞を診断する方法において 、製薬上許容できる媒体で調合された請求項20に記載の結合体の診断上有効な 量を前記被験者に投与するステップと、前記標識を検出するステップとを含む方 法。 25.アミノ酸配列(配列識別番号の残基24〜40) KSSQSVLYSANHKNYLA を含む、分離された、LL2 mAbのVK領域の相補性決定領域1(CDR1 )ポリペプチドと、 アミノ酸配列(配列識別番号2の残基56〜62) WASTRES を含む、LL2 mAbのVK領域の分離CDR2ポリペプチドと、 アミノ酸配列(配列識別番号2の残基95〜103) HQYLSSWTF を含む、LL2 mAbのVK領域の分離CDR3ポリペプチドと、 アミノ酸配列(配列識別番号4の残基31〜35) SYWLH を含む、LL2 mAbのVH領域の分離CDR1ポリペプチドと、 アミノ酸配列(配列識別番号4の残基50〜66) YINPRNDYTEYNQNFKD を含む、LL2 mAbのVH領域の分離CDR2ポリペプチドと、 アミノ酸配列(配列識別番号4の残基99〜105) RDITTFY を含む、LL2 mAbのVH領域の分離CDR3ポリペプチドと を含む、請求項18に記載のhLL2 mAb。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US28957694A | 1994-08-12 | 1994-08-12 | |
US08/289,576 | 1994-08-12 | ||
US289,576 | 1994-08-12 | ||
PCT/US1995/009641 WO1996004925A1 (en) | 1994-08-12 | 1995-08-11 | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
Publications (2)
Publication Number | Publication Date |
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JPH10505231A true JPH10505231A (ja) | 1998-05-26 |
JP3053873B2 JP3053873B2 (ja) | 2000-06-19 |
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ID=23112129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP8507371A Expired - Lifetime JP3053873B2 (ja) | 1994-08-12 | 1995-08-11 | B細胞リンパ腫細胞および白血病細胞に特異的な免疫結合体およびヒト化抗体 |
Country Status (10)
Country | Link |
---|---|
US (6) | US5789554A (ja) |
EP (1) | EP0771208B1 (ja) |
JP (1) | JP3053873B2 (ja) |
AT (1) | ATE306930T1 (ja) |
AU (1) | AU3272695A (ja) |
CA (1) | CA2195557C (ja) |
DE (1) | DE69534530T2 (ja) |
ES (1) | ES2251723T3 (ja) |
IL (1) | IL114909A (ja) |
WO (1) | WO1996004925A1 (ja) |
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JP2010022372A (ja) * | 2002-05-02 | 2010-02-04 | Ucb Pharma Sa | 生物学的製剤 |
US7691588B2 (en) | 2003-03-13 | 2010-04-06 | Chugai Seiyaku Kabushiki Kaisha | Ligand having agonistic activity to mutated receptor |
US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
US7993642B2 (en) | 2003-12-12 | 2011-08-09 | Chugai Seiyaku Kabushiki Kaisha | Anti-MPL antibodies |
US8034903B2 (en) | 2000-10-20 | 2011-10-11 | Chugai Seiyaku Kabushiki Kaisha | Degraded TPO agonist antibody |
US8158385B2 (en) | 2002-10-11 | 2012-04-17 | Chugai Seiyaku Kabushiki Kaisha | Cell death-inducing agent |
US8945543B2 (en) | 2005-06-10 | 2015-02-03 | Chugai Seiyaku Kabushiki Kaisha | Stabilizer for protein preparation comprising meglumine and use thereof |
JP2015516984A (ja) * | 2012-04-26 | 2015-06-18 | バイオアトラ、エルエルシー | 抗cd22抗体 |
US9241994B2 (en) | 2005-06-10 | 2016-01-26 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 |
US9493569B2 (en) | 2005-03-31 | 2016-11-15 | Chugai Seiyaku Kabushiki Kaisha | Structural isomers of sc(Fv)2 |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
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AU3272695A (en) * | 1994-08-12 | 1996-03-07 | Immunomedics Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
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US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
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CN1326565C (zh) * | 1997-10-14 | 2007-07-18 | 中外制药株式会社 | 淋巴细胞肿瘤抗体的增强剂 |
US20010033839A1 (en) * | 1999-10-04 | 2001-10-25 | Emilio Barbera-Guillem | Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation |
US6224866B1 (en) | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
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- 1995-08-11 IL IL11490995A patent/IL114909A/xx not_active IP Right Cessation
- 1995-08-11 DE DE69534530T patent/DE69534530T2/de not_active Expired - Lifetime
- 1995-08-11 CA CA002195557A patent/CA2195557C/en not_active Expired - Lifetime
- 1995-08-11 JP JP8507371A patent/JP3053873B2/ja not_active Expired - Lifetime
- 1995-08-11 WO PCT/US1995/009641 patent/WO1996004925A1/en active IP Right Grant
- 1995-08-11 EP EP95929338A patent/EP0771208B1/en not_active Expired - Lifetime
- 1995-08-11 AT AT95929338T patent/ATE306930T1/de active
- 1995-08-11 ES ES95929338T patent/ES2251723T3/es not_active Expired - Lifetime
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1996
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2003
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2004
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Cited By (21)
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US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
US8586039B2 (en) | 2000-10-20 | 2013-11-19 | Chugai Seiyaku Kabushiki Kaisha | Degraded TPO agonist antibody |
US8034903B2 (en) | 2000-10-20 | 2011-10-11 | Chugai Seiyaku Kabushiki Kaisha | Degraded TPO agonist antibody |
JP2010022372A (ja) * | 2002-05-02 | 2010-02-04 | Ucb Pharma Sa | 生物学的製剤 |
JP2013230158A (ja) * | 2002-05-02 | 2013-11-14 | Ucb Pharma Sa | 生物学的製剤 |
US8158385B2 (en) | 2002-10-11 | 2012-04-17 | Chugai Seiyaku Kabushiki Kaisha | Cell death-inducing agent |
US7691588B2 (en) | 2003-03-13 | 2010-04-06 | Chugai Seiyaku Kabushiki Kaisha | Ligand having agonistic activity to mutated receptor |
WO2004087763A1 (ja) * | 2003-03-31 | 2004-10-14 | Chugai Seiyaku Kabushiki Kaisha | Cd22に対する改変抗体およびその利用 |
US7993642B2 (en) | 2003-12-12 | 2011-08-09 | Chugai Seiyaku Kabushiki Kaisha | Anti-MPL antibodies |
US9493569B2 (en) | 2005-03-31 | 2016-11-15 | Chugai Seiyaku Kabushiki Kaisha | Structural isomers of sc(Fv)2 |
US11168344B2 (en) | 2005-03-31 | 2021-11-09 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
US8945543B2 (en) | 2005-06-10 | 2015-02-03 | Chugai Seiyaku Kabushiki Kaisha | Stabilizer for protein preparation comprising meglumine and use thereof |
US9241994B2 (en) | 2005-06-10 | 2016-01-26 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 |
US9777066B2 (en) | 2005-06-10 | 2017-10-03 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 |
US10934344B2 (en) | 2006-03-31 | 2021-03-02 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
JP2015516984A (ja) * | 2012-04-26 | 2015-06-18 | バイオアトラ、エルエルシー | 抗cd22抗体 |
US9856323B2 (en) | 2012-04-26 | 2018-01-02 | Bioatla, Llc | Anti-CD22 antibodies |
US11124576B2 (en) | 2013-09-27 | 2021-09-21 | Chungai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
US11649262B2 (en) | 2015-12-28 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
Also Published As
Publication number | Publication date |
---|---|
JP3053873B2 (ja) | 2000-06-19 |
US6187287B1 (en) | 2001-02-13 |
US20050106108A1 (en) | 2005-05-19 |
ES2251723T3 (es) | 2006-05-01 |
EP0771208B1 (en) | 2005-10-19 |
EP0771208A1 (en) | 1997-05-07 |
DE69534530D1 (de) | 2006-03-02 |
US20070172920A1 (en) | 2007-07-26 |
DE69534530T2 (de) | 2006-07-06 |
IL114909A0 (en) | 1995-12-08 |
US20040013607A1 (en) | 2004-01-22 |
CA2195557C (en) | 2006-10-17 |
CA2195557A1 (en) | 1996-02-22 |
US5789554A (en) | 1998-08-04 |
EP0771208A4 (en) | 2000-01-19 |
AU3272695A (en) | 1996-03-07 |
ATE306930T1 (de) | 2005-11-15 |
IL114909A (en) | 1999-10-28 |
WO1996004925A1 (en) | 1996-02-22 |
US20020102254A1 (en) | 2002-08-01 |
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