JP4891079B2 - 免疫参照電極を有する免疫測定装置 - Google Patents
免疫参照電極を有する免疫測定装置 Download PDFInfo
- Publication number
- JP4891079B2 JP4891079B2 JP2006526295A JP2006526295A JP4891079B2 JP 4891079 B2 JP4891079 B2 JP 4891079B2 JP 2006526295 A JP2006526295 A JP 2006526295A JP 2006526295 A JP2006526295 A JP 2006526295A JP 4891079 B2 JP4891079 B2 JP 4891079B2
- Authority
- JP
- Japan
- Prior art keywords
- immunosensor
- sample
- sensor
- antibody
- conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
第1固相化抗体を含み、固相化抗体、標的分析対象物質、標識抗体の間のサンドイッチ構造に基づいて第1信号を発生し、該第1信号が、前記標識抗体の非特異的結合の程度から生じる成分をもつ、電気化学センサである第1免疫センサと、
第2固相化抗体を含み、免疫参照センサとして機能し、前記非特異的結合の程度と同等か又は予測されうる限りに相関する第2信号を発生し、そして、試料中に存在するが前記標的分析対象物質ではない内因性又は外因性タンパク質と前記第2固相化抗体との間の免疫複合体を有する、電気化学センサである第2免疫センサと、
を含んで構成されることを特徴とする免疫センサシステムを提供することにある。
第1固相化抗体、標的分析対象物質、標識抗体の間のサンドイッチ構造に基づいて第1信号を発生し、該第1信号が、前記標識抗体の非特異的結合の程度から生じる成分をもつ、電気化学センサである第1免疫センサと、免疫参照センサとして機能し、前記非特異的結合の程度と同等か又は予測されうる限りに相関する第2信号を発生し、そして、第2固相化抗体と内因性又は外因性タンパク質との間の免疫複合体を有する、電気化学センサである第2免疫センサと、を含んで構成される免疫センサシステムに、前記標的分析対象物質に加えて該標的分析対象物質ではない前記内因性又外因性タンパク質を含有した試料を接触させること、
前記第1免疫センサ及び第2免疫センサを洗浄液で洗浄すること、
試料中の分析対象物質濃度に対する補正値の決定に、前記第1免疫センサからの第1信号及び前記第2免疫センサからの第2信号を使用すること、
を含むことを特徴とする方法を提供することにある。
塩試薬と、試料のイオン強度を増加させる充分な試料の処理手段と、を備え、試料が接触した場合にバフィーコート干渉を減少させる、全血試料を受ける(受信する)導管を含んで構成されることを特徴とする免疫測定装置を開示する。
イオン強度を増加させることで、試料が免疫センサに接触したときにバフィーコート干渉を減少させるように、免疫測定装置に、全血試料に対する塩試薬を添加すること、を含むことを特徴とする方法を開示する。
標的分析対象物質に対する第1固相化抗体、標的分析対象物質、標識抗体の間のサンドイッチ構造に基づいて電気化学信号を発生する、血液試料の免疫センサを含んで構成され、
前記免疫センサのセンサ表面が、
標的分析対象物質ではないが試料に存在する内因性又外因性タンパク質との間に免疫複合体を生成する、前記センサ表面の少なくとも一部に被覆される第2固相化抗体を含んで構成されることを特徴とする免疫センサシステムを開示する。
免疫センサ及びバルク伝導度センサを備え、血液試料を受ける(受信する)導管と、
前記センサからの信号を処理し、等価血漿分析対象物質濃度を決定する計算手段と、
を含んで構成されることを特徴とする電気化学免疫測定装置を開示する。
(a)血液試料を免疫センサに接触させること、
(b)前記血液試料をバルク伝導度センサに接触させて、その抵抗を測定すること、
(c)既知の伝導度を有し、及び、免疫センサに結合する分析対象物質の量に関連して検出可能な生成物を生成する充分な試薬を含む水溶液を、前記免疫センサ及び伝導度センサに接触させること、
(d)前記免疫センサにおいて前記生成物が生じる信号を測定すること、
(e)前記免疫センサからの信号をアルゴリズム手段によって分析対象物質濃度に変換すること、
(f)前記測定された血液試料の抵抗から血液試料のヘマトクリット値を計算すること、
(g)前記計算した分析対象物質濃度を前記血液のヘマトクリット値を用いて補正すること、
を含むことを特徴とする方法を開示する。
1.C無、R無:血液の引き込みは認められなかった。
2.C無、R有:保持チャンバを試薬で確実に被覆しなかったため結果は上記1に同じ。
3.C有、R無:数週間の間は、迅速な血液の引き込みが確認されたが、時間の経過と
共に引き込み率が低下。
4.C有、R有:血液の引き込みは迅速良好で、更に、6ヵ月(一般的な商品寿命)の
間、引き込みが持続。
表面−第1抗体(Ab1)〜分析対象物質〜Ab2−酵素 酵素+S→P 式(1)
表面〜Ab2−酵素 酵素+S→P 式(2)
表面〜分析対象物質−Ab2−酵素 酵素+S→P 式(3)
補正信号=IS−IRS 式(4)
iNet = ParamAct-ParamRef-c0(ナノアンペア) 式(5)
ここで、係数c0は、全血や血漿が未導入である場合のamp0及びampl間におけるバイアス、即ち、分析対象物質が存在しない場合のあらゆるバイアスとして決定される、カートリッジの製造ロットに固有な任意の値である。
iTCorr = iNet *(1+ c1 *(ATemp-TempC)) 式(6)
ここで、係数c1(per degree)の値は、一般に、カートリッジの製造ロットに固有のものではなく、カートリッジの製造工程に固有のものである。また、係数c1は、一般的に、相対的に小さな値となる(例えば、1〜3%)。当業者であれば、これを温度−依存実験から測定できることを認識可能である。
fCond = c2 * ResHct2 + c3 * ResHct + c4 式(7)
ここで、ResHctは、試料が試薬によって補正された後のヘマトクリット(伝導率)センサにおける抵抗である。
ResHct < MaxPlasmaCondであれば fCond = 1 に設定 式(8)
ResHct > MaxPlasmaCond 且つ fCond < MinfCondであれば、
fCond = MinfCond に設定 式(9)
ここで、MaxPlasmaCond = 1050、及びMinfCond = 0.8である。
iCorr= iTCorr/fCond 式(10)
[cTnI](ng/mL) = c6*iCorr/(c5*c6-iCorr) 式(11)
[cTnI](ng/mL) = c7*iCorr2 + c7*c8*iCorr 式(12)
[cTnI](ng/mL) = c6*iCorr/(c5*c6-iCorr)+ c7*iCorr2 + c7*c8*iCorr
= c6*iCorr/(c5*c6-iCorr)+ c7 * Corr2 + Linear* iCorr 式(13)
iCorr > 0.9*c5*c6であれば、iCorr = 0. 9*c5*c6に設定 式(14)
H2N−C6H4−OH → HN=C6H4=O+2H++2e−
1) 25〜50uLの試料が、試料注入口167に導入され、該試料注入口167からキャピラリーストップ151まで充填される。キャピラリーストップ151は、カバー及びベースの各構成要素をつなぎ合わせる接着テープに設けられた0.012インチのレーザ切除穴である。ユーザは、スナップ・フラップ(snap flap)上に取り付けられたラテックスゴムディスクを回転させて試料注入口167を閉じ、カートリッジを分析装置に挿入する。
2) 分析装置がカートリッジに接触すると、モータ駆動プランジャが箔袋161を押圧し、洗浄/分析液体が中央導管158に流れ込む。
3) 別個のモータ駆動プランジャが試料ダイヤフラム156に接触し、該試料ダイヤフラム156が、計量された試料セグメントを試料導管に沿って(試薬領域R1〜R2にかけて)押し出す。これにより、試料は、伝導度センサを介してセンサチップ153で検出される。このセンサチップはキャプチャー領域R3に配置されている。
4) 試料は、センサとの結合を促進するために制御時間だけ、予め定められ及び制御された方法下において、R2〜R5との間を試料ダイヤフラム156によって往復させられる。
5) 試料は、カートリッジの廃棄領域(R8)方向に押し出され、セルロース又は類似の吸収ウィック(wick)によって提供される受動的ポンプ157に接触させられる。このウィックを濡らす動作は、空気の流れを密閉する。この密閉によって、試料ダイヤフラム156が発生する超過圧力を排気するための排気機能が取り除かれる。能動的ベントは、図16に示した「制御エアーベント」になる。
6) 試料導管の急速な排気(モータ駆動プランジャを試料ダイヤフラム156から引き戻すことにより生じる)は、(ベントからの)空気と第2導管からの洗浄/分析液体との混合物を、図16のR5とR4との間に設けられた注入口に移動させる。試料導管において、急速な排気を繰り返すと、空気で区分けされた連続する液体セグメントが生み出され、センサチップを横断し試料注入口方向へと(即ち、R4、R3、R2、R1へと順番に)導かれる。これによりセンサは、洗浄されて余分な試薬が除去され、さらに、分析に適した試薬で湿らされるようになる。また、箔袋からの洗浄/分析液体は、中央の洗浄/分析液体導管内のR7及びR6における加えられた試薬によって、さらに補正される。
7) 洗浄/分析液体セグメントは、センサチップに対して分析液体の薄層だけが提供されるように、低速で試料注入口方向に引っ張られる。この段階で電気化学分析が実行される。分析方法は、好ましくはアンペロメトリであるが、ポテンショメトリ又はインピーダンス検出であってもよい。
8) カートリッジを分析装置から外すことができるように、分析装置の機構が後退する。
Claims (26)
- 干渉を減少させる免疫センサシステムであって、
第1固相化抗体を含み、固相化抗体、標的分析対象物質、標識抗体の間のサンドイッチ構造に基づいて第1信号を発生し、該第1信号が、前記標識抗体の非特異的結合の程度から生じる成分をもつ、電気化学センサである第1免疫センサと、
第2固相化抗体を含み、免疫参照センサとして機能し、前記非特異的結合の程度と同等か又は予測されうる限りに相関する第2信号を発生し、そして、試料中に存在するが前記標的分析対象物質ではない内因性又は外因性タンパク質と前記第2固相化抗体との間の免疫複合体を有する、電気化学センサである第2免疫センサと、
を含んで構成されることを特徴とする免疫センサシステム。 - 前記第1免疫センサ及び前記第2免疫センサが、アンペロメトリック電気化学センサであることを特徴とする請求項1に記載の免疫センサシステム。
- 前記第1免疫センサ及び前記第2免疫センサが、ポテンショメトリックセンサ、電界効果トランジスタセンサ、電気伝導度センサ、温度測定センサ、音波測定センサの群から選択されることを特徴とする請求項1に記載の免疫センサシステム。
- 当該免疫センサシステムが、試料中の分析対象物質を測定する使い捨てカートリッジであることを特徴とする請求項1〜3のいずれかに記載の免疫センサシステム。
- 前記標的分析対象物質が、血液試料中における、トロポニンI、トロポニンT、クレアチンキナーゼMB、プロカルシトニン、ヒト絨毛性性腺刺激ホルモン(HCG)、N末端プロ脳性ナトリウム利尿ペプチド(NTproBNP)、プロ脳性ナトリウム利尿ペプチド(proBNP)、脳性ナトリウム利尿ペプチド(BNP)、ミオグロビンからなる群から選択されることを特徴とする請求項1〜4のいずれかに記載の免疫センサシステム。
- 前記第2免疫センサの固相化抗体が、血漿タンパク質に対するものであることを特徴とする請求項1〜5のいずれかに記載の免疫センサシステム。
- 前記第2免疫センサの固相化抗体が、ヒト血清アルブミン(HSA)、ウシ血清アルブミン(BSA)、フィブリノゲン及びIgG fc領域からなる群から選択されたタンパク質に対するものであることを特徴とする請求項1〜5のいずれかに記載の免疫センサシステム。
- 前記試料中の内因性又は外因性タンパク質が、前記免疫センサシステムに試料を100秒間接触させている間に、前記第2免疫センサ上の固相化抗体の50%以上と結合するのに充分な濃度であることを特徴とする請求項1〜7のいずれかに記載の免疫センサシステム。
- 前記第2免疫センサの固相化抗体が、略1×10−7M〜1×10−15Mの親和定数を有することを特徴とする請求項1〜8のいずれかに記載の免疫センサシステム。
- 前記第1免疫センサ及び前記第2免疫センサの双方の抗体が、0.01〜5.0μmの直径を有する微粒子に固定されていることを特徴とする請求項1〜9のいずれかに記載の免疫センサシステム。
- 前記内因性又は外因性タンパク質が、前記第2免疫センサにおける抗体の親和定数と比較して少なくとも3桁以上の濃度で血液試料に存在することを特徴とする請求項1〜10のいずれかに記載の免疫センサシステム。
- 免疫センサシステムにおける干渉を減少させて標的分析対象物質を分析する方法であって、
第1固相化抗体、標的分析対象物質、標識抗体の間のサンドイッチ構造に基づいて第1信号を発生し、該第1信号が、前記標識抗体の非特異的結合の程度から生じる成分をもつ、電気化学センサである第1免疫センサと、免疫参照センサとして機能し、前記非特異的結合の程度と同等か又は予測されうる限りに相関する第2信号を発生し、そして、第2固相化抗体と内因性又は外因性タンパク質との間の免疫複合体を有する、電気化学センサである第2免疫センサと、を含んで構成される免疫センサシステムに、前記標的分析対象物質に加えて該標的分析対象物質ではない前記内因性又外因性タンパク質を含有した試料を接触させること、
前記第1免疫センサ及び前記第2免疫センサを洗浄液で洗浄すること、
試料中の分析対象物質濃度に対する補正値の決定に、前記第1免疫センサからの第1信号及び前記第2免疫センサからの第2信号を使用すること、
を含むことを特徴とする方法。 - 前記第1免疫センサ及び前記第2免疫センサが、アンペロメトリック電気化学センサであることを特徴とする請求項12に記載の方法。
- 前記第1免疫センサ及び前記第2免疫センサが、ポテンショメトリックセンサ、電界効果トランジスタセンサ、電気伝導度センサ、温度測定センサ、音波測定センサの群から選択されたものであることを特徴とする請求項12に記載の方法。
- 前記免疫センサシステムが、試料中の分析対象物質を測定する使い捨てカートリッジであることを特徴とする請求項12〜14のいずれかに記載の方法。
- 前記標的分析対象物質が、トロポニンI、トロポニンT、クレアチンキナーゼMB、プロカルシトニン、ヒト絨毛性性腺刺激ホルモン(HCG)、N末端プロ脳性ナトリウム利尿ペプチド(NTproBNP)、プロ脳性ナトリウム利尿ペプチド(proBNP)、脳性ナトリウム利尿ペプチド(BNP)、ミオグロビンからなる群から選択されることを特徴とする請求項12〜15のいずれかに記載の方法。
- 前記第2免疫センサの固相化抗体が、血漿タンパク質に対するものであることを特徴とする請求項12〜16のいずれかに記載の方法。
- 前記第2免疫センサの固相化抗体が、ヒト血清アルブミン(HSA)、ウシ血清アルブミン(BSA)、フィブリノゲン及びIgG fc領域からなる群から選択されたタンパク質に対するものであることを特徴とする請求項12〜16のいずれかに記載の方法。
- 前記試料中の内因性又は外因性タンパク質が、前記免疫センサシステムに試料を100秒間接触させている間に、前記第2免疫センサ上の固相化抗体の50%以上と結合するのに充分な濃度であることを特徴とする請求項12〜18のいずれかに記載の方法。
- 前記第2免疫センサの固相化抗体が、略1×10−7M〜1×10−15Mの親和定数を有することを特徴とする請求項12〜19のいずれかに記載の方法。
- 前記内因性タンパク質が、略100ng/ml以上の濃度のHSAであることを特徴とする請求項12〜20のいずれかに記載の方法。
- 前記内因性又は外因性タンパク質が、前記第2免疫センサにおける抗体の親和定数と比較して少なくとも3桁以上の濃度で血液試料に存在することを特徴とする請求項12〜21のいずれかに記載の方法。
- 前記第1免疫センサ及び前記第2免疫センサの双方の抗体が、0.01〜5.0μmの直径を有する微粒子に固定されていることを特徴とする請求項12〜22のいずれかに記載の方法。
- 前記微粒子が、カルボン酸塩修飾ポリスチレンビーズであることを特徴とする請求項23に記載の方法。
- 前記第1免疫センサ及び前記第2免疫センサが、洗浄効率のモニタに用いられることを特徴とする請求項12〜24のいずれかに記載の方法。
- 前記第1免疫センサ及び前記第2免疫センサからの信号が、不適当な抗凝固処理試料を含む異常状態にある試料の検出に用いられることを特徴とする請求項12〜24のいずれかに記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/658,529 | 2003-09-10 | ||
US10/658,529 US7723099B2 (en) | 2003-09-10 | 2003-09-10 | Immunoassay device with immuno-reference electrode |
