ATE291225T1 - Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung - Google Patents

Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung

Info

Publication number
ATE291225T1
ATE291225T1 AT96943641T AT96943641T ATE291225T1 AT E291225 T1 ATE291225 T1 AT E291225T1 AT 96943641 T AT96943641 T AT 96943641T AT 96943641 T AT96943641 T AT 96943641T AT E291225 T1 ATE291225 T1 AT E291225T1
Authority
AT
Austria
Prior art keywords
platform
moving fluid
centrifugal acceleration
informatics
automatic laboratory
Prior art date
Application number
AT96943641T
Other languages
English (en)
Inventor
Alec Mian
Stephen G Kieffer-Higgins
George D Corey
Original Assignee
Gamera Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamera Bioscience Corp filed Critical Gamera Bioscience Corp
Application granted granted Critical
Publication of ATE291225T1 publication Critical patent/ATE291225T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/005—Circuit elements having no moving parts for measurement techniques, e.g. measuring from a distance; for detection devices, e.g. for presence detection; for sorting measured properties (testing); for gyrometers; for analysis; for chromatography
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0048—Electric operating means therefor using piezoelectric means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0057—Operating means specially adapted for microvalves actuated by fluids the fluid being the circulating fluid itself, e.g. check valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00826—Quartz
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00963—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00986—Microprocessor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00993—Design aspects
    • B01J2219/00995—Mathematical modeling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00782—Type of codes reprogrammmable code
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Plasma & Fusion (AREA)
  • Fluid Mechanics (AREA)
  • Theoretical Computer Science (AREA)
  • Ecology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Fluid-Pressure Circuits (AREA)
AT96943641T 1995-12-05 1996-12-05 Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung ATE291225T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US821595P 1995-12-05 1995-12-05
US826795P 1995-12-06 1995-12-06
US881995P 1995-12-18 1995-12-18
US2375696P 1996-08-12 1996-08-12
PCT/US1996/019514 WO1997021090A1 (en) 1995-12-05 1996-12-05 Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics

Publications (1)

Publication Number Publication Date
ATE291225T1 true ATE291225T1 (de) 2005-04-15

Family

ID=27485750

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96943641T ATE291225T1 (de) 1995-12-05 1996-12-05 Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung

Country Status (11)

Country Link
EP (1) EP0865606B1 (de)
JP (1) JP2002503331A (de)
KR (1) KR100306951B1 (de)
CN (1) CN1208464A (de)
AT (1) ATE291225T1 (de)
AU (1) AU702403B2 (de)
CA (1) CA2239613A1 (de)
DE (1) DE69634490T2 (de)
MX (1) MX9804463A (de)
NO (1) NO982563L (de)
WO (1) WO1997021090A1 (de)

