JP5765820B2 - 乱用防止制御放出オピオイド投薬形態 - Google Patents
乱用防止制御放出オピオイド投薬形態 Download PDFInfo
- Publication number
- JP5765820B2 JP5765820B2 JP2012204455A JP2012204455A JP5765820B2 JP 5765820 B2 JP5765820 B2 JP 5765820B2 JP 2012204455 A JP2012204455 A JP 2012204455A JP 2012204455 A JP2012204455 A JP 2012204455A JP 5765820 B2 JP5765820 B2 JP 5765820B2
- Authority
- JP
- Japan
- Prior art keywords
- opioid
- naloxone
- pharmaceutical composition
- oxycodone
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Air Bags (AREA)
Description
本発明は、制御放出される鎮痛性薬学的処方物に関する。より詳細には、本発明は、乱用を抑止する制御放出された鎮痛性錠剤に関する。
オピオイド化合物は、長い間、それらの強力な鎮痛特性と、それらの乱用についての高い可能性との両方について知られてきた。疼痛の制御には非常に効果的であるが、オピオイドはまた、依存性でもあり得る。オピオイド(特に、ヘロインだが、モルフィン、コデイン、オキシコドン、ヒドロモルフォン、オキシモルフォンなども含む)の乱用は、現代社会における問題である。オピオイド常用者は、種々の違法な供給源から薬物を得ることができる。これらのストリートドラッグは、疑わしい品質のものである。従って、潜在的乱用者にとって、処方された薬学的オピオイドは、特に、それらの高い純度および信頼性の有る投薬量に起因して、薬物供給源として魅力的であり得る。
乱用防止制御放出オピオイド錠剤は、高い経口:非経口の効力比(すなわち経口:非経口>1)を有するオピオイドアンタゴニスト(例えば、ナロキソン)を、長期にわたり投与された制御放出処方物においては、オピオイドの効果をブロックするのにも、オピオイドの副作用を弱めるのにも不充分なレベルであるが、全てを一度に投与された場合、そのオピオイドの陶酔効果を抑制するのに必要とされるより高いレベルで含む、組み合わせである。組み合わせ錠剤が破壊されて、制御放出特性が崩壊した場合、オピオイドおよびオピオイドアンタゴニストは、1用量の即時放出産物として放出され、そしてこのアンタゴニストは、このアゴニストの陶酔効果をブロックする。このオピオイドアンタゴニストは、制御放出マトリクス中に含まれ、そして経時的に、このオピオイドアゴニストと共に放出される。
上記に加えて、本発明は、以下の手段を提供する:
(項目1)
経口用薬学的組成物であって、該薬学的組成物は、以下:
制御放出マトリクス;
オピオイドアゴニスト;
オピオイドアンタゴニスト、
を含み、
該オピオイドアンタゴニストは、非経口投与されたときに、経口投与されたときより高い拮抗効果を有し;
ここで、該オピオイドアンタゴニストは、該制御放出マトリクスが破壊されて、該組成物が即時放出のために不適切に投与された場合に、オピオイドの効果をブロックし、そして/または使用中止を誘導するのに、有効な経口量で該組成物中に存在し;
ここで、アンタゴニストレベルが、適切な経口投与レジメの下では、阻害性レセプターおよび興奮性レセプターの両方をブロックすることによりオピオイドの効果をブロックするにも、該興奮性レセプターを選択的にブロックすることによりオピオイドの副作用を弱めるにも有効でないように、該制御放出マトリクスが、該オピオイドアンタゴニストの放出速度を制御するように選択され、そして組み込まれている、経口用薬学的組成物。
(項目2)
前記オピオイドアンタゴニストの放出速度が、前記オピオイドアゴニストの放出速度の約100%〜約25%である、項目1に記載の薬学的組成物。
(項目3)
前記オピオイドアンタゴニストの放出速度が、前記オピオイドアゴニストの放出速度の約100%である、項目1に記載の薬学的組成物。
(項目4)
前記オピオイドアンタゴニストの放出速度が、前記オピオイドアゴニストの放出速度の約50%である、項目1に記載の薬学的組成物。
(項目5)
前記オピオイドアンタゴニストの放出速度が、前記オピオイドアゴニストの放出速度の約25%である、項目1に記載の薬学的組成物。
(項目6)
前記オピオイドアンタゴニストの経口:非経口の効力比が、少なくとも約10:1である、項目1に記載の薬学的組成物。
(項目7)
前記オピオイドアンタゴニストの経口:非経口の効力比が、少なくとも約25:1である、項目1に記載の薬学的組成物。
(項目8)
前記オピオイドアンタゴニストの経口:非経口の効力比が、少なくとも約100:1である、項目1に記載の薬学的組成物。
(項目9)
項目1に記載の薬学的組成物であって、前記オピオイドアゴニストが、モルフィン、オキシコドン、レボルフェノール、メペルジン、ヒドロコドン、コデイン、ジヒドロコデイン、ヒドロモルフォン、プロポキシフェン、メタドン、およびオキシモルフォンからなる群より選択される、薬学的組成物。
(項目10)
項目1に記載の薬学的組成物であって、前記オピオイドアンタゴニストが、ナロキソン;ナルトレキソン;N−シクロプロピルメチル−7,8−ジヒドロ−14−ヒドロキシノルモルフィノン;および21−シクロプロピルz,−(1−ヒドロキシ−1−メチルエチル)−6,14−エンド−エタノ−テトラヒドロオリパビン(またはジフェノルフィン)およびそれらの薬学的に受容可能な塩からなる群より選択される、薬学的組成物。
(項目11)
前記オピオイドアンタゴニストが、ナロキソンである、項目1に記載の薬学的組成物。
(項目12)
前記オピオイドアゴニストが、オキシコドンである、項目1に記載の薬学的組成物。
(項目13)
前記オピオイドアゴニストが、約10mg〜160mgのオキシコドン用量と薬学的に等価な濃度で存在する、項目1に記載の薬学的組成物。
(項目14)
項目1に記載の薬学的組成物であって、前記アンタゴニストの前記放出速度が、1用量の該組成物では、経口有効量のアンタゴニストを利用可能にしないが、2以上の用量の該組成物が、破壊されてかまたは破壊されずに組み合わせられて、乱用用量の前記オピオイドアゴニストを達成する場合、該オピオイドアンタゴニストが、経口有効ブロックレベルで利用可能である速度である、薬学的組成物。
(項目15)
薬学的組成物であって、以下:
制御放出マトリクス;
オピオイドアゴニスト;
オピオイドアンタゴニスト、
を含み、
該オピオイドアンタゴニストは、非経口投与されたときに、経口投与されたときより高い拮抗効果を有し;
ここで、該オピオイドアンタゴニストは、該制御放出マトリクスが破壊され、2以上の用量の該組成物が組み合わせられて乱用用量の該オピオイドアゴニストをもたらす場合、オピオイドアンタゴニストの量が、経口で服用された際に、該オピオイドの効果をブロックし、そして/または使用中止を誘導するのに十分であるように該組成物中の該オピオイドアゴニストの乱用用量数に比例した量で該組成物中に存在し;
ここで、アンタゴニストレベルが、適切な経口投与レジメの下で、阻害性レセプターおよび興奮性レセプターをブロックすることにより該オピオイドの作用をブロックするにも、興奮性レセプターを選択的にブロックすることによりオピオイドの副作用を弱めるにも、有効でないように、該制御放出マトリクスは、該オピオイドアンタゴニストの放出速度
を制御するために選択され、そして組み込まれる、薬学的組成物。
(項目16)
項目15に記載の薬学的組成物であって、前記アンタゴニストの前記放出速度は、1用量の該組成物では、経口有効量のアンタゴニストを利用可能にしないが、2以上の用量の該組成物が、破壊されてかまたは破壊されずに組み合わせられて、前記オピオイドアゴニストの乱用用量を可能にする際に、該オピオイドアンタゴニストは、経口で有効なブロックレベルで利用可能である速度である、薬学的組成物。
(項目17)
経口用薬学的組成物であって、該薬学的組成物は、以下:
制御放出マトリクス;
約10mg〜160mgのオキシコドン;
約2mg〜160mgのナロキソン、
を含み、
ここで、オキシコドンのナロキソンに対する比率は、約4〜5:1から1:1であり;
ここで該制御放出マトリクスは、12時間までの期間にわたり薬学的有効性を維持するようにオキシコドンの放出速度を制御するため、およびナロキソンレベルが、適切な経口投与レジメの下で、阻害レセプターおよび興奮性レセプターの両方をブロックすることにより該オピオイドの効果をブロックするにも、興奮性レセプターを選択的にブロックすることによりオピオイド副作用を弱めるにも有効でないように、該ナロキソンの放出速度を制御するために選択されそして組み込まれている、薬学的組成物。
(項目18)
経口用薬学的組成物であって、該経口用薬学的組成物は、重量%で以下:
約3〜35%のオピオイドアゴニスト;
約2〜20%のオピオイドアンタゴニスト;
約10〜50%の微結晶セルロース(NF);
約30〜70%のアンモニオメタクリレートコポリマー(NF);および
少なくとも1つの賦形剤を含み、
該少なくとも1つの賦形剤は、以下:
約5%までのコロイド状二酸化ケイ素(NF);
約5%までのラウリル硫酸ナトリウム(NF);
約2%までの水酸化マグネシウム(USP);
約15%までのポビドン(USP);
約5%までのステアリン酸、NF;および
約5%までのステアリン酸マグネシウム、NF、
からなる群より選択され、ここで該制御放出組成物は、インタクトな形態で経口服用された場合、治療有効速度で該オキシコドンを放出し、かつ該オピオイドの効果をブロックし、そして/または使用中止を誘導するのに有効でない速度で該ナロキソンを放出するように適合させた制御放出処方物である、経口用薬学的組成物。
(項目19)
項目18に記載の経口用薬学的組成物であって、前記オピオイドアゴニストが、モルフィン、オキシコドン、レボルフェノール、メペルジン、ヒドロコドン、コデイン、ジヒドロコデイン、ヒドロモルフィン、プロポキシフェン、メタドン、およびオキシモルフォンからなる群より選択され、そして前記オピオイドアンタゴニストが、ナロキソン;ナルトレキソン;N−シクロプロピルメチル−7,8−ジヒドロ−14−ヒドロキシノルモルフィノン;および21−シクロプロピルz,−(1−ヒドロキシ−1−メチルエチル)−6,14−エンド−エタノ−テトラヒドロオリパビン(またはジフェノルフィン)およびそれらの薬学的に受容可能な塩からなる群より選択される、経口用薬学的組成物。
(項目20)
前記オピオイドアゴニストが、塩酸オキシコドンであり、かつ前記オピオイドアンタゴニストがナロキソンである、項目18に記載の経口用薬学的組成物。
本発明は、特定のオピオイドアンタゴニストが経口での低用量では効果的でないという原理を使用する。従って、オピオイドの作用に有害な影響を与えることなく、経口有効量の大量のアンタゴニストを含む錠剤から長期間にわたり経口低用量を投与し得る(制御放出)。しかし、アンタゴニストが一度に全て投与される場合、それは、オピオイドの効果をブロックし、そして依存症の個体における使用中止を誘導し得る。
Claims (25)
- 制御放出マトリクスを含む経口用制御放出薬学的組成物であって、該制御放出マトリクスは、以下:
10mg〜160mgのオキシコドン;および
2mg〜160mgのナロキソン、
を含み、
ここで、該オキシコドンおよび該ナロキソンは、5:1から1:1の比率で存在し;
ここで、該制御放出マトリクスは、10時間にわたり該ナロキソンの90%より多くが該組成物から放出されるように、該ナロキソンおよび該オキシコドンを放出する、薬学的組成物。 - 前記オキシコドンは、10〜80mgの量で存在する、請求項1に記載の薬学的組成物。
- 前記オキシコドンは、10〜40mgの量で存在する、請求項1〜2のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンは、10mgの量で存在し、そして前記ナロキソンは2〜10mgの量で存在する、請求項1〜3のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンは20mgの量で存在し、前記ナロキソンは5〜20mgの量で存在する、請求項1〜3のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンは40mgの量で存在し、前記ナロキソンは8〜40mgの量で存在する、請求項1〜3のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンは80mgの量で存在し、前記ナロキソンは16〜80mgの量で存在する、請求項1〜2のいずれか1項に記載の薬学的組成物。
- 前記ナロキソンは2〜40mgの量で存在する、請求項1〜3のいずれか1項に記載の薬学的組成物。
- 前記ナロキソンは5〜20mgの量で存在する、請求項1〜3または8のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンは、オキシコドン塩酸塩の形態である、請求項1〜9のいずれか1項に記載の薬学的組成物。
- 前記ナロキソンは、薬学的に受容可能なその塩の形態である、請求項1〜10のいずれか1項に記載の薬学的組成物。
- 前記ナロキソンの放出速度が、前記オキシコドンの放出速度の100%〜25%である、請求項1〜11のいずれか1項に記載の薬学的組成物。
- 前記ナロキソンの放出速度が、前記オキシコドンの放出速度の100%である、請求項1〜12のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンの20〜30%が、1時間にわたり前記組成物から放出される、請求項1〜13のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンの60〜70%が、4時間にわたり前記組成物から放出される、請求項1〜14のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンの90%より多くが、10時間にわたり前記組成物から放出される、請求項1〜15のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンおよび前記ナロキソンが、4時間より多くの期間にわたり放出される、請求項1〜16のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンおよび前記ナロキソンが、8〜12時間の期間にわたり放出される、請求項1〜17のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンおよび前記ナロキソンが、24時間の期間にわたり放出される、請求項1〜17のいずれか1項に記載の薬学的組成物。
- 前記オキシコドンおよび前記ナロキソンが、4:1〜1:1の比率で存在する、請求項1〜19のいずれか1項に記載の薬学的組成物。
- 制御放出マトリクスを含む経口用制御放出薬学的組成物であって、該制御放出マトリクスは、以下:
10mg〜80mgのオキシコドン塩酸塩;および
2mg〜40mgのナロキソンの薬学的に受容可能な塩、
を含み、
ここで、該オキシコドン塩酸塩および該ナロキソンの薬学的に受容可能な塩に対する比率は、4:1から1:1であり;
ここで該制御放出マトリクスは、10時間にわたり該ナロキソンの薬学的に受容可能な塩の90%より多くが該組成物から放出されるように、該ナロキソンの薬学的に受容可能な塩および該オキシコドン塩酸塩を放出し、
該ナロキソンの薬学的に受容可能な塩の放出速度が、該オキシコドン塩酸塩の放出速度の100%〜25%である、薬学的組成物。 - 前記薬学的に受容可能な組成物は、錠剤の形態である、請求項1〜21のいずれか1項に記載の薬学的組成物。
- 前記ナロキソンまたは薬学的に受容可能なその塩は、前記薬学的組成物が、インタクト形態で経口摂取される場合、退薬症状を誘導するのに有効ではない速度で放出される、請求項1〜22のいずれか1項に記載の薬学的組成物。
- 疼痛を処置するための医薬の製造における、請求項1〜23のいずれか1項に記載の組成物の使用。
- 疼痛の処置において使用するために、請求項1〜23のいずれか1項に記載の組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29043901P | 2001-05-11 | 2001-05-11 | |
US60/290,439 | 2001-05-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009017380A Division JP2009102405A (ja) | 2001-05-11 | 2009-01-28 | 乱用防止制御放出オピオイド投薬形態 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014125979A Division JP5977784B2 (ja) | 2001-05-11 | 2014-06-19 | 乱用防止制御放出オピオイド投薬形態 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012246319A JP2012246319A (ja) | 2012-12-13 |
JP5765820B2 true JP5765820B2 (ja) | 2015-08-19 |
Family
ID=23116001
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002588978A Expired - Lifetime JP4522652B2 (ja) | 2001-05-11 | 2002-05-10 | 乱用防止制御放出オピオイド投薬形態 |
JP2009017380A Pending JP2009102405A (ja) | 2001-05-11 | 2009-01-28 | 乱用防止制御放出オピオイド投薬形態 |
JP2012204455A Expired - Lifetime JP5765820B2 (ja) | 2001-05-11 | 2012-09-18 | 乱用防止制御放出オピオイド投薬形態 |
JP2014125979A Expired - Lifetime JP5977784B2 (ja) | 2001-05-11 | 2014-06-19 | 乱用防止制御放出オピオイド投薬形態 |
JP2015110130A Expired - Lifetime JP6203782B2 (ja) | 2001-05-11 | 2015-05-29 | 乱用防止制御放出オピオイド投薬形態 |
JP2016196952A Withdrawn JP2016222732A (ja) | 2001-05-11 | 2016-10-05 | 乱用防止制御放出オピオイド投薬形態 |
JP2018022019A Pending JP2018080209A (ja) | 2001-05-11 | 2018-02-09 | 乱用防止制御放出オピオイド投薬形態 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002588978A Expired - Lifetime JP4522652B2 (ja) | 2001-05-11 | 2002-05-10 | 乱用防止制御放出オピオイド投薬形態 |
JP2009017380A Pending JP2009102405A (ja) | 2001-05-11 | 2009-01-28 | 乱用防止制御放出オピオイド投薬形態 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014125979A Expired - Lifetime JP5977784B2 (ja) | 2001-05-11 | 2014-06-19 | 乱用防止制御放出オピオイド投薬形態 |
JP2015110130A Expired - Lifetime JP6203782B2 (ja) | 2001-05-11 | 2015-05-29 | 乱用防止制御放出オピオイド投薬形態 |
JP2016196952A Withdrawn JP2016222732A (ja) | 2001-05-11 | 2016-10-05 | 乱用防止制御放出オピオイド投薬形態 |
JP2018022019A Pending JP2018080209A (ja) | 2001-05-11 | 2018-02-09 | 乱用防止制御放出オピオイド投薬形態 |
Country Status (10)
Country | Link |
---|---|
US (20) | US20030065002A1 (ja) |
EP (1) | EP1387673B1 (ja) |
JP (7) | JP4522652B2 (ja) |
CN (1) | CN1525851A (ja) |
AT (1) | ATE493130T1 (ja) |
AU (2) | AU2002305559B2 (ja) |
CA (1) | CA2446550C (ja) |
DE (1) | DE60238756D1 (ja) |
ES (1) | ES2361148T3 (ja) |
WO (1) | WO2002092060A1 (ja) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
ES2412409T3 (es) | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
GEP20053614B (en) | 2000-02-08 | 2005-09-26 | Euro Celtique Sa | Compositions for Oral Administration Containing Opioid Agonist |
CA2446550C (en) | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20030004177A1 (en) * | 2001-05-11 | 2003-01-02 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
US8329216B2 (en) * | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
WO2003004030A1 (en) | 2001-07-06 | 2003-01-16 | Endo Pharmaceuticals, Inc. | Oxymorphone controlled release formulations |
BR0210855A (pt) * | 2001-07-06 | 2006-10-24 | Penwest Pharmaceuticals Compan | Método de fabricação de formulações de liberação prolongada |
WO2003007802A2 (en) * | 2001-07-18 | 2003-01-30 | Euro-Celtique, S.A. | Pharmaceutical combinations of oxycodone and naloxone |
JP2005523876A (ja) * | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | 乱用の可能性が低減したオピオイド製剤 |
PT2939696E (pt) | 2001-10-18 | 2016-06-17 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opióides |
CA2708900C (en) | 2002-04-05 | 2019-06-04 | Purdue Pharma | Pharmaceutical preparation containing oxycodone and naloxone |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DK1551372T3 (en) * | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES |
EP1551402A4 (en) * | 2002-09-23 | 2009-05-27 | Verion Inc | PHARMACEUTICAL COMPOSITIONS NOT INDUCING ABUSE |
US20040202717A1 (en) * | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
CL2004000927A1 (es) * | 2003-04-30 | 2005-01-28 | Purdue Pharma Lp | Forma de dosificacion transdermica que comprende un agente activo, una superficie proxima y una superficie distal. |
US7182955B2 (en) | 2003-04-30 | 2007-02-27 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
RS50817B (sr) | 2004-03-30 | 2010-08-31 | Euro-Celtique S.A. | Dozni oblik otporan na promene koji sadrži adsorbenti i sredstvo sa suprotnim dejstvom |
EP1604667A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome |
EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US7827983B2 (en) * | 2004-12-20 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Method for making a pharmaceutically active ingredient abuse-prevention device |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
GB0506982D0 (en) * | 2005-04-06 | 2005-05-11 | Mw Encap Ltd | Abuse resistant capsules |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
CN101330903B (zh) * | 2005-12-13 | 2015-07-08 | 生物递送科学国际公司 | 防滥用的经黏膜给药装置 |
EP1810678A1 (de) | 2006-01-19 | 2007-07-25 | Holger Lars Hermann | Verwendung einer Kombination von Morphin und Naloxon zur Drogensubstitution |
US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
US8916195B2 (en) * | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
EP2526932B1 (en) * | 2006-06-19 | 2017-06-07 | Alpharma Pharmaceuticals LLC | Pharmaceutical composition |
KR101230804B1 (ko) | 2006-07-21 | 2013-02-08 | 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 | 향상된 흡수를 갖는 경점막 전달 장치 |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
DE202006018609U1 (de) * | 2006-08-29 | 2007-05-16 | Euro-Celtique S.A. | Verwendung von Opioidformulierungen in nadellosen Vorrichtungen zur Medikamentenverabreichung |
EP1897543A1 (en) | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Buprenorphine- wafer for drug substitution therapy |
WO2008068471A1 (en) | 2006-12-04 | 2008-06-12 | Orexo Ab | New non-abusable pharmaceutical composition comprising opioids |
US20090124650A1 (en) * | 2007-06-21 | 2009-05-14 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol |
US20100151014A1 (en) * | 2008-12-16 | 2010-06-17 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
US8623418B2 (en) * | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
AU2008346870A1 (en) * | 2007-12-17 | 2009-07-16 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
RU2010129907A (ru) | 2007-12-17 | 2012-01-27 | Лабофарм Инк. (CA) | Лекарственная форма с контролируемым высвобождением, предотвращающая неправильное употребление |
CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
PE20110422A1 (es) * | 2008-07-07 | 2011-07-01 | Euro Celtique Sa | Composicion farmaceutica que comprende antagonistas opioides |
ES2414856T3 (es) * | 2008-12-12 | 2013-07-23 | Paladin Labs Inc. | Formulaciones de fármaco narcótico con potencial de adicción disminuido |
ES2509497T3 (es) | 2008-12-16 | 2014-10-17 | Paladin Labs Inc. | Formulación de liberación controlada para evitar un uso indebido |
WO2010078486A2 (en) | 2008-12-31 | 2010-07-08 | Upsher-Smith Laboratories, Inc. | Opioid-containing oral pharmaceutical compositions and methods |
PT2405915T (pt) | 2009-03-10 | 2019-01-29 | Euro Celtique Sa | Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona |
WO2010144865A2 (en) | 2009-06-12 | 2010-12-16 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
BR112012001466A2 (pt) | 2009-07-22 | 2020-08-11 | Grünenthal GmbH | forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem |
NZ596667A (en) | 2009-07-22 | 2013-09-27 | Gruenenthal Chemie | Hot-melt extruded controlled release dosage form |
CA2773521C (en) | 2009-09-17 | 2017-01-24 | Upsher-Smith Laboratories, Inc. | A sustained-release product comprising a combination of a non-opioid amine and a non-steroidal anti-inflammatory drug |
TWI605814B (zh) * | 2010-03-11 | 2017-11-21 | 惠氏有限責任公司 | 甲基拿淬松(methylnaltrexone)之口服製劑及親脂性鹽 |
JP5838199B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス.エイ. | 活性剤を含まない顆粒およびその顆粒を含む錠剤の製造 |
MX344846B (es) | 2010-05-10 | 2017-01-10 | Euro-Celtique S A * | Combinacion de granulos cargados activos con activos adicionales. |
SE1251371A1 (sv) | 2010-05-10 | 2012-12-27 | Euro Celtique Sa | Farmaceutiska kompositioner innefattande hydromorfon och naloxon |
CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
PE20131126A1 (es) | 2010-09-02 | 2013-10-21 | Gruenenthal Chemie | Forma de dosificacion resistente a alteracion que comprende un polimero anionico |
MX348054B (es) | 2011-07-29 | 2017-05-25 | Gruenenthal Gmbh | Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco. |
CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
EP3939569A1 (en) | 2011-09-19 | 2022-01-19 | Orexo AB | New abuse-resistant pharmaceutical composition for the treatment of opioid dependence |
MX349725B (es) * | 2011-11-17 | 2017-08-10 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica oral a prueba de manipulacion que comprende un agente antagonista y/o aversivo opioide, oxido de polialquileno y un polimero anionico. |
US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
EP2819656A1 (en) | 2012-02-28 | 2015-01-07 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
CA2868413C (en) | 2012-04-17 | 2021-07-20 | Purdue Pharma L.P. | Systems and methods for treating an opioid-induced adverse pharmacodynamic response |
SI2838512T1 (sl) | 2012-04-18 | 2018-11-30 | Gruenenthal Gmbh | Pred posegi in prehitrim sproščanjem odporna farmacevtska oblika odmerka |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
CA2877774C (en) | 2012-07-12 | 2017-07-18 | Mallinckrodt Llc | Extended release, abuse deterrent pharmaceutical compositions |
US10322120B2 (en) | 2012-07-31 | 2019-06-18 | Persion Pharmaceuticals Llc | Treating pain in patients with hepatic impairment |
US9675587B2 (en) * | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
CA2913209A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
EP3024461B1 (en) | 2013-07-23 | 2020-05-13 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
EA032013B1 (ru) * | 2013-10-31 | 2019-03-29 | Сайма Лэбс Инк. | Препятствующие злоупотреблению гранулированные лекарственные формы с немедленным высвобождением |
US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
DE112014005175T5 (de) | 2013-11-13 | 2016-07-21 | Euro-Celtique S.A. | Hydromorphon und Naloxon für die Behandlung von Schmerzen und Opioid-Darm-Dysfunktions-Syndrom |
BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
CN106572980A (zh) | 2014-05-12 | 2017-04-19 | 格吕伦塔尔有限公司 | 包含他喷他多的防篡改即释胶囊制剂 |
EP3148512A1 (en) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US9849124B2 (en) | 2014-10-17 | 2017-12-26 | Purdue Pharma L.P. | Systems and methods for treating an opioid-induced adverse pharmacodynamic response |
CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
EP3554548A4 (en) | 2016-12-19 | 2020-08-19 | The Regents of The University of California | NON-CRUSHABLE PILL FORMULATIONS |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
EP3965733A4 (en) | 2019-05-07 | 2023-01-11 | Clexio Biosciences Ltd. | ABUSE DETERRENT DOSAGE FORMS CONTAINING ESKETAMINE |
US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
Family Cites Families (269)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2770569A (en) | 1952-08-01 | 1956-11-13 | Hoffmann La Roche | Analgesic compositions |
US3173877A (en) | 1957-09-09 | 1965-03-16 | Wyandotte Chemicals Corp | Detergent compositions comprising inorganic esters of epoxyhydrocarbon polymers |
US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
NL271831A (ja) | 1960-11-29 | |||
US3493657A (en) | 1961-03-14 | 1970-02-03 | Mozes Juda Lewenstein | Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine |
US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
NL6714885A (ja) | 1967-11-02 | 1969-05-06 | ||
US3541006A (en) | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
US3541005A (en) | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
US3773955A (en) | 1970-08-03 | 1973-11-20 | Bristol Myers Co | Analgetic compositions |
US3879555A (en) | 1970-11-16 | 1975-04-22 | Bristol Myers Co | Method of treating drug addicts |
US3676557A (en) | 1971-03-02 | 1972-07-11 | Endo Lab | Long-acting narcotic antagonist formulations |
GB1390772A (en) | 1971-05-07 | 1975-04-16 | Endo Lab | Oral narcotic composition |
FR2183546B1 (ja) | 1972-05-10 | 1975-06-20 | Servier Lab | |
US3965256A (en) | 1972-05-16 | 1976-06-22 | Synergistics | Slow release pharmaceutical compositions |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US3916889A (en) | 1973-09-28 | 1975-11-04 | Sandoz Ag | Patient ventilator apparatus |
US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
US3966040A (en) | 1975-03-05 | 1976-06-29 | Hazelwood John E | Combined vibratory feeder drive unit, vibratory feeder bowl, and parts separator |
US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
US4126684A (en) | 1976-02-11 | 1978-11-21 | Ciba-Geigy Corporation | 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse |
US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
LU77339A1 (ja) * | 1977-05-16 | 1979-01-19 | ||
US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4237140A (en) | 1979-05-18 | 1980-12-02 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and acetaminophen |
US4293539A (en) | 1979-09-12 | 1981-10-06 | Eli Lilly And Company | Controlled release formulations and method of treatment |
IE49324B1 (en) | 1979-12-19 | 1985-09-18 | Euro Celtique Sa | Controlled release compositions |
US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
ZA82490B (en) * | 1981-02-12 | 1983-09-28 | Wyeth John & Brother Ltd | Treating shock |
US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
US4608376A (en) | 1981-10-16 | 1986-08-26 | Carolyn McGinnis | Opiate agonists and antagonists |
US4987136A (en) | 1982-03-16 | 1991-01-22 | The Rockefeller University | Method for controlling gastrointestinal dysmotility |
JPS59500418A (ja) | 1982-03-16 | 1984-03-15 | ザ ロツクフエラ− ユニバ−シテイ | 胃腸能動作用障害を回復する方法 |
US4443428A (en) | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
US4451470A (en) | 1982-07-06 | 1984-05-29 | E. I. Du Pont De Nemours And Company | Analgesic, antagonist, and/or anorectic 14-fluoromorphinans |
US4803208A (en) | 1982-09-30 | 1989-02-07 | Sloan-Kettering Institute For Cancer Research | Opiate agonists and antagonists |
GB8332556D0 (en) | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
US5266574A (en) | 1984-04-09 | 1993-11-30 | Ian S. Zagon | Growth regulation and related applications of opioid antagonists |
US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
DE3434946A1 (de) | 1984-09-22 | 1986-04-03 | Basf Ag, 6700 Ludwigshafen | Diarylacetylene, ihre herstellung und verwendung |
US4573995A (en) | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
GB8430346D0 (en) | 1984-11-30 | 1985-01-09 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
US4806341A (en) | 1985-02-25 | 1989-02-21 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration |
ZA861211B (en) | 1985-02-25 | 1987-10-28 | Lilly Co Eli | Analgesic composition |
GB8514665D0 (en) | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
FR2585246A1 (fr) | 1985-07-26 | 1987-01-30 | Cortial | Procede d'obtention de formes pharmaceutiques solides a liberation prolongee |
GB8521350D0 (en) | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
JPS63500799A (ja) | 1985-09-06 | 1988-03-24 | ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド | 持続性オピオイド拮抗作用を得るための方法および組成物 |
US4760069A (en) | 1985-09-23 | 1988-07-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
US4889860A (en) | 1985-09-23 | 1989-12-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
US4722928A (en) | 1985-12-02 | 1988-02-02 | E. I. Du Pont De Nemours And Company | N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes |
US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
US4719215A (en) | 1986-03-07 | 1988-01-12 | University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
US4861781A (en) | 1986-03-07 | 1989-08-29 | The University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
US5316759A (en) | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
GB8613689D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB8613688D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
DE3750145T2 (de) | 1986-06-10 | 1994-11-03 | Euro Celtique Sa | Zusammensetzung mit kontrollierter Freisetzung von Dihydrocodein. |
US4769372A (en) | 1986-06-18 | 1988-09-06 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
US4785000A (en) | 1986-06-18 | 1988-11-15 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
US4970075A (en) | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
US5356900A (en) | 1986-10-07 | 1994-10-18 | Bernard Bihari | Method of treating chronic herpes virus infections using an opiate receptor antagonist |
GB8626098D0 (en) | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
US4806543A (en) | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
GB8628728D0 (en) | 1986-12-02 | 1987-01-07 | Euro Celtique Sa | Spheroids |
GB8705083D0 (en) | 1987-03-04 | 1987-04-08 | Euro Celtique Sa | Spheroids |
GB8728294D0 (en) | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
DE3812567A1 (de) | 1988-04-15 | 1989-10-26 | Basf Ag | Verfahren zur herstellung pharmazeutischer mischungen |
US4873076A (en) | 1988-04-29 | 1989-10-10 | Baker Cummins Pharmaceuticals, Inc. | Method of safely providing anesthesia or conscious sedation |
GB8813064D0 (en) | 1988-06-02 | 1988-07-06 | Euro Celtique Sa | Controlled release dosage forms having defined water content |
US4882335A (en) | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
EP0352361A1 (en) | 1988-07-29 | 1990-01-31 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
US5236714A (en) | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
CA2002492A1 (en) | 1988-11-11 | 1990-05-11 | Sandra T. A. Malkowska | Pharmaceutical ion exchange resin composition |
US5102887A (en) | 1989-02-17 | 1992-04-07 | Arch Development Corporation | Method for reducing emesis and nausea induced by the administration of an emesis causing agent |
US5096715A (en) | 1989-11-20 | 1992-03-17 | Alko Ltd. | Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist |
US5075341A (en) | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for ***e abuse |
US5086058A (en) | 1990-06-04 | 1992-02-04 | Alko Ltd. | Method for treating alcoholism with nalmefene |
FR2669336B1 (fr) | 1990-11-20 | 1993-01-22 | Adir | Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
HU208633B (en) | 1991-02-04 | 1993-12-28 | Alkaloida Vegyeszeti Gyar | Process for production of analgetic compositions as applicable for blocking of opioid-binding spaces /2-receptors/ causing respiration depression |
US5486362A (en) | 1991-05-07 | 1996-01-23 | Dynagen, Inc. | Controlled, sustained release delivery system for treating drug dependency |
JP3178541B2 (ja) | 1991-05-29 | 2001-06-18 | キヤノン株式会社 | 画像処理方法及び装置 |
US5149538A (en) | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
KR100221695B1 (ko) | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
GB9117361D0 (en) | 1991-08-12 | 1991-09-25 | Euro Celtique Sa | Oral dosage form |
DK0566709T5 (da) | 1991-09-06 | 2009-05-18 | Ortho Mcneil Janssen Pharm | Præparat indeholdende et tramadolmateriale og acetaminophen og anvendelse deraf |
US5215758A (en) | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
US5225440A (en) | 1991-09-13 | 1993-07-06 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase |
US5656295A (en) | 1991-11-27 | 1997-08-12 | Euro-Celtique, S.A. | Controlled release oxycodone compositions |
US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5286493A (en) | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
US5958459A (en) | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
GB9203689D0 (en) | 1992-02-20 | 1992-04-08 | Euro Celtique Sa | Pharmaceutical composition |
GB9204354D0 (en) | 1992-02-28 | 1992-04-08 | Biokine Tech Ltd | Compounds for medicinal use |
PT647137E (pt) | 1992-06-22 | 2008-11-24 | Univ California | Antagonistas dos receptores da glicina e a sua utilização |
US5352680A (en) | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
US5256669A (en) | 1992-08-07 | 1993-10-26 | Aminotek Sciences, Inc. | Methods and compositions for treating acute or chronic pain and drug addiction |
US5324351A (en) | 1992-08-13 | 1994-06-28 | Euroceltique | Aqueous dispersions of zein and preparation thereof |
US5512578A (en) * | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
US5633259A (en) | 1992-09-21 | 1997-05-27 | United Biomedical, Inc. | Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction |
EP0668764A1 (en) | 1992-09-21 | 1995-08-30 | QIN, Bo-yi | Methods for identifying and using low/non-addictive opioid analgesics |
US20010006967A1 (en) | 1992-09-21 | 2001-07-05 | Stanley M. Crain | Method of simultaneously enhancing analgesic potency and attenuating adverse side effects caused by tramadol and other bimodally-acting opioid agonists |
US5472943A (en) | 1992-09-21 | 1995-12-05 | Albert Einstein College Of Medicine Of Yeshiva University, | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists |
US5580876A (en) * | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
US6096756A (en) | 1992-09-21 | 2000-08-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
US5869097A (en) | 1992-11-02 | 1999-02-09 | Alza Corporation | Method of therapy comprising an osmotic caplet |
US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
US5321012A (en) | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
US5585348A (en) | 1993-02-10 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia |
US5352683A (en) | 1993-03-05 | 1994-10-04 | Virginia Commonwealth University Medical College Of Virginia | Method for the treatment of chronic pain |
CA2115792C (en) | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
US5409944A (en) | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
US5457208A (en) | 1993-06-21 | 1995-10-10 | Regents Of The University Of Minnesota | Kappa opioid receptor antagonists |
US5436265A (en) | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
NZ260883A (en) | 1993-07-01 | 1997-06-24 | Euro Celtique Sa | Oral sustained-release medicaments containing morphine |
IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US5879705A (en) | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
DE4325465B4 (de) | 1993-07-29 | 2004-03-04 | Zenz, Michael, Prof. Dr.med. | Orales pharmazeutisches Präparat für die Schmerztherapie |
GB9319568D0 (en) | 1993-09-22 | 1993-11-10 | Euro Celtique Sa | Pharmaceutical compositions and usages |
EP0647448A1 (en) | 1993-10-07 | 1995-04-12 | Euroceltique S.A. | Orally administrable opioid formulations having extended duration of effect |
PT654263E (pt) | 1993-11-23 | 2002-06-28 | Euro Celtique Sa | Metodo para a preparacao de uma composicao de libertyacao prolongada |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
US5500227A (en) | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
US5376662A (en) | 1993-12-08 | 1994-12-27 | Ockert; David M. | Method of attenuating nerve injury induced pain |
US5834477A (en) | 1993-12-08 | 1998-11-10 | The United States Of America As Represented By The Secretary Of The Army | Opiate analgesic formulation with improved safety |
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US6077533A (en) | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
US5411745A (en) | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
US5460826A (en) | 1994-06-27 | 1995-10-24 | Alza Corporation | Morphine therapy |
GB9414699D0 (en) * | 1994-07-21 | 1994-09-07 | Slagel David | Aqueous foamable composition |
US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
US5593994A (en) | 1994-09-29 | 1997-01-14 | The Dupont Merck Pharmaceutical Company | Prostaglandin synthase inhibitors |
US5866154A (en) | 1994-10-07 | 1999-02-02 | The Dupont Merck Pharmaceutical Company | Stabilized naloxone formulations |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
ES2421306T3 (es) | 1994-12-12 | 2013-08-30 | Omeros Corporation | Solución de irrigación y procedimiento para inhibir el dolor, la inflamación y los espasmos |
GB9426102D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Pharmacuetical compositions |
US5692500A (en) | 1995-01-09 | 1997-12-02 | Gaston-Johansson; Fannie | Pain measurement and recording tool and method |
US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
US5578725A (en) | 1995-01-30 | 1996-11-26 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
BE1009257A3 (nl) * | 1995-03-21 | 1997-01-07 | Universiteit Gent Lab Voor Far | Farmaceutische matrix. |
US20020006964A1 (en) | 1995-05-16 | 2002-01-17 | Young James W. | Methods of using and compositions comprising (+) sibutramine optionally in combination with other pharmacologically active compounds |
US5510368A (en) | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
CA2195119C (en) | 1995-06-09 | 2001-09-11 | Mark Chasin | Formulations and methods for providing prolonged local anesthesia |
US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
GB9517883D0 (en) | 1995-09-01 | 1995-11-01 | Euro Celtique Sa | Improved pharmaceutical ion exchange resin composition |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
US5811126A (en) | 1995-10-02 | 1998-09-22 | Euro-Celtique, S.A. | Controlled release matrix for pharmaceuticals |
AUPN603895A0 (en) | 1995-10-19 | 1995-11-09 | University Of Queensland, The | Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids |
US5998434A (en) | 1995-12-06 | 1999-12-07 | Eli Lilly And Company | Composition for treating pain |
CN100475210C (zh) * | 1996-03-08 | 2009-04-08 | 尼科梅德丹麦有限公司 | 改进释放的多单位剂量组合物 |
DE69709646T2 (de) | 1996-03-12 | 2002-08-14 | Alza Corp., Palo Alto | Zusammensetzung und dosisform mit einem opioid-antagonisten |
US6103258A (en) | 1996-04-12 | 2000-08-15 | Simon; David Lew | Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics |
WO1997045091A2 (en) | 1996-05-31 | 1997-12-04 | Euro-Celtique, S.A. | Sustained release oxycodone formulations with no fed/fast effect |
DE19651551C2 (de) | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioidantagonisthaltige galenische Formulierung |
WO1998035679A1 (de) | 1997-02-14 | 1998-08-20 | Gödecke Aktiengesellschaft | Stabilisierung von naloxonhydrochlorid |
DE29719704U1 (de) | 1997-02-14 | 1998-01-22 | Gödecke AG, 10587 Berlin | Stabile Zubereitungen von Naloxonhydrochlorid |
US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
DE19710008A1 (de) | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
US5780479A (en) | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
US6207142B1 (en) | 1997-04-14 | 2001-03-27 | Janssen Pharmaceutica N.V. | Compositions containing an antifungal and a cationic agent |
ES2263211T3 (es) | 1997-07-02 | 2006-12-01 | Euro-Celtique S.A. | Formulaciones de tramadol de liberacion sostenida estabilizada. |
AU3690297A (en) | 1997-07-30 | 1999-02-22 | Universite De Montreal | Portable and programmable interactive visual analogue scale data-logger device |
CA2302754C (en) | 1997-09-04 | 2011-11-08 | Novoneuron, Inc. | Noribogaine in the treatment of pain and drug addiction |
US6066339A (en) * | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
ATE210983T1 (de) | 1997-11-03 | 2002-01-15 | Stada Arzneimittel Ag | Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum |
US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
US5972954A (en) | 1997-11-03 | 1999-10-26 | Arch Development Corporation | Use of methylnaltrexone and related compounds |
US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
ES2412409T3 (es) * | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
JP2001526229A (ja) * | 1997-12-22 | 2001-12-18 | ユーロ−セルティーク,エス.エイ. | オピオイド投薬剤形の乱用を防止する方法 |
TR200002759T2 (tr) | 1998-03-27 | 2001-02-21 | Pharmacia & Upjohn Company | Bacak uyuşması sendromunun tedavisinde kabergolin kullanımı. |
DE19857766A1 (de) | 1998-05-28 | 1999-12-02 | Krewel Meuselbach Gmbh | Retardiertes Schmerzmittel enthaltend Tilidin |
SE9803760D0 (sv) | 1998-11-04 | 1998-11-04 | Jan Hedner | Sätt att behandla och diagnostisera syndromet restless legs och motsvarande medel |
FR2787715B1 (fr) | 1998-12-23 | 2002-05-10 | Synthelabo | Composition pharmaceutique comprenant un compose hypnotique ou un de ses sels pharmaceutiquement acceptables |
DE19859636A1 (de) | 1998-12-23 | 2000-06-29 | Hexal Ag | Kontrolliert freisetzende pharmazeutische Zusammensetzung mit Tilidinmesylat als Wirkstoff |
DE19901085C2 (de) | 1999-01-14 | 2003-12-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einer selbstklebenden Matrix, enthaltend organische Säure-Additionssalze von Alkaloiden des Morphin- bzw. Morphinantyps |
US6194382B1 (en) | 1999-03-03 | 2001-02-27 | Albert Einstein College Of Medicine Of Yeshiva University | Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
US6765010B2 (en) | 1999-05-06 | 2004-07-20 | Pain Therapeutics, Inc. | Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects |
US20030178031A1 (en) | 1999-05-07 | 2003-09-25 | Du Pen, Inc. | Method for cancer pain treatment |
US20030118641A1 (en) | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
US6451007B1 (en) * | 1999-07-29 | 2002-09-17 | Dale E. Koop | Thermal quenching of tissue |
DE19938823A1 (de) | 1999-08-19 | 2001-02-22 | Boehringer Ingelheim Pharma | Medikamentöse Behandlung des Restless Leg Syndroms |
US6258042B1 (en) | 1999-09-17 | 2001-07-10 | James S. Factor | Visual analog scale and method of use for the diagnosis and/or treatment of physical pain |
US6451806B2 (en) * | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
JP2003513045A (ja) | 1999-11-01 | 2003-04-08 | ロデバ・リミテッド | 便秘及び過敏性大腸症候群を治療・処置するための組成物 |
DK1244447T3 (da) | 1999-11-29 | 2007-04-23 | Adolor Corp | Nye fremgangsmåder og sammensætninger indeholdende opioider og deres antagonister |
JP2001174985A (ja) * | 1999-12-15 | 2001-06-29 | Sumitomo Chem Co Ltd | 顔料分散感光液、その製造方法及びそれを用いる着色画像の形成方法 |
WO2001052851A1 (en) | 2000-01-22 | 2001-07-26 | Albert Shulman | Methods for the treatment of substance abuse |
GEP20053614B (en) | 2000-02-08 | 2005-09-26 | Euro Celtique Sa | Compositions for Oral Administration Containing Opioid Agonist |
US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
DE60119696T2 (de) | 2000-03-15 | 2007-01-25 | Wolfgang Ross Sadee | Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch |
AU5956001A (en) | 2000-05-05 | 2001-11-20 | Pain Therapeutics Inc | Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists |
WO2001085257A2 (en) | 2000-05-05 | 2001-11-15 | Pain Therapeutics, Inc. | Opioid antagonist compositions and dosage forms |
EP1292307A2 (en) | 2000-06-09 | 2003-03-19 | The Regents of The University of California | Method of treating pain using nalbuphine and opioid antagonists |
US7223421B2 (en) | 2000-06-30 | 2007-05-29 | Mcneil-Ppc, Inc. | Teste masked pharmaceutical particles |
GB0026137D0 (en) | 2000-10-25 | 2000-12-13 | Euro Celtique Sa | Transdermal dosage form |
AR031152A1 (es) | 2000-10-31 | 2003-09-10 | Upjohn Co | Tratamientos nuevos para el sindrome de piernas inquietas |
SK12822003A3 (sk) | 2001-04-19 | 2004-04-06 | Warner - Lambert Company Llc | Fúzne bicyklické alebo tricyklické aminokyseliny |
UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
CA2446550C (en) * | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20030004177A1 (en) * | 2001-05-11 | 2003-01-02 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
DE10131113A1 (de) | 2001-06-28 | 2003-01-23 | Siemens Linear Motor Systems G | Rotations-Elektromotor |
WO2003004009A1 (en) | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Pharmaceutical composition |
WO2003007802A2 (en) | 2001-07-18 | 2003-01-30 | Euro-Celtique, S.A. | Pharmaceutical combinations of oxycodone and naloxone |
MXPA04001206A (es) | 2001-08-06 | 2004-07-08 | Euro Celtique Sa | Composiciones y metodos para prevenir el abuso de opioides. |
WO2003013433A2 (en) | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Sequestered antagonist formulations |
AU2002323032B2 (en) * | 2001-08-06 | 2005-02-24 | Euro-Celtique S.A. | Opioid agonist formulations with releasable and sequestered antagonist |
US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
KR20040060917A (ko) | 2001-08-06 | 2004-07-06 | 유로-셀티크 소시에떼 아노뉨 | 오피오이드 남용을 방지하기 위한 조성물 및 방법 |
US20050049475A1 (en) | 2001-09-06 | 2005-03-03 | Hans Gregersen | Method and apparatus for stimulating a bodily hollow system and method and apparatus for measuring reactions to stimuli of such system |
US20040234602A1 (en) | 2001-09-21 | 2004-11-25 | Gina Fischer | Polymer release system |
EP1429744A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Morphine polymer release system |
WO2003026676A1 (en) | 2001-09-24 | 2003-04-03 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful for the treatment of restless limb syndrome and periodic limb movement disorder |
US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
ES2397376T3 (es) | 2002-03-06 | 2013-03-06 | Euro-Celtique S.A. | Escala analógica para medir el dolor |
RU2004130441A (ru) | 2002-03-14 | 2005-05-20 | Еуро-Селтик, С.А. (Lu) | Композиции налтрексона гидрохлорида |
CA2708900C (en) | 2002-04-05 | 2019-06-04 | Purdue Pharma | Pharmaceutical preparation containing oxycodone and naloxone |
US20030191147A1 (en) | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
EP1364649A1 (en) | 2002-05-23 | 2003-11-26 | Cilag AG | Adduct of topiramate and tramadol hydrochioride and uses thereof |
CA2491572C (en) | 2002-07-05 | 2010-03-23 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
RU2222260C1 (ru) | 2002-07-08 | 2004-01-27 | Сибирский государственный медицинский университет | Способ дифференцированной оценки степени функциональной активности тонкой кишки |
EP1551402A4 (en) | 2002-09-23 | 2009-05-27 | Verion Inc | PHARMACEUTICAL COMPOSITIONS NOT INDUCING ABUSE |
CN100500130C (zh) | 2003-01-23 | 2009-06-17 | 株式会社太平洋 | 缓释制剂及其制备方法 |
PL2368554T3 (pl) | 2003-04-08 | 2015-05-29 | Progenics Pharm Inc | Preparaty farmaceutyczne zawierające metylonaltrekson |
TWI357815B (en) | 2003-06-27 | 2012-02-11 | Euro Celtique Sa | Multiparticulates |
US20050053659A1 (en) | 2003-09-10 | 2005-03-10 | Pace Gary W. | Methods and compositions for reducing the risk associated with the administration of opioid analgesics in patients with diagnosed or undiagnosed respiratory illness |
TWI350762B (en) | 2004-02-12 | 2011-10-21 | Euro Celtique Sa | Particulates |
RS50817B (sr) * | 2004-03-30 | 2010-08-31 | Euro-Celtique S.A. | Dozni oblik otporan na promene koji sadrži adsorbenti i sredstvo sa suprotnim dejstvom |
US7700626B2 (en) | 2004-06-04 | 2010-04-20 | Adolor Corporation | Compositions containing opioid antagonists |
EP1604667A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome |
EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
GB2418854B (en) | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
KR20090029856A (ko) | 2005-01-28 | 2009-03-23 | 유로-셀띠끄 소시에떼 아노님 | 알코올 저항성 제형 |
EP1695700A1 (en) | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
US20070092576A1 (en) | 2005-10-20 | 2007-04-26 | Adolor Corporation | Compositions containing opioid antagonists |
EP1813276A1 (en) | 2006-01-27 | 2007-08-01 | Euro-Celtique S.A. | Tamper resistant dosage forms |
US20070185145A1 (en) | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
US20090312358A1 (en) | 2006-03-22 | 2009-12-17 | Trustees Of Boston University | Method for management of diarrhea |
EP2012790A4 (en) | 2006-04-19 | 2009-07-01 | Smith Jill P | TREATMENT OF INFLAMMATORY AND ULCEROUS DISEASES OF THE COLON USING OPIOID ANTAGONISTS |
DE202006018609U1 (de) | 2006-08-29 | 2007-05-16 | Euro-Celtique S.A. | Verwendung von Opioidformulierungen in nadellosen Vorrichtungen zur Medikamentenverabreichung |
TW200817048A (en) | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
EP2042176A1 (en) | 2007-09-26 | 2009-04-01 | Euro-Celtique S.A. | Use of a combination of an opioid agonist and an opioid antagonist for the treatment of Crohn's disease |
PE20110422A1 (es) | 2008-07-07 | 2011-07-01 | Euro Celtique Sa | Composicion farmaceutica que comprende antagonistas opioides |
PT2405915T (pt) | 2009-03-10 | 2019-01-29 | Euro Celtique Sa | Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona |
NZ606123A (en) | 2010-08-13 | 2015-03-27 | Euro Celtique Sa | Use of binders for manufacturing storage stable formulations |
-
2002
- 2002-05-10 CA CA2446550A patent/CA2446550C/en not_active Expired - Lifetime
- 2002-05-10 ES ES02734389T patent/ES2361148T3/es not_active Expired - Lifetime
- 2002-05-10 EP EP02734389A patent/EP1387673B1/en not_active Expired - Lifetime
- 2002-05-10 AT AT02734389T patent/ATE493130T1/de not_active IP Right Cessation
- 2002-05-10 CN CNA028097297A patent/CN1525851A/zh active Pending
- 2002-05-10 US US10/143,111 patent/US20030065002A1/en not_active Abandoned
- 2002-05-10 DE DE60238756T patent/DE60238756D1/de not_active Expired - Lifetime
- 2002-05-10 WO PCT/US2002/015022 patent/WO2002092060A1/en active Application Filing
- 2002-05-10 AU AU2002305559A patent/AU2002305559B2/en not_active Expired
- 2002-05-10 JP JP2002588978A patent/JP4522652B2/ja not_active Expired - Lifetime
-
2007
- 2007-09-14 US US11/901,232 patent/US20080069881A1/en not_active Abandoned
-
2008
- 2008-07-03 AU AU2008202967A patent/AU2008202967B2/en not_active Expired
-
2009
- 2009-01-28 JP JP2009017380A patent/JP2009102405A/ja active Pending
-
2012
- 2012-06-12 US US13/494,431 patent/US20120252832A1/en not_active Abandoned
- 2012-09-18 JP JP2012204455A patent/JP5765820B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-26 US US13/777,537 patent/US20130172382A1/en not_active Abandoned
- 2013-10-30 US US14/067,821 patent/US9084729B2/en not_active Expired - Fee Related
- 2013-12-20 US US14/136,443 patent/US8969369B2/en not_active Expired - Fee Related
-
2014
- 2014-03-11 US US14/205,204 patent/US9056051B2/en not_active Expired - Fee Related
- 2014-06-19 JP JP2014125979A patent/JP5977784B2/ja not_active Expired - Lifetime
-
2015
- 2015-05-29 US US14/725,379 patent/US9168252B2/en not_active Expired - Fee Related
- 2015-05-29 JP JP2015110130A patent/JP6203782B2/ja not_active Expired - Lifetime
- 2015-05-29 US US14/725,369 patent/US9161937B2/en not_active Expired - Fee Related
- 2015-09-18 US US14/859,200 patent/US9283221B2/en not_active Expired - Fee Related
- 2015-09-18 US US14/859,195 patent/US9283216B2/en not_active Expired - Fee Related
-
2016
- 2016-02-03 US US15/014,995 patent/US9358230B1/en not_active Expired - Fee Related
- 2016-02-03 US US15/015,019 patent/US9345701B1/en not_active Expired - Fee Related
- 2016-05-19 US US15/159,465 patent/US9511066B2/en not_active Expired - Lifetime
- 2016-05-19 US US15/159,737 patent/US9480685B2/en not_active Expired - Lifetime
- 2016-09-29 US US15/280,621 patent/US20170014406A1/en not_active Abandoned
- 2016-09-29 US US15/280,541 patent/US20170014405A1/en not_active Abandoned
- 2016-10-05 JP JP2016196952A patent/JP2016222732A/ja not_active Withdrawn
-
2018
- 2018-02-09 JP JP2018022019A patent/JP2018080209A/ja active Pending
- 2018-02-15 US US15/898,018 patent/US20180185353A1/en not_active Abandoned
- 2018-02-15 US US15/898,069 patent/US20180169090A1/en not_active Abandoned
- 2018-12-17 US US16/222,720 patent/US20190111051A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6203782B2 (ja) | 乱用防止制御放出オピオイド投薬形態 | |
AU2002305559A1 (en) | Abuse-resistant controlled-release opioid dosage form | |
AU2015210453B2 (en) | Abuse Resistant Controlled Release Opioid Dosage Form | |
AU2013270469C1 (en) | Abuse-Resistant Controlled-Release Opioid Dosage Form |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120918 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131219 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140318 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140324 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140418 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140423 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140516 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140521 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140619 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140930 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141226 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150130 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150227 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150331 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150519 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20150529 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150612 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5765820 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |