JP6909559B2 - Oph活性増強剤 - Google Patents
Oph活性増強剤 Download PDFInfo
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- JP6909559B2 JP6909559B2 JP2016072165A JP2016072165A JP6909559B2 JP 6909559 B2 JP6909559 B2 JP 6909559B2 JP 2016072165 A JP2016072165 A JP 2016072165A JP 2016072165 A JP2016072165 A JP 2016072165A JP 6909559 B2 JP6909559 B2 JP 6909559B2
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- oph
- oph activity
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Description
<実施例>
<構成>
<試験>
本試験に用いた試料は、以下の通りである。
メトキシフラボン類として
(試料1)4',5,7-trihydroxy-3',5'-dimethoxyflavone (tricin:トリシン)
(試料2)3,5,7,3',4'-pentamethoxy flavone(3,5,7,3',4'-ペンタメトキシフラボン)
(試料3)3,5,7,4'-tetramethoxy flavone(3,5,7,4'-テトラメトキシフラボン)
(試料4)3,5,7-trimethoxy flavone(3,5,7-トリメトキシフラボン)
(試料5)5,7,4'-trimethoxy flavone(5,7,4'-トリメトキシフラボン)
(試料6)5,7-dimethoxy flavone(5,7-ジメトキシフラボン)
(試料7)5,6,7,3',4'-pentamethoxy flavone (sinensetin:シネンセチン)
(試料8)5,6,7,8,3',4'-hexamethoxy flavone (nobiletin:ノビレチン)
(試料9)5,6,7,8,4'-pentamethoxy flavone (tangeretin:タンゲレチン)
OPHとしてacylamino-acid releasing enzyme (AARE)、OPHの反応基質としてN-acetyl-L-alaninep-nitroanilide(AAPA) 溶液を使用した。測定にはOPHを0.01U/mL、0.005U/mL、0.001U/mLに調製して使用した。96ウェルマイクロプレートの各wellにOPH、AAPA、試料溶液を混合添加し、37℃に設定したインキュベーター内で4時間反応させた反応液の405nmにおける吸光度をマイクロプレートリーダーで測定した。
(式1)OPH活性増強作用(%)=(試料のOPH反応速度/RefのOPH反応速度) ×100
各試料のOPH活性増強作用を図3に示す。なお、結合する官能基は、以下の通りである。H:水素、OH:ヒドロキシ(hydroxy)基、MeO:メトキシ(methoxy)基、Glc:グリコシル(glycosyl)基、Gal:ガレート(gallate)基。
<効果>
Claims (6)
- 3,5,7,3',4'‐ペンタメトキシフラボン、3,5,7,4'−テトラメトキシフラボン、3,5,7−トリメトキシフラボン、5,7,4'−トリメトキシフラボン、5,7−ジメトキシフラボン、シネンセチン、ノビレチン、タンゲレチンのいずれか一以上を含有するOPH活性増強剤。
- 請求項1に記載のOPH活性増強剤を含有するOPH活性増強用医薬品。
- 請求項1に記載のOPH活性増強剤を含有するOPH活性増強用医薬部外品。
- 請求項1に記載のOPH活性増強剤を含有するOPH活性増強用食品。
- 請求項1に記載のOPH活性増強剤を含有するOPH活性増強用食品添加物。
- 請求項1に記載のOPH活性増強剤を含有するOPH活性増強用化粧品。
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JP2016072165A JP6909559B2 (ja) | 2016-03-31 | 2016-03-31 | Oph活性増強剤 |
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JP2016072165A JP6909559B2 (ja) | 2016-03-31 | 2016-03-31 | Oph活性増強剤 |
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JP2017178889A JP2017178889A (ja) | 2017-10-05 |
JP6909559B2 true JP6909559B2 (ja) | 2021-07-28 |
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Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4992164B2 (ja) * | 2000-04-19 | 2012-08-08 | 日油株式会社 | 化粧料組成物 |
JP2005213178A (ja) * | 2004-01-29 | 2005-08-11 | Maruzen Pharmaceut Co Ltd | TNF−α産生抑制剤、エストロゲン様作用剤及び皮膚外用剤 |
WO2005082351A1 (ja) * | 2004-03-02 | 2005-09-09 | Eisai R & D Management Co., Ltd. | 神経変性疾患治療剤 |
CN101052391A (zh) * | 2004-11-08 | 2007-10-10 | 爱科来株式会社 | 过氧化物酶体增殖物激活受体(ppar)活化剂以及使用了该活化剂的药品、补充剂、功能性食品和食品添加剂 |
JP5667358B2 (ja) * | 2009-06-03 | 2015-02-12 | 富士産業株式会社 | 柑橘類果皮の麹菌発酵組成物 |
US20120114771A1 (en) * | 2009-07-08 | 2012-05-10 | Arkray Inc. | Oxidized Protein Hydrolase Activity Enhancer |
JP2014508139A (ja) * | 2011-01-21 | 2014-04-03 | インダストリー−アカデミック コオペレイション ファウンデーション、ヨンセイ ユニバーシティ | フラボン系化合物の新規な用途 |
WO2013100111A1 (ja) * | 2011-12-27 | 2013-07-04 | 油田 正樹 | サーチュイン活性化剤 |
JP2013241354A (ja) * | 2012-05-18 | 2013-12-05 | Oriza Yuka Kk | ホスホジエステラーゼ2阻害剤 |
WO2013191236A1 (ja) * | 2012-06-21 | 2013-12-27 | 小太郎漢方製薬株式会社 | 中枢神経変性疾患の改善および/または治療用組成物 |
KR101989014B1 (ko) * | 2013-08-14 | 2019-06-13 | 주식회사 엘지생활건강 | 피부 재생, 주름개선, 항염증 및 피부 미백용 조성물 |
KR20150040618A (ko) * | 2013-10-07 | 2015-04-15 | 동아대학교 산학협력단 | 검은생강으로부터 분리한 화합물을 유효성분으로 포함하는 알츠하이머성 치매의 예방 또는 치료용 조성물 |
AU2015256997B2 (en) * | 2014-05-09 | 2020-07-09 | Suntory Holdings Limited | NOX inhibitor and NFkB inhibitor containing methoxyflavone |
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