JP6829636B2 - 抗白髪剤 - Google Patents
抗白髪剤 Download PDFInfo
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- JP6829636B2 JP6829636B2 JP2017061437A JP2017061437A JP6829636B2 JP 6829636 B2 JP6829636 B2 JP 6829636B2 JP 2017061437 A JP2017061437 A JP 2017061437A JP 2017061437 A JP2017061437 A JP 2017061437A JP 6829636 B2 JP6829636 B2 JP 6829636B2
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Description
[被験物質1(1.0体積%のベルゲニアリグラタ抽出物を含む培地)の調製]
15μLのパシャンベエキスSK(0.5質量%のベルゲニアリグラタ根エキスを含むベルゲニアリグラタ抽出物;香栄興業株式会社製)を1485μLのMedium254(HMGSを1.0体積%含む表皮メラニン細胞用増殖培地;以下、「Medium254(HMGS含)」と称する)に添加し、混和後にフィルター濾過処理を行うことにより1.0体積%のベルゲニアリグラタ抽出物を含む培地を調製した。
パシャンベエキスSKの代わりにサンショウ抽出液−J(0.18質量%のサンショウ果皮エキスを含むサンショウ果皮抽出物;丸善製薬株式会社製)を用い、終濃度が1.0体積%となるように使用したこと以外は被験物質1の調製と同様の操作を行うことにより1.0体積%のサンショウ果皮抽出物を含む培地を調製した。
パシャンベエキスSKの代わりにホップ抽出液BG−JN(1.8質量%のホップ花エキスを含むホップ花抽出物;丸善製薬株式会社製)を用い、ホップ花抽出物の終濃度が1.0体積%となるように使用したこと以外は被験物質1の調製と同様の操作を行うことにより1.0体積%のホップ花抽出物を含む培地を調製した。
ブタンジオールを終濃度が1.0体積%となるようにMedium254(HMGS含)に添加し、陰性対照1を調製した。
ヒトメラノサイトはMedium254(HMGS含)を培養液とし、T75フラスコを用いてCO2インキュベーター(5体積%CO2、37℃)内で必要細胞数に達するまで培養した。その後、T75フラスコから培地を除き、10mLのHEPESを添加、細胞を洗浄後に3mLのトリプシン/EDTA溶液を加え、すぐに2mLの添加したトリプシン/EDTA溶液を除去、室温にて1〜2分静置し、細胞を剥離した。その後、10mLのHEPESを加え細胞を回収し、さらに10mLのトリプシン中和液を添加・混合し、その細胞溶液を170×g、5分間遠心した。沈殿(細胞)にMedium254(HMGS含)を添加、懸濁後に細胞数を血球計算板にて測定することによりヒトメラノサイトを調製した。
培養して得られたヒトメラノサイトを1.5×105cells/0.5mL/ウェルの24ウェルプレートに播種し、CO2インキュベーター内(5体積%CO2、37℃)で、24時間培養後、ウェルに被験物質1〜3、陰性対照1をそれぞれ0.5mLずつ添加した。その後、24時間培養し、細胞を回収した。
[被験物質4(2.0質量%のベルゲニアリグラタ抽出物を含むサンプル)の調製]
エタノールを50.00質量%、l−メントールを0.40質量%、リン酸二水素ナトリウムを0.04質量%、リン酸一水素ナトリウムを0.03質量%、パシャンベエキスSKを2.0質量%、及び精製水を47.53質量%となる様に配合し、被験物質4を調製した。
パシャンベエキスSKを用いず、精製水を49.53質量%使用したこと以外は被験物質4と同様にして、陰性対照2を調製した。
2名の被験者(被験者1及び2)から頭皮に被験物質4を塗布した後、それぞれ5本の毛髪をピンセットで抜去し、チューブに入れた。得られた毛根部の細胞からトータルRNAを回収した。また、陰性対照2についても同様の操作を行った。
Claims (1)
- ベルゲニアリグラタ抽出物を有効成分とするMITF−M活性促進剤。
Priority Applications (1)
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JP2017061437A JP6829636B2 (ja) | 2017-03-27 | 2017-03-27 | 抗白髪剤 |
Applications Claiming Priority (1)
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JP2017061437A JP6829636B2 (ja) | 2017-03-27 | 2017-03-27 | 抗白髪剤 |
Publications (2)
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JP2018162235A JP2018162235A (ja) | 2018-10-18 |
JP6829636B2 true JP6829636B2 (ja) | 2021-02-10 |
Family
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Family Applications (1)
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JP2017061437A Active JP6829636B2 (ja) | 2017-03-27 | 2017-03-27 | 抗白髪剤 |
Country Status (1)
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JP (1) | JP6829636B2 (ja) |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0543424A (ja) * | 1991-08-14 | 1993-02-23 | Sansho Seiyaku Co Ltd | 毛髪用外用剤 |
JP2749218B2 (ja) * | 1991-08-27 | 1998-05-13 | サントリー株式会社 | 美白用化粧料組成物 |
JPH05139951A (ja) * | 1991-11-21 | 1993-06-08 | Noevir Co Ltd | 美白化粧料 |
JP3430577B2 (ja) * | 1993-09-03 | 2003-07-28 | 花王株式会社 | 染毛料 |
JPH1046142A (ja) * | 1996-07-30 | 1998-02-17 | Shiseido Co Ltd | 抗酸化剤 |
JPH11228339A (ja) * | 1998-02-13 | 1999-08-24 | Ichimaru Pharcos Co Ltd | メラニン生成抑制剤及び皮膚外用剤 |
JP2004196669A (ja) * | 2002-12-16 | 2004-07-15 | Kose Corp | メラノサイト増殖抑制剤及びそれを含有する皮膚外用剤 |
JP2004315492A (ja) * | 2003-04-18 | 2004-11-11 | Koei Kogyo Kk | 抗老化化粧料 |
JP2004315491A (ja) * | 2003-04-18 | 2004-11-11 | Koei Kogyo Kk | 皮膚外用剤 |
JP2005206474A (ja) * | 2004-01-20 | 2005-08-04 | Shiseido Co Ltd | 頭皮頭髪用組成物 |
JP2006028143A (ja) * | 2004-07-21 | 2006-02-02 | Shiseido Co Ltd | Mitf遺伝子発現促進物質 |
JP2006241102A (ja) * | 2005-03-04 | 2006-09-14 | Kanebo Cosmetics Inc | Scf遊離抑制剤及び皮膚外用組成物 |
JP2006257060A (ja) * | 2005-03-15 | 2006-09-28 | Koei Kogyo Kk | テストステロン5α−レダクターゼ阻害剤及びそれを配合した頭髪用剤及び皮膚外用剤。 |
JP4589799B2 (ja) * | 2005-04-26 | 2010-12-01 | 花王株式会社 | 育毛剤 |
JP2007320950A (ja) * | 2006-05-30 | 2007-12-13 | Koei Kogyo Kk | ヒアルロニダーゼ阻害剤及び皮膚外用剤組成物 |
JP2010195730A (ja) * | 2009-02-26 | 2010-09-09 | Kao Corp | ドーパオキシダーゼ活性促進剤およびメラニン産生促進剤 |
JP2012051916A (ja) * | 2011-10-14 | 2012-03-15 | Koei Kogyo Kk | α−グルコシダーゼ阻害剤 |
JP2016172723A (ja) * | 2015-03-16 | 2016-09-29 | 大正製薬株式会社 | 毛髪用剤 |
JP6655299B2 (ja) * | 2015-04-03 | 2020-02-26 | クラシエホームプロダクツ株式会社 | 毛髪化粧料組成物 |
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2017
- 2017-03-27 JP JP2017061437A patent/JP6829636B2/ja active Active
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