JP2014084298A - 体臭抑制用の皮膚外用組成物 - Google Patents
体臭抑制用の皮膚外用組成物 Download PDFInfo
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- JP2014084298A JP2014084298A JP2012234342A JP2012234342A JP2014084298A JP 2014084298 A JP2014084298 A JP 2014084298A JP 2012234342 A JP2012234342 A JP 2012234342A JP 2012234342 A JP2012234342 A JP 2012234342A JP 2014084298 A JP2014084298 A JP 2014084298A
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- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
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Abstract
【解決手段】 (A)バラ科バラ属植物抽出物と(B)ボタン科ボタン属植物抽出物とを組み合わせて、体臭抑制用の皮膚外用組成物を調製する。当該皮膚外用組成物は、特に加齢臭を抑制するため、とりわけノネナールを抑制するために用いられる。好ましくは、(A)バラ科バラ属植物抽出物はエイジツエキスであり、(B)ボタン科ボタン属植物抽出物はシャクヤクエキスである。本発明の皮膚外用組成物は好ましくは、リーブオン型で用いられる。
【選択図】なし
Description
[項1] (A)バラ科バラ属植物抽出物及び(B)ボタン科ボタン属植物抽出物を含有する、体臭抑制用の皮膚外用組成物。
[項2] 加齢臭を抑制する、項1に記載の皮膚外用組成物。
[項3] ノネナールを抑制する、項1又は2に記載の皮膚外用組成物。
[項4] リーブオン型として用いられる、項1〜3のいずれかに記載の皮膚外用組成物。
[項5] (A)成分として、ムルチノシドAを含有する植物抽出物を含む、項1〜4のいずれかに記載の皮膚外用組成物。
[項6] (A)成分として、エイジツエキスを含む、項1〜5のいずれかに記載の皮膚外用組成物。
[項7] (B)成分として、ペオニフロリンを含有する植物抽出物を含む、項1〜6のいずれかに記載の皮膚外用組成物。
[項8] (B)成分として、シャクヤクエキスを含む、項1〜7のいずれかに記載の皮膚外用組成物。
[項9] (A)バラ科バラ属植物抽出物と(B)ボタン科ボタン属植物抽出物とを、体臭発生が気になる皮膚の部位に適用することを特徴とする、体臭抑制方法。
なお、本明細書中で使用される用語は、特に他を言及しない限り、当該分野で通常用いられる意味で用いられている点が理解されるべきである。
本発明による体臭抑制用の皮膚外用組成物は、(A)バラ科バラ属植物抽出物及び(B)ボタン科ボタン属植物抽出物を含有する。
本発明の体臭抑制用の皮膚外用組成物は、バラ科バラ属植物抽出物(以下、単に(A)成分ともいう)を含有する。
gallica)、コウシンバラ(Rosa chinensis)、ダマスクバラ(Rosa damascena)、センチフォリアバラ(Rosa centifolia)、ハイブリッドローズ(Rosa
hybrida)、ハマナス(Rosa rugosa)、ヤマハマナス(Rosa moschata)、モスカータバラ(Rosa moschata)、ロサアルバ(Rosa
alba)、ロサエグレンテリア(Rosa rubiginosa)、ロサルビギノサ(Rosa rubiginosa)、サンショウバラ(Rosa hirtula)、タカネイバラ(Rosa aciculaisis)、テリハノイバラ(Rosa wichuraiana)、サクライバラ(Rosa
uchiyamana)、モリイバラ(Rosa jasminoides)、フジイバラ(Rosa fujisanensis)、ヤマイバラ(Rosa
sambucina)、ヤブイバラ(Rosa onoei)、ミヤコイバラ(Rosa paniculigera)、テリハノイバラ(Rosa luciae)、カラフトイバラ(Rosa
amblyotis)、オオタカネバラ(Rosa acicularis)、タカネバラ(Rosa nipponensis)、ナニワイバラ(Rosa
laevigata)、カカヤンバラ(Rosa bracteata)、モッコウバラ(Rosa banksiae)等を挙げることができるが、これらに限定されない。より確実に高い効果を発揮できるという観点から、好ましくは、バラ科バラ属植物は、ノイバラ、イザヨイバラ、カニナバラ、ガリカバラ、コウシンバラ、ダマスクバラ、センチフォリアバラ、ハイブリッドローズ、ハマナス、ヤマハマナス、モスカータバラ、ロサアルバ、ロサエグレンテリア、又はロサルビギノサであり、特に好ましくはノイバラである。
これらのバラ科バラ属植物抽出物は、1種類のみを単独で用いても良いし、又は2種以上を組み合わせて用いても良い。
本発明の体臭抑制用の皮膚外用組成物は、上記(A)成分に加えて、ボタン科ボタン属植物抽出物(以下、単に(B)成分ともいう)を含有する。
obovata)、ボタン(Paeonia suffruticosa)等を挙げることができるが、これらに限定されない。好ましくは、ボタン科ボタン属植物はシャクヤク、オランダシャクヤク又はボタンであり、特に好ましくはシャクヤクである。
これらのボタン科ボタン属植物抽出物は、1種類のみを単独で用いても良いし、又は2種以上を組み合わせて用いても良い。
上記成分の含有量は、皮膚への使用感や効果を考慮して適宜選択できるが、通常、組成物全体に対して0.0001〜20重量%程度、好ましくは0.001〜10重量%程度とするのがよい。
上記成分の含有量は、皮膚への使用感や効果を考慮して適宜選択できるが、通常、組成物全体に対して0.0001〜10重量%程度、好ましくは0.001〜5重量%程度とするのがよい。
−オレイルアルコールエーテルやPOE−セチルアルコールエーテル等のPOE−アルキルエーテル;ソルビタンモノオレエート、ソルビタンモノイソステアレート及びソルビタンモノラウレート等のソルビタンエステル;POE−ソルビタンモノオレエート、POE−ソルビタンモノイソステアレート、及びPOE−ソルビタンモノラウレート等のPOE−ソルビタンエステル;グリセリンモノオレエート、グリセリンモノステアレート、及びグリセリンモノミリステート等のグリセリン脂肪酸エステル;POE−グリセリンモノオレエート、POE−グリセリンモノステアレート、及びPOE−グリセリンモノミリステート等のPOE−グリセリン脂肪酸エステル;POE−ジヒドロコレステロールエステル、POE−硬化ヒマシ油、及びPOE−硬化ヒマシ油イソステアレート等のPOE−硬化ヒマシ油脂肪酸エステル;POE−オクチルフェニルエーテル等のPOE−アルキルアリールエーテル;モノイソステアリルグリセリルエーテルやモノミリスチルグリセリルエーテル等のグリセリンアルキルエーテル;POE−モノステアリルグリセリルエーテル、POE−モノミリスチルグリセリルエーテル等のPOE−グリセリンアルキルエーテル;ジグリセリルモノステアレート、デカグリセリルデカステアレート、デカグリセリルデカイソステアレート、及びジグリセリルジイソステアレート等のポリグリセリン脂肪酸エステル、等の各種非イオン界面活性剤:あるいはレシチン、水素添加レシチン、サポニン、サーファクチンナトリウム、コレステロール、胆汁酸などの天然由来の界面活性剤等を例示することができる。
刺激低減剤としては、例えば、甘草エキス、アルギン酸ナトリウムなどが挙げられる。
単一円筒形回転粘度計に関する説明を以下に記載する。単一円筒形回転粘度計は、液体中の円筒を一定角速度で回転させたときのトルクを測定する粘度計である。あらかじめ粘度計校正用標準液を用いて実験的に装置定数KBを定めることにより、液体の粘度ηを次式によって算出する。
η=KB
× T/ω
η:液体の粘度(mPa・s)
KB:装置定数(rad/cm3)
ω:角速度(rad/s)
T:円筒面に作用するトルク(10-7N・m)
前述したように、バラ科バラ属植物抽出物及びボタン科ボタン属植物抽出物を組み合わせて用いることにより、体臭を効果的に抑制できることが確認されている。
従って、本発明は更に別の観点から、(A)バラ科バラ属植物抽出物と(B)ボタン科ボタン属植物抽出物とを、体臭発生が気になる皮膚の部位に適用することを特徴とする、体臭抑制方法を提供する。
上記方法において、(A)及び(B)成分の種類やその配合割合、他に配合され得る成分の種類やその配合割合、使用態様等については、上記「(1.体臭抑制用の皮膚外用組成物)」で記載されたものと同様である。
Trap DCC18(シリカモノリス捕集剤, ジーエルサイエンス株式会社製)を三角フラスコのシリコンラバーに吊り、密栓後、室温で2時間静置させた。2時間後、Mono
Trap DCC18を回収し、溶媒抽出するためにMT Extract Cup(ジーエルサイエンス株式会社製)に入れ、そこにクロロホルム1mL添加した後、超音波を5分間照射した。このようにして得られた各抽出液を、後述の測定条件下でガスクロマトグラフィー(GC)測定を行うことにより、trans-2-ノネナールを定量した。
・機種:ガスクロマトグラフGC-17A(株式会社島津製作所製)
・カラム:DB-WAX 30m×0.53mmφ×1μm(Agilent
Technologies製)
・キャリヤーガス:He, 圧力:100kPa,
全流量:272ml/min
・スプリット比 20:1
・温度条件:60℃→昇温(20℃/min)→200℃, 7min
・注入口:250℃、検出器:250℃(FID)
・注入量:1μl
trans-2-ノネナール抑制率(%)={(コントロールでの値−各実施例又は比較例での値)/コントロールでの値}×100 (式I)
1,3-ブチレングリコール 3重量%
濃グリセリン 3重量%
シャクヤクエキス 1重量%
エイジツエキス 1重量%
チャエキス 0.5重量%
ハマメリスエキス 0.1重量%
アクリル酸・メタクリル酸アルキル共重合体 0.2重量%
エデト酸ナトリウム水和物 0.05重量%
トリエタノールアミン 0.2重量%
パラオキシ安息香酸メチル 0.05重量%
香料 0.01重量%
精製水 残部
合計 100重量%
1,3-ブチレングリコール 3重量%
濃グリセリン 3重量%
シャクヤクエキス 1重量%
エイジツエキス 1重量%
キサンタンガム 0.1重量%
トリエタノールアミン 0.2重量%
香料 0.01重量%
エタノール 3重量%
精製水 残部
合計 100重量%
イソノナン酸イソノニル 2重量%
シクロペンタシロキサン 2重量%
モノステアリン酸ソルビタン 0.3重量%
べヘネス−20 0.35重量%
1,3-ブチレングリコール 3重量%
濃グリセリン 3重量%
シャクヤクエキス 0.8重量%
エイジツエキス 0.8重量%
アクリル酸・メタクリル酸アルキル共重合体 0.25重量%
エデト酸ナトリウム水和物 0.05重量%
トリエタノールアミン 0.25重量%
パラオキシ安息香酸メチル 0.05重量%
香料 0.01重量%
精製水 残部
合計 100重量%
Claims (9)
- (A)バラ科バラ属植物抽出物及び(B)ボタン科ボタン属植物抽出物を含有する、体臭抑制用の皮膚外用組成物。
- 加齢臭を抑制する、請求項1に記載の皮膚外用組成物。
- ノネナールを抑制する、請求項1又は2に記載の皮膚外用組成物。
- リーブオン型として用いられる、請求項1〜3のいずれかに記載の皮膚外用組成物。
- (A)成分として、ムルチノシドAを含有する植物抽出物を含む、請求項1〜4のいずれかに記載の皮膚外用組成物。
- (A)成分として、エイジツエキスを含む、請求項1〜5のいずれかに記載の皮膚外用組成物。
- (B)成分として、ペオニフロリンを含有する植物抽出物を含む、請求項1〜6のいずれかに記載の皮膚外用組成物。
- (B)成分として、シャクヤクエキスを含む、請求項1〜7のいずれかに記載の皮膚外用組成物。
- (A)バラ科バラ属植物抽出物と(B)ボタン科ボタン属植物抽出物とを、体臭発生が気になる皮膚の部位に適用することを特徴とする、体臭抑制方法。
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