JP4823615B2 - アレルゲン低減化組成物 - Google Patents
アレルゲン低減化組成物 Download PDFInfo
- Publication number
- JP4823615B2 JP4823615B2 JP2005261034A JP2005261034A JP4823615B2 JP 4823615 B2 JP4823615 B2 JP 4823615B2 JP 2005261034 A JP2005261034 A JP 2005261034A JP 2005261034 A JP2005261034 A JP 2005261034A JP 4823615 B2 JP4823615 B2 JP 4823615B2
- Authority
- JP
- Japan
- Prior art keywords
- allergen
- hydroxy
- proline
- reducing
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 239000013566 allergen Substances 0.000 claims abstract description 59
- 239000000835 fiber Substances 0.000 claims abstract description 44
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- 229920000642 polymer Polymers 0.000 claims abstract description 17
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
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- 238000011282 treatment Methods 0.000 claims description 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
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- 241000238876 Acari Species 0.000 abstract description 12
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- PMMYEEVYMWASQN-IMJSIDKUSA-N cis-4-Hydroxy-L-proline Chemical compound O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 description 3
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Description
(1)式(I)
(3)前記式(I)で表されるヒドロキシプロリンの誘導体、その重合体又はそれらの塩の含有率が0.01〜30重量%である前記(1)又は(2)に記載のアレルゲン低減化組成物。
(5)前記(1)〜(3)のいずれかに記載のアレルゲン低減化組成物を付着又は固着してなる繊維又は繊維製品。
(6)前記(1)〜(3)のいずれかに記載のアレルゲン低減化組成物を付着又は固着してなるマスク。
精製は、例えば結晶化、クロマトグラフィー等の通常の方法が用いられる。
本発明のアレルゲン低減化組成物として、前記式(I)で表されるヒドロキシプロリン誘導体、その重合体又はそれらの塩を含有し、更に必要に応じてバインダーを含有する処理液を用いて、浸漬処理、噴霧処理、散布処理、吸尽加工処理等の公知の方法により、該組成物を繊維又は繊維製品に付着させ、乾燥等をさせることにより固着させることができる。
(実施例1、2) アレルゲン低減化組成物
表1に示す各組成のものを混合、充分攪拌することにより、均一な溶液を得た。なお、表1に示す配合比率は、すべて重量%である。
N−アセチル−トランス−4−ヒドロキシ−L−プロリン3重量%を含む99.5%エタノール溶液を作製し、これを不織布製使い捨てマスク(ユニ・チャーム製)、紙製使い捨てマスク(丸三産業製)の表面に噴霧処理した後、乾燥させてアレルゲン低減化マスクを作製した。また、ガーゼ製花粉対策マスク(ロート製薬製)に対しては、中間層のフィルター部分にN−アセチル−トランス−4−ヒドロキシ−L−プロリン3重量%を含む99.5%エタノール溶液を噴霧処理した後に乾燥させて、アレルゲン低減化マスクを作製した。使用感はいずれのマスクも良好であった。
N−アセチル−トランス−4−ヒドロキシ−L−プロリン3重量%、グレープフルーツフレーバー0.05重量%を含む99.5%エタノール溶液を作製し、これを不織布製使い捨てマスク(ユニ・チャーム製)の表面に噴霧処理した後に乾燥させて、アレルゲン低減化マスクを作製した。
N−アセチル−トランス−4−ヒドロキシ−L−プロリン3重量%、アルギニン塩酸塩1重量%を含む99.5%エタノール溶液を作製し、これを不織布製使い捨てマスク(ユニ・チャーム製)の表面に噴霧処理した後に乾燥させて、アレルゲン低減化マスクを作製した。
N−アセチル−トランス−4−ヒドロキシ−L−プロリン3重量%を含む99.5%エタノール溶液を作製し、これを不織布製使い捨ててマスク(ユニ・チャーム製)の表面に噴霧処理した後に乾燥させ、裏面にプロリン3重量%を含む99.5%エタノール溶液を噴霧処理して乾燥させた。
N−アセチル−トランス−4−ヒドロキシ−L−プロリン3重量%を含む99.5%エタノール溶液を作製し、これを掃除用不織布製使い捨てワイパー(クレシア製)の表面に噴霧処理した後に乾燥させて、アレルゲン低減化ワイパーを作製した。
N−アセチル−トランス−4−ヒドロキシ−L−プロリン5重量%を含む99.5%エタノール溶液を作製し、これに白色綿ブロード布又はポリエチレンテレフタレート(PET)布をパディング法により浸漬処理した後、110℃で2分間乾燥させて、アレルゲン低減化生地(布)をそれぞれ作製した。
標準ハウスダストに含まれるダニアレルゲンDerf2 約2μgを含むリン酸緩衝液(pH7.2)1mLに対し、実施例1〜2で得られた溶液を0.15mL反応させた。これらの試料について、酵素免疫測定法(ELISA)のサンドイッチ法にて、ダニアレルゲンDerf2の低減化効果を調べた。
結果を表2に示す。
実施例8で得られたアレルゲン低減化生地についてアレルゲン低減化試験を行った。比較例として、タンニン酸の5%水溶液(特開昭61−44821号該当品)に、白色綿ブロード布又はポリエチレンテレフタレート(PET)布をパディング法により浸漬処理した後、110℃で2分間乾燥させて得られた生地についてもアレルゲン低減化試験を行った。
結果を表3に示す。
Claims (7)
- 前記式(I)で表されるヒドロキシプロリンの誘導体、その重合体又はそれらの塩を含有することを特徴とする、アレルゲンが存在する環境中に処理するためのアレルゲン低減化組成物。
- 前記式(I)において、R1がカルボキシ、R2がアセチル、R3がヒドロキシ、R4が水素である請求項1又は2記載のアレルゲン低減化組成物。
- 前記式(I)で表されるヒドロキシプロリンの誘導体、その重合体又はそれらの塩の含有率が0.01〜30重量%である請求項1〜3のいずれか1項に記載のアレルゲン低減化組成物。
- 請求項1〜4のいずれか1項に記載のアレルゲン低減化組成物を配合してなるエアゾール剤又はスプレー剤。
- 請求項1〜4のいずれか1項に記載のアレルゲン低減化組成物を付着又は固着してなる繊維又は繊維製品。
- 請求項1〜4のいずれか1項に記載のアレルゲン低減化組成物を付着又は固着してなるマスク。
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