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
CN1230216A (zh) 1996-07-08 1999-09-29 伯斯坦恩实验室股份有限公司 可断裂信号元件装置和方法
GB9620934D0 (en) 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
WO1998012559A1 (en) 1996-09-20 1998-03-26 Demers James P Spatially addressable combinatorial chemical arrays in cd-rom format
WO1998028623A1 (en) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
AP9901660A0 (en) * 1997-02-28 1999-09-30 Burstein Lab Inc Laboratory in a disk.
EP1959255A3 (de) * 1997-04-04 2008-09-24 Caliper Life Sciences, Inc. Biochemische Analysatoren mit geschlossenem Regelkreis
DE19716683C1 (de) * 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Vorrichtung zur getrennten, gekapselten Aufnahme einer Mehrzahl gleicher oder unterschiedlicher Stoffe
AU7591998A (en) 1997-05-23 1998-12-11 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
DE19729352A1 (de) * 1997-07-09 1999-01-14 Basf Ag Zentrifugierverfahren zur Probencharakterisierung
US6073482A (en) * 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
CA2301095A1 (en) 1997-08-15 1999-02-25 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
AU2002306207B2 (en) * 1997-08-15 2005-02-24 Bioprocessors, Corp. Apparatus for performing assays at reaction sites
US6143152A (en) * 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
EP1420252A3 (de) * 1997-12-30 2004-08-04 Remacle, José Methode zur Detektion und/oder Quantifizierung eines Zielmoleküls durch Binden an ein Bindungsmolekül, das auf eine Disc-Oberfläche fixiert ist
ATE313079T1 (de) * 1997-12-30 2005-12-15 Jose Remacle Verfahren mit auf einer disc-oberfläche gebundenen einfangsmolekül
US6857449B1 (en) 1998-01-20 2005-02-22 Caliper Life Sciences, Inc. Multi-layer microfluidic devices
US6100535A (en) * 1998-01-29 2000-08-08 The Regents Of The University Of California Rotary confocal scanner for detection of capillary arrays
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6196979B1 (en) 1998-08-24 2001-03-06 Burstein Technologies, Inc. Cassette and applicator for biological and chemical sample collection
DE19852835A1 (de) * 1998-11-17 2000-05-18 Stratec Biomedical Systems Ag Probenträger
DE19858443A1 (de) * 1998-12-17 2000-07-06 Inst Mikrotechnik Mainz Gmbh Verfahren zum Abgeben eines Fluids, fluidisches Bauteil sowie Vorrichtung zur Handhabung solcher Bauteile
GB9828785D0 (en) * 1998-12-30 1999-02-17 Amersham Pharm Biotech Ab Sequencing systems
US6503359B2 (en) 1999-03-05 2003-01-07 Burstein Technologies, Inc. Monomolecular adhesion methods for manufacturing microfabricated multilaminate devices
SE9901100D0 (sv) 1999-03-24 1999-03-24 Amersham Pharm Biotech Ab Surface and tis manufacture and uses
WO2000069560A1 (en) * 1999-05-14 2000-11-23 Gamera Bioscience Corporation A centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
US7332326B1 (en) 1999-05-14 2008-02-19 Tecan Trading Ag Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
CN100533146C (zh) 1999-05-19 2009-08-26 埃佩多夫阵列技术股份有限公司 鉴定和/或定量靶化合物的方法
US6406605B1 (en) 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
JP2004529312A (ja) * 1999-06-18 2004-09-24 ガメラ バイオサイエンス コーポレイション 小型化均一アッセイ用のデバイスおよび方法
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
EP1192006B1 (de) * 1999-06-22 2008-05-14 Tecan Trading AG Vorrichtungen zur durchfuehrung von miniaturisierten in vitro amplifizierungsassays
US6660147B1 (en) * 1999-07-16 2003-12-09 Applera Corporation High density electrophoresis device and method
US6495104B1 (en) * 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US7088650B1 (en) 1999-08-23 2006-08-08 Worthington Mark O Methods and apparatus for optical disc data acquisition using physical synchronization markers
US6888951B1 (en) 1999-08-23 2005-05-03 Nagaoka & Co., Ltd. Methods and apparatus for analyzing operational and analyte data acquired from optical disc
GB2355717A (en) * 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US7390459B2 (en) * 1999-12-13 2008-06-24 Illumina, Inc. Oligonucleotide synthesizer
WO2001047638A2 (en) * 1999-12-23 2001-07-05 Gyros Ab Integrated microfluidic disc
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
SE9904802D0 (sv) 1999-12-23 1999-12-23 Amersham Pharm Biotech Ab Microfluidic surfaces
KR100359820B1 (ko) * 2000-05-10 2002-11-07 엘지전자 주식회사 생체시료 검출 및 분석장치, 및 이의 이용방법
JP2003533681A (ja) 2000-05-15 2003-11-11 テカン・トレーディング・アクチェンゲゼルシャフト ミクロ流体装置および細胞ベースの分析を実行する方法
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
EP2388074B1 (de) * 2000-06-28 2013-12-11 3M Innovative Properties Co. Verbesserte Probenverarbeitungsvorrichtungen sowie Systeme und Verfahren dafür
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
JP4773035B2 (ja) * 2000-06-28 2011-09-14 スリーエム イノベイティブ プロパティズ カンパニー 強化サンプル処理装置、システムおよび方法
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
WO2002084302A2 (en) * 2000-11-08 2002-10-24 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
US7026131B2 (en) 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
AU2002216743A1 (en) * 2000-11-27 2002-06-03 Burstein Technologies, Inc. Dual bead assays including optical biodiscs and methods relating thereto
US7079468B2 (en) 2000-12-08 2006-07-18 Burstein Technologies, Inc. Optical discs for measuring analytes
US6760298B2 (en) 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
US6995845B2 (en) * 2000-12-08 2006-02-07 Burstein Technologies, Inc. Methods for detecting analytes using optical discs and optical disc readers
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
US6653625B2 (en) 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
WO2002068697A2 (en) * 2001-02-28 2002-09-06 Burstein Technologies, Inc. Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
JP2004529463A (ja) * 2001-03-19 2004-09-24 ユィロス・アクチボラグ マイクロ流体システム（ｍｓ）
JP4199544B2 (ja) 2001-03-19 2008-12-17 ユィロス・パテント・アクチボラグ マイクロ流体システム（ｅｄｉ）
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
CA2442345A1 (en) * 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (ms)
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
CN1639557A (zh) 2001-04-11 2005-07-13 伯斯坦技术公司 包括分析盘的多参数化验以及涉及该化验的方法
US7201873B2 (en) 2001-04-16 2007-04-10 Tosoh Corporation Fine channel device, method for producing the fine channel device and use of the same
AUPR458201A0 (en) 2001-04-23 2001-05-24 Commonwealth Scientific And Industrial Research Organisation Fluid properties evaluation
USRE44943E1 (en) 2001-04-23 2014-06-10 Commonwealth Scientific And Industrial Research Organisation Fluid properties evaluation
KR100566459B1 (ko) * 2001-05-25 2006-03-31 가부시키가이샤 히타치세이사쿠쇼 화학 물질 정제 구조체
US7141416B2 (en) 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
WO2003018198A1 (en) 2001-08-28 2003-03-06 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
AU2002335715A1 (en) * 2001-09-07 2003-03-24 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
SE0103108D0 (sv) 2001-09-17 2001-09-17 Gyros Microlabs Ab Rotary drive in an instrument for analysis of microscale liquid sample volumes
ATE477054T1 (de) 2001-09-17 2010-08-15 Gyros Patent Ab Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit
JP2005503560A (ja) * 2001-09-17 2005-02-03 ユロス・アクチボラゲット ミクロ流体機器用のメソッド・ハンドラ
CA2464476A1 (en) * 2001-10-24 2003-05-01 Burstein Technologies, Inc. Optical biological disk analyser
AU2002362005A1 (en) * 2001-11-19 2003-06-10 Burstein Technologies, Inc. Methods and apparatus for blood typing with optical bio-discs
CA2468041A1 (en) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
NL1019446C2 (nl) * 2001-11-28 2003-06-02 Ibis Technologies B V Drager voor gebruik bij het bepalen van deeltjes in een monster en werkwijze voor de vervaardiging van zo een drager, en werkwijze voor het bepalen van deeltjes in een monster.
NL1019875C2 (nl) * 2001-11-28 2003-06-02 Ibis Technologies B V Drager voor gebruik bij het bepalen van deeltjes in een monster en werkwijze voor de vervaardiging van zo een drager, en werkwijze voor het bepalen van deeltjes in een monster.
JP4301952B2 (ja) * 2001-12-14 2009-07-22 アークレイ株式会社 試料測定用ディバイス
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
EP1458482B1 (de) * 2001-12-21 2012-03-14 3M Innovative Properties Company Füllen von vorrichtungen zur probenbehandlung durch zentrifugation
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7221783B2 (en) 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
WO2003082730A1 (en) * 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
US6955738B2 (en) 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
AU2003224586A1 (en) * 2002-04-30 2003-11-17 Gyros Ab Integrated microfluidic device (ea)
ATE256870T1 (de) * 2002-05-03 2004-01-15 Trace Biotech Ag Vorrichtung und verfahren zum lysieren von zellen
US7083974B2 (en) 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
US7198759B2 (en) 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
JP2005533651A (ja) * 2002-07-26 2005-11-10 アプレラ コーポレイション 求心力による流体の移動を助長するミクロチャンネル設計特徴
US7135147B2 (en) 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7201881B2 (en) 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US20060096906A1 (en) 2002-10-13 2006-05-11 Adam Rubin Microfluid biomolecule separation system
AU2003283064B2 (en) * 2002-11-20 2009-06-04 Qiagen Gmbh Centrifugal device and method for performing binding assays
AU2002952797A0 (en) * 2002-11-20 2002-12-05 Bio-Molecular Holdings Pty Limited Centrifugal device and method using same
CN101158447B (zh) * 2002-12-04 2012-12-26 斯宾克斯公司 流体的可程控微量控制用装置和方法
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
JP4519124B2 (ja) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ 微小流動性デバイスの内部の壁
EP1607748B1 (de) * 2003-03-24 2013-05-15 Sony Corporation Nukleinsäurenextraktions-Kit und Nukleinsäurenextraktionsverfahren
CN1280428C (zh) * 2003-05-19 2006-10-18 清华大学 一种基于微小颗粒的生物芯片***及其应用
US7247487B2 (en) 2003-06-18 2007-07-24 Ortho-Clinical Diagnostics Reducing working fluid dilution in liquid systems
US7390464B2 (en) 2003-06-19 2008-06-24 Burstein Technologies, Inc. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
JPWO2005012916A1 (ja) * 2003-08-05 2006-09-21 太陽誘電株式会社 試料分析装置及びディスク状試料分析媒体
KR101149880B1 (ko) * 2003-08-13 2012-05-24 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
US7723099B2 (en) 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
US7582261B2 (en) 2003-11-18 2009-09-01 Sharp Kabuhsiki Kaisha Electricity supplying device, electricity supplying apparatus, sample detection device, and sample detection apparatus
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
CA2559778C (en) 2004-03-26 2011-07-05 Infectio Recherche Inc. Removable microfluidic flow cell
US7059352B2 (en) 2004-03-31 2006-06-13 Lifescan Scotland Triggerable passive valve for use in controlling the flow of fluid
US7665303B2 (en) 2004-03-31 2010-02-23 Lifescan Scotland, Ltd. Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit
US7156117B2 (en) 2004-03-31 2007-01-02 Lifescan Scotland Limited Method of controlling the movement of fluid through a microfluidic circuit using an array of triggerable passive valves
KR20070006754A (ko) * 2004-04-21 2007-01-11 도레이 가부시끼가이샤 랩온칩용 기판
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP1795898B1 (de) * 2004-09-30 2014-03-12 ARKRAY, Inc. Analysevorrichtung
JP3955618B2 (ja) 2005-01-28 2007-08-08 松下電器産業株式会社 血液処理装置及び血液導入方法
JP2006242613A (ja) * 2005-03-01 2006-09-14 Matsushita Electric Ind Co Ltd 試料分析装置
EP1899064A2 (de) * 2005-06-03 2008-03-19 Spinx, Inc. Dosimeter zur programmierbaren manipulation von fluiden auf mikromassstab
DE102005025640A1 (de) 2005-06-03 2006-12-07 Scienion Ag Mikrodispenser und zugehöriges Betriebsverfahren
US7919323B2 (en) 2005-06-15 2011-04-05 Rhodia Operations Microfluidic flow devices for determining parameters of physical and/or chemical transformations
FR2887241B1 (fr) * 2005-06-15 2008-01-11 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ou chimique, et son utilisation
WO2007005974A2 (en) 2005-07-01 2007-01-11 Honeywell International, Inc. A flow metered analyzer
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
JP2007040814A (ja) * 2005-08-03 2007-02-15 Matsushita Electric Ind Co Ltd 吸光度測定用センサ及び吸光度測定方法
JP4664785B2 (ja) * 2005-09-16 2011-04-06 株式会社Ｅｃｉ ディスク及び該ディスクを用いた光学式顕微鏡による細胞の計数観察装置
DE102005048260A1 (de) * 2005-10-07 2007-04-12 Albert-Ludwigs-Universität Freiburg Verfahren und Vorrichtung zum Handhaben einer flüssigen Probe unter Verwendung einer Rotation mit einem zeitlich veränderlichen Drehvektor
DE102005048233A1 (de) * 2005-10-07 2007-04-12 Albert-Ludwigs-Universität Freiburg Vorrichtung und Verfahren zum Handhaben einer flüssigen Probe unter Verwendung einer Siphon-Struktur
JP4531677B2 (ja) * 2005-10-24 2010-08-25 パナソニック株式会社 アッセイ方法、それを実施するためのセンサデバイス、およびセンサデバイス用測定装置
WO2007055573A1 (en) * 2005-11-14 2007-05-18 Rijk Zwaan Zaadteelt En Zaadhandel B.V. Method for removing a fluid from a container and device therefor
WO2007069940A1 (en) 2005-12-12 2007-06-21 Gyros Patent Ab Microfluidic assays and microfluidic devices
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7927559B2 (en) 2006-05-09 2011-04-19 Koninklijke Philips Electronics N.V. Assay device
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
KR101343034B1 (ko) 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
KR100851980B1 (ko) * 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
FR2907226B1 (fr) * 2006-10-13 2008-12-12 Rhodia Recherches & Tech Dispositif d'analyse fluidique,dispositif de determination de caracteristiques d'un fluide comprenant ce dispositif d'analyse,procedes de mise en oeuvre et procede de criblage correspondants
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2095103A2 (de) * 2006-11-21 2009-09-02 Bioscale, Inc. Verfahren und vorrichtung zur aufarbeitung von analyten
JP4969236B2 (ja) * 2006-12-22 2012-07-04 ローム株式会社 生体分子または生体関連物質の測定方法
GB2458855B (en) 2007-02-05 2011-06-08 Intelligent Bio Systems Inc A system for imaging treated bio-molecules in a flow-cell using a non-lasing light source
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
KR101239764B1 (ko) 2007-04-05 2013-03-06 삼성전자주식회사 원심력 기반의 미세유동 시스템 및 상기 미세유동 시스템용바이오 카트리지
JP4819945B2 (ja) 2007-04-09 2011-11-24 パナソニック株式会社 チャンバを含む流路部位を有する基板、およびそれを用いて液体を移送する方法
KR101278154B1 (ko) * 2007-04-16 2013-06-27 삼성전자주식회사 원심력 기반의 미세유동 장치, 이를 구비한 미세유동시스템 및, 상기 미세유동 장치의 홈 위치 결정 방법
JP4918589B2 (ja) 2007-05-10 2012-04-18 パナソニック株式会社 チャンバを有する流路部位を含む基板、およびそれを含む多段送液装置
DE102007030347A1 (de) * 2007-06-29 2009-01-02 Ducrée, Jens, Dr. Integrierter Rotor
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
EP3741869A1 (de) 2007-07-13 2020-11-25 Handylab, Inc. Materialien zur erfassung von polynukleotiden und verfahren zur verwendung davon
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
DE102007046305A1 (de) * 2007-09-27 2009-04-02 Robert Bosch Gmbh Mikrofluidisches Bauelement sowie Herstellungsverfahren
EP3447494B1 (de) * 2007-10-04 2020-07-15 PHC Holdings Corporation Analyseverfahren mit einer analysevorrichtung
KR101368178B1 (ko) 2008-01-07 2014-02-26 삼성전자주식회사 미세유동장치 내의 유체 흐름 경로에 필터를 형성하는 방법
WO2009091187A2 (en) * 2008-01-15 2009-07-23 Lg Electronics Inc. Bio-disc
ES2863914T3 (es) * 2008-07-01 2021-10-13 Icagen Llc Método para medir el transporte de analitos a través de barreras usando un tubo de rayos X
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8037354B2 (en) 2008-09-18 2011-10-11 Honeywell International Inc. Apparatus and method for operating a computing platform without a battery pack
WO2010038952A2 (en) 2008-10-01 2010-04-08 Samsung Electronics Co., Ltd., Centrifugal-based microfluid apparatus, method of fabricationg the same, and method of testing samples using the microfluidic apparatus
GB2464721C (en) 2008-10-23 2013-08-14 Biosurfit Sa Jet deflection device
GB2466644B (en) 2008-12-30 2011-05-11 Biosurfit Sa Liquid handling
KR20100101526A (ko) * 2009-03-09 2010-09-17 삼성전자주식회사 스트로보 박막 화학 분석 장치 및 이를 이용한 분석 방법
KR20110009022A (ko) * 2009-07-20 2011-01-27 삼성전자주식회사 디스크형 미세유동장치 및 이를 이용하는 혈액검사장치
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
GB2476474B (en) 2009-12-22 2012-03-28 Biosurfit Sa Surface plasmon resonance detection system
US8828246B2 (en) * 2010-02-18 2014-09-09 Anpac Bio-Medical Science Co., Ltd. Method of fabricating micro-devices
GB2479139A (en) 2010-03-29 2011-10-05 Biosurfit Sa A liquid distribution and metering device
CN101907631B (zh) * 2010-07-19 2012-07-25 中国科学院长春光学精密机械与物理研究所 微流控芯片内的双液体毛细微流控制阀及其制作方法
CN102441356B (zh) * 2010-10-12 2013-08-21 扬博科技股份有限公司 离心式微流体装置
EP2660608B1 (de) * 2010-12-28 2019-04-17 Hitachi High-Technologies Corporation Vorbehandlungssystem mit einer zentrifugaltrennungsvorrichtung
GB201100152D0 (en) * 2011-01-06 2011-02-23 Epistem Ltd Genedrive RFID
DE102011008788B3 (de) * 2011-01-14 2012-05-03 Institut Für Photonische Technologien E.V. Anordnung zur Durchführung einer Einzelprobenanalyse und -manipulation für die Raman-Mikrospektroskopie
CA2827614C (en) * 2011-03-08 2019-07-02 Universite Laval Fluidic centripetal device
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
JP6235462B2 (ja) 2011-05-18 2017-11-22 スリーエム イノベイティブ プロパティズ カンパニー 試料処理装置内で材料の選択された体積の存在を検出するためのシステム及び方法
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的***和方法
ES2755078T3 (es) 2011-05-18 2020-04-21 Diasorin S P A Sistemas y métodos para medición volumétrica en un dispositivo de procesamiento de muestra
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
AU2012315595B2 (en) 2011-09-30 2015-10-22 Becton, Dickinson And Company Unitized reagent strip
WO2013062152A1 (ko) * 2011-10-26 2013-05-02 한국기초과학지원연구원 나선형 미세유로를 이용한 단백질 결정화 조건 고속 스크리닝 장치 및 방법
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CA2858160C (en) * 2011-12-07 2019-10-15 Royal Melbourne Institute Of Technology Centrifugal microfluidic device
US9933348B2 (en) 2011-12-08 2018-04-03 Biosurfit, S.A. Sequential aliqoting and determination of an indicator of sedimentation rate
KR101252260B1 (ko) * 2011-12-12 2013-04-08 포항공과대학교 산학협력단 디스크형 미세 유체 시스템 및 혈구의 변형도 측정 방법
KR101252259B1 (ko) * 2011-12-12 2013-04-08 포항공과대학교 산학협력단 디스크형 미세 유체 시스템 및 혈액 상태 확인 방법
US8741235B2 (en) * 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
EP3139149A1 (de) 2011-12-29 2017-03-08 Ibis Biosciences, Inc. Zusammensetzungen und verfahren zur probenvorbereitung
CA2863637C (en) 2012-02-03 2021-10-26 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
KR20140009607A (ko) * 2012-07-11 2014-01-23 삼성전자주식회사 검사장치 및 그 제어방법
CN104838267B (zh) 2012-10-08 2018-02-23 通用电气公司 用于lal反应物质测试的向心微流体平台
EP2781919A1 (de) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Verfahren/Vorrichtung zur Erzeugung eines korrigierten Werts einer Analytenkonzentration in einer Körperflüssigkeitsprobe
WO2014210207A1 (en) * 2013-06-25 2014-12-31 University Of Washington Through Its Center For Commercialization Self-digitization of sample volumes
CA2966215A1 (en) * 2014-10-30 2016-05-06 Sightline Innovation Inc. System, method and apparatus for pathogen detection
WO2016158139A1 (ja) * 2015-03-31 2016-10-06 ソニー株式会社 電気的特性測定装置、電気的特性測定方法、血液状態解析システム、及び該方法をコンピューターに実現させるための電気的特性測定用プログラム
KR101738765B1 (ko) 2015-08-25 2017-06-08 한국과학기술원 나노 입자 합성 고속대량스크리닝용 마이크로 디바이스 및 이를 이용한 나노 입자 합성 방법
CN106501499B (zh) * 2015-09-07 2019-12-17 埃克西亚斯医药有限公司 可移动测量单元
CN105717186B (zh) * 2016-02-01 2018-06-29 常熟理工学院 回转式介电电泳微流控分析装置
FR3050664B1 (fr) * 2016-04-27 2018-05-25 Microfactory Systeme d'evaluation in vitro de l'efficacite d'un deodorant.
CN109414710B (zh) * 2016-07-28 2021-02-05 医疗过滤有限公司 磁力混合器及方法
CN115253383A (zh) 2016-10-03 2022-11-01 泰尔茂比司特公司 模块化盒
EP3315963A1 (de) * 2016-10-26 2018-05-02 Fuchs Petrolub SE Probenaufnahmeelement, analysenset und verfahren zur analyse eines liquids, insbesondere einer kühlschmierstoffemulsion
EP3450959A1 (de) * 2017-09-05 2019-03-06 Biosurfit, S.A. Detektionsverfahren
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
US10273528B1 (en) 2017-11-17 2019-04-30 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
CN108287134B (zh) * 2017-12-28 2020-11-24 南京邮电大学 单颗粒生物探针及其等离子体生物存储器的构建方法
CN108279192A (zh) * 2018-01-29 2018-07-13 北京市劳动保护科学研究所 一种可吸入颗粒物粒径分级装置
CN108514897A (zh) * 2018-04-11 2018-09-11 刘涵青 一种用于中学化学学生实验的微流控芯片
KR101872667B1 (ko) * 2018-04-14 2018-06-28 주식회사 스탠더드시험연구소 밸브조립체의 검증시험을 위한 열수력 성능시험설비
CN108490331B (zh) * 2018-04-17 2023-11-17 西安派瑞功率半导体变流技术股份有限公司 Gct芯片门/阴极阻断特性圆周法测试台
CN108970655A (zh) * 2018-06-04 2018-12-11 东莞东阳光科研发有限公司 一种微流控芯片的磁珠转移装置
CA3106136A1 (en) * 2018-07-09 2020-01-16 Sandstone Diagnostics, Inc. Devices and methods for plasma separation and storage
KR20200009859A (ko) * 2018-07-20 2020-01-30 재단법인대구경북과학기술원 원심 밸브 제어 장치
WO2020100039A1 (en) * 2018-11-13 2020-05-22 National Research Council Of Canada World-to-chip automated interface for centrifugal microfluidic platforms
US10512911B1 (en) 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US10900078B2 (en) 2019-03-14 2021-01-26 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
CN110404599A (zh) * 2019-08-23 2019-11-05 上海沃迪智能装备股份有限公司 一种用于学习人工移液操作的移液枪
CN111167528B (zh) * 2019-11-25 2021-09-07 北京世纪沃德生物科技有限公司 一种微流控芯片的反应腔室
KR102309531B1 (ko) * 2020-01-29 2021-10-07 성균관대학교산학협력단 땀 속의 바이오 분자 검출을 위한 미세유체소자 및 이를 이용한 웨어러블 바이오센서 패치
CN111380743B (zh) * 2020-03-16 2022-09-23 东华理工大学 一种混杂样品顺次软电离装置
TW202234045A (zh) 2020-10-23 2022-09-01 日商滋吾堂股份有限公司 目標物質檢測方法、設備和試劑
US20230366848A1 (en) * 2020-10-28 2023-11-16 Horiba Advanced Techno, Co., Ltd. Water quality meter data processing device, water quality meter data processing system and water quality meter data processing method
WO2022242549A1 (zh) * 2021-05-16 2022-11-24 深圳市品学优技术有限公司 一种反应及其驱动装置
CN113295645A (zh) * 2021-05-20 2021-08-24 天津工业大学 基于四叶草型的太赫兹混合网络检测芯片
KR102622195B1 (ko) * 2021-12-02 2024-01-05 세메스 주식회사 약액 검사 장치와, 이를 포함하는 기판 처리 장치 및 기판을 처리하는 약액을 검사하는 방법
DE102021214281A1 (de) * 2021-12-14 2023-06-15 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zum Splitten dreidimensionaler Agglomerate
KR102623409B1 (ko) * 2021-12-27 2024-01-10 세메스 주식회사 약액 검사 장치 및 이를 포함하는 기판 처리 장치
CN114965995B (zh) * 2022-05-20 2023-04-11 河南申友医学检验所有限公司 一种免疫层析分析检测***及方法
CN115144310A (zh) * 2022-07-01 2022-10-04 重庆交通大学 一种旋桨式絮凝沉降试验装置及方法
KR20240012129A (ko) * 2022-07-20 2024-01-29 연세대학교 산학협력단 광학 기반 유체 제어 바이오칩 및 이의 제조와 유체 제어 방법
CN116593356B (zh) * 2023-06-05 2023-11-17 南京工业大学 一种利用磁纳米毛刷搅拌检测微量溶液粘度的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3679367A (en) * 1970-09-14 1972-07-25 Technicon Instr Apparatus for determining the pack volume of particulates in liquid mixtures
US4940527A (en) * 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
EP0305210B1 (de) * 1987-08-27 1993-12-08 Biotrack, Inc. Gerät und Verfahren zur Verdünnung und Mischung von Flüssigkeitsproben
US4999304A (en) * 1987-12-28 1991-03-12 Miles Inc. Dynamic braking centrifuge
EP0417305A4 (en) * 1989-03-07 1992-04-22 Idemitsu Petrochemical Co. Ltd. Analyzer of liquid sample and analyzing method of liquid sample using said analyzer
JPH03245049A (ja) * 1990-02-22 1991-10-31 Idemitsu Petrochem Co Ltd 液体試料分析用ディスク
DE69303898T3 (de) * 1992-05-01 2007-01-18 Trustees Of The University Of Pennsylvania Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen
JPH06265447A (ja) * 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
DE4410224C2 (de) * 1994-03-24 1996-02-29 Meinhard Prof Dr Knoll Miniaturisiertes Durchfluß-Analysesystem

Also Published As

Publication number Publication date
EP0865606A1 (de) 1998-09-23
DE69634490T2 (de) 2006-03-02
MX9804463A (es) 1998-12-31
NO982563L (no) 1998-08-05
CN1208464A (zh) 1999-02-17
DE69634490D1 (de) 2005-04-21
AU702403B2 (en) 1999-02-18
EP0865606B1 (de) 2005-03-16
KR19990072013A (ko) 1999-09-27
KR100306951B1 (ko) 2001-11-15
JP2002503331A (ja) 2002-01-29
WO1997021090A1 (en) 1997-06-12
NO982563D0 (no) 1998-06-04
CA2239613A1 (en) 1997-06-12
AU1283397A (en) 1997-06-27

Similar Documents

Publication Publication Date Title
ATE291225T1 (de) Vorrichtung und verfahren zum bewegen von fluiden mittels zentrifugalbeschleunigung bei der automatischen laborbehandlung
DE60012562D1 (de) Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
WO1998053311A3 (en) Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
DE69823673D1 (de) Vorrichtung und verfahren zur tropfenmikrochemie
ATE111224T1 (de) Kapillare durchflussvorrichtung und verfahren zur messung der aktivierten partiellen thromboplastinzeit.
ATE395136T1 (de) Vorrichtungen zur durchfuehrung von miniaturisierten in vitro amplifizierungsassays
DE69432122T2 (de) Verfahren und vorrichtung zum nachweis von hämolysis in flüssigen proben
ATE133493T1 (de) Gerät zum einsammeln von blut
WO2001087487A3 (en) Bidirectional flow centrifugal microfluidic devices
ATE255464T1 (de) Analytische testvorrichtung mit orientierte durchgehende kanäle besitzendem substrat und verbesserte verfahren und vorrichtung zum gebrauch derselben
EP1959255A3 (de) Biochemische Analysatoren mit geschlossenem Regelkreis
DE69229478D1 (de) Vorrichtung und verfahren zur dosierung von flüssigkeitsproben
ES2023189B3 (es) Sistema de separacion mediante tecnicas de coalescencia.
DE69716543T2 (de) Vorrichtung zum Entnehmen und Analysieren von flüssigen Proben, wie Blutproben
ATE93972T1 (de) Geraet zur analyse von biologischen fluessigkeiten.
ATE263963T1 (de) Vorrichtung zur feststellung von viskositätsänderungen in fluidproben, sowie ein verfahren dazu
DE69719782D1 (de) Vorrichtung und verfahren zum durchfuehren von assays
DE3870211D1 (de) Verfahren und vorrichtung zum bestimmen der zeitspanne, die eine fluessigkeit zur aenderung ihres physischen zustandes benoetigt.
DE69021851D1 (de) Verfahren und Vorrichtung zum Abscheiden von Kohlenwasserstoffmonoxid aus Wasserstoff enthaltenden Gasgemischen.
WO2003006946A3 (en) Method and instrument for automated analysis of fluid-based processing systems
DE69926845D1 (de) Verfahren zum überwachen von gas(en) in einer dielektrischen flüssigkeit
EP1577010A3 (de) Mikrosystemplattform und Verwendung davon
DE3682704D1 (de) Test kit zum durchfuehren von chemischen analysen.
ATE200303T1 (de) Verfahren und vorrichtung zur schnellen trennung und/oder umwandlung von substraten
DE3687847D1 (de) Verfahren zum selbsttaetigen nachweis von gewinnungsreaktionen und vorrichtung zu diesem zweck.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties