JOP20180028A1 - مركب ببتيد - Google Patents

مركب ببتيد

Info

Publication number
JOP20180028A1
JOP20180028A1 JOP/2018/0028A JOP20180028A JOP20180028A1 JO P20180028 A1 JOP20180028 A1 JO P20180028A1 JO P20180028 A JOP20180028 A JO P20180028A JO P20180028 A1 JOP20180028 A1 JO P20180028A1
Authority
JO
Jordan
Prior art keywords
peptide compound
medicament
peptide
tyr
glu
Prior art date
Application number
JOP/2018/0028A
Other languages
English (en)
Inventor
Taiji Asami
Mari Adachi
Naoki Nishizawa
Ayumu Niida
Shiro Takekawa
Yoko Kanematsu
Tomoko Morimoto
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of JOP20180028A1 publication Critical patent/JOP20180028A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

يتعلق الاختراع الحالي بمركب ببتيد peptide compound جديد له تأثير تنشيطي على مستقبلات عديد الببتيد المفرز للإنسولين المعتمد على جلوكوز glucose-dependent insulinotropic polypeptide (GIP) وباستخدام مركب الببتيد peptide compound كدواء. بصفة خاصة، تم توفير ببتيد peptide يحتوي على ترتيب متمثل بالصيغة (I) أو ملح من ذلك ودواء يحتويه. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2 (I) حيث يكون كل رمز كما تحدد هنا.
JOP/2018/0028A 2017-03-31 2017-03-31 مركب ببتيد JOP20180028A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2017072556 2017-03-31

Publications (1)

Publication Number Publication Date
JOP20180028A1 true JOP20180028A1 (ar) 2019-01-30

Family

ID=62089992

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2018/0028A JOP20180028A1 (ar) 2017-03-31 2017-03-31 مركب ببتيد
JOP/2019/0211A JOP20190211A1 (ar) 2017-03-31 2017-06-16 ببتيد منشط لمستقبل gip

Family Applications After (1)

Application Number Title Priority Date Filing Date
JOP/2019/0211A JOP20190211A1 (ar) 2017-03-31 2017-06-16 ببتيد منشط لمستقبل gip

Country Status (21)

Country Link
US (2) US10435445B2 (ar)
EP (1) EP3601329A1 (ar)
JP (2) JP7175912B2 (ar)
KR (1) KR20190134626A (ar)
CN (1) CN110709414A (ar)
AR (1) AR111346A1 (ar)
AU (2) AU2018246553B2 (ar)
BR (1) BR112019020438A2 (ar)
CA (1) CA3058361A1 (ar)
CL (1) CL2019002790A1 (ar)
CO (1) CO2019012271A2 (ar)
EA (1) EA201992327A1 (ar)
EC (1) ECSP19078239A (ar)
IL (1) IL269581B1 (ar)
JO (2) JOP20180028A1 (ar)
MA (1) MA48998A (ar)
PE (1) PE20200675A1 (ar)
PH (1) PH12019502252A1 (ar)
SG (1) SG11201908542QA (ar)
TW (1) TWI801373B (ar)
WO (1) WO2018181864A1 (ar)

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CN115335395A (zh) * 2020-03-25 2022-11-11 武田药品工业株式会社 Gip受体激动剂肽化合物的qd给药及其用途
CN115916812A (zh) * 2020-03-25 2023-04-04 武田药品工业株式会社 Gip受体激动剂肽化合物及其用途
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EP4299057A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4180060A1 (en) 2021-11-15 2023-05-17 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
WO2023084118A1 (en) 2021-11-15 2023-05-19 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
TW202330584A (zh) 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途
WO2023193727A1 (zh) * 2022-04-07 2023-10-12 广东众生睿创生物科技有限公司 多肽在制备治疗和/或预防糖尿病及肥胖症及其相关疾病药物中的制药用途
EP4299052A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and a permeation enhancer
EP4299071A1 (en) 2022-07-01 2024-01-03 Adocia Compositions comprising a peptide or a protein and an acylated amino acid

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Also Published As

Publication number Publication date
MA48998A (fr) 2020-02-05
TWI801373B (zh) 2023-05-11
BR112019020438A2 (pt) 2020-06-09
JP2023012547A (ja) 2023-01-25
JP2020515612A (ja) 2020-05-28
KR20190134626A (ko) 2019-12-04
CO2019012271A2 (es) 2020-08-21
JOP20190211A1 (ar) 2019-09-15
US10435445B2 (en) 2019-10-08
PH12019502252A1 (en) 2020-06-29
EP3601329A1 (en) 2020-02-05
JP7175912B2 (ja) 2022-11-21
AU2018246553A1 (en) 2019-10-17
WO2018181864A1 (en) 2018-10-04
US20180298070A1 (en) 2018-10-18
PE20200675A1 (es) 2020-06-11
IL269581A (en) 2019-11-28
CA3058361A1 (en) 2018-10-04
AU2018246553B2 (en) 2021-11-11
US20200140505A1 (en) 2020-05-07
IL269581B1 (en) 2024-02-01
CL2019002790A1 (es) 2020-05-29
AR111346A1 (es) 2019-07-03
CN110709414A (zh) 2020-01-17
SG11201908542QA (en) 2019-10-30
EA201992327A1 (ru) 2020-02-19
ECSP19078239A (es) 2019-12-27
TW201841936A (zh) 2018-12-01
AU2022200837A1 (en) 2022-03-03
US11174301B2 (en) 2021-11-16

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