JP5306818B2 - 縮合複素環化合物 - Google Patents

縮合複素環化合物 Download PDF

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Publication number
JP5306818B2
JP5306818B2 JP2008539837A JP2008539837A JP5306818B2 JP 5306818 B2 JP5306818 B2 JP 5306818B2 JP 2008539837 A JP2008539837 A JP 2008539837A JP 2008539837 A JP2008539837 A JP 2008539837A JP 5306818 B2 JP5306818 B2 JP 5306818B2
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group
compound
optionally substituted
methyl
reaction
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Japanese (ja)
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JPWO2008047821A1 (ja
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常雄 安間
泰史 宮本
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
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  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
JP2008539837A 2006-10-18 2007-10-17 縮合複素環化合物 Expired - Fee Related JP5306818B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008539837A JP5306818B2 (ja) 2006-10-18 2007-10-17 縮合複素環化合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006284418 2006-10-18
JP2006284418 2006-10-18
JP2008539837A JP5306818B2 (ja) 2006-10-18 2007-10-17 縮合複素環化合物
PCT/JP2007/070228 WO2008047821A1 (fr) 2006-10-18 2007-10-17 Composé hétérocyclique fusionné

Publications (2)

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JPWO2008047821A1 JPWO2008047821A1 (ja) 2010-02-25
JP5306818B2 true JP5306818B2 (ja) 2013-10-02

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JP2008539837A Expired - Fee Related JP5306818B2 (ja) 2006-10-18 2007-10-17 縮合複素環化合物

Country Status (4)

Country Link
US (1) US8492405B2 (de)
EP (2) EP2298772A1 (de)
JP (1) JP5306818B2 (de)
WO (1) WO2008047821A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7549501A (en) * 2000-06-16 2002-01-02 Biogen Inc Angiogenesis-modulating compositions and uses
WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
MX2008012928A (es) 2006-04-04 2009-03-06 Univ California Antagonistas de pi3-cinasa.
US8318746B2 (en) 2007-04-27 2012-11-27 Takeda Pharmaceutical Company Limited Nitrogen-containing five-membered heterocyclic compound
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
CN104926815B (zh) 2008-01-04 2017-11-03 英特利凯恩有限责任公司 某些化学实体、组合物和方法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
UY32126A (es) 2008-09-25 2010-04-30 Takeda Pharmaceutical Composición farmacéutica sólida
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors
US8697709B2 (en) 2008-10-16 2014-04-15 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
JPWO2010076884A1 (ja) 2008-12-29 2012-06-21 武田薬品工業株式会社 新規縮合環化合物およびその用途
EP2427195B1 (de) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclische verbindungen und ihre verwendung
EP2440541A1 (de) 2009-06-09 2012-04-18 Takeda Pharmaceutical Company Limited Neue kondensierte cyclische verbindung und ihre verwendung
US20120129878A1 (en) 2009-07-28 2012-05-24 Takeda Pharmaceutical Company Limited Tablet
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
TW201206911A (en) 2010-04-27 2012-02-16 Takeda Pharmaceutical Bicyclic compound
CN103002738A (zh) 2010-05-21 2013-03-27 英特利凯恩有限责任公司 用于激酶调节的化学化合物、组合物和方法
UA108888C2 (xx) 2010-06-16 2015-06-25 Кристал аміду
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
JP5816626B2 (ja) 2010-09-17 2015-11-18 武田薬品工業株式会社 糖尿病治療剤
AU2011326427B2 (en) 2010-11-10 2016-01-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
EP2649062B1 (de) 2010-11-30 2015-04-08 Takeda Pharmaceutical Company Limited Bicyclische verbindungen als hemmer der acetyl-coa-carboxylase (acc)
BR112013017670B1 (pt) 2011-01-10 2022-07-19 Infinity Pharmaceuticals, Inc Processos de preparação de isoquinolinonas e formas sólidas de isoquinolinonas
JP5945545B2 (ja) 2011-02-17 2016-07-05 武田薬品工業株式会社 光学活性なジヒドロベンゾフラン誘導体の製造法
WO2012148540A1 (en) 2011-02-23 2012-11-01 Intellikine, Llc Combination of kanase inhibitors and uses threof
WO2013012915A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
CA2846431A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (de) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren
EP2781521A4 (de) * 2011-10-19 2015-03-04 Kowa Co Neue spiroindolinverbindung und medizinischer wirkstoff damit
WO2013061962A1 (ja) 2011-10-24 2013-05-02 武田薬品工業株式会社 二環性化合物
EP2802571A1 (de) 2012-01-12 2014-11-19 Takeda Pharmaceutical Company Limited Benzimidazolderivate als mch-rezeptorantagonisten
WO2013122028A1 (ja) 2012-02-13 2013-08-22 武田薬品工業株式会社 芳香環化合物
US9181186B2 (en) 2012-02-13 2015-11-10 Takeda Pharmaceutical Company Limited Aromatic ring compound
US20150011549A1 (en) 2012-02-15 2015-01-08 Takeda Pharmaceutical Company Limited Tablet
WO2013126015A1 (en) 2012-02-23 2013-08-29 N. V. Nutricia Composition comprising non- digestible oligosaccharides
JP6106179B2 (ja) 2012-02-24 2017-03-29 武田薬品工業株式会社 芳香環化合物
CA2868713A1 (en) 2012-03-29 2013-10-03 Takeda Pharmaceutical Company Limited Aromatic ring compound
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP2848621A4 (de) 2012-05-10 2016-06-01 Takeda Pharmaceutical Aromatische ringverbindung
US9505772B2 (en) 2012-05-10 2016-11-29 Takeda Pharmaceutical Company Limited Aromatic ring compound
JP6122879B2 (ja) 2012-06-05 2017-04-26 武田薬品工業株式会社 固形製剤
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
JP2015127299A (ja) 2012-07-19 2015-07-09 武田薬品工業株式会社 固形製剤
RU2015115631A (ru) 2012-09-26 2016-11-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Модулирование ire1
ES2629729T3 (es) 2013-03-14 2017-08-14 Takeda Pharmaceutical Company Limited Derivados de espiro azetidina asoxazol y uso de los mismos como antagonistas de sstr5
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2014165816A1 (en) 2013-04-05 2014-10-09 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
US9199963B2 (en) 2013-07-09 2015-12-01 Takeda Pharmaceutical Company Limited Heterocyclic compound
PT3031799T (pt) 2013-08-09 2018-07-04 Takeda Pharmaceuticals Co Composto aromático
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MY175778A (en) 2013-10-04 2020-07-08 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
JO3442B1 (ar) 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN106456628A (zh) 2014-03-19 2017-02-22 无限药品股份有限公司 用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
CN107073066B (zh) 2014-09-11 2021-09-17 加利福尼亚大学董事会 mTORC1抑制剂
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017048702A1 (en) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2018016227A (es) 2016-06-24 2019-07-08 Infinity Pharmaceuticals Inc Terapias de combinacion.
JOP20180029A1 (ar) 2017-03-30 2019-01-30 Takeda Pharmaceuticals Co مركب حلقي غير متجانس
JPWO2018181847A1 (ja) 2017-03-31 2020-03-05 武田薬品工業株式会社 芳香環化合物
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
AR111199A1 (es) 2017-03-31 2019-06-12 Takeda Pharmaceuticals Co Compuesto aromático agonista de gpr40
SG11202009338SA (en) 2018-03-23 2020-10-29 Carmot Therapeutics Inc Modulators of g-protein coupled receptors
IL278335B1 (en) 2018-05-01 2024-05-01 Revolution Medicines Inc C26-linked rapamycin analogs as MTOR inhibitors
ES2945560T3 (es) 2018-05-01 2023-07-04 Revolution Medicines Inc Análogos de rapamicina unidos en C40, C28 y C-32 como inhibidores de mTOR
WO2020045326A1 (ja) 2018-08-27 2020-03-05 株式会社スコヒアファーマ 安息香酸エステル化合物
US20220016215A1 (en) 2018-09-24 2022-01-20 Takeda Phaarmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
EP3856768A2 (de) 2018-09-24 2021-08-04 Takeda Pharmaceutical Company Limited Gip-rezeptor-agonist-peptidverbindungen und deren verwendungen
EP4126921A2 (de) 2020-03-25 2023-02-08 Takeda Pharmaceutical Company Limited Qd-dosierung von gip-rezeptoragonisten-peptidverbindungen und verwendungen davon
JP2023524603A (ja) 2020-03-25 2023-06-12 武田薬品工業株式会社 Ｇｉｆ受容体アゴニストペプチド化合物及びその使用
BR112023023559A2 (pt) 2021-05-13 2024-02-06 Carmot Therapeutics Inc Moduladores de receptores acoplados à proteína g
WO2023169456A1 (en) 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Heterocyclic glp-1 agonists
WO2023179542A1 (en) 2022-03-21 2023-09-28 Gasherbrum Bio , Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024125602A1 (en) 2022-12-15 2024-06-20 Gasherbrum Bio, Inc. Salts and solid forms of a compound having glp-1 agonist activity
WO2024131869A1 (en) 2022-12-22 2024-06-27 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024138048A1 (en) 2022-12-22 2024-06-27 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2001302546A (ja) * 2000-03-22 2001-10-31 Pfizer Prod Inc Ｉｉ型糖尿病を発症する危険性の高い個体を予防的に処置する方法
JP2001333778A (ja) * 2000-05-26 2001-12-04 Akihiko Shiraishi グルコキナーゼ活性化物質、糖尿病治療薬及び抗肥満薬
JP2003201279A (ja) * 2001-10-29 2003-07-18 Japan Tobacco Inc インドール化合物及びその医薬用途
WO2003091213A1 (fr) * 2002-04-25 2003-11-06 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amide ou sels de ces derives
JP2004508376A (ja) * 2000-09-06 2004-03-18 アストラゼネカ　アクチボラグ グリコーゲンホスホリラーゼ阻害剤としての二環式ピロリルアミド
JP2004196702A (ja) * 2002-12-18 2004-07-15 Yamanouchi Pharmaceut Co Ltd 新規なアミド誘導体又はその塩
US20040142938A1 (en) * 2002-11-14 2004-07-22 Sher Philip M. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
WO2004113345A1 (ja) * 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
WO2005063738A1 (ja) * 2003-12-29 2005-07-14 Banyu Pharmaceutical Co.,Ltd 新規２－へテロアリール置換ベンズイミダゾール誘導体
JP2005537333A (ja) * 2002-06-27 2005-12-08 ノボ・ノルデイスク・エー／エス 治療薬としてのアリールカルボニル誘導体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2592354B2 (ja) * 1990-11-30 1997-03-19 富士写真フイルム株式会社 新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料
AU6944296A (en) 1995-09-13 1997-04-01 Takeda Chemical Industries Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents
GB9803228D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
EP1391460A1 (de) 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclische Pyrrolylamide als Glycogenphosphorylase-Inhibitoren
ATE479429T1 (de) 2000-04-28 2010-09-15 Takeda Pharmaceutical Antagonisten des melanin-konzentrierenden hormons
AU2001256733A1 (en) 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
US20050054696A1 (en) 2001-10-29 2005-03-10 Takeshi Nakamura Indole compounds and medicinal use thereof
JP2006510590A (ja) * 2002-09-06 2006-03-30 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アレルギー及び喘息の処置のためのヒスタミンｈ４受容体モジュレーターの使用
DE60305052T2 (de) 2002-09-06 2006-12-21 Janssen Pharmaceutica N.V. Thienopyrrolyl und furanopyrrolyl verbindungen und deren verwendung als histamin h4 rezeptor liganden
JP4204532B2 (ja) 2004-10-28 2009-01-07 Ｇａｃ株式会社 収納庫
EP1844051A1 (de) 2005-01-19 2007-10-17 Biolipox AB Zur behandlung von enzündungen geeignete thienopyrrole
JP2006284418A (ja) 2005-04-01 2006-10-19 Jsr Corp ウエハ検査用プローブカードおよびウエハ検査装置
EP1883638A1 (de) * 2005-04-04 2008-02-06 OSI Pharmaceuticals, Inc. Pyrrolo[2,3-d]imidazole für die behandlung von hyperproliferativen erkrankungen
EP2308839B1 (de) 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Kondensierte heterozyklische verbindungen
WO2007096334A1 (en) * 2006-02-24 2007-08-30 Pfizer Italia Srl Pyrrolopyrrolones active as kinase inhibitors
WO2008005456A2 (en) * 2006-06-30 2008-01-10 Sepracor Inc. Fused heterocyclic inhibitors of d-amino acid oxidase
US20080058395A1 (en) * 2006-06-30 2008-03-06 Sepracor Inc. Fused heterocyclic inhibitors of D-amino acid oxidase
US7579370B2 (en) 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
WO2008089453A2 (en) * 2007-01-18 2008-07-24 Sepracor Inc. Inhibitors of d-amino acid oxidase

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2001302546A (ja) * 2000-03-22 2001-10-31 Pfizer Prod Inc Ｉｉ型糖尿病を発症する危険性の高い個体を予防的に処置する方法
JP2001333778A (ja) * 2000-05-26 2001-12-04 Akihiko Shiraishi グルコキナーゼ活性化物質、糖尿病治療薬及び抗肥満薬
JP2004508376A (ja) * 2000-09-06 2004-03-18 アストラゼネカ　アクチボラグ グリコーゲンホスホリラーゼ阻害剤としての二環式ピロリルアミド
JP2003201279A (ja) * 2001-10-29 2003-07-18 Japan Tobacco Inc インドール化合物及びその医薬用途
WO2003091213A1 (fr) * 2002-04-25 2003-11-06 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amide ou sels de ces derives
JP2005537333A (ja) * 2002-06-27 2005-12-08 ノボ・ノルデイスク・エー／エス 治療薬としてのアリールカルボニル誘導体
US20040142938A1 (en) * 2002-11-14 2004-07-22 Sher Philip M. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
JP2004196702A (ja) * 2002-12-18 2004-07-15 Yamanouchi Pharmaceut Co Ltd 新規なアミド誘導体又はその塩
WO2004113345A1 (ja) * 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
WO2005063738A1 (ja) * 2003-12-29 2005-07-14 Banyu Pharmaceutical Co.,Ltd 新規２－へテロアリール置換ベンズイミダゾール誘導体

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