PCT/US2004/029498 WO2005026689A2 (en) | 2003-09-10 | 2004-09-09 | Immunoassay device with immuno-reference electrode |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010213232A Division JP5250007B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213231A Division JP5361834B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213230A Division JP5232207B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213233A Division JP5142338B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007505319A JP2007505319A (ja) | 2007-03-08 |
JP4891079B2 true JP4891079B2 (ja) | 2012-03-07 |
Family
ID=34312688
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006526295A Expired - Fee Related JP4891079B2 (ja) | 2003-09-10 | 2004-09-09 | 免疫参照電極を有する免疫測定装置 |
JP2010213231A Active JP5361834B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213232A Expired - Fee Related JP5250007B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213230A Expired - Fee Related JP5232207B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213233A Expired - Fee Related JP5142338B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010213231A Active JP5361834B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213232A Expired - Fee Related JP5250007B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213230A Expired - Fee Related JP5232207B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
JP2010213233A Expired - Fee Related JP5142338B2 (ja) | 2003-09-10 | 2010-09-24 | 免疫参照電極を有する免疫測定装置 |
Country Status (5)
Country | Link |
---|---|
US (6) | US7723099B2 (ja) |
EP (2) | EP2551671B1 (ja) |
JP (5) | JP4891079B2 (ja) |
CA (3) | CA2538826C (ja) |
WO (1) | WO2005026689A2 (ja) |
Families Citing this family (333)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
WO2002051438A2 (en) | 2000-12-22 | 2002-07-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (rgm) and its modulators |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
US7214300B2 (en) * | 2001-06-04 | 2007-05-08 | Epocal Inc. | Integrated electrokinetic devices and methods of manufacture |
US6896778B2 (en) * | 2001-06-04 | 2005-05-24 | Epocal Inc. | Electrode module |
US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US20060134713A1 (en) * | 2002-03-21 | 2006-06-22 | Lifescan, Inc. | Biosensor apparatus and methods of use |
US7842234B2 (en) | 2002-12-02 | 2010-11-30 | Epocal Inc. | Diagnostic devices incorporating fluidics and methods of manufacture |
US7767068B2 (en) * | 2002-12-02 | 2010-08-03 | Epocal Inc. | Heterogeneous membrane electrodes |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US8626257B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | Analyte sensor |
US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US7722817B2 (en) * | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
US7723099B2 (en) * | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
DE602004029092D1 (de) | 2003-12-05 | 2010-10-21 | Dexcom Inc | Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
EP2316331B1 (en) | 2003-12-09 | 2016-06-29 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
EP2977757B1 (en) | 2004-04-07 | 2017-09-13 | Abbott Laboratories | Disposable chamber for analyzing biologic fluids |
US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7857760B2 (en) | 2004-07-13 | 2010-12-28 | Dexcom, Inc. | Analyte sensor |
US7946984B2 (en) | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
US20090076360A1 (en) | 2007-09-13 | 2009-03-19 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
US20070231794A1 (en) * | 2005-09-21 | 2007-10-04 | Combimatrix Corporation | Process to detect binding events on an electrode microarray using enzymes |
CA2624562A1 (en) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Binding domains of proteins of the repulsive guidance molecule (rgm) protein family and functional fragments thereof, and their use |
US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
JP2007240425A (ja) * | 2006-03-10 | 2007-09-20 | Kyushu Institute Of Technology | 電気化学的抗原検出法とそのための装置並びに検出チップ |
EP2059811A2 (en) * | 2006-08-18 | 2009-05-20 | 3M Innovative Properties Company | Methods of detection using acousto-mechanical detection systems |
US20080220448A1 (en) * | 2006-09-01 | 2008-09-11 | Blincko Stuart J | Antigenic protein conjugates and process for preparing same |
US8865398B2 (en) | 2006-09-01 | 2014-10-21 | Abbott Laboratories | Combination hepatitis C virus antigen and antibody detection method |
GB0617276D0 (en) * | 2006-09-04 | 2006-10-11 | Suresensors | Device |
WO2008042918A2 (en) * | 2006-10-04 | 2008-04-10 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US7776605B2 (en) | 2006-10-26 | 2010-08-17 | Abbott Laboratories | Assay for cardiac troponin autoantibodies |
EP2097750A2 (en) * | 2006-10-26 | 2009-09-09 | Abbott Laboratories | Immunoassay of analytes in samples containing endogenous anti-analyte antibodies |
US20080305512A1 (en) * | 2006-10-26 | 2008-12-11 | Mattingly Phillip G | Assay for cardiac troponin autoantibodies |
JP5319549B2 (ja) | 2006-12-29 | 2013-10-16 | アボット・ラボラトリーズ | 溶液内捕捉イムノアッセイで使用する非変性細胞溶解試薬 |
US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
US7863035B2 (en) | 2007-02-15 | 2011-01-04 | Osmetech Technology Inc. | Fluidics devices |
US20080280377A1 (en) | 2007-05-08 | 2008-11-13 | Abbott Laboratories | Human b-type natriuretic peptide assay having reduced cross-reactivity with other peptide forms |
US20200037875A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US8003060B2 (en) * | 2007-05-18 | 2011-08-23 | Axela Inc. | Reaction vessel with integrated optical and fluid control elements |
US8288111B2 (en) * | 2007-05-24 | 2012-10-16 | Abbott Laboratories | Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites |
US20080306444A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US20090053736A1 (en) * | 2007-08-21 | 2009-02-26 | Mattingly Phillip G | Homogeneous Chemiluminescent Immunoassay for Analysis of Iron Metalloproteins |
US7608361B2 (en) * | 2007-08-22 | 2009-10-27 | Stauffer John E | Alkali metal battery |
WO2009051901A2 (en) | 2007-08-30 | 2009-04-23 | Pepex Biomedical, Llc | Electrochemical sensor and method for manufacturing |
WO2009032760A2 (en) | 2007-08-30 | 2009-03-12 | Pepex Biomedical Llc | Electrochmical sensor and method for manufacturing |
US20090068635A1 (en) * | 2007-09-06 | 2009-03-12 | Muerhoff Anthony S | Indirectly labelled assay conjugates and methods of preparing and using same |
US8138318B2 (en) | 2007-09-13 | 2012-03-20 | Abbott Laboratories | Hepatitis B pre-S2 nucleic acid |
US20100136520A1 (en) * | 2007-09-13 | 2010-06-03 | Abbott Laboratories | Detecting hepatitis b virus |
US20090098531A1 (en) * | 2007-09-13 | 2009-04-16 | Abbott Laboratories | Detecting hepatitis b virus |
EP4098177A1 (en) | 2007-10-09 | 2022-12-07 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US20100267055A1 (en) * | 2007-10-21 | 2010-10-21 | Abbott Laboratories | One-step immunoassays exhibiting increased sensitivity and specificity |
US8283124B2 (en) * | 2007-10-25 | 2012-10-09 | Abbott Laboratories | Compositions for detecting antibodies to Babesia microti and methods of uses thereof |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
US20090111117A1 (en) * | 2007-10-26 | 2009-04-30 | University Of Washington | Device and method for detecting complex formation |
JP4956715B2 (ja) * | 2007-12-03 | 2012-06-20 | 国立大学法人 東京大学 | 目的物質の測定方法 |
US9839395B2 (en) | 2007-12-17 | 2017-12-12 | Dexcom, Inc. | Systems and methods for processing sensor data |
JP5134692B2 (ja) | 2007-12-19 | 2013-01-30 | アボット・ラボラトリーズ | 免疫アッセイのための免疫抑制剤薬剤抽出試薬 |
US20090203037A1 (en) | 2007-12-27 | 2009-08-13 | Abbott Laboratories | Anti-T. Cruzi Antibodies and Methods of Use |
WO2009086411A2 (en) * | 2007-12-27 | 2009-07-09 | Abbott Laboratories | Negative mimic antibody for use as a blocking reagent in bnp immunoassays |
EP2252196A4 (en) | 2008-02-21 | 2013-05-15 | Dexcom Inc | SYSTEMS AND METHOD FOR PROCESSING, TRANSMITTING AND DISPLAYING SENSOR DATA |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
US8030471B2 (en) * | 2008-03-06 | 2011-10-04 | Abbott Laboratories | Plasmodium malariae and Plasmodium ovale genes and uses thereof |
US8268981B2 (en) * | 2008-03-06 | 2012-09-18 | Abbott Laboratories | Plasmodium malariae and plasmodium ovale genes and uses thereof |
US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
US20090286329A1 (en) * | 2008-05-19 | 2009-11-19 | Abbott Laboratoires | Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides |
US20090286256A1 (en) * | 2008-05-19 | 2009-11-19 | Abbott Laboratories | Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides |
US8924159B2 (en) | 2008-05-30 | 2014-12-30 | Abbott Diabetes Care Inc. | Method and apparatus for providing glycemic control |
WO2009149185A2 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
EP2297209A4 (en) | 2008-06-03 | 2012-08-01 | Abbott Lab | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF |
US8741287B2 (en) | 2008-06-18 | 2014-06-03 | Abbott Laboratories | PlGF-1 assay and kits and components thereof |
US20100015655A1 (en) * | 2008-07-17 | 2010-01-21 | Abbott Laboratories | Methods and Kits for Detecting and Quantifying Damage Caused by a Parasite |
US11235323B2 (en) | 2008-08-27 | 2022-02-01 | Life Technologies Corporation | Apparatus for and method of processing biological samples |
EP2331954B1 (en) * | 2008-08-27 | 2020-03-25 | Life Technologies Corporation | Apparatus for and method of processing biological samples |
WO2010028014A1 (en) | 2008-09-03 | 2010-03-11 | Abbott Laboratories | Assays and kits for determining hiv-1 tropism |
EP3795987B1 (en) | 2008-09-19 | 2023-10-25 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
US20100105150A1 (en) * | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
US9445755B2 (en) | 2008-11-14 | 2016-09-20 | Pepex Biomedical, Llc | Electrochemical sensor module |
US8951377B2 (en) | 2008-11-14 | 2015-02-10 | Pepex Biomedical, Inc. | Manufacturing electrochemical sensor module |
US8506740B2 (en) | 2008-11-14 | 2013-08-13 | Pepex Biomedical, Llc | Manufacturing electrochemical sensor module |
US8168165B2 (en) | 2008-12-23 | 2012-05-01 | Abbott Laboratories | Alkylated interleukin-18 compositions |
US8349325B2 (en) | 2008-12-23 | 2013-01-08 | Abbott Laboratories | Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making |
CA2749041C (en) | 2008-12-31 | 2019-09-03 | Abbott Point Of Care Inc. | Method and device for immunoassay using obligonucleotide conjugates |
US8241915B2 (en) * | 2009-01-14 | 2012-08-14 | Abbott Laboratories | Methods and kits for detecting hemoglobin in test samples |
CN102365372B (zh) | 2009-01-31 | 2016-05-25 | Abbvie公司 | 预测和监控对于Aurora激酶B抑制剂疗法的应答的标记 |
US9045800B2 (en) * | 2009-02-11 | 2015-06-02 | Abbvie Inc. | Methods and compositions for identifying, classifying and monitoring subject having Bcl-2 family inhibitor-resistant tumors and cancers |
US8030026B2 (en) | 2009-02-24 | 2011-10-04 | Abbott Laboratories | Antibodies to troponin I and methods of use thereof |
SG173705A1 (en) | 2009-03-05 | 2011-09-29 | Abbott Lab | Il-17 binding proteins |
US8283162B2 (en) | 2009-03-10 | 2012-10-09 | Abbott Laboratories | Antibodies relating to PIVKAII and uses thereof |
US8084272B2 (en) | 2009-03-25 | 2011-12-27 | Abbott Point Of Care Inc. | Amelioration of heterophile antibody immunosensor interference |
US9446194B2 (en) | 2009-03-27 | 2016-09-20 | Dexcom, Inc. | Methods and systems for promoting glucose management |
US8063193B2 (en) | 2009-03-27 | 2011-11-22 | Abbott Laboratories | Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof |
GB2473868A (en) | 2009-09-28 | 2011-03-30 | Invitrogen Dynal As | Apparatus and method of automated processing of biological samples |
US20100291709A1 (en) * | 2009-05-13 | 2010-11-18 | Abbott Laboratories | Human nt-pro b-type natriuretic peptide assay having reduced cross-reactivity with other peptide forms |
WO2011002936A2 (en) | 2009-06-30 | 2011-01-06 | Abbott Laboratories | Markers of xmrv infection and uses thereof |
JP5728005B2 (ja) * | 2009-06-30 | 2015-06-03 | コーニンクレッカ フィリップス エヌ ヴェ | 磁気センサ装置、このような装置の作動方法及びサンプル |
US9351677B2 (en) | 2009-07-02 | 2016-05-31 | Dexcom, Inc. | Analyte sensor with increased reference capacity |
EP3970610A3 (en) | 2009-07-02 | 2022-05-18 | Dexcom, Inc. | Analyte sensors and methods of manufacturing same |
US20110024305A1 (en) * | 2009-07-29 | 2011-02-03 | Ervin Matthew H | Differential Amplifier Sensor Architecture for Increased Sensing Selectivity |
CA2771575A1 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
JP5715137B2 (ja) * | 2009-08-31 | 2015-05-07 | アボット・ラボラトリーズAbbott Laboratories | 主要有害心イベントの予測のためのバイオマーカーおよびその使用 |
JP5311406B2 (ja) * | 2009-09-10 | 2013-10-09 | 独立行政法人産業技術総合研究所 | 免疫センサ |
WO2011041463A2 (en) | 2009-09-30 | 2011-04-07 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8377669B2 (en) | 2009-11-17 | 2013-02-19 | Abbott Point Of Care Inc. | Reducing leukocyte interference in non-competitive immunoassays |
US8389293B2 (en) * | 2009-11-17 | 2013-03-05 | Abbott Point Of Care Inc. | Reducing leukocyte interference in competitive immunoassays |
US8455212B2 (en) * | 2009-11-21 | 2013-06-04 | Abbott Laboratories | Assays for human NT-pro B-type natriuretic peptide, human pro B-type natriuretic peptide and human B-type natriuretic peptide |
US9000769B2 (en) | 2009-11-23 | 2015-04-07 | Proxim Diagnostics | Controlled electrochemical activation of carbon-based electrodes |
US8652788B2 (en) | 2009-12-02 | 2014-02-18 | Abbott Laboratories | Assay for diagnosis of cardiac myocyte damage |
US8835120B2 (en) * | 2009-12-02 | 2014-09-16 | Abbott Laboratories | Assay for cardiac troponin-T (cTnT) |
US20110136141A1 (en) | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Peptide reagents and method for inhibiting autoantibody antigen binding |
US8183002B2 (en) | 2009-12-03 | 2012-05-22 | Abbott Laboratories | Autoantibody enhanced immunoassays and kits |
JP5951498B2 (ja) | 2009-12-08 | 2016-07-13 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 網膜神経線維層変性の治療に使用するためのrgmaタンパク質に対するモノクローナル抗体 |
EP2512647A2 (en) | 2009-12-18 | 2012-10-24 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge |
JP5609107B2 (ja) * | 2009-12-28 | 2014-10-22 | 東ソー株式会社 | トロポニンiの免疫測定方法 |
US8877034B2 (en) * | 2009-12-30 | 2014-11-04 | Lifescan, Inc. | Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity |
US8101065B2 (en) * | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
SG183872A1 (en) | 2010-03-02 | 2012-11-29 | Abbvie Inc | Therapeutic dll4 binding proteins |
US20110229921A1 (en) | 2010-03-18 | 2011-09-22 | Abbott Laboratories | METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS |
US9199233B2 (en) | 2010-03-31 | 2015-12-01 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with deflecting top panel |
WO2011129382A1 (en) | 2010-04-16 | 2011-10-20 | Abbott Japan Co. Ltd. | Methods and reagents for diagnosing rheumatoid arthritis |
US8476079B2 (en) | 2010-04-30 | 2013-07-02 | Abbott Point Of Care Inc. | Reagents for reducing leukocyte interference in immunoassays |
PL2571532T3 (pl) | 2010-05-14 | 2017-10-31 | Abbvie Inc | Białka wiążące IL-1 |
US8394325B2 (en) | 2010-06-14 | 2013-03-12 | Abbott Point Of Care Inc. | Magnetic beads for reducing leukocyte interference in immunoassays |
WO2011163558A1 (en) | 2010-06-25 | 2011-12-29 | Abbott Laboratories | Materials and methods for assay of anti-hepatitis c virus (hcv) antibodies |
US20120009196A1 (en) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Monoclonal antibodies against hepatitis c virus core protein |
UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US9120862B2 (en) | 2010-07-26 | 2015-09-01 | Abbott Laboratories | Antibodies relating to PIVKA-II and uses thereof |
PE20131412A1 (es) | 2010-08-03 | 2014-01-19 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US9233370B2 (en) | 2010-08-05 | 2016-01-12 | Abbott Point Of Care Inc. | Magnetic immunosensor and method of use |
EP2600973B1 (en) | 2010-08-05 | 2016-05-25 | Abbott Point Of Care, Inc. | Immunoassay method and device with magnetically susceptible bead capture |
US9329175B2 (en) | 2010-08-05 | 2016-05-03 | Abbott Point Of Care Inc. | Oscillating immunoassay method and device |
WO2012019108A1 (en) | 2010-08-05 | 2012-02-09 | Abbott Point Of Care Inc. | Magnetic immunosensor with trench configuration and method of use |
WO2012024513A2 (en) | 2010-08-18 | 2012-02-23 | Abbott Laboratories | Molecular detection of xmrv infection |
WO2012024518A1 (en) | 2010-08-18 | 2012-02-23 | Abbott Laboratories | Molecular detection of xmrv infection |
PE20140229A1 (es) | 2010-08-26 | 2014-03-27 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US8932445B2 (en) | 2010-09-30 | 2015-01-13 | Cilag Gmbh International | Systems and methods for improved stability of electrochemical sensors |
US8617370B2 (en) | 2010-09-30 | 2013-12-31 | Cilag Gmbh International | Systems and methods of discriminating between a control sample and a test fluid using capacitance |
US20120115244A1 (en) | 2010-11-09 | 2012-05-10 | Abbott Laboratories | Materials and methods for immunoassay of pterins |
US9050595B2 (en) | 2010-12-03 | 2015-06-09 | Abbott Point Of Care Inc. | Assay devices with integrated sample dilution and dilution verification and methods of using same |
US9034634B2 (en) | 2010-12-03 | 2015-05-19 | Abbott Point Of Care Inc. | Sample metering device and assay device with integrated sample dilution |
US9052309B2 (en) | 2010-12-03 | 2015-06-09 | Abbott Point Of Care Inc. | Ratiometric immunoassay method and blood testing device |
CN103282124B (zh) * | 2010-12-03 | 2016-05-18 | 雅培医护站股份有限公司 | 具有整合的样品稀释的样品计量装置和测定装置 |
EP2655417A2 (en) | 2010-12-21 | 2013-10-30 | AbbVie Inc. | Il-1 -alpha and -beta bispecific dual variable domain immunoglobulins and their use |
EP2658653B1 (en) | 2010-12-30 | 2015-03-04 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion |
AU2010366640B2 (en) * | 2010-12-31 | 2016-06-02 | Cilag Gmbh International | Systems and methods for high accuracy analyte measurement |
KR101889100B1 (ko) * | 2011-04-12 | 2018-08-16 | 엘지전자 주식회사 | 진단용 카트리지 및 진단용 카트리지 제어 방법 |
FI20115057L (fi) * | 2011-01-21 | 2012-07-22 | Wallac Oy | Menetelmä ja laite yhden tai useamman näytealueen leikkaamiseksi näytteen kantajasta |
ES2847578T3 (es) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Calibración avanzada de sensor de analito y detección de errores |
WO2012162151A2 (en) | 2011-05-20 | 2012-11-29 | Pepex Biomedical, Inc. | Manufacturing electrochemical sensor modules |
JP2014515476A (ja) | 2011-05-20 | 2014-06-30 | アボットジャパン株式会社 | 非特異的結合を減少させるためのイムノアッセイ方法及び試薬 |
CA2836236C (en) | 2011-05-27 | 2020-04-28 | Abbott Point Of Care Inc. | Tsh immunoassays and processes for performing tsh immunoassays in the presence of endogenous contaminants in restricted wash formats |
US9199234B2 (en) | 2011-05-27 | 2015-12-01 | Abbott Point Of Care Inc. | TSH antibodies for point-of-care immunoassay formats |
EP2715356B1 (en) * | 2011-05-27 | 2017-04-26 | Abbott Point of Care Inc. | Tsh immunoassays employing scavenging reagents for cross-reacting endocrine glycoprotein hormone analogues |
WO2013003718A1 (en) | 2011-06-30 | 2013-01-03 | Abbott Point Of Care Inc. | Methods and devices for determining sensing device usability |
US9201034B2 (en) | 2011-06-30 | 2015-12-01 | Abbott Point Of Care Inc. | Methods and devices for determining sensing device usability |
US20130000378A1 (en) | 2011-06-30 | 2013-01-03 | Abbott Point Of Care Inc. | Methods and Devices for Sensing Device Signal Correction |
US9792838B2 (en) | 2011-06-30 | 2017-10-17 | Abbott Point Of Care Inc. | Methods and devices for determining sensing device usability |
US10641768B2 (en) * | 2011-07-08 | 2020-05-05 | Abbott Japan Co. Ltd. | Methods and kits for decreasing interferences from leukocytes in specific binding assays |
US9638663B2 (en) | 2011-07-25 | 2017-05-02 | Proxim Diagnostics Corporation | Cartridge for diagnostic testing |
US9670538B2 (en) | 2011-08-05 | 2017-06-06 | Ibis Biosciences, Inc. | Nucleic acid sequencing by electrochemical detection |
WO2013028980A1 (en) | 2011-08-24 | 2013-02-28 | Abbott Point Of Care, Inc. | Biologic fluid sample analysis cartridge |
US9655964B2 (en) | 2011-10-24 | 2017-05-23 | Abbvie Inc. | Bispecific antibodies directed against TNF-α and IL-17 |
AR088513A1 (es) | 2011-10-24 | 2014-06-18 | Abbvie Inc | Inmunoenlazantes dirigidos contra esclerostina |
MX356933B (es) | 2011-12-14 | 2018-06-20 | Abbvie Deutschland | Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro. |
US10118958B2 (en) | 2011-12-14 | 2018-11-06 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
US9873119B2 (en) | 2011-12-28 | 2018-01-23 | Ibis Biosciences, Inc. | Multiple- analyte assay device and system |
UY34556A (es) | 2011-12-30 | 2013-07-31 | Abbvie Inc | Dominio variable dual de inmunoglobulinas y sus usos |
AR089529A1 (es) | 2011-12-30 | 2014-08-27 | Abbvie Inc | Proteinas de union especificas duales dirigidas contra il-13 y/o il-17 |
US8993248B2 (en) | 2011-12-31 | 2015-03-31 | Abbott Laboratories | Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use |
KR101338175B1 (ko) * | 2012-01-13 | 2013-12-09 | 주식회사 아이센스 | 시료 중 하나 이상의 검출성분을 검출하기 위한 센서용 카트리지 |
EP2805158B8 (en) * | 2012-01-16 | 2020-10-07 | Abram Scientific, Inc. | Methods and devices for measuring physical properties of fluid |
WO2013112922A1 (en) | 2012-01-27 | 2013-08-01 | AbbVie Deutschland GmbH & Co. KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
US9075042B2 (en) | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
AR091755A1 (es) | 2012-07-12 | 2015-02-25 | Abbvie Inc | Proteinas de union a il-1 |
US8847335B2 (en) | 2012-08-28 | 2014-09-30 | Stmicroelectronics Pte Ltd. | Membrane structure for electrochemical sensor |
MY171664A (en) | 2012-11-01 | 2019-10-22 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulins and uses thereof |
BR112015012958B1 (pt) | 2012-12-03 | 2022-03-15 | Pepex Biomedical, Inc | Módulo sensor para detectar um analito em uma amostra de sangue |
BR112015012014A2 (pt) | 2012-12-04 | 2017-07-11 | Abbvie Inc | proteínas de ligação específicas duais penetrando a barreira hematoencefálica (bbb) |
WO2014097877A1 (ja) * | 2012-12-19 | 2014-06-26 | コニカミノルタ株式会社 | センサーチップおよびこれを用いたspfs免疫蛍光測定システム |
US9671398B2 (en) | 2012-12-28 | 2017-06-06 | Abbott Point Of Care Inc. | Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays |
WO2014106001A2 (en) | 2012-12-28 | 2014-07-03 | Abbvie, Inc. | Dual specific binding proteins having a receptor sequence |
US9856319B2 (en) | 2012-12-28 | 2018-01-02 | Abbvie Inc. | Monovalent binding proteins |
WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
US9952168B2 (en) | 2013-01-28 | 2018-04-24 | Sony Corporation | Impedance measuring device for biological samples and impedance measuring system for biological samples |
US9623409B2 (en) | 2013-03-11 | 2017-04-18 | Cue Inc. | Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes |
US10545161B2 (en) | 2013-03-11 | 2020-01-28 | Cue Health Inc. | Systems and methods for detection and quantification of analytes |
KR102358124B1 (ko) | 2013-03-11 | 2022-02-08 | 큐 헬스 인코퍼레이티드 | 분석물의 검출 및 정량을 위한 시스템 및 방법 |
EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
JP2016512241A (ja) | 2013-03-14 | 2016-04-25 | アボット・ラボラトリーズAbbott Laboratories | 改良された抗体検出のためのhcvns3組換え抗原およびこの突然変異体 |
WO2014159615A2 (en) | 2013-03-14 | 2014-10-02 | Abbott Point Of Care Inc | Thermal control system for controlling the temperature of a fluid |
US20140271453A1 (en) | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Methods for the early detection of lung cancer |
US9488663B2 (en) | 2013-03-14 | 2016-11-08 | Abbott Point Of Care Inc. | Electrochemical methods and devices for amending urine samples for immunosensor detection |
US9651547B2 (en) | 2013-03-14 | 2017-05-16 | Abbott Point Of Care Inc. | Electrochemical methods and devices for amending urine samples for immunosensor detection |
WO2014158272A1 (en) | 2013-03-14 | 2014-10-02 | Abbott Laboratories | Hcv antigen-antibody combination assay and methods and compositions for use therein |
WO2014159077A1 (en) * | 2013-03-14 | 2014-10-02 | Bayer Healthcare Llc | Normalized calibration of analyte concentration determinations |
US9469686B2 (en) | 2013-03-15 | 2016-10-18 | Abbott Laboratories | Anti-GP73 monoclonal antibodies and methods of obtaining the same |
US10234425B2 (en) | 2013-03-15 | 2019-03-19 | Qorvo Us, Inc. | Thin film bulk acoustic resonator with signal enhancement |
WO2014150883A1 (en) | 2013-03-15 | 2014-09-25 | Abbott Point Of Care Inc. | Glutamate oxidase mutagenesis for diagnostic testing |
US9157910B2 (en) | 2013-03-15 | 2015-10-13 | Abbott Laboratories | Assay with increased dynamic range |
US9562874B2 (en) | 2013-03-15 | 2017-02-07 | Abbott Point Of Care Inc. | Biosensor with improved interference characteristics |
US9005901B2 (en) | 2013-03-15 | 2015-04-14 | Abbott Laboratories | Assay with internal calibration |
TW201446800A (zh) | 2013-03-15 | 2014-12-16 | Abbvie Inc | 針對TNFα之雙特異性結合蛋白 |
CA2904448A1 (en) | 2013-03-15 | 2014-09-18 | Tariq Ghayur | Dual specific binding proteins directed against il-1.beta. and/or il-17 |
US10316311B2 (en) * | 2013-04-08 | 2019-06-11 | Helix Biopharma Corp. | Antibody-urease conjugates |
ES2893348T3 (es) | 2013-05-23 | 2022-02-08 | Qorvo Us Inc | Conjunto fluido de dos piezas |
WO2014190292A1 (en) | 2013-05-23 | 2014-11-27 | Rapid Diagnostek | Sensors, methods of making and devices |
WO2015031626A1 (en) | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
WO2015051379A2 (en) | 2013-10-06 | 2015-04-09 | Abbvie Inc. | Dual specific binding proteins directed against immune cell receptors and autoantigens |
US9770207B2 (en) | 2013-12-23 | 2017-09-26 | Verily Life Sciences Llc | Sensor electrodes in a bio-compatible device |
AU2014374055B2 (en) | 2013-12-30 | 2018-11-08 | Epimab Biotherapeutics Inc. | Fabs-in-tandem immunoglobulin and uses thereof |
CN106133512A (zh) | 2014-01-27 | 2016-11-16 | 株式会社日立高新技术 | 自动分析装置 |
JP6369533B2 (ja) * | 2014-02-25 | 2018-08-08 | コニカミノルタ株式会社 | 測定方法および測定装置 |
USD745423S1 (en) | 2014-05-12 | 2015-12-15 | Cue Inc. | Automated analyzer test cartridge and sample collection device for analyte detection |
CN107003264B (zh) | 2014-06-04 | 2020-02-21 | 普佩克斯生物医药有限公司 | 电化学传感器和使用先进印刷技术制造电化学传感器的方法 |
US20160002343A1 (en) | 2014-06-11 | 2016-01-07 | Abbvie Inc. | Blood-brain barrier (bbb) penetrating dual specific binding proteins for treating brain and neurological diseases |
EP3623794B1 (en) | 2014-06-18 | 2022-03-02 | Zoetis Denmark Aps | A microfluidic detection system and a microfluidic cartridge |
JP2017521654A (ja) | 2014-06-27 | 2017-08-03 | アボット・ラボラトリーズAbbott Laboratories | ヒトペギウイルス2(HPgV−2)を検出するための組成物および方法 |
US10073091B2 (en) | 2014-08-08 | 2018-09-11 | Ortho-Clinical Diagnostics, Inc. | Lateral flow assay device |
US10247741B2 (en) | 2014-09-26 | 2019-04-02 | Abbott Point Of Care Inc. | Microfabricated device with micro-environment sensors for assaying coagulation in fluid samples |
CN104297473B (zh) * | 2014-09-26 | 2015-10-21 | 济南大学 | 一种三维结构rGO-MWCNT-Pd无标记猪细小病毒传感器制备方法及应用 |
US10048282B2 (en) * | 2014-09-26 | 2018-08-14 | Abbott Point Of Care Inc. | Cartridge device with fluidic junctions for coagulation assays in fluid samples |
KR102441636B1 (ko) | 2014-10-29 | 2022-09-13 | 아보트 러보러터리즈 | Ns3 포획 펩타이드를 사용한 대상체 항-hcv 항체 검출 검정 |
MX2017005888A (es) * | 2014-11-07 | 2018-02-09 | Proteosense | Dispositivos, sistemas y metodos para la deteccion de analitos. |
CN107208091A (zh) | 2014-11-11 | 2017-09-26 | 雅培分子公司 | 杂交探针和方法 |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
WO2016160976A2 (en) | 2015-03-30 | 2016-10-06 | Abbvie Inc. | Monovalent tnf binding proteins |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
KR20230165349A (ko) | 2015-07-17 | 2023-12-05 | 큐 헬스 인코퍼레이티드 | 분석물질의 증진된 검출 및 정량을 위한 시스템 및 방법 |
JP6239562B2 (ja) | 2015-09-14 | 2017-11-29 | 株式会社東芝 | 照明デバイスおよびそれを備えるバイオ情報計測装置 |
JP6318125B2 (ja) * | 2015-09-16 | 2018-04-25 | 株式会社Lsiメディエンス | 電気的分析方法 |
US20170089905A1 (en) | 2015-09-28 | 2017-03-30 | Abbott Japan Co., Ltd. | Methods of diagnosing hepatocellular carcinoma and pancreatic cancer |
IL260937B2 (en) | 2016-02-06 | 2024-07-01 | Epimab Biotherapeutics Inc | FABS antibodies one by one and their uses |
US20170363620A1 (en) | 2016-06-17 | 2017-12-21 | Abbott Laboratories | BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF) |
EP3279667A1 (en) | 2016-08-02 | 2018-02-07 | Abbott Laboratories | Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd) |
JP2018036154A (ja) * | 2016-08-31 | 2018-03-08 | 国立大学法人大阪大学 | 標的物質の電気的検出方法、定量方法、検出システム、定量システム及び試薬 |
JP6949397B2 (ja) * | 2016-08-31 | 2021-10-13 | 国立大学法人大阪大学 | 標的物質の電気的定量方法、定量システム及び試薬 |
JP6760384B2 (ja) * | 2016-09-14 | 2020-09-23 | コニカミノルタ株式会社 | 測定方法 |
JP2019530875A (ja) | 2016-10-03 | 2019-10-24 | アボット・ラボラトリーズAbbott Laboratories | 患者サンプルにおけるuch−l1状況を評価する改善された方法 |
JP2018071995A (ja) * | 2016-10-24 | 2018-05-10 | 新日本無線株式会社 | コルチゾール濃度分析チップおよびそれを用いた測定方法 |
US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
CN110214274B (zh) | 2016-12-09 | 2023-07-25 | 雅培医护站股份有限公司 | 使用免疫传感器和磁免疫传感器的扩展范围的免疫测定装置 |
US10871488B2 (en) | 2016-12-09 | 2020-12-22 | Abbott Point Of Care Inc. | Crossover analytical systems and methods using an immunosensor and magnetic immunosensor |
US10928388B2 (en) | 2016-12-09 | 2021-02-23 | Abbott Point Of Care Inc. | Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity |
WO2018107013A1 (en) | 2016-12-09 | 2018-06-14 | Abbott Point Of Care Inc. | Dual range cardiac troponin immunoassay devices and methods using immunosensor and magnetic immunosensor |
WO2018107016A1 (en) | 2016-12-09 | 2018-06-14 | Abbott Point Of Care Inc. | Ameliorated crosstalk immunoassay test device for determining a concentration of an analyte |
CN110192109B (zh) | 2016-12-09 | 2023-07-28 | 雅培医护站股份有限公司 | 用于扩展范围的灵敏度的联合免疫测定和磁免疫测定***和装置 |
US11237161B2 (en) | 2017-01-25 | 2022-02-01 | Cue Health Inc. | Systems and methods for enhanced detection and quantification of analytes |
JP7346300B2 (ja) | 2017-03-23 | 2023-09-19 | アボット・ラボラトリーズ | 早期バイオマーカーであるユビキチンカルボキシ末端ヒドロラーゼl1を使用する、ヒト対象における外傷性脳損傷の程度の診断及び決定の一助となるための方法 |
AU2018250688B2 (en) | 2017-04-15 | 2024-07-04 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
US10877038B2 (en) | 2017-04-28 | 2020-12-29 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
BR112019024701A2 (pt) | 2017-05-25 | 2020-06-09 | Abbott Lab | métodos para auxiliar na determinação se um exame de imagem deve ser realizado em um indivíduo humano que sofreu ou pode ter sofrido uma lesão na cabeça com o uso de biomarcadores precoces |
JP7269183B2 (ja) | 2017-05-30 | 2023-05-08 | アボット・ラボラトリーズ | 心臓トロポニンiを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法 |
WO2019010131A1 (en) | 2017-07-03 | 2019-01-10 | Abbott Laboratories | IMPROVED METHODS FOR MEASURING CARBOXY TERMINATION HYDROLASE LEVELS OF UBIQUITIN L1 IN BLOOD |
WO2019035079A1 (en) | 2017-08-17 | 2019-02-21 | Abbott Point Of Care Inc. | DEVICES, SYSTEMS AND METHODS FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS |
JP2021500162A (ja) | 2017-10-24 | 2021-01-07 | デックスコム・インコーポレーテッド | 事前接続された分析物センサ |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
US11499962B2 (en) | 2017-11-17 | 2022-11-15 | Ultima Genomics, Inc. | Methods and systems for analyte detection and analysis |
US10273528B1 (en) | 2017-11-17 | 2019-04-30 | Ultima Genomics, Inc. | Methods and systems for analyte detection and analysis |
CN111094983A (zh) | 2017-12-09 | 2020-05-01 | 雅培实验室 | 使用胶质细胞原纤维酸性蛋白(gfap)和/或泛素羧基末端水解酶l1(uch-l1)帮助诊断和评价已遭受骨科损伤并已遭受或可能已遭受头部损伤诸如轻度创伤性脑损伤(tbi)的患者的方法 |
AU2018378084A1 (en) | 2017-12-09 | 2020-05-14 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of GFAP and UCH-L1 |
US11103867B2 (en) | 2017-12-13 | 2021-08-31 | International Business Machines Corporation | Localized surface modification for microfluidic applications |
CN111699391A (zh) | 2017-12-29 | 2020-09-22 | 雅培实验室 | 用于诊断和评估创伤性脑损伤的新型生物标志物和方法 |
KR20210005051A (ko) | 2018-04-30 | 2021-01-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 카나비노이드 수용체 유형 1 (cb1) 결합 단백질들과 이의 용도 |
WO2019213619A1 (en) | 2018-05-04 | 2019-11-07 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
CN112384797A (zh) | 2018-07-06 | 2021-02-19 | Qorvo美国公司 | 动态范围增加的体声波谐振器 |
US10512911B1 (en) * | 2018-12-07 | 2019-12-24 | Ultima Genomics, Inc. | Implementing barriers for controlled environments during sample processing and detection |
WO2020180695A1 (en) | 2019-03-01 | 2020-09-10 | Abbott Laboratories | Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease |
US11118223B2 (en) | 2019-03-14 | 2021-09-14 | Ultima Genomics, Inc. | Methods, devices, and systems for analyte detection and analysis |
US20220236267A1 (en) * | 2019-05-28 | 2022-07-28 | Brian Kamradt | Filter toxin and antigen detector |
CN110231336B (zh) * | 2019-06-18 | 2021-09-28 | 济南大学 | 一种石墨烯/聚苯胺纳米线阵列免疫传感器的制备方法 |
JP7485755B2 (ja) | 2019-08-07 | 2024-05-16 | アボット・ラボラトリーズ | アッセイ干渉物質を検出し、ダイナミックレンジを増大させる方法 |
US11776684B2 (en) | 2019-09-26 | 2023-10-03 | Pacesetter, Inc | Method and device for managing energy usage by a medical device |
CN112675933A (zh) * | 2019-10-18 | 2021-04-20 | 利多(香港)有限公司 | 一种用于检测分析物的微流控芯片 |
CN112986553A (zh) * | 2019-12-14 | 2021-06-18 | 南京岚煜生物科技有限公司 | 一种免疫电极的制备方法 |
CA3175523A1 (en) | 2020-04-13 | 2021-10-21 | Antti Virtanen | Methods, complexes and kits for detecting or determining an amount of a .beta.-coronavirus antibody in a sample |
EP3906843B1 (en) | 2020-05-08 | 2022-12-14 | Pacesetter, Inc. | System for verifying a pathologic episode using an accelerometer |
EP4193151A1 (en) | 2020-08-04 | 2023-06-14 | Abbott Rapid Diagnostics International Unlimited Company | Assays for detecting sars-cov-2 |
US20220043000A1 (en) | 2020-08-04 | 2022-02-10 | Abbott Laboratories | Methods and kits for detecting sars-cov-2 protein in a sample |
US12021555B2 (en) | 2020-10-30 | 2024-06-25 | Pacesetter, Inc. | Implantable medical device and method for managing a physical layer utilized during a wireless connection |
US20220170948A1 (en) | 2020-12-01 | 2022-06-02 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a human subject having received a head computerized tomography scan that is negative for a tbi |
WO2023102384A1 (en) | 2021-11-30 | 2023-06-08 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
WO2022147178A1 (en) | 2020-12-30 | 2022-07-07 | Abbott Laboratories | Improved methods, reagents and kits for detergent-based inactivation of betacoronavirus prior to and/or while assessing a biological sample for sars-cov-2 antigen or antibody |
WO2022147147A1 (en) | 2020-12-30 | 2022-07-07 | Abbott Laboratories | Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample |
EP4341699A1 (en) | 2021-05-18 | 2024-03-27 | Abbott Laboratories | Methods of evaluating brain injury in a pediatric subject |
BR112023026199A2 (pt) | 2021-06-14 | 2024-03-05 | Abbott Lab | Métodos para diagnosticar ou auxiliar no diagnóstico de lesão cerebral causada por energia acústica, energia eletromagnética, onda de sobrepressurização e/ou rajada de vento |
US20220409143A1 (en) | 2021-06-28 | 2022-12-29 | Pacesetter, Inc. | Method and system for optimizing filter settings of an implantable medical device |
EP4392783A1 (en) | 2021-08-27 | 2024-07-03 | Abbott Laboratories | Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample |
WO2023034777A1 (en) | 2021-08-31 | 2023-03-09 | Abbott Laboratories | Methods and systems of diagnosing brain injury |
WO2023044345A1 (en) * | 2021-09-15 | 2023-03-23 | Massachusetts Institute Of Technology | A microbial electrochemical technology to detect and degrade organophosphate pesticides |
JP2023048922A (ja) * | 2021-09-28 | 2023-04-07 | キヤノン株式会社 | マイクロ分析チップ |
JP2023048924A (ja) * | 2021-09-28 | 2023-04-07 | キヤノン株式会社 | マイクロ分析チップ |
CA3232176A1 (en) | 2021-09-30 | 2023-04-06 | Beth MCQUISTON | Methods and systems of diagnosing brain injury |
AU2022423989A1 (en) | 2021-12-28 | 2024-07-04 | Abbott Laboratories | Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan |
US20230346258A1 (en) | 2022-04-28 | 2023-11-02 | Pacesetter, Inc. | System for determining change in position of an implanted medical device within an implant pocket |
WO2024044288A1 (en) | 2022-08-26 | 2024-02-29 | Abbott Laboratories | Use of cardiac troponin and galectin-3 to differentiate myocardial infarction type i and type ii |
WO2024059692A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
WO2024059708A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Biomarkers and methods for differentiating between mild and supermild traumatic brain injury |
WO2024102383A1 (en) | 2022-11-10 | 2024-05-16 | Abbott Laboratories | Methods of identifying macrotroponin in biological samples |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0367171A (ja) * | 1989-05-08 | 1991-03-22 | Biotrack Inc | 多分析装置 |
JP2000515966A (ja) * | 1996-07-11 | 2000-11-28 | イーツェーベー インスティテュート ファー ヒェモ−ウント ビオゼンゾリック ミュンスター エー.ファー. | 定量的蛍光マーク・アフィニティ・テストを行うための装置および方法 |
WO2002010754A2 (en) * | 2000-07-31 | 2002-02-07 | Cambridge Life Sciences Plc | Assay apparatus |
JP2003161733A (ja) * | 2001-09-14 | 2003-06-06 | Matsushita Electric Ind Co Ltd | 特異結合分析方法および特異結合分析デバイス |
JP2003294680A (ja) * | 2002-03-29 | 2003-10-15 | Techno Medica Co Ltd | 電気化学式バイオセンサー |
Family Cites Families (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US337164A (en) * | 1886-03-02 | Device for disinfecting | ||
US3853467A (en) * | 1973-08-15 | 1974-12-10 | Gen Electric | Method and apparatus for immunological detection of biological particles |
JPS5558166A (en) | 1978-10-26 | 1980-04-30 | Asahi Chemical Ind | White corpuscle graduating filter and method of sampling white corpuscle |
US4280815A (en) * | 1979-06-18 | 1981-07-28 | Technicon Instruments Corporation | Electrochemiluminescent immunoassay and apparatus therefor |
US5156953A (en) * | 1979-12-26 | 1992-10-20 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
JPS56115727A (en) | 1980-02-19 | 1981-09-11 | Kuraray Co Ltd | Carrier for immobilizing physiologically active substance |
JPS58153154A (ja) * | 1982-03-09 | 1983-09-12 | Ajinomoto Co Inc | 修飾電極 |
US4454007A (en) * | 1983-01-27 | 1984-06-12 | E. I. Du Pont De Nemours And Company | Ion-selective layered sensor and methods of making and using the same |
US4997526A (en) * | 1985-03-19 | 1991-03-05 | Eic Laboratories, Inc. | Assaying for a biologically active component |
US4584130A (en) | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
US4722889A (en) * | 1985-04-02 | 1988-02-02 | Leeco Diagnostics, Inc. | Immunoassays using multiple monoclonal antibodies and scavenger antibodies |
US4686479A (en) * | 1985-07-22 | 1987-08-11 | Young Chung C | Apparatus and control kit for analyzing blood sample values including hematocrit |
CA1254616A (en) * | 1985-11-11 | 1989-05-23 | Calum J. Mcneil | Electrochemical enzymic assay procedures |
DE3776081D1 (de) * | 1986-04-22 | 1992-02-27 | Toray Industries | Mikroelektrode fuer elektrochemische analyse. |
DE3627814A1 (de) | 1986-08-16 | 1988-02-25 | Fresenius Ag | Vorrichtung zur bestimmung des haematokrit |
US4959307A (en) | 1986-09-05 | 1990-09-25 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
US5079142A (en) * | 1987-01-23 | 1992-01-07 | Synbiotics Corporation | Orthogonal flow immunoassays and devices |
US5540828A (en) | 1987-06-08 | 1996-07-30 | Yacynych; Alexander | Method for making electrochemical sensors and biosensors having a polymer modified surface |
ZA889546B (en) | 1987-12-24 | 1990-08-29 | Igen Inc | Chemical sensors employing catalytic antibodies |
JP2501860B2 (ja) | 1988-03-15 | 1996-05-29 | 日立金属株式会社 | 磁気センサ―及び電流センサ―並びにこれを用いた装置 |
US5096669A (en) | 1988-09-15 | 1992-03-17 | I-Stat Corporation | Disposable sensing device for real time fluid analysis |
US5063081A (en) * | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5081063A (en) * | 1989-07-20 | 1992-01-14 | Harris Corporation | Method of making edge-connected integrated circuit structure |
CA2003942A1 (en) | 1989-09-26 | 1991-03-26 | Julie Lia Rudolph | Solid assay support systems |
US4980065A (en) * | 1989-10-18 | 1990-12-25 | Lehigh University | Separation of mixtures by aqueous two-phase systems |
JPH03179248A (ja) * | 1989-12-08 | 1991-08-05 | Nippon Telegr & Teleph Corp <Ntt> | 電気化学分析用微小孔アレイ電極およびその製造方法 |
US5069669A (en) * | 1989-12-11 | 1991-12-03 | Design Opportunity Corp. | Expandable finger guard for a hypodermic needle cap |
JP3067171B2 (ja) | 1990-07-11 | 2000-07-17 | 日本電気株式会社 | 表示機能付無線選択呼び出し受信機 |
USD337164S (en) * | 1990-07-19 | 1993-07-06 | I-Stat Corporation | Cartridge for a blood monitoring analyzer |
US5112455A (en) * | 1990-07-20 | 1992-05-12 | I Stat Corporation | Method for analytically utilizing microfabricated sensors during wet-up |
IT1243492B (it) | 1990-11-23 | 1994-06-15 | Eniricerche Spa | Composizioni acquose gelificabili contenenti polimeri con particolari gruppi funzionali chelanti utili per il recupero del petrolio da un giacimento. |
US5254315A (en) * | 1991-07-26 | 1993-10-19 | E. I. Du Pont De Nemours And Company | Carrier device |
JP2922040B2 (ja) | 1992-01-10 | 1999-07-19 | ポーラ化成工業株式会社 | プロテインa分子膜により抗体タンパク質を固定化する方法及び抗体固定膜 |
JP3064635B2 (ja) | 1992-01-29 | 2000-07-12 | エヌオーケー株式会社 | グルコ−スバイオセンサ |
JP3648258B2 (ja) * | 1992-02-13 | 2005-05-18 | 株式会社東芝 | 核酸鎖検出法 |
US5208649A (en) * | 1992-02-20 | 1993-05-04 | University Of Cincinnati | Assembly for front face testing |
US5807752A (en) * | 1992-09-11 | 1998-09-15 | Boehringer Mannheim Corporation | Assay using an unblocked solid phase with immobilized analyte binding partner |
SE9203118D0 (sv) * | 1992-10-26 | 1992-10-26 | Pharmacia Biosensor Ab | A method of preventing undesired binding in solid phase assays |
US5512492A (en) * | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
WO1994028414A1 (en) | 1993-05-29 | 1994-12-08 | Cambridge Life Sciences Plc | Sensors based on polymer transformation |
US5821399A (en) * | 1993-07-16 | 1998-10-13 | I-Stat Corporation | Automatic test parameters compensation of a real time fluid analysis sensing device |
US5756362A (en) | 1993-10-12 | 1998-05-26 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoaggregation assay and test device |
CA2175056A1 (en) * | 1993-10-28 | 1995-05-04 | Imants R. Lauks | Fluid sample collection and introduction device |
US5447440A (en) * | 1993-10-28 | 1995-09-05 | I-Stat Corporation | Apparatus for assaying viscosity changes in fluid samples and method of conducting same |
US5762770A (en) * | 1994-02-21 | 1998-06-09 | Boehringer Mannheim Corporation | Electrochemical biosensor test strip |
JP3338551B2 (ja) | 1994-03-17 | 2002-10-28 | 塩野義製薬株式会社 | ヒト血清アルブミンの測定方法 |
AU2365895A (en) * | 1994-04-26 | 1995-11-16 | Regents Of The University Of Michigan, The | Unitary sandwich enzyme immunoassay cassette, device and method of use |
CA2152756A1 (en) * | 1994-06-28 | 1995-12-29 | Tadakazu Yamauchi | Method and device for specific binding assay |
US5627041A (en) * | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
US5639630A (en) * | 1995-05-16 | 1997-06-17 | Bayer Corporation | Method and reagent composition for performing leukocyte differential counts on fresh and aged whole blood samples, based on intrinsic peroxidase activity of leukocytes |
AU6248796A (en) | 1995-05-19 | 1996-11-29 | Universal Health-Watch, Inc. | Rapid self-contained assay format |
US5581906A (en) * | 1995-06-07 | 1996-12-10 | The Procter & Gamble Company | Multiple zone limiting orifice drying of cellulosic fibrous structures apparatus therefor, and cellulosic fibrous structures produced thereby |
JP4078460B2 (ja) | 1995-06-09 | 2008-04-23 | 東洋紡績株式会社 | 血漿分離フィルター、それを用いる血漿分離方法および血漿分離装置 |
JP3517031B2 (ja) * | 1995-06-09 | 2004-04-05 | 日清紡績株式会社 | 生物学的活性物質の分析法 |
US6346387B1 (en) | 1995-06-27 | 2002-02-12 | Xanthon, Inc. | Detection of binding reactions using labels detected by mediated catalytic electrochemistry |
ATE291225T1 (de) | 1995-12-05 | 2005-04-15 | Gamera Bioscience Corp | Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung |
DE19602861C2 (de) * | 1996-01-28 | 1997-12-11 | Meinhard Prof Dr Knoll | Probenahmesystem für in Trägerflüssigkeiten enthaltene Analyte sowie Verfahren zu seiner Herstellung |
US5869971A (en) * | 1996-05-17 | 1999-02-09 | Sendx Medical, Inc. | Method and apparatus for ratiometric measurement of hematocrit |
DE19781229C2 (de) | 1996-06-17 | 2002-02-28 | Mercury Diagnostics Inc | Elektrochemische Testvorrichtung und Verfahren zu deren Herstellung |
ZA975891B (en) * | 1996-07-05 | 1998-07-23 | Combimatrix Corp | Electrochemical solid phase synthesis of polymers |
US6087088A (en) * | 1997-01-31 | 2000-07-11 | Bayer Corporation | Binding assays using more than one label for determining analyte in the presence of interfering factors |
US6159681A (en) | 1997-05-28 | 2000-12-12 | Syntrix Biochip, Inc. | Light-mediated method and apparatus for the regional analysis of biologic material |
SE9703314D0 (sv) * | 1997-09-15 | 1997-09-15 | Sangtec Medical Ab | Capacity affinity sensor |
DE69819996T2 (de) * | 1997-09-27 | 2004-09-02 | Horiba Ltd. | Gerät für die Zählung von Blutzellen und zur immunologischen Bestimmung unter Verwendung von Vollblut |
JP3810534B2 (ja) | 1997-10-17 | 2006-08-16 | 松下電器産業株式会社 | ヘマトクリット値測定用素子およびヘマトクリット値の測定方法 |
US6030827A (en) * | 1998-01-23 | 2000-02-29 | I-Stat Corporation | Microfabricated aperture-based sensor |
US7297312B2 (en) * | 1998-03-16 | 2007-11-20 | University Of Cincinnati | Simultaneous multianalyte electrochemical assay based on spatial resolution |
US6322963B1 (en) * | 1998-06-15 | 2001-11-27 | Biosensor Systems Design., Inc. | Sensor for analyte detection |
US6395235B1 (en) * | 1998-08-21 | 2002-05-28 | Argonaut Technologies, Inc. | Devices and methods for accessing reaction vessels |
US6475372B1 (en) * | 2000-02-02 | 2002-11-05 | Lifescan, Inc. | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
US6451610B1 (en) * | 1999-04-14 | 2002-09-17 | International Technidyne Corporation | Method and apparatus for coagulation based assays |
US6180417B1 (en) * | 1999-04-22 | 2001-01-30 | Bayer Corporation | Immunochromatographic assay |
