JP6643252B2 - ネブライザ - Google Patents
ネブライザ Download PDFInfo
- Publication number
- JP6643252B2 JP6643252B2 JP2016566222A JP2016566222A JP6643252B2 JP 6643252 B2 JP6643252 B2 JP 6643252B2 JP 2016566222 A JP2016566222 A JP 2016566222A JP 2016566222 A JP2016566222 A JP 2016566222A JP 6643252 B2 JP6643252 B2 JP 6643252B2
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- JP
- Japan
- Prior art keywords
- nebulizer
- locking
- container
- display device
- housing part
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006199 nebulizer Substances 0.000 title claims description 236
- 230000004913 activation Effects 0.000 claims description 122
- 230000000903 blocking effect Effects 0.000 claims description 64
- 239000012530 fluid Substances 0.000 claims description 42
- 230000005540 biological transmission Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 17
- 230000008569 process Effects 0.000 claims description 16
- 238000005507 spraying Methods 0.000 claims description 16
- 230000007246 mechanism Effects 0.000 claims description 9
- 238000007906 compression Methods 0.000 claims description 4
- 230000006835 compression Effects 0.000 claims description 4
- 238000006073 displacement reaction Methods 0.000 claims description 3
- 238000001994 activation Methods 0.000 description 121
- 230000037431 insertion Effects 0.000 description 38
- 238000003780 insertion Methods 0.000 description 38
- 239000000243 solution Substances 0.000 description 20
- 230000036961 partial effect Effects 0.000 description 15
- 238000005273 aeration Methods 0.000 description 9
- 239000000443 aerosol Substances 0.000 description 7
- 230000003213 activating effect Effects 0.000 description 6
- 239000003570 air Substances 0.000 description 6
- 239000011888 foil Substances 0.000 description 6
- 238000003825 pressing Methods 0.000 description 6
- 238000005553 drilling Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 230000001012 protector Effects 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 238000005452 bending Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000004146 energy storage Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
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- A61M15/0025—Mouthpieces therefor with caps
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- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
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- B05B11/108—Means for counting the number of dispensing strokes
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- G—PHYSICS
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- G06M3/02—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine
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- G06M3/00—Counters with additional facilities
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- G06M3/021—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine with drums type indicating means
- G06M3/022—Counters with additional facilities for performing an operation at a predetermined value of the count, e.g. arresting a machine with drums type indicating means by subtracting
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Biophysics (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Nozzles (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Closures For Containers (AREA)
- Cosmetics (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Description
1 ネブライザ
2 流体
3 容器
4 バッグ
5 圧力発生器
6 ホルダ
7 駆動バネ
8 阻止要素
9 搬送チューブ
10 逆止弁
11 圧力チャンバ
12 ノズル
13 マウスピース
14 エアロゾル
15 空気供給開口部
16 上側ハウジング部分
17 内側部分
17a 内側部分の上側部分
17b 内側部分の下側部分
18 ハウジング部分(下側部分)
19 保持要素
20 曝気バネ
21 容器ベース
22 穿孔要素
23 通気孔
24 ネブライザハウジング
25 表示デバイス
26 ロッキングデバイス
27 マウスピースカバー
28 ヘッド
29 容器ハウジング
30 容器縁部
31 表示器ハウジング
31a 窓
32 把持セクション
33 上側部分
34 下側部分
35 表示要素
36 起動要素
37 マーキング
38 起動アーム
39 起動部分
40 伝達部
41 歯車
42 ウォーム
43 歯
44 心棒セクション
45 軸受セクション
46 軸受部分
47 起動バネ
48 穿孔部分
49 穿孔先端
50 ホイル
51 窪み
52 駆動部分
53 底部
54 挿入開口部
55 支持構造
56 可撓性アーム
57 溝
58 ラチェット
59 面
60 突起
61 阻止部分
62 制御部分
63 制御部
64 保持ノーズ
65 保持凹部
66 ロッキング要素
67 ロッキングバネ
68 ポケット
69 係合部分
70 カバー
71 アクチュエータ
72 摺動ガイド
73 ベース部分
74 保護体
75 溝
76 突起
77 ロッキング部材
78 傾斜面
79 制御面
80 傾斜部分
81 制御部分
82 カウンター部分
83 軸受面
Claims (24)
- 流体(2)のためのネブライザ(1)であって、
前記流体(2)を収容する容器(3)を有し、該容器(3)は、別の容器(3)と取替可能であり、
搬送要素、圧力チャンバ(11)及びノズル(12)を備える、前記流体(2)を搬送及び噴霧するための送出機構を有し、前記ネブライザ(1)の引張工程において、前記容器(3)は軸線方向に下向きに移動し、流体(2)は前記搬送要素によって前記容器(3)から出て前記圧力チャンバ(11)に入るように搬送され、噴霧工程において前記容器(3)は軸線方向に上向きに移動し、前記圧力チャンバ(11)中の前記流体(2)は加圧され、前記ノズル(12)を通じて小出しされ、
前記容器(3)を用いて実施されたか又は依然として可能な使用回数を計数し、及び/又は示すための表示デバイス(25)を有し、該表示デバイス(25)は前記容器(3)に固定され又は前記容器(3)に配置され、そして該表示デバイス(25)は、前記引張工程の間及び前記噴霧工程の間、前記ネブライザ(1)内で前記容器(3)と共に軸線方向に移動可能であり、該表示デバイス(25)は表示要素(35)及び、前記表示デバイス(25)の軸線方向の移動に応じて前記表示要素(35)の回転送りを起動する起動要素(36)及び、前記表示要素(35)を回転送りするための伝達部(40)を備え、
現在の容器(3)を用いて予め決められた使用回数が到達されたか又は超過された後にのみ前記ネブライザ(1)の更なる使用を阻止するようになったロッキングデバイス(26)と、
を含み、
前記ネブライザ(1)が、前記ネブライザ(1)の上側ハウジング部分(16)に対する下側ハウジング部分(18)の回転によって引張状態になり、この回転は、前記ネブライザ(1)の前記引張工程を完了するために必要な全回転角度の回転を含み、
前記ロッキングデバイス(26)は、前記回転を前記全回転角度の後半の中間回転位置で阻止するようになっている、
ことを特徴とするネブライザ(1)。 - 前記ロッキングデバイス(26)は、ロッキング位置と非ロッキング位置との間で移動可能なロッキング要素(66)を含み、
前記ロッキングデバイス(26)は、前記ロッキング要素(66)が前記ロッキング位置にあるとき、前記ネブライザ(1)の更なる使用を阻止し、前記前記ロッキング要素(66)が前記非ロッキング位置にあるとき、前記ネブライザ(1)の更なる使用を阻止しないことを特徴とする請求項1に記載のネブライザ(1)。 - 前記ロッキング位置において、前記ロッキング要素(66)は、前記上側ハウジング部分(16)と形状適合により軸線方向に係合して、前記下側ハウジング部分(18)と前記上側ハウジング部分(16)との間の相対回転を阻止することを特徴とする請求項2に記載のネブライザ(1)。
- 前記ロッキング位置において、前記ロッキング要素(66)は、複数の係合部分(69)によって、前記上側ハウジング部分(16)に形成されたそれぞれのポケット(68)内へ係合して、前記下側ハウジング部分(18)と前記上側ハウジング部分(16)との間の相対回転を阻止することを特徴とする請求項2又は請求項3に記載のネブライザ(1)。
- 前記ロッキングデバイス(26)は、前記ロッキング要素(66)を前記ロッキング位置へと付勢するロッキングバネ(67)を備えることを特徴とする請求項2又は請求項3又は請求項4に記載のネブライザ(1)。
- 前記下側ハウジング部分(18)は、前記容器(3)を取り替えるために前記ネブライザ(1)の他の部分から取り外し可能であり、前記ロッキングバネ(67)は、前記下側ハウジング部分(18)の前記上側ハウジング部分(16)から離れる軸線方向の変位時に、前記ロッキング要素(66)が少なくとも前記次の引張工程中に前記ロッキング位置内に移動するように、前記ロッキング要素(66)を前記ロッキング位置へ付勢することを特徴とする請求項5に記載のネブライザ(1)。
- 前記ネブライザ(1)は、前記下側ハウジング部分(18)が解除可能に取り付けられる内側部分(17)を備え、前記下側ハウジング部分(18)は、前記容器(3)を取り替えるために前記内側部分(17)から取り外し可能であり、前記下側ハウジング部分(18)が前記内側部分(17)に取り付けられたとき前記下側ハウジング部分(18)は前記内側部分(17)を取り囲み、前記下側ハウジング部分(18)が前記上側ハウジング部分(16)に対して回転させられると前記内側部分(17)は前記下側ハウジング部分(18)と共に回転するようにし、
前記ロッキング位置において、前記ロッキング要素(66)は、前記ネブライザ(1)の前記上側ハウジング部分(16)に対する前記ネブライザ(1)の前記内側部分(17)の回転を阻止することを特徴とする請求項2から請求項5のいずれか1項に記載のネブライザ(1)。 - 前記ロッキングデバイス(26)は、前記ネブライザ(1)の前記内側部分(17)の円周上に配置された複数のロッキング要素(66)を備え、前記ロッキング要素(66)は、複数のロッキングバネ(67)によって前記ロッキング位置へ同時に付勢されることを特徴とする請求項7に記載のネブライザ(1)。
- 前記ロッキングバネ(67)は、螺旋バネであることを特徴とする請求項5、請求項6、又は請求項7が請求項5又は請求項6を引用するときの請求項8に記載のネブライザ(1)。
- 前記ロッキングバネ(67)は、リーフバネであることを特徴とする請求項5、請求項6、又は請求項7が請求項5又は請求項6を引用するときの請求項8に記載のネブライザ(1)。
- 前記ロッキングバネ(67)は、圧縮バネであることを特徴とする請求項5、請求項6、又は請求項7が請求項5又は請求項6を引用するときの請求項8に記載のネブライザ(1)。
- 前記ロッキングバネ(67)は、前記ネブライザ(1)の前記上側ハウジング(16)内に配置されていることを特徴とする、請求項5、請求項6、及び請求項7が請求項5又は請求項6を引用するときの請求項8、及び請求項9、請求項10、請求項11のいずれか1項に記載のネブライザ(1)。
- 前記ロッキング要素(66)及び前記ロッキングバネ(67)は、別々の部品によって形成されることを特徴とする、請求項5、請求項6、及び請求項7が請求項5又は請求項6を引用するときの請求項8、及び請求項9、請求項10、請求項11、請求項12のいずれか1項に記載のネブライザ(1)。
- 前記ロッキング要素(66)は、1つの剛性部品によって形成されることを特徴とする請求項2から請求項13のいずれか1項に記載のネブライザ(1)。
- 前記ロッキング要素(66)は、半径方向にのみ移動可能であることを特徴とする請求項4または、請求項4に従属する請求項5から請求項14のいずれか1項に記載のネブライザ(1)。
- 前記ロッキング要素(66)は、本質的又は単に軸線方向に移動可能であることを特徴とする請求項2から請求項14のいずれか1項に記載のネブライザ(1)。
- 前記ロッキングデバイス(26)は、少なくとも1つの傾斜面(78)を有する軸線方向に移動可能なロッキング部材(77)を含み、前記ロッキング部材(77)は、前記ロッキング要素(66)を前記ロッキング位置に半径方向に移動させるために、前記少なくとも1つの傾斜面(78)を通じて前記ロッキング要素(66)と相互作用することを特徴とする請求項2から請求項15のいずれか1項に記載のネブライザ(1)。
- 前記ロッキング要素(66)は、摺動ブロックとして形成されることを特徴とする請求項2から請求項15および請求項17のいずれか1項に記載のネブライザ(1)。
- 前記ネブライザ(1)の現在の容器(3)が新しい容器(3)に取り替えられた後に該ネブライザが使用可能となるように前記回転の阻止を解除するために、前記ロッキング要素(66)は、前記ロッキング位置から前記非ロッキング位置に復帰できることを特徴とする請求項2から請求項18のいずれか1項に記載のネブライザ(1)。
- 前記表示デバイス(25)は、各容器(3)を用いて予め決められた使用回数が到達されたか又は超過された時にのみ、前記ロッキングデバイス(26)に前記ネブライザ(1)を更なる使用からロックするようにさせ、
前記容器(3)を取り替えるために、前記ネブライザ(1)の他の部分から取り外し可能な前記下側ハウジング部分(18)は、前記予め決められた使用回数分使用されたことを示す前記表示デバイス(25)を有する各容器(3)が新しいか又はリセットされた表示デバイス(25)を有する新しい容器(3)と取り替えられた後に、前記ロッキングデバイス(26)が自動的に解除されるように、前記ネブライザ(1)の内側部分(17)に完全に取り付けることができることを特徴とする請求項1から請求項19のいずれか1項に記載のネブライザ(1)。 - 前記下側ハウジング部分(18)は、前記下側ハウジング部分(18)が前記ネブライザ(1)の内側部分(17)に完全に取り付けられたときに、前記ロッキング要素(66)を前記非ロッキング位置へ軸線方向に押し込む、軸線方向に延びるアクチュエータ(71)を含むことを特徴とする請求項16に記載のネブライザ(1)。
- 前記容器(3)が取り替えられた後、前記下側ハウジング部分(18)が、前記ネブライザ(1)の内側部分(17)に完全に取り付けられたときにのみ、前記ロッキング要素(66)はその非ロッキング位置に移動して、新しい容器(3)で該ネブライザ(1)を使用できるようにすることを特徴とする請求項20に記載のネブライザ(1)。
- 前記容器(3)を用いて予め決められた使用回数に到達されたとき、前記表示デバイス(25)はロック状態にあり、前記表示デバイス(25)は阻止部分(61)を備え、前記ロック状態にある前記表示デバイス(25)のために、前記ネブライザ(1)中の前記容器(3)の軸線方向可動性が前記阻止部分(61)によって制限され、これにより、引張工程の間の前記容器(3)の移動によって軸線方向力をもたらし、この軸線方向力によって、前記ロック状態での軸線方向の更なる引張移動中に、前記下側ハウジング部分(18)が下向きに又は前記上側ハウジング部分(18)から離れるように動かされることを特徴とする請求項1から請求項22のいずれか1項に記載のネブライザ(1)。
- 前記下側ハウジング部分(18)の前記ネブライザ(1)の内側部分(17)に対する完全な取り付けは、前記表示デバイス(25)が前記ロック状態にある時は可能ではないことを特徴とする請求項23に記載のネブライザ(1)。
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