JP7053678B2 - リガンド結合mbp膜、使用及び製造方法 - Google Patents
リガンド結合mbp膜、使用及び製造方法 Download PDFInfo
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- JP7053678B2 JP7053678B2 JP2019566063A JP2019566063A JP7053678B2 JP 7053678 B2 JP7053678 B2 JP 7053678B2 JP 2019566063 A JP2019566063 A JP 2019566063A JP 2019566063 A JP2019566063 A JP 2019566063A JP 7053678 B2 JP7053678 B2 JP 7053678B2
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Description
本発明は、リガンド結合マルチブロックポリマー(「MBP」)イソポーラス材料、それらの調製、及び実験室、スケールアップ又は商業環境、例えばこれらに限定されないが、タンパク質の精製と生産プロセスに必要な分離技術、及び特に、カラムベースのアフィニティ分離の代替品として、並びに興味対象の分析物を監視及び検出するためのセンサ、のための、分析、検出及び分離プロトコルにおける使用に関する。
タンパク質精製は、R&Dから大規模製造まで、生体分子分離市場における重要かつ挑戦的な態様である。タンパク質精製プロセス全体の主要なボトルネックは、多数の分離プロトコルに関係していることが広く認識されている。現在のタンパク質精製の1つの態様には、多孔質膜、複数のサイズレジームの相互接続された細孔を持つサポートされた多孔性材料、を使用したアフィニティ分離が含まれる。多くの場合、アフィニティ分離に有用な前記多孔質膜は、反応性基(とりわけ、カルボン酸基が開示されている)を生物学的活性剤、例えば、とりわけプロテインA、に結合することにより形成される。前記膜は高分子材料でできている。反応性基は、直接にはポリマーの一部であり得るか、又は後続の処理により前記反応性基を形成する前駆体を介して形成され得る。
ブロックコポリマー、ターポリマー、テトラポリマー、一括マルチブロックポリマー(MBP)材料/構造は、材料又は構造が階層的に多孔性であるように(複数の長さスケールの細孔を有する)、自己組織化によって形成された材料/構造の少なくとも一部とともに開示される。前記自己組織化ポリマー材料は、マクロ細孔、メソ細孔又はミクロ細孔のうち少なくとも1つを含有し、その少なくともいくつかはイソポーラスである。ミクロ細孔は、0.1~1nmの直径を有すると定義される。メソ細孔は、1nm~200nmの直径を持つと定義される。マクロ細孔は、200nmから1000μmの直径を持つと定義される。
それらの全体に組み込まれている参照対象主題
Claims (23)
- 自己組織化ポリマー材料であって、当該材料は、
メソ細孔及びミクロ細孔のうち少なくとも1つ、かつ、その少なくともいくつかはイソポーラスであり、及び
少なくとも2つが化学的に異なるポリマーブロックを含む少なくとも1つのマルチブロックポリマー(MBP)、
を含み、ここで、
前記MBPの少なくとも1つのポリマーブロックが疎水性ブロックであり、
前記MBPの少なくとも1つが親水性ブロックであり、
前記MBPの少なくとも1つポリマーブロックは、親和性リガンドで共有結合的又は非共有結合的に修飾され、前記親和性リガンドは、標的種と結合する親和性を有する、自己組織化ポリマー材料。 - 当該材料が非対称又は対称である、請求項1に記載の自己組織化ポリマー材料。
- 単一の一体型のスケーラブルな構造内にマクロポーラスドメイン及びメソポーラス壁構造を含む、請求項1に記載の自己組織化ポリマー材料。
- マクロ多孔質連続ドメインをさらに含む、請求項2に記載の自己組織化ポリマー材料。
- 当該材料は非対称であり、且つメソ細孔及びマクロ細孔を有する、請求項4に記載の自己組織化ポリマー材料。
- 請求項1に記載の自己組織化ポリマー材料であって、ここで、
a.前記親和性リガンドは、共有結合によって前記MBPの前記少なくとも1つのポリマーブロック上で官能化されている、又は
b.前記親和性リガンドは、非共有結合によって前記MBPの前記少なくとも1つのポリマーブロック上で官能化されている、又は
c.前記MBPの前記少なくとも1つのポリマーブロックは、連結分子をさらに含み、且つ前記親和性リガンドは、前記連結分子を介して前記MBPの少なくとも1つのポリマーブロック上で官能化されている、自己組織化ポリマー材料。 - 請求項1に記載の材料を製造する方法であって、
a.非共有付着により親和性リガンドでMBPの表面を修飾すること;又は
b.親和性リガンドの後続の付着のための官能性を提供するリンカーで前記MBPを修飾すること;又は
c.フィルムへの製造前に、前記MBPの前記ブロックを親和性リガンド若しくはリンカーで修飾することであって、前記親和性リガンド若しくは前記リンカーを有する階層的多孔性を包含する三次元ブロックターポリマー構造を前記MPBに提供すること;又は
d.リンカー若しくは親和性リガンドで修飾された前記MBPの量を、前記MBPの化学量論に対して変化させることであって、利用可能なサイトの10~100%を修飾するために、時間、温度、及び修飾剤の濃度を変更することを含むこと;又は
e.リンカー若しくは親和性リガンドの一体的であるが別個の物理層を提供するため、前記材料の表面に共有若しくは非共有部分によって連結材料をコンフォーマルにコーティングすること;又は
f.前記MBP構造のメソ細孔に加えて、マイクロポーラス材料を前記フィルム内に組み込むことにより、前記自己組織化ポリマー材料にミクロ細孔を設けること;又は
g.
i.二次元に、若しくは
ii.三次元に、若しくは
iii.リソグラフィによるパターンに、若しくは
iv.修飾された材料の一部分若しくは複数部分を未修飾のフィルム若しくは別の基板に取り付けることにより、
配置するため、親和性リガンド若しくはリンカーで修飾された材料のジオメトリ及び面積を制御すること;
を含む方法。 - サポート上に固定化された請求項1に記載の自己組織化ポリマー材料を含む、物品。
- テキスタイルと一体化した請求項1に記載の自己組織化ポリマー材料を含む、物品。
- 請求項1に記載の材料を含むセンサ。
- 興味対象の分析物を分離する及び/又は検出するプロセスであって、当該プロセスは、
興味対象の前記分析物を含有する媒体を請求項1に記載の自己組織化ポリマー材料と接触させること、及び
興味対象の前記分析物を前記媒体から分離すること、
を含むプロセス。 - 興味対象の前記分析物がタンパク質である、請求項11に記載のプロセス。
- 分離は、前記分析物が前記自己組織化ポリマー材料の親和性リガンドに結合する標的種である、結合及び溶出操作を伴う、請求項11に記載のプロセス。
- 興味対象の分析物又は種を検出する方法であって、当該方法は、
請求項10に記載のセンサを興味対象の分析物又は種と接触させること、及び
興味対象の前記分析物又は種と前記親和性リガンドとの間の相互作用の結果としての光学的及び電気的変化のうち少なくとも1つを測定すること、
を含む方法。 - 前記マクロポーラス連続ドメインの構造的フィーチャは、改善された対流溶液の流れ、及び迅速な処理を提供し、且つ、前記自己組織化ポリマー材料のメソポーラス壁構造は、高密度の表面官能化のために高い表面積を作り出す、請求項3に記載の材料。
- 前記分析物が核酸を含む、請求項11に記載のプロセス。
- 請求項1に記載の自己組織化ポリマー材料を含む材料を利用するデバイスであって、前記自己組織化ポリマー材料は、クロスフローカセット若しくはモジュール、又はらせん状に巻かれたモジュールの、平らなシートとして、プリーツ状のパックの形態である、デバイス。
- 請求項17に記載のデバイスを利用するプロセスであって、当該プロセスが結合及び溶出操作を含むプロセス。
- 分子又は懸濁粒子の分離のための請求項17に記載のデバイスを利用するプロセスであって、当該プロセスが濾過操作を含むプロセス。
- 前記非共有付着が吸着を含む、請求項7に記載の材料。
- 前記マイクロポーラス材料がゼオライト又はマイクロポーラス炭素である、請求項7に記載の材料。
- 前記標的種が抗体、タンパク質、DNA及び核酸からなる群から選択される、請求項1に記載の自己組織化ポリマー材料。
- 前記親和性リガンドがプロテインA、プロテインA/G、プロテインL、ビオチン、ジゴキシゲニン、ジニトロフェノール、及び核酸からなる群から選択される、請求項1に記載の自己組織化ポリマー材料。
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EP3585506A1 (en) | 2020-01-01 |
EP3585506A4 (en) | 2021-01-13 |
SG11201907674WA (en) | 2019-09-27 |
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CA3054137C (en) | 2023-02-21 |
CN110785219A (zh) | 2020-02-11 |
US11567072B2 (en) | 2023-01-31 |
JP2020511306A (ja) | 2020-04-16 |
US20200232978A1 (en) | 2020-07-23 |
MX2019010056A (es) | 2019-10-09 |
KR102308806B1 (ko) | 2021-10-07 |
CN110785219B (zh) | 2022-10-28 |
CA3054137A1 (en) | 2018-08-30 |
WO2018156731A1 (en) | 2018-08-30 |
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