US6287451B1 (en) * | 1999-06-02 | 2001-09-11 | Handani Winarta | Disposable sensor and method of making |
JP2001091512A (ja) | 1999-07-16 | 2001-04-06 | Matsushita Electric Ind Co Ltd | 血液成分分析装置 |
US6858185B1 (en) * | 1999-08-25 | 2005-02-22 | Caliper Life Sciences, Inc. | Dilutions in high throughput systems with a single vacuum source |
AU6932300A (en) | 1999-08-25 | 2001-03-19 | Caliper Technologies Corporation | Dilutions in high throughput systems with a single vacuum source |
US7078167B2 (en) * | 1999-09-17 | 2006-07-18 | Agilent Technologies, Inc. | Arrays having background features and methods for using the same |
WO2001038873A2 (en) | 1999-11-24 | 2001-05-31 | Biotronic Technologies, Inc. | Devices and methods for detecting analytes using electrosensor having capture reagent |
JP2001183378A (ja) * | 1999-12-27 | 2001-07-06 | Fuji Photo Film Co Ltd | 固相担体表面へのdna断片の固定方法及びdnaチップ |
US6509196B1 (en) * | 2000-01-04 | 2003-01-21 | Response Biomedical Corp. | Compensation for non-specific signals in quantitative immunoassays |
US6521265B1 (en) * | 2000-02-09 | 2003-02-18 | Biolife, L.L.C. | Method for applying a blood clotting agent |
JP2001318101A (ja) | 2000-05-08 | 2001-11-16 | Arkray Inc | カートリッジ |
JP3963066B2 (ja) | 2000-05-09 | 2007-08-22 | ウシオ電機株式会社 | オーバランセンサを備えたステージ装置 |
KR100348351B1 (ko) * | 2000-05-24 | 2002-08-09 | 주식회사 바이오디지트 | 전기화학 멤브레인 스트립 바이오센서 |
US6528321B1 (en) * | 2000-06-26 | 2003-03-04 | Beckman Coulter, Inc. | Opposable-element chromatographic assay device for detection of analytes in whole blood samples |
PL359335A1 (en) * | 2000-07-14 | 2004-08-23 | Lifescan Inc | Electrochemical method for measuring chemical reaction rates |
KR100852265B1 (ko) * | 2000-07-19 | 2008-08-14 | 가부시키가이샤 에바라 세이사꾸쇼 | 공기 중 오존제거재의 제조방법 |
JP3771788B2 (ja) * | 2000-09-01 | 2006-04-26 | 株式会社堀場製作所 | テオフィリン測定装置 |
EP1320753A2 (en) * | 2000-09-25 | 2003-06-25 | Abbott Laboratories | Methods and kits for decreasing interferences of assay samples containing plasma or serum in specific binding assays by using a large polycation |
US20020155033A1 (en) * | 2000-10-06 | 2002-10-24 | Protasis Corporation | Fluid Separate conduit cartridge |
US20020155476A1 (en) * | 2000-10-20 | 2002-10-24 | Nader Pourmand | Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample |
JP4627912B2 (ja) | 2000-11-09 | 2011-02-09 | パナソニック株式会社 | バイオセンサ |
US7087389B2 (en) * | 2001-02-09 | 2006-08-08 | Council Of Scientific & Industrial Research | Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity |
GB0103516D0 (en) * | 2001-02-13 | 2001-03-28 | Cole Polytechnique Federale De | Apparatus for dispensing a sample |
DE10111392A1 (de) * | 2001-03-09 | 2002-09-12 | Chromeon Gmbh | Bioanalytisches Messverfahren unter Verwendung von Oxidasen |
EP1376127B9 (en) | 2001-03-09 | 2010-09-29 | Mitsubishi Chemical Medience Corporation | Method of measuring whole blood |
CN100405051C (zh) * | 2001-05-30 | 2008-07-23 | 爱-森斯株式会社 | 生物传感器 |
US7531362B2 (en) * | 2001-06-07 | 2009-05-12 | Medmira Inc. | Rapid diagnostic assay |
US7351375B2 (en) * | 2001-07-18 | 2008-04-01 | Arkray, Inc. | Implement and device for analysis |
WO2003019171A1 (en) * | 2001-08-24 | 2003-03-06 | Sensor-Tech Limited | Methods for producing highly sensitive potentiometric sensors |
US10539561B1 (en) * | 2001-08-30 | 2020-01-21 | Customarray, Inc. | Enzyme-amplified redox microarray detection process |
DE60212776T2 (de) * | 2001-09-14 | 2007-06-28 | Matsushita Electric Industrial Co., Ltd., Kadoma | Spezifisches Bindungsanalyseverfahren |
FI118061B (fi) * | 2001-09-24 | 2007-06-15 | Beanor Oy | Menetelmä ja bioanturi analyysiä varten |
JP2003107090A (ja) * | 2001-09-28 | 2003-04-09 | Nitto Denko Corp | 免疫クロマトグラフ用標識複合体組成物 |
GB0129816D0 (en) * | 2001-12-13 | 2002-01-30 | The Technology Partnership Plc | Testing device for chemical or biochemical analysis |
KR100475634B1 (ko) * | 2001-12-24 | 2005-03-15 | 주식회사 아이센스 | 일정 소량의 시료를 빠르게 도입할 수 있는 시료도입부를구비한 바이오 센서 |
US7049150B2 (en) * | 2001-12-28 | 2006-05-23 | Varian, Inc. | Binding assay device with non-absorbent carrier material |
EP1536818A2 (en) * | 2002-03-26 | 2005-06-08 | Dyax Corp. | Fibrinogen binding moieties |
JP2003294860A (ja) | 2002-04-04 | 2003-10-15 | Takuwa Corp | 簡易型降雨強度計 |
US7067150B2 (en) | 2002-04-16 | 2006-06-27 | Scepter Holdings, Inc. | Delivery systems for functional ingredients |
US20040106190A1 (en) * | 2002-12-03 | 2004-06-03 | Kimberly-Clark Worldwide, Inc. | Flow-through assay devices |
WO2004053483A2 (en) * | 2002-12-11 | 2004-06-24 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
US7722817B2 (en) * | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
US7723099B2 (en) | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
JP5273212B2 (ja) | 2011-06-24 | 2013-08-28 | 大日本印刷株式会社 | 固体高分子形燃料電池用ガスケット付き電解質膜−電極接合体の製造方法 |
-
2003
- 2003-09-10 US US10/658,529 patent/US7723099B2/en not_active Expired - Fee Related
-
2004
- 2004-09-09 CA CA2538826A patent/CA2538826C/en active Active
- 2004-09-09 EP EP12179659.3A patent/EP2551671B1/en active Active
- 2004-09-09 EP EP04809719.0A patent/EP1668347B1/en active Active
- 2004-09-09 CA CA2878648A patent/CA2878648C/en active Active
- 2004-09-09 JP JP2006526295A patent/JP4891079B2/ja not_active Expired - Fee Related
- 2004-09-09 WO PCT/US2004/029498 patent/WO2005026689A2/en active Application Filing
- 2004-09-09 CA CA2973834A patent/CA2973834C/en active Active
-
2010
- 2010-02-18 US US12/708,429 patent/US7910352B2/en not_active Expired - Lifetime
- 2010-02-18 US US12/708,445 patent/US8168439B2/en not_active Expired - Fee Related
- 2010-02-18 US US12/708,472 patent/US8309364B2/en not_active Expired - Lifetime
- 2010-02-18 US US12/708,479 patent/US8808626B2/en not_active Expired - Lifetime
- 2010-02-18 US US12/708,458 patent/US8460922B2/en not_active Expired - Lifetime
- 2010-09-24 JP JP2010213231A patent/JP5361834B2/ja active Active
- 2010-09-24 JP JP2010213232A patent/JP5250007B2/ja not_active Expired - Fee Related
- 2010-09-24 JP JP2010213230A patent/JP5232207B2/ja not_active Expired - Fee Related
- 2010-09-24 JP JP2010213233A patent/JP5142338B2/ja not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0367171A (ja) * | 1989-05-08 | 1991-03-22 | Biotrack Inc | 多分析装置 |
JP2000515966A (ja) * | 1996-07-11 | 2000-11-28 | イーツェーベー インスティテュート ファー ヒェモ−ウント ビオゼンゾリック ミュンスター エー.ファー. | 定量的蛍光マーク・アフィニティ・テストを行うための装置および方法 |
WO2002010754A2 (en) * | 2000-07-31 | 2002-02-07 | Cambridge Life Sciences Plc | Assay apparatus |
JP2003161733A (ja) * | 2001-09-14 | 2003-06-06 | Matsushita Electric Ind Co Ltd | 特異結合分析方法および特異結合分析デバイス |
JP2003294680A (ja) * | 2002-03-29 | 2003-10-15 | Techno Medica Co Ltd | 電気化学式バイオセンサー |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4891079B2 (ja) | 免疫参照電極を有する免疫測定装置 | |
JP4461393B2 (ja) | 改善した試料クロージャを有する免疫測定装置 | |
US20110201312A1 (en) | Method for distributing contact information between applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070626 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100427 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100720 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100727 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100826 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100902 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100924 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110215 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110509 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111122 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111215 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4891079 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141222 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |