JP5728388B2 - 水中油型乳化化粧料 - Google Patents
水中油型乳化化粧料 Download PDFInfo
- Publication number
- JP5728388B2 JP5728388B2 JP2011539388A JP2011539388A JP5728388B2 JP 5728388 B2 JP5728388 B2 JP 5728388B2 JP 2011539388 A JP2011539388 A JP 2011539388A JP 2011539388 A JP2011539388 A JP 2011539388A JP 5728388 B2 JP5728388 B2 JP 5728388B2
- Authority
- JP
- Japan
- Prior art keywords
- oil
- emulsified cosmetic
- water
- zinc oxide
- oxide powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002537 cosmetic Substances 0.000 title claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 54
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 68
- -1 silane compound Chemical class 0.000 claims description 44
- 239000000843 powder Substances 0.000 claims description 40
- 239000002245 particle Substances 0.000 claims description 35
- 229920001577 copolymer Polymers 0.000 claims description 22
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 16
- 150000004706 metal oxides Chemical class 0.000 claims description 16
- 229910044991 metal oxide Inorganic materials 0.000 claims description 15
- 229920002401 polyacrylamide Polymers 0.000 claims description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 229910000077 silane Inorganic materials 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 8
- 229920001282 polysaccharide Polymers 0.000 claims description 8
- 239000005017 polysaccharide Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 7
- 229920002674 hyaluronan Polymers 0.000 claims description 7
- 229960003160 hyaluronic acid Drugs 0.000 claims description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 239000007764 o/w emulsion Substances 0.000 claims description 5
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 4
- 238000004381 surface treatment Methods 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- OUZOBPPZPCBJAR-UHFFFAOYSA-N 14-methylpentadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C OUZOBPPZPCBJAR-UHFFFAOYSA-N 0.000 claims description 3
- LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 claims description 3
- YICVJSOYNBZJAK-UHFFFAOYSA-N 14-methylpentadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C YICVJSOYNBZJAK-UHFFFAOYSA-N 0.000 claims description 3
- SAMYFBLRCRWESN-UHFFFAOYSA-N 16-methylheptadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C SAMYFBLRCRWESN-UHFFFAOYSA-N 0.000 claims description 3
- VRBHTEGUHVNKEA-UHFFFAOYSA-N 16-methylheptadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C VRBHTEGUHVNKEA-UHFFFAOYSA-N 0.000 claims description 3
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 claims description 3
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 claims description 3
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 claims description 3
- ODMZDMMTKHXXKA-QXMHVHEDSA-N 8-methylnonyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCCCCCC(C)C ODMZDMMTKHXXKA-QXMHVHEDSA-N 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- HQRJTRSKPWEIII-OCANKYAHSA-N icosan-9-yl (z,12r)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCC\C=C/C[C@H](O)CCCCCC HQRJTRSKPWEIII-OCANKYAHSA-N 0.000 claims description 3
- 229940078568 isocetyl myristate Drugs 0.000 claims description 3
- 229940078545 isocetyl stearate Drugs 0.000 claims description 3
- 229940113915 isostearyl palmitate Drugs 0.000 claims description 3
- WDQLRUYAYXDIFW-RWKIJVEZSA-N (2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 WDQLRUYAYXDIFW-RWKIJVEZSA-N 0.000 claims description 2
- DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 claims description 2
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 claims description 2
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 claims description 2
- 229920000189 Arabinogalactan Polymers 0.000 claims description 2
- 239000001904 Arabinogalactan Substances 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229920001503 Glucan Polymers 0.000 claims description 2
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 claims description 2
- 229920001543 Laminarin Polymers 0.000 claims description 2
- 239000005717 Laminarin Substances 0.000 claims description 2
- 229920001491 Lentinan Polymers 0.000 claims description 2
- 229920002097 Lichenin Polymers 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- 229920002305 Schizophyllan Polymers 0.000 claims description 2
- 229920002000 Xyloglucan Polymers 0.000 claims description 2
- 235000019312 arabinogalactan Nutrition 0.000 claims description 2
- 229940074979 cetyl palmitate Drugs 0.000 claims description 2
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 claims description 2
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 2
- QAKXLTNAJLFSQC-UHFFFAOYSA-N hexadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC QAKXLTNAJLFSQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940100463 hexyl laurate Drugs 0.000 claims description 2
- 229910052809 inorganic oxide Inorganic materials 0.000 claims description 2
- 229940115286 lentinan Drugs 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 229940078812 myristyl myristate Drugs 0.000 claims description 2
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 claims description 2
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 claims description 2
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 claims description 2
- 235000019423 pullulan Nutrition 0.000 claims description 2
- 230000009257 reactivity Effects 0.000 claims description 2
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 claims description 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229940014041 hyaluronate Drugs 0.000 claims 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 31
- 229920001296 polysiloxane Polymers 0.000 description 23
- 239000010419 fine particle Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 19
- 239000011787 zinc oxide Substances 0.000 description 18
- 239000011734 sodium Substances 0.000 description 15
- 238000011282 treatment Methods 0.000 description 15
- 238000011156 evaluation Methods 0.000 description 13
- 238000010438 heat treatment Methods 0.000 description 13
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 11
- 230000006750 UV protection Effects 0.000 description 11
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 229920002125 Sokalan® Polymers 0.000 description 8
- 239000004584 polyacrylic acid Substances 0.000 description 8
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical compound CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 description 6
- 229960003493 octyltriethoxysilane Drugs 0.000 description 6
- 239000002002 slurry Substances 0.000 description 6
- 230000002123 temporal effect Effects 0.000 description 6
- 239000011573 trace mineral Substances 0.000 description 6
- 235000013619 trace mineral Nutrition 0.000 description 6
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 6
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 230000002349 favourable effect Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 229910052742 iron Inorganic materials 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
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- 238000003756 stirring Methods 0.000 description 5
- 230000000475 sunscreen effect Effects 0.000 description 5
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- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 4
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 4
- 150000001343 alkyl silanes Chemical class 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 238000000034 method Methods 0.000 description 4
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- 239000002904 solvent Substances 0.000 description 4
- 229910052726 zirconium Inorganic materials 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- WPKYZIPODULRBM-UHFFFAOYSA-N azane;prop-2-enoic acid Chemical compound N.OC(=O)C=C WPKYZIPODULRBM-UHFFFAOYSA-N 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
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- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 3
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 3
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- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 2
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
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- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 2
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- ARJOQCYCJMAIFR-UHFFFAOYSA-N prop-2-enoyl prop-2-enoate Chemical compound C=CC(=O)OC(=O)C=C ARJOQCYCJMAIFR-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- JLGNHOJUQFHYEZ-UHFFFAOYSA-N trimethoxy(3,3,3-trifluoropropyl)silane Chemical compound CO[Si](OC)(OC)CCC(F)(F)F JLGNHOJUQFHYEZ-UHFFFAOYSA-N 0.000 description 1
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- JLQFVGYYVXALAG-CFEVTAHFSA-N yasmin 28 Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 JLQFVGYYVXALAG-CFEVTAHFSA-N 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Description
従って、本発明の課題は、高い紫外線防御効果を有しつつ、経時安定性、使用感に優れた水中油型乳化化粧料を提供することにある。
ここで、平均粒子径は、透過型電子顕微鏡写真中、任意の視野の任意の粒子20個について、長軸と短軸との相加平均を粒子径とみなした。平均粒子厚さは、透過型電子顕微鏡写真の同視野中の厚さを読み取り、読み取れるすべての粒子の厚さの算術平均より求めた。平均板状比は、(平均粒子径)/(平均粒子厚さ)により求め、小数点以下を四捨五入した値とした。
平均粒子厚さは0.01〜0.2μmであり、好ましくは0.01〜0.1μm、より好ましくは0.01〜0.05μmである。この平均粒子厚さが0.01μm未満の場合は薄片状形態が崩れ易く、0.2μmを超える場合は化粧料に配合した場合に不快感を生じさせるので、実用的ではない。
平均板状比は3以上であり、好ましくは5以上、さらに好ましくは7以上である。また平均板状比の上限は30以下が好ましい。この平均板状比が3未満の場合は透明性が低下する。
+2価以上の微量元素としては、鉄、ジルコニウム、カルシウム、マンガン、マグネシウム、イットリウム等の金属が挙げられる。これらは単独でも2種以上を組み合わせても用いることもでき、組み合わせの例としては、ジルコニウムと鉄、ジルコニウムとマグネシウム、鉄とマグネシウム、鉄とカルシウム等を挙げることができる。微量元素の含有量は、紫外線防御能の点から、(A)薄片状酸化亜鉛粉末に含有されている亜鉛量100モルに対して、好ましくは0.005〜1.0モルであり、より好ましくは0.01〜0.5モルである。
また、これらは前記(A)薄片状酸化亜鉛粉末と同様に、+2価以上の微量元素を含有させることができ、鉄、ジルコニウム、カルシウム、マンガン、マグネシウム、イットリウム等の金属を、単独又は2種以上を適宜組み合わせて、前記微粒子金属酸化物粉末に含有させることができる。
その内、2−(4−ジエチルアミノ−2−ヒドロキシベンゾイル)−安息香酸ヘキシルエステルの含有量は、水中油型乳化化粧料の総量に対して、0.01〜8質量%とすることが好ましく、最も好適には0.05〜3質量%である。
説明にあたり、以下の実施例で用いた粉末の製造方法につき、説明する。
なお、実施例2、3は参考例であって、特許請求の範囲に包含されるものではない。
硫酸亜鉛1.6×10-1モル、硫酸ナトリウム3.8×10-2モル及び微量元素の塩として硫酸第一鉄1.6×10-4モルを、5×10-2モル硫酸水溶液315mLに溶解した。次に、この溶液をホモミキサーにより6000r.p.m.で攪拌しながら、2N水酸化ナトリウム水溶液230mLを15秒間で投入し(pH=12.8)、沈殿を生成させたのち、10分間攪拌を継続した。その後、100℃で90分間熟成し、濾過、水洗し、230℃で約10時間乾燥して、紫外線吸収性粉末を得た。このようにして得られた粉末を走査型電子顕微鏡で観察し、薄片状粒子(平均粒子径0.25μm、平均粒子厚さ0.019μm、板状比13、鉄元素含有量0.11mol%)であることを確認した。
製造例1で製造した薄片状酸化亜鉛粉末93質量部とオクチルトリエトキシシラン7質量部と、トルエンからなるスラリーを作成し、ビーズミル(シンマルエンタープライゼス社製ダイノミル)を用いて粉砕・解砕を行った。次いで、トルエンを減圧下に加熱留去した後、送風気流型乾燥機を用いて150℃にて4時間加熱処理し、オクチルトリエトキシシラン処理薄片状酸化亜鉛粉末を得た。
製造例1で製造した薄片状酸化亜鉛粉末93質量部とメチルハイドロジェンポリシロキサン(KF−99P、信越化学工業社製)7質量部とイソプロピルアルコールからなるスラリーを作成し、よく攪拌・粉砕した後、溶媒を減圧下に加熱留去し、空気中150℃で4時間加熱処理を行い、メチルハイドロジェンポリシロキサン表面処理薄片状酸化亜鉛粉末を得た。
微粒子酸化亜鉛粉末(略球状、平均粒子径0.02μm)93質量部とオクチルトリエトキシシラン7質量部と、トルエンからなるスラリーを作成し、ビーズミル(シンマルエンタープライゼス社製ダイノミル)を用いて粉砕・解砕を行った。次いで、トルエンを減圧下に加熱留去した後、送風気流型乾燥機を用いて150℃にて4時間加熱処理し、オクチルトリエトキシシラン処理微粒子酸化亜鉛粉末を得た。
微粒子酸化亜鉛粉末(略球状、平均粒子径0.02μm)95質量部とメチルハイドロジェンポリシロキサン(KF−99P、信越化学工業社製)5質量部とイソプロピルアルコールからなるスラリーを作成し、よく攪拌・粉砕した後、溶媒を減圧下に加熱留去し、空気中150℃で4時間加熱処理を行い、メチルハイドロジェンポリシロキサン表面処理微粒子酸化亜鉛粉末を得た。
微粒子酸化チタン粉末(略球状、平均粒子径0.017μm)95質量部とメチルハイドロジェンポリシロキサン(KF−99P、信越化学工業社製)5質量部とイソプロピルアルコールからなるスラリーを作成し、よく攪拌・粉砕した後、溶媒を減圧下に加熱留去し、空気中160℃で4時間加熱処理を行い、メチルハイドロジェンポリシロキサン表面処理微粒子酸化チタン粉末を得た。
製造例6で用いた微粒子酸化チタン粉末の代わりに、顔料級タルクを用い、同様の製造方法による処理を行い、メチルハイドロジェンポリシロキサン表面処理タルクを得た。また、黄酸化鉄、黒酸化鉄についても、同様に処理し、それぞれメチルハイドロジェンポリシロキサン表面処理黄色酸化鉄、メチルハイドロジェンポリシロキサン黒酸化鉄を得た。
下記表1に記載した配合組成の水中油型乳化化粧料を下記の製法にて調製した。得られた水中油型乳化化粧料について、下記評価試験を行った。評価結果を合わせて表1に示す。
(1)紫外線防御効果
SPFアナライザー(Optometices社)を用いてSPF値を測定し、以下の基準で示した。
〔UVB防御効果評価基準〕
A:SPF値が40以上
B:SPF値が30以上40未満
C:SPF値が20以上30未満
D:SPF値が20未満
〔UVA防御効果評価基準〕
a:T(UVA)が20%未満
b:T(UVA)が20%以上25%未満
c:T(UVA)が25%以上
専門パネラーを評価項目ごとに10名ずつ用意し(但し、品目によりパネラーが重複する場合もある)、パネラーが製剤を実際に使用し、実施例1〜12、比較例1〜5については「塗布後の透明感がある」、「塗布時の滑らかさ」に関して、下記評価基準に従って、評価を行った。全パネラーの合計点数から、表1に使用感評価結果を示す。
〔パネラー評価基準〕
評価基準 点数
効果が高いように感じられる 5
効果が感じられる 4
効果がやや感じられる 3
効果がわずかしか感じられない 2
効果が感じられない 1
〔使用感評価結果〕
A:合計点数が40点以上
B:合計点数が35点以上40点未満
C:合計点数が25点以上35点未満
D:合計点数が25点未満
各試料を60℃の恒温槽に1ヶ月間保管し、1ヶ月後の状態を観察し、以下の判定基準を用いて判定した。
〔保存安定性判定基準〕
A:変化なし
B:やや粘度変化が見られる
C:明らかな粘度変化が見られる
D:分離している
A:成分(1)〜(10)を分散機で均一に混合し、70℃に加熱する。
B:成分(11)〜(16)を70℃で攪拌しながら均一に混合する。
C:Bを攪拌しながら、徐々にAを添加し、予備乳化を行う。
D:Cを40℃まで冷却し、成分(17)〜(19)を徐々に加え攪拌し、ホモミキサーにて均一に混合した後、脱気、冷却を行い、水中油型乳化化粧料を得た。
下記表2に記載した配合組成の水中油型乳化化粧料を下記の製法にて調製した。得られた水中油型乳化化粧料について、上記評価基準に基づき、使用感(べたつき感のなさ、しっとり感がある)、経時安定性、紫外線防御効果に関する評価を行った。評価結果を合わせて表2に示す。
A:成分(1)〜(7)を70℃で加熱溶解し、均一に混合する。
B:成分(8)〜(12)を70℃で均一に溶解混合する。
C:Bを攪拌しながら、徐々にAを添加し、予備乳化する。
D:Cを40℃まで冷却し、成分(13)〜(15)を徐々に加え攪拌し、ホモミキサーにて均一に混合した後、脱気、冷却を行い、乳化化粧料を得た。
(成分) (質量%)
アルキルシラン処理薄片状酸化亜鉛(製造例2) 10.0
シリコーン処理微粒子酸化亜鉛(製造例5) 5.0
シリコーン処理酸化チタン(製造例6) 10.0
シリコーン処理タルク(製造例7) 3.0
シリコーン処理黄酸化鉄(製造例7) 0.8
シリコーン処理黒酸化鉄(製造例7) 0.16
イソヘキサデカン 5.0
メチルトリメチコン 5.0
パラメトキシ桂皮酸オクチル 5.0
ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル 1.0
PEG−60水添ヒマシ油 2.0
1,3−ブチレングリコール 6.0
SEPIGEL 501 3.0
(ポリアクリルアミド20質量%含有:SEPPIC社製)
サクシノグリカン 0.2
カルボキシメチルセルロース 0.3
エタノール 5.0
精製水 残 量
下記に示す成分及び常法に従い、水中油型日焼け止め化粧料を調整した。該水中油型日焼け止め乳液は、UV−Aカット効果、使用性、経時安定性、並び耐水性において優れたものであった。
(成分) (質量%)
アルキルシラン処理薄片状酸化亜鉛(製造例2) 10.0
シリコーン処理酸化亜鉛(製造例3) 10.0
パラメトキシケイ皮酸2−エチルヘキシル 4.0
ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル 1.0
ポリメチルシルセスキオキサン 3.0
ジメチルポリシロキサン 5.0
ミリスチン酸オクチルドデシル 5.0
SIMULGEL EG 3.0
(アクリル酸Na/アクリロイルジメチルタウリン)コポリマー
37.5質量%含有:SEPPIC社製)
グリセリン 3.0
トリメチルシロキシケイ酸 0.5
エタノール 0.5
フェノキシエタノール 0.5
エデト酸三ナトリウム 0.01
キサンタンガム 0.1
ヒアルロン酸ナトリウム 0.1
精製水 残 量
Claims (6)
- (A)炭素数1〜20のアルキル基若しくはフルオロアルキル基を有し、無機酸化物と反応性を有するシラン化合物又はシラザン化合物で表面処理された、平均粒子径0.1〜1μm、平均粒子厚さ0.01〜0.2μm及び平均板状比3以上である酸化亜鉛粉末と、(B)(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)コポリマー、(アクリル酸Na/アクリロイルジメチルタウリン)コポリマー、及びポリアクリルアミドからなる群から選択される1種以上を含有することを特徴とする水中油型乳化化粧料。
- さらに(C)平均粒子径0.01〜1μm、平均板状比3未満の金属酸化物粉末を含有し、前記成分(A)と成分(C)の質量比(A/C)が、1/5〜10/1である請求項1記載の水中油型乳化化粧料。
- さらに(D)炭素数12〜22の直鎖脂肪酸と、炭素数6〜24の直鎖又は分岐アルコールとのエステルを含有する請求項1又は2記載の水中油型乳化化粧料。
- 前記(D)エステルが、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、パルミチン酸セチル、ステアリン酸ステアリル、オレイン酸デシル、オレイン酸オレイル、リシノール酸セチル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、ミリスチン酸オクチルドデシル、パルミチン酸2−エチルヘキシル、パルミチン酸イソセチル、パルミチン酸イソステアリル、ステアリン酸2−エチルヘキシル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸オクチルドデシル、及びリシノール酸オクチルドデシルからなる群より選ばれる1種以上である請求項3記載の水中油型乳化化粧料。
- さらに、(E)プルラン、デキストラン、シクロソフォラン、ラミナリン、シゾフィラン、レンチナン、アラビノガラクタン、バーレイグルカン、リケナン、サクシノグリカン、キシログルカン、ローカストビーンガム、キサンタンガム、キトサン、プスツラン、カラギーナン、ヒアルロン酸及びその塩からなる群から選択される1種又は2種以上の多糖類を含有する請求項1〜4のいずれか1項記載の水中油型乳化化粧料。
- 前記(E)多糖類がヒアルロン酸、ヒアルロン酸アルカリ金属塩又はキサンタンガムである請求項5記載の水中油型乳化化粧料。
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JP6741836B2 (ja) * | 2019-08-13 | 2020-08-19 | 花王株式会社 | 水中油型乳化化粧料 |
WO2021044975A1 (ja) * | 2019-09-05 | 2021-03-11 | 株式会社 資生堂 | 油中水型組成物 |
JP7474050B2 (ja) * | 2019-12-26 | 2024-04-24 | 花王株式会社 | 水中油型乳化化粧料 |
JP2022133786A (ja) * | 2021-03-02 | 2022-09-14 | 株式会社 資生堂 | 化粧料 |
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Also Published As
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JPWO2011055761A1 (ja) | 2013-03-28 |
KR101769170B1 (ko) | 2017-08-17 |
HK1173385A1 (en) | 2013-05-16 |
EP2497456B1 (en) | 2017-08-16 |
WO2011055761A1 (ja) | 2011-05-12 |
TWI411447B (zh) | 2013-10-11 |
TW201125589A (en) | 2011-08-01 |
US20120251603A1 (en) | 2012-10-04 |
EP2497456A4 (en) | 2015-07-29 |
CN102695493A (zh) | 2012-09-26 |
CN102695493B (zh) | 2014-07-23 |
ES2643036T3 (es) | 2017-11-21 |
EP2497456A1 (en) | 2012-09-12 |
US8673329B2 (en) | 2014-03-18 |
KR20120102620A (ko) | 2012-09-18 |
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