JP7462338B2 - 抗疲労剤 - Google Patents
抗疲労剤 Download PDFInfo
- Publication number
- JP7462338B2 JP7462338B2 JP2022107500A JP2022107500A JP7462338B2 JP 7462338 B2 JP7462338 B2 JP 7462338B2 JP 2022107500 A JP2022107500 A JP 2022107500A JP 2022107500 A JP2022107500 A JP 2022107500A JP 7462338 B2 JP7462338 B2 JP 7462338B2
- Authority
- JP
- Japan
- Prior art keywords
- ornithine
- salt
- fatigue
- present
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Description
(a)松、及び稲から選ばれる少なくとも1種の植物素材
(b)アスパルテーム、トレハロース、及び還元パラチノースから選ばれる少なくとも1種の甘味剤
(c)グルタミン、グルタミン酸、グリシン、ヒスチジン、イソロイシン、ロイシン、リジン、メチオニン、フェニルアラニン、チロシン、及びアンセリンから選ばれる少なくとも1種のアミノ酸類
(d)ビタミンB1、ビタミンB6、ビタミンB12、ビタミンE、ナイアシン、葉酸、ビタミンK、及び亜鉛から選ばれる少なくとも1種のビタミン・ミネラル類
本発明の抗疲労剤の有効成分となるオルニチンとしては、L-オルニチンであってもよく、D-オルニチンであってもよいが、L-オルニチンであることが好ましい。オルニチンは、化学合成により得られたもの、発酵に得られたもの等、その製造方法は問わない。また、オルニチンの塩としては、薬学的に許容される塩であれば特に制限されるものではなく、例えば、無機酸塩、有機酸塩、金属塩を挙げることができる。オルニチンは、医薬品、試薬等として市販されており、これらの市販品を用いることができる。
本発明の抗疲労剤においては、オルニチン又はその塩と共に、有効成分として、松、及び稲から選ばれる少なくとも1種の植物素材を用いることが好ましい。
本発明の抗疲労剤においては、オルニチン又はその塩と共に、有効成分として、アスパルテーム、トレハロース、及び還元パラチノースから選ばれる少なくとも1種の甘味剤を用いることが好ましい。本発明の甘味剤は、甘味を呈するものを意味し、甘味料としての使用目的に限定されない。
本発明の抗疲労剤においては、オルニチン又はその塩と共に、有効成分として、グルタミン、グルタミン酸、グリシン、ヒスチジン、イソロイシン、ロイシン、リジン、メチオニン、フェニルアラニン、チロシン、及びアンセリンから選ばれる少なくとも1種のアミノ酸類(塩を含む)を用いることが好ましい。塩としては、例えば、ナトリウム塩、塩酸塩等を挙げることができる。
本発明の抗疲労剤においては、オルニチン又はその塩と共に、有効成分として、ビタミンB1、ビタミンB6、ビタミンB12、ビタミンE、ナイアシン、葉酸、ビタミンK、及び亜鉛から選ばれる少なくとも1種のビタミン・ミネラル類を用いることが好ましい。なお、本発明のミネラル類としての亜鉛は、亜鉛を含む化合物の形態を含む。
[実施例1]
(1)マウス筋芽細胞株C2C12を、5×103cells/wellとなるよう96well plateへ播種した。
(2)一晩、前培養し、培養上清除去後、下記表1及び表2に示すようにサンプル添加を行った。
各サンプルを5mg/mL(もしくは1.28mg/mL)となるよう10%FBS-DMEMへ溶解し、1h転倒撹拌後、フィルタリングを行ったものを原液とした。ただし、疎水性サンプルは、50mg/mLとなるようDMSOへ溶解したものを原液とした。
稲(米ぬか)については、市販品を用いた。
ヨモギについては、生葉の微粉砕末を用いた。
下記成分からなるタブレットを製造した。
フラクトオリゴ糖 20mg
松樹皮抽出物 10mg
アルギニン 20mg
イソロイシン 5mg
ロイシン 5mg
リジン 2mg
ビタミンE 1mg
二酸化ケイ素 30mg
シェラック 20mg
下記混合物400mgをソフトカプセルに封入し、カプセル剤を製造した。
アルギニン 60mg
リジン 8mg
葉酸 10mg
ビタミンB1 10mg
ナイアシン 10mg
グリセリン脂肪酸エステル 5mg
二酸化ケイ素 37mg
下記成分を混合して常法により顆粒剤(3000mg)を製造した。
米ぬか抽出物 200mg
グルタミン 60mg
グルタミン酸 40mg
ビタミンB12 10mg
グルコン酸亜鉛 5mg
乳糖 50mg
難消化性デキストリン 25mg
ショ糖脂肪酸エステル 10mg
下記成分からなる液剤(100mL)を製造した。
トレハロース 400mg
L-オルニチン塩酸塩 400mg
松樹皮抽出物 100mg
ナイアシン 60mg
葉酸 50mg
ビタミンC 50mg
ビタミンB12 30mg
クエン酸 20mg
香料 適量
水 残部
Claims (3)
- オルニチン又はその塩と、アスパルテームとを含有することを特徴とする食品組成物(ただし、以下の(1)~(3)の経口組成物を除く)。
(1)デキストロース一水和物、マルトデキストリン、クレアチン一水和物、リンゴ酸クレアチン、タウリン酸クレアチン、L-リジン塩酸塩、N-アセチル-L-バリン、L-バリンα-ケトグルタル酸塩、L-バリンエチルエステル塩酸塩、L-イソロイシンピログルタミン酸塩、L-イソロイシンエチルエステル塩酸塩、N-アセチル-L-フェニルアラニン、L-スレオニン、L-ヒスチジン、L-ヒスチジンα-ケトグルタル酸塩、及びL-メチオニンを含有する筋肉増強用経口組成物
(2)コエンザイムQ10、ヒアルロン酸、オルニチン塩酸塩、ポリフェノール及び食物繊維を含有するダイエット用飲料
(3)オルニチン又はその塩と、アスパルテームと、酢とを含有する経口組成物 - オルニチン又はその塩と、トレハロースとを含有することを特徴とする食品組成物(ただし、以下の(1)~(5)の経口組成物を除く)。
(1)アスタキサンチン、システインペプチド、ビタミンC及びセラミドを含有する美容用飲料
(2)オルニチンを含有するチーズ
(3)分岐鎖アミノ酸又はその塩と、オルニチン又はその塩と、グルタミン又はその塩と、トレハロースとを含有するヘモグロビン尿症又はミオグロビン尿症の予防又は治療用経口組成物
(4)ナメコを含有する食品組成物
(5)ブナシメジを含有する食品組成物 - オルニチン又はその塩と、還元パラチノースとを含有することを特徴とする食品組成物(ただし、以下の(1)及び(2)の経口組成物を除く)。
(1)オルニチン、クルクミン及び葛の花を含有するサプリメント
(2)コエンザイムQ10、ヒアルロン酸、オルニチン塩酸塩、ポリフェノール及び食物繊維を含有するダイエット用飲料
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