JP4607458B2 - 新規なアリールおよびへテロアリールピペラジン - Google Patents
新規なアリールおよびへテロアリールピペラジン Download PDFInfo
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- JP4607458B2 JP4607458B2 JP2003565978A JP2003565978A JP4607458B2 JP 4607458 B2 JP4607458 B2 JP 4607458B2 JP 2003565978 A JP2003565978 A JP 2003565978A JP 2003565978 A JP2003565978 A JP 2003565978A JP 4607458 B2 JP4607458 B2 JP 4607458B2
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- Prior art keywords
- alkyl
- compound
- aryl
- alkoxy
- halogen
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- 0 C*=C(C)N=C(C)CCCC(C)=C Chemical compound C*=C(C)N=C(C)CCCC(C)=C 0.000 description 7
- FWNIKQWATNXYFL-UHFFFAOYSA-N C(C1CC1)Oc(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1 Chemical compound C(C1CC1)Oc(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1 FWNIKQWATNXYFL-UHFFFAOYSA-N 0.000 description 1
- DXEDOOBZMDWWKF-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)nc2c1cc(C(F)(F)F)cc2 Chemical compound CC(C)N(CC1)CCN1c(cc1)nc2c1cc(C(F)(F)F)cc2 DXEDOOBZMDWWKF-UHFFFAOYSA-N 0.000 description 1
- SYYWFXYMTMEHBU-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)nc2c1cc(C1CCCCC1)cc2 Chemical compound CC(C)N(CC1)CCN1c(cc1)nc2c1cc(C1CCCCC1)cc2 SYYWFXYMTMEHBU-UHFFFAOYSA-N 0.000 description 1
- CCSIBTQQYGOZJC-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)nnc1-c(cc1OC)ccc1OC Chemical compound CC(C)N(CC1)CCN1c(cc1)nnc1-c(cc1OC)ccc1OC CCSIBTQQYGOZJC-UHFFFAOYSA-N 0.000 description 1
- PLNNLVMWFVQQCI-UHFFFAOYSA-N CC(C)N(CC1)CCN1c1cc(Cl)c(-c2ccccc2)nn1 Chemical compound CC(C)N(CC1)CCN1c1cc(Cl)c(-c2ccccc2)nn1 PLNNLVMWFVQQCI-UHFFFAOYSA-N 0.000 description 1
- GVCWILDLGZCPSF-UHFFFAOYSA-N CCC(CC)N(CC1)CCN1c(cc1)ccc1C(C1CC1)=O Chemical compound CCC(CC)N(CC1)CCN1c(cc1)ccc1C(C1CC1)=O GVCWILDLGZCPSF-UHFFFAOYSA-N 0.000 description 1
- ZUGDWIGHTLXJCC-UHFFFAOYSA-N CCC(CC)N(CC1)CCN1c(nc1)ccc1C(N(C)Cc1ccccc1)=O Chemical compound CCC(CC)N(CC1)CCN1c(nc1)ccc1C(N(C)Cc1ccccc1)=O ZUGDWIGHTLXJCