JPH06501242A - 1―ピペリジニルアルカノイルアリールスルホンアミド誘導体類 - Google Patents
1―ピペリジニルアルカノイルアリールスルホンアミド誘導体類Info
- Publication number
- JPH06501242A JPH06501242A JP3510423A JP51042391A JPH06501242A JP H06501242 A JPH06501242 A JP H06501242A JP 3510423 A JP3510423 A JP 3510423A JP 51042391 A JP51042391 A JP 51042391A JP H06501242 A JPH06501242 A JP H06501242A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- compound according
- methanesulfonamide
- compound
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Tires In General (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims (34)
- 1.式 ▲数式、化学式、表等があります▼ [式中Rは水素、ハロゲン、C1−4アルキル、C1−4アルコキシ、CF3、 SR1、NHC(O)R2、NH2、又はONであり、R1は水素又はC1−4 アルキルであり、R2はC1−4アルキルであり、XはCO又はCHOHを表わ し、mは整数1‐3であり、またAlkはC1‐4アルキルである]の化合物、 及び製薬上受け入れられるその付加塩類。
- 2.XがCHOHである、特許請求の範囲第1項に記載の化合物。
- 3.XがCOである、特許請求の範囲第1項に記載の化合物。
- 4.mが1である、特許請求の範囲第3項に記載の化合物。
- 5.mが2である、特許請求の範囲第3項に記載の化合物。
- 6.Alkがメチルである、特許請求の範囲第5項に記載の化合物。
- 7.上記の化合物がN−[4−[[4−(2,3−ジメトキシベンゾィル)−1 −ピペリジニル]アセチル]−フェニル]メタンスルホンアミドである、特許請 求の範囲第1項に記載の化合物。
- 8.上記の化合物がN−[4−[[4−(3,4−ジフルオロベンゾイル)−1 −ピペリジニル]アセチル]−フェニル]メタンスルホンアミドである、特許請 求の範囲第1項に記載の化合物。
- 9.上記の化合物がN−[4−[[4−(2,4,6−トリメチルベンゾイル) −1−ピペリジニル〕アセチル]−フェニル]メタンスルホンアミドである、特 許請求の範囲第1項に記載の化合物。
- 10.上記の化合物がN−4[[4−[4−(メチルチオ)ベンゾイル)−1− ピペリジニル]アセチル]−フエニル]メタンスルホンアミドである、特許請求 の範囲第1項に記載の化合物。
- 11.上記の化合物がN−[4[[4−(2−エトキシベンソイル)−1−ピペ リジニル]アセチル]−フェニル]メタンスルホンアミドである、特許請求の範 囲第1項に記載の化合物。
- 12.上記の化合物がN−[4−[[4−(2,3−ジメトキシフェニル)ヒド ロキシメチル]−1−ピペリジニル]アセチル]−フェニル]メタンスルホンア ミドである、特許請求の範囲第1項に記載の化合物。
- 13.上記の化合物がN[4−[[4−[(4−フルオロフェニル)ヒドロキシ メチル]−1−ピペリジニル〕アセチル]フェニル]メタンスルホンアミドであ る、特許請求の範囲第1項に記載の化合物。
- 14.上記の化合物がN−[4−[4−[4−(4−フルオロベンゾイル)−1 −ピペリジニル]オキソアチルコフェニル]メタンスルホンアミド−塩酸塩であ る、特許請求の範囲第1項に記載の化合物。
- 15.上記の化合物がN−[4−[3[4−(4−フルオロベンゾイル)−1− ピペリジニルユオキソブロビル]フェニル]メタンスルホンアミド−塩酸塩であ る、特許請求の範囲第1項に記載の化合物。
- 16.上記の化合物がN−[4−[3−[4−(4−フルオロベンゾイル)−1 −ピペリジニル]−1−オキソブロビル]フェニル]メタンスルホンアミドであ る、特許請求の範囲第1項に記載の化合物。
- 17.上記の化合物がN−[4−[[(4−クロロベンゾイル)−1−ピペリジ ニル]アセチル]フェニル]メタンスルホンアミドである、特許請求の範囲第1 項に記載の化合物。
- 18.上記の化合物がN−[4−[[(4−クロロベンゾイル)−1−ピペリジ ニル]オキソブロビル]フェニル]メタンスルホンアミドである、特許請求の範 囲第1項に記載の化合物。
- 19.上記の化合物がN−[4−[[4−[(3.4−ジフルオロベンゾイル) −レピペリジニル]−1−オキソブロビル]フェニル]メタンスルホンアミドで ある、特許請求の範囲第1項に記載の化合物。
- 20.上記の化合物がN{4−[4−[[4−(3,4−ジフルオロフェニル) ヒドロキシメチル]−1−ピペリジニル]アセチル]フェニル]メダンスルホン アミドである、特許請求の範囲第1項に記載の化合物。
- 21.上記の化合物がN−[4[3−[4−[(3,4−ジフルオロフェニル) ヒドロキシメチル]−1−ピペリジニル]オキソブロビル]フエニル]メタンス ルホンアミドである、特許請求の範囲第1項に記載の化合物。
- 22.上記の化合物がN[4−[3−[4−(4−フルオロベンゾイル)−1− ピペリジニル]−1−オキソブロビル]フェニル〕メタンスルホンアミドである 、特許請求の範囲第1項に記載の化合物。
- 23.上記の化合物がN−[4−[4−(4−アセトアミドベンゾイル)−1− ピペリジニル]アセチル]フェニル]メタンスルホンアミドである、特許請求の 範囲第1項に記載の化合物。
- 24.上記の化合物がN−[4−[[4−(4−アミノベンゾイル)−1−ピペ リジニル]アセチル]フェニル]メタンスルホンアミド塩酸塩である、特許請求 の範囲第1項に記載の化合物。
- 25.上記の化合物がN−[4−[[3−(2−メトキシベンゾイル)−1−ピ ペリジニル]アセチル]フェニル]メタンスルホンアミド塩酸塩である、特許請 求の範囲第1項に記載の化合物。
- 26.上記の化合物がN−[4−[[3−(4−フルオロベンゾイル)−1−ピ ペリジニル]アセチル]フェニル]メタンスルホンアミドである、特許請求の範 囲第1項に記載の化合物。
- 27.上記の化合物がN−[4−[[3−(3,4−ジフルオロベンゾイル)− 1−ビヘリジニル]アセチル]フエニル]メタンスルホンアミドである、特許請 求の範囲第1項に記載の化合物。
- 28.上記の化合物がN−[4−[[3−(4−クロロベンソイル)−1−ビパ リジニル]アセチル]フェニル〕メタンスルホンアミドである、特許請求の範囲 第1項に記載の化合物。
- 29.上記の化合物がN−[4−[[4−(4−フルオロフエニル)ヒドロキシ メチル]−1−ピペリジニル]アセチル]フェニル]メタンスルホンアミドであ る、特許請求の範囲第1項に記載の化合物。
- 30.Xがピペリジン環の4−位置に結合される、特許請求の範囲第1、2又は 3項のいずれカーに記載の化合物。
- 31.特許請求の範囲第1‐30項のいずれか−に記載の化合物の有効電圧必要 な患者に投与することを含めてなる、心臓不整脈の処置法。
- 32.製薬上受け入れられる担体と混合された特許請求の範囲第‐30項に記載 の化合物の有効量を含めてなス製剤組成物。
- 33.特許請求の範囲第1‐30項の任意の一つに記載の化合物の、医薬品とし ての用途。
- 34.特許請求の範囲第1‐30項の任意の一つに記載の化合物の、心臓不整脈 用の薬品製造における用途。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53478490A | 1990-06-07 | 1990-06-07 | |
US534,784 | 1990-06-07 | ||
PCT/US1991/003323 WO1991018603A1 (en) | 1990-06-07 | 1991-05-15 | 1-pyperidinyl alkanoylarylsulfonamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06501242A true JPH06501242A (ja) | 1994-02-10 |
JP3032294B2 JP3032294B2 (ja) | 2000-04-10 |
Family
ID=24131528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3510423A Expired - Lifetime JP3032294B2 (ja) | 1990-06-07 | 1991-05-15 | 1―ピペリジニルアルカノイルアリールスルホンアミド誘導体類 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0532629B1 (ja) |
JP (1) | JP3032294B2 (ja) |
KR (1) | KR100200461B1 (ja) |
AT (1) | ATE144899T1 (ja) |
AU (1) | AU650031B2 (ja) |
CA (1) | CA2084082C (ja) |
DE (1) | DE69123052T2 (ja) |
DK (1) | DK0532629T3 (ja) |
ES (1) | ES2096651T3 (ja) |
FI (1) | FI98456C (ja) |
GR (1) | GR3022327T3 (ja) |
HU (1) | HU214587B (ja) |
NO (1) | NO179205C (ja) |
WO (1) | WO1991018603A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6784192B2 (en) | 2000-01-20 | 2004-08-31 | Eisai Co., Ltd. | Piperidine compound and pharmaceutical composition thereof |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6954194A (en) * | 1993-06-23 | 1995-01-17 | Merrell Dow Pharmaceuticals Inc. | Piperidin-1-yl-2,2-dialkylpropanonearylsulfonamide derivatives |
EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
TWI249526B (en) * | 1998-03-13 | 2006-02-21 | Aventis Pharma Inc | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
WO2004078715A1 (ja) | 2003-03-07 | 2004-09-16 | Astellas Pharma Inc. | 2,6-ジ置換スチリルを有する含窒素へテロ環誘導体 |
JP5400843B2 (ja) * | 2011-09-06 | 2014-01-29 | 本田技研工業株式会社 | 車両構造 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
PH23283A (en) * | 1986-02-26 | 1989-06-30 | Eisai Co Ltd | Piperidine derivative, pharmaceutical composition containing the same and method of use thereof |
PH25458A (en) * | 1987-08-24 | 1991-07-01 | Eisai Co Ltd | Piperidine derivatives, therapeutic, preventive agents |
US5093341A (en) * | 1987-12-17 | 1992-03-03 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl piperidine derivatives useful as antithrombolytic agents |
US5064838A (en) * | 1988-01-21 | 1991-11-12 | Merrell Dow Pharmaceuticals | 1,4-disubstituted-piperidinyl compounds as pain relievers |
NZ236501A (en) * | 1989-12-21 | 1992-12-23 | Merrell Dow Pharma | Piperidine derivatives and antithrombotic compositions |
-
1991
- 1991-05-15 AU AU79922/91A patent/AU650031B2/en not_active Expired
- 1991-05-15 DK DK91911167.4T patent/DK0532629T3/da active
- 1991-05-15 WO PCT/US1991/003323 patent/WO1991018603A1/en active IP Right Grant
- 1991-05-15 DE DE69123052T patent/DE69123052T2/de not_active Expired - Lifetime
- 1991-05-15 CA CA002084082A patent/CA2084082C/en not_active Expired - Lifetime
- 1991-05-15 JP JP3510423A patent/JP3032294B2/ja not_active Expired - Lifetime
- 1991-05-15 AT AT91911167T patent/ATE144899T1/de not_active IP Right Cessation
- 1991-05-15 ES ES91911167T patent/ES2096651T3/es not_active Expired - Lifetime
- 1991-05-15 HU HU9203856A patent/HU214587B/hu not_active IP Right Cessation
- 1991-05-15 EP EP91911167A patent/EP0532629B1/en not_active Expired - Lifetime
-
1992
- 1992-12-04 FI FI925518A patent/FI98456C/fi active
- 1992-12-04 NO NO924694A patent/NO179205C/no not_active IP Right Cessation
- 1992-12-05 KR KR1019920703112A patent/KR100200461B1/ko not_active IP Right Cessation
-
1997
- 1997-01-22 GR GR960403347T patent/GR3022327T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6784192B2 (en) | 2000-01-20 | 2004-08-31 | Eisai Co., Ltd. | Piperidine compound and pharmaceutical composition thereof |
Also Published As
Publication number | Publication date |
---|---|
FI98456C (fi) | 1997-06-25 |
FI925518A0 (fi) | 1992-12-04 |
NO179205B (no) | 1996-05-20 |
NO179205C (no) | 1996-08-28 |
KR930700441A (ko) | 1993-03-15 |
DK0532629T3 (da) | 1996-11-25 |
NO924694L (no) | 1992-12-04 |
EP0532629A1 (en) | 1993-03-24 |
ES2096651T3 (es) | 1997-03-16 |
WO1991018603A1 (en) | 1991-12-12 |
KR100200461B1 (ko) | 1999-06-15 |
HU9203856D0 (en) | 1993-04-28 |
HUT64517A (en) | 1994-01-28 |
DE69123052T2 (de) | 1997-03-06 |
CA2084082A1 (en) | 1991-12-08 |
EP0532629B1 (en) | 1996-11-06 |
JP3032294B2 (ja) | 2000-04-10 |
FI98456B (fi) | 1997-03-14 |
AU650031B2 (en) | 1994-06-09 |
HU214587B (hu) | 1998-04-28 |
FI925518A (fi) | 1992-12-04 |
EP0532629A4 (ja) | 1994-03-09 |
NO924694D0 (no) | 1992-12-04 |
DE69123052D1 (de) | 1996-12-12 |
ATE144899T1 (de) | 1996-11-15 |
CA2084082C (en) | 2002-03-19 |
GR3022327T3 (en) | 1997-04-30 |
AU7992291A (en) | 1991-12-31 |
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