JP6251682B2 - メラノーマ治療の治療の組み合わせ及び方法 - Google Patents
メラノーマ治療の治療の組み合わせ及び方法 Download PDFInfo
- Publication number
- JP6251682B2 JP6251682B2 JP2014538892A JP2014538892A JP6251682B2 JP 6251682 B2 JP6251682 B2 JP 6251682B2 JP 2014538892 A JP2014538892 A JP 2014538892A JP 2014538892 A JP2014538892 A JP 2014538892A JP 6251682 B2 JP6251682 B2 JP 6251682B2
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- etbr
- mpk
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552893P | 2011-10-28 | 2011-10-28 | |
| US61/552,893 | 2011-10-28 | ||
| US201261678978P | 2012-08-02 | 2012-08-02 | |
| US61/678,978 | 2012-08-02 | ||
| PCT/US2012/061533 WO2013063001A1 (fr) | 2011-10-28 | 2012-10-24 | Associations thérapeutiques et méthodes de traitement du mélanome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017161010A Division JP2018027948A (ja) | 2011-10-28 | 2017-08-24 | メラノーマ治療の治療の組み合わせ及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532648A JP2014532648A (ja) | 2014-12-08 |
| JP2014532648A5 JP2014532648A5 (fr) | 2015-12-17 |
| JP6251682B2 true JP6251682B2 (ja) | 2017-12-20 |
Family
ID=48168400
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538892A Expired - Fee Related JP6251682B2 (ja) | 2011-10-28 | 2012-10-24 | メラノーマ治療の治療の組み合わせ及び方法 |
| JP2017161010A Withdrawn JP2018027948A (ja) | 2011-10-28 | 2017-08-24 | メラノーマ治療の治療の組み合わせ及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017161010A Withdrawn JP2018027948A (ja) | 2011-10-28 | 2017-08-24 | メラノーマ治療の治療の組み合わせ及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2776051A4 (fr) |
| JP (2) | JP6251682B2 (fr) |
| KR (1) | KR20140097205A (fr) |
| CN (1) | CN104039340B (fr) |
| AR (1) | AR088509A1 (fr) |
| AU (1) | AU2012328980A1 (fr) |
| BR (1) | BR112014009953A2 (fr) |
| CA (1) | CA2850034A1 (fr) |
| CL (1) | CL2014001092A1 (fr) |
| CO (1) | CO7151543A2 (fr) |
| EA (1) | EA201490879A1 (fr) |
| IL (1) | IL232135A0 (fr) |
| IN (1) | IN2014CN03062A (fr) |
| MX (1) | MX2014004991A (fr) |
| PE (1) | PE20142312A1 (fr) |
| SG (1) | SG11201401815XA (fr) |
| TW (1) | TW201325613A (fr) |
| WO (1) | WO2013063001A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY193562A (en) | 2011-08-01 | 2022-10-19 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| US9216170B2 (en) | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
| PL3169361T3 (pl) | 2014-07-15 | 2019-11-29 | Hoffmann La Roche | Kompozycje do leczenia nowotworu z użyciem związków antagonistycznych wiązania osi pd-1 i inhibitorów mek |
| KR20170058432A (ko) | 2014-10-10 | 2017-05-26 | 화이자 인코포레이티드 | 상승 효과적 아우리스타틴 조합 |
| WO2017024032A2 (fr) * | 2015-08-03 | 2017-02-09 | Enb Therapeutics, Llc | Compositions et procédés pour traiter des cancers associés à l'activation d'etbr |
| FR3053042B1 (fr) | 2016-06-24 | 2018-08-10 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Anticorps dirige contre le sous-type b des recepteurs aux endothelines et ses utilisations |
| NZ755835A (en) | 2017-01-17 | 2023-12-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
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2012
- 2012-10-24 WO PCT/US2012/061533 patent/WO2013063001A1/fr active Application Filing
- 2012-10-24 EP EP12842985.9A patent/EP2776051A4/fr not_active Withdrawn
- 2012-10-24 BR BR112014009953A patent/BR112014009953A2/pt not_active IP Right Cessation
- 2012-10-24 KR KR1020147013878A patent/KR20140097205A/ko not_active Application Discontinuation
- 2012-10-24 CA CA2850034A patent/CA2850034A1/fr not_active Abandoned
- 2012-10-24 SG SG11201401815XA patent/SG11201401815XA/en unknown
- 2012-10-24 IN IN3062CHN2014 patent/IN2014CN03062A/en unknown
- 2012-10-24 PE PE2014000603A patent/PE20142312A1/es not_active Application Discontinuation
- 2012-10-24 EA EA201490879A patent/EA201490879A1/ru unknown
- 2012-10-24 AR ARP120103974A patent/AR088509A1/es unknown
- 2012-10-24 AU AU2012328980A patent/AU2012328980A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2018027948A (ja) | 2018-02-22 |
| CO7151543A2 (es) | 2014-12-29 |
| CN104039340B (zh) | 2017-04-05 |
| IL232135A0 (en) | 2014-05-28 |
| CN104039340A (zh) | 2014-09-10 |
| CL2014001092A1 (es) | 2014-07-25 |
| MX2014004991A (es) | 2014-05-22 |
| PE20142312A1 (es) | 2015-01-25 |
| EP2776051A4 (fr) | 2015-06-17 |
| SG11201401815XA (en) | 2014-05-29 |
| JP2014532648A (ja) | 2014-12-08 |
| EA201490879A1 (ru) | 2014-08-29 |
| BR112014009953A2 (pt) | 2017-12-05 |
| CA2850034A1 (fr) | 2013-05-02 |
| IN2014CN03062A (fr) | 2015-07-31 |
| EP2776051A1 (fr) | 2014-09-17 |
| WO2013063001A1 (fr) | 2013-05-02 |
| AR088509A1 (es) | 2014-06-11 |
| TW201325613A (zh) | 2013-07-01 |
| KR20140097205A (ko) | 2014-08-06 |
| AU2012328980A1 (en) | 2014-04-24 |
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