JP7493337B2 - 流体インジェクタシステムにおける動的圧力制御のための方法 - Google Patents
流体インジェクタシステムにおける動的圧力制御のための方法 Download PDFInfo
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Description
本出願は、2017年8月31日に出願された、「System and Method for Dynamic Pressure Equalization in a Fluid Injector System」と題する米国仮特許出願第62/552,433号の優先権を主張するものであり、上記仮特許出願の開示は、その全体が本明細書に組み込まれる。
々な実施形態によれば、流体インジェクタ10は、造影剤と生理食塩水とを別々にまたは混合物として送達するように構成され得る(例えば、特定の時間にわたって特定の量の生理食塩水を送達し、続いて特定の時間にわたって特定の量の造影剤を送達する、または指定された比率の造影剤および生理食塩水を(つまり、「デュアルフロー」プロセスで)送達し、続いて指定された時間にわたって第2の量の生理食塩水を送達して、チューブから患者に造影剤を流す)。技術者は、所望の生理食塩水量、造影剤量、造影剤と生理食塩水との特定の比率の混合物を溶液ごとに所望の流量、時間、および量で送達するために、特定の注入プロトコルをインジェクタにプログラムする(または事前に作成されたプロトコルを使用する)ことができる。流体インジェクタ10は、シリンジ12を流体で満たすための少なくとも1つのバルク流体源(図示せず)を有してもよく、特定の実施形態では、流体インジェクタ10は、複数のシリンジのそれぞれを所望の流体で満たすための複数のバルク流体源を複数のシリンジのそれぞれに1つずつ有してもよい。
図10に示すような圧力制御なしの注入プロトコルと比較して、上述のプロセスを使用して実行された注入の注入パラメータを示すグラフが図9に示されている。具体的には、図9は、上述の圧力制御プロセスを使用して実行される流体注入の時間314に対する流量(mL/秒)312のグラフ310を示している。図9に示されるように、注入の第1のフェーズ316は、約0~16秒の間に行われる。約5秒の第1のフェーズ316の短いランプ時間の後、流量は第1のフェーズ内で約5mL/秒で安定する。いくつかの例では、第1のフェーズ中または第1のフェーズの前にシリンジを事前に加圧することにより、ランプ時間を除去できる。注入の第2のフェーズ318は、約16秒~30秒の間に行われる。約5mL/秒の流量が、第2のフェーズ318全体で提供される。特に、上述の圧力制御プロセスの結果として、流量が安定するまでランプ時間は必要ないことに留意されたい。代わりに、注入の第1のフェーズから第2のフェーズへの移行中および第2のフェーズ全体で、約5mL/秒で流体の実質的に連続した流れが提供される。
12 シリンジ
12a シリンジ
12b シリンジ
13 シリンジポート
14 プランジャ
15 長手方向軸
16 駆動部材/ピストン
17 流体経路セット
18 円筒形のシリンジバレル
19 駆動部材/ピストン
20 近位端
21 外面
22 ノズル
23 内面
24 遠位端
25 内部容積
30 挿入部
31 モータ
32 圧力ジャケット
34 転動形ダイヤフラムシリンジ
36 中空の本体
38 内部容積
40 前部または遠位端
42 後部または近位端
44 側壁
46 閉鎖端壁
48 放出ネック
50 中央部分
52 駆動部材係合部分
54 ハウジング
56 複数患者用使い捨てシステム(MUDS)
58 シリンジ
58a シリンジ
58b シリンジ
58c シリンジ
60 バルク流体コネクタ
62 MUDS流体経路
64 フレーム
66 充填ポート
68 放出口
70 マニホールド
72 弁
74 流体出口ライン
76 ポート
102 流体送達システム
104 コントローラ
106 センサ
108 センサ
110 流体インジェクタ
112 第1のシリンジ
114 第2のシリンジ
117 導管
119 側壁
150 拘束構造
152 破線
178 弁
180 弁
310 グラフ
312 流量
314 時間
316 第1のフェーズ
318 第2の注入フェーズ
410 グラフ
412 流量
414 時間
416 第1のフェーズ
418 第2のフェーズ
510 グラフ
512 線
514 線
516 第1のフェーズ
518 第2のフェーズ
F 流体
F1 流体
F2 流体
F3 流体
Claims (14)
- 流体送達システムにおける動的圧力制御のための方法であって、前記流体送達システムは、
多フェーズ流体送達システムであって、第1の流体を収容するように構成された少なくとも1つの第1の流体リザーバと、第2の流体を収容するように構成された少なくとも1つの第2の流体リザーバと、前記第1の流体リザーバからの前記第1の流体および前記第2の流体リザーバからの前記第2の流体を導くための流体導管であって、各流体リザーバは、それぞれの弁によって独立して選択的に前記導管と流体連通状態にある流体導管と、前記第1の流体を前記第1の流体リザーバから排出するための少なくとも1つの第1の駆動部材および前記第2の流体を前記第2の流体リザーバから排出するための少なくとも1つの第2の駆動部材を備えるインジェクタと、を備える、多フェーズ流体送達システムを有し、
前記方法は、
a)前記流体送達システムのコントローラが、第1の注入フェーズの際に前記第1の流体を前記第1の流体リザーバから前記導管内に排出するために前記第1の駆動部材を前進させるステップであって、前記第1の流体が第1の流体圧力まで加圧される、ステップと、
b)前記流体送達システムの前記コントローラが、目標値を提供するために、前記第1の注入フェーズの際に前記第1の流体圧力を測定するステップであって、前記目標値が前記第1の注入フェーズの前記測定された流体圧力に基づく、ステップと、
c)前記第2の流体リザーバの前記弁を閉じることにより前記第2の流体リザーバが前記導管から流体隔離状態にある間に、前記流体送達システムの前記コントローラが、前記第2の流体リザーバ内の前記第2の流体の流体圧力を前記目標値まで上昇または低下させるために前記第2の駆動部材を前進または後退させるステップと、
d)前記流体送達システムの前記コントローラが、前記第2の流体リザーバの前記弁を開くことにより前記第2の流体リザーバを前記導管と流体連通状態で配置するステップと、
e)前記流体送達システムの前記コントローラが、前記目標値に等しい第2の流体圧力で前記第2の流体を前記第2の流体リザーバから前記導管内に排出するために前記第2の駆動部材を前進させるステップと、を含む、方法。 - 前記第2の流体を前記第2の流体リザーバから前記導管内に排出するために前記第2の駆動部材を前進させる前に、前記導管と流体連通しないように、前記流体送達システムの前記コントローラが前記第1の流体リザーバを隔離することをさらに含む、請求項1に記載の方法。
- 前記目標値が前記第1の流体圧力に実質的に等しい、請求項1または2に記載の方法。
- 前記目標値が前記第1の流体圧力より大きい、請求項1または2に記載の方法。
- 前記目標値が前記第1の流体圧力より小さい、請求項1または2に記載の方法。
- 前記流体送達システムの前記コントローラが、前記第2の流体を前記第2の流体リザーバから排出するために前記第2の駆動部材を前進させることは、所定の比率の前記第1の流体および前記第2の流体のデュアルフロー流体送達を提供するために、前記流体送達システムの前記コントローラが、前記第1の流体を前記第1の流体リザーバから排出するために前記第1の駆動部材を前進させ続けることをさらに含む、請求項1から5のいずれか一項に記載の方法。
- 前記流体送達システムの前記コントローラが、前記デュアルフロー流体送達を提供するために前記第1の流体圧力および前記第2の流体圧力を調整することをさらに含み、前記所定の比率が、1:99の前記第1の流体の前記第2の流体に対する比率から99:1の前記第1の流体の前記第2の流体に対する比率の範囲の指定された比率である、請求項6に記載の方法。
- 前記第1の流体がイメージング造影剤を含み、前記第2の流体が生理食塩水を含む、請求項1から7のいずれか一項に記載の方法。
- 前記第1の流体リザーバおよび前記少なくとも前記第2の流体リザーバが、シリンジおよび圧縮バッグからなる群から独立して選択される流体リザーバである、請求項1から8のいずれか一項に記載の方法。
- 前記第1の流体リザーバおよび前記少なくとも前記第2の流体リザーバのうちの少なくとも1つがシリンジである、請求項1から9のいずれか一項に記載の方法。
- 前記第1の流体リザーバおよび前記少なくとも前記第2の流体リザーバがシリンジである、請求項1から10のいずれか一項に記載の方法。
- 前記導管と選択可能に流体連通状態にあり、少なくとも第3の流体を前記導管内に排出するための流体インジェクタの少なくとも1つの第3の駆動部材と動作可能に係合する、少なくとも1つの第3の流体リザーバをさらに備える、請求項1から11のいずれか一項に記載の方法。
- 前記それぞれの弁のそれぞれが、各流体リザーバが流体容器と流体連通状態にあるが前記導管と流体隔離状態にある第1の充填位置と、各流体リザーバが前記流体容器および前記導管と流体隔離状態にある第2の閉鎖位置と、各流体リザーバが前記導管と流体連通状態にあるが前記流体容器と流体隔離状態にある第3の送達位置と、を有する、請求項1に記載の方法。
- 前記それぞれの弁のそれぞれが、流体インジェクタのプロセッサに接続され、かつ、前記流体インジェクタの前記プロセッサによって動作可能に制御される、請求項1から13のいずれか一項に記載の方法。
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US11779702B2 (en) | 2023-10-10 |
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