JP6997624B2 - 乾癬を治療するためのコルチコステロイドおよびレチノイドを含む局所用組成物 - Google Patents
乾癬を治療するためのコルチコステロイドおよびレチノイドを含む局所用組成物 Download PDFInfo
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- JP6997624B2 JP6997624B2 JP2017563568A JP2017563568A JP6997624B2 JP 6997624 B2 JP6997624 B2 JP 6997624B2 JP 2017563568 A JP2017563568 A JP 2017563568A JP 2017563568 A JP2017563568 A JP 2017563568A JP 6997624 B2 JP6997624 B2 JP 6997624B2
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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- 208000009056 telangiectasis Diseases 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960001350 tofacitinib Drugs 0.000 description 1
- UJLAWZDWDVHWOW-YPMHNXCESA-N tofacitinib Chemical compound C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C1=NC=NC2=C1C=CN2 UJLAWZDWDVHWOW-YPMHNXCESA-N 0.000 description 1
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Classifications
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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Landscapes
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
・59人の被験者を、IDP-118ローションに(「IDP 118群」)、
・63人の被験者を、0.01%のHPローションに(「HP群」)、
・59人の被験者を、0.045%のTazローションに(「Taz群」)、
・31人の被験者を、ローションビヒクルに(「ビヒクル群」)。
0.01%のプロピオン酸ハロベタゾールおよび0.045%のタザロテンを含むIDP-118の有効性が、示され、論じられている。
Claims (9)
- 乾癬を治療するための局所用医薬組成物であって、該組成物が、
(a)前記組成物の0.01質量%の濃度でのプロピオン酸ハロベタゾール、
(b)前記組成物の0.045質量%の濃度でのタザロテン、および
(c)皮膚科学的に許容される担体、
を含む、局所用医薬組成物。 - 前記組成物が水中油エマルションである、請求項1記載の局所用医薬組成物。
- 前記プロピオン酸ハロベタゾールおよび前記タザロテンが、前記エマルションの液体油成分中に溶けている、請求項2記載の局所用医薬組成物。
- 前記液体油成分が、ジカルボン酸エステル(DCAE)、モノカルボン酸エステル(MCAE)、またはそれらの組合せを含む、請求項3記載の局所用医薬組成物。
- 前記水中油エマルションの油相が、セバシン酸ジエチルおよび軽油を含む液体油成分を含む、請求項2記載の局所用医薬組成物。
- 前記エマルションがローションである、請求項2記載の局所用医薬組成物。
- 前記エマルションがクリームである、請求項2記載の局所用医薬組成物。
- 前記エマルションの水相が、(C10~C30)アルキルアクリレートにより修飾され、アリルペンタエリトリトールと架橋した、アクリル酸の高分子であるカルボマーコポリマーおよびアリルスクロースまたはアリルペンタエリトリトールと架橋したアクリル酸の高分子であるカルボマーホモポリマーを含む、請求項5記載の局所用医薬組成物。
- 前記セバシン酸ジエチルが前記組成物の2.5~3.5質量%の濃度で存在し、前記軽油が前記組成物の7.5~8.5質量%の濃度で存在し、前記カルボマーコポリマーが前記組成物の0.3~0.5質量%の濃度で存在し、前記カルボマーホモポリマーが前記組成物の0.5~0.7質量%の濃度で存在する、請求項8記載の局所用医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201562181481P | 2015-06-18 | 2015-06-18 | |
US62/181,481 | 2015-06-18 | ||
PCT/US2016/035991 WO2016205001A1 (en) | 2015-06-18 | 2016-06-06 | Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis |
Publications (3)
Publication Number | Publication Date |
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JP2018526325A JP2018526325A (ja) | 2018-09-13 |
JP2018526325A5 JP2018526325A5 (ja) | 2019-07-11 |
JP6997624B2 true JP6997624B2 (ja) | 2022-01-17 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2017563568A Active JP6997624B2 (ja) | 2015-06-18 | 2016-06-06 | 乾癬を治療するためのコルチコステロイドおよびレチノイドを含む局所用組成物 |
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US (7) | US10251895B2 (ja) |
EP (1) | EP3310389B1 (ja) |
JP (1) | JP6997624B2 (ja) |
KR (2) | KR102643849B1 (ja) |
CN (1) | CN108282998B (ja) |
AU (1) | AU2016279801B2 (ja) |
BR (1) | BR112017027332B1 (ja) |
CA (1) | CA2988577A1 (ja) |
CY (1) | CY1123354T1 (ja) |
DK (1) | DK3310389T3 (ja) |
ES (1) | ES2812451T3 (ja) |
HR (1) | HRP20201250T1 (ja) |
HU (1) | HUE050603T2 (ja) |
LT (1) | LT3310389T (ja) |
MX (1) | MX2017015990A (ja) |
PL (1) | PL3310389T3 (ja) |
PT (1) | PT3310389T (ja) |
RS (1) | RS60672B1 (ja) |
SI (1) | SI3310389T1 (ja) |
WO (1) | WO2016205001A1 (ja) |
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US11957753B2 (en) | 2010-11-22 | 2024-04-16 | Bausch Health Ireland Limited | Pharmaceutical formulations containing corticosteroids for topical administration |
KR102643849B1 (ko) * | 2015-06-18 | 2024-03-07 | 밸리언트 파마슈티컬즈 노오쓰 아메리카 엘엘씨 | 건선을 치료하기 위한 코르티코스테로이드 및 레티노이드를 포함하는 국소 조성물 |
CN108024954A (zh) * | 2015-07-13 | 2018-05-11 | 瑞迪博士实验室有限公司 | 局部用类视黄醇组合物 |
BR112019023817A8 (pt) * | 2017-05-12 | 2022-12-06 | Bausch Health Us Llc | Composições tópicas e métodos para o tratamento de doenças da pele |
US11311482B2 (en) * | 2017-05-12 | 2022-04-26 | Bausch Health Us, Llc | Topical compositions and methods for treating skin diseases |
JP7065895B2 (ja) * | 2017-06-23 | 2022-05-12 | ラボラトリオス・サルバト・ソシエダッド・アノニマ | クロベタゾールの水中油型ナノエマルジョン組成物 |
US10653656B2 (en) | 2018-04-05 | 2020-05-19 | Bausch Health Ireland Limited | Topical pharmaceutical compositions for treating skin conditions |
EP3775116A4 (en) * | 2018-04-05 | 2022-03-23 | Bausch Health Ireland Limited | POLYMER EMULSION DISTRIBUTION SYSTEMS |
US10945952B2 (en) | 2019-03-14 | 2021-03-16 | Crescita Therapeutics Inc. | Rinse-off compositions and uses thereof for delivery of active agents |
KR102327827B1 (ko) | 2019-11-01 | 2021-11-18 | 한국과학기술연구원 | 강황 추출물을 유효성분으로 포함하고 자외선 처리를 포함하는 건선 개선용 조성물 |
CN113116891B (zh) * | 2019-12-30 | 2024-07-16 | 重庆华邦制药有限公司 | 一种乳膏及其制备方法 |
KR102527907B1 (ko) | 2020-09-14 | 2023-05-03 | 한국과학기술연구원 | 무산상자 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
KR102451304B1 (ko) | 2020-09-14 | 2022-10-07 | 한국과학기술연구원 | 꿩의다리속 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
KR102461001B1 (ko) | 2020-09-14 | 2022-11-01 | 한국과학기술연구원 | 술패랭이꽃 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
KR20230041257A (ko) | 2021-09-17 | 2023-03-24 | 한국과학기술연구원 | 시미시푸고라이드 에이를 유효성분으로 포함하는 건선 개선용 조성물 |
KR20230041255A (ko) | 2021-09-17 | 2023-03-24 | 한국과학기술연구원 | 눈개승마 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
CN113975249B (zh) * | 2021-10-14 | 2023-01-03 | 中山大学·深圳 | Tris-BNP纳米颗粒的制备及其在皮肤疾病治疗中的应用 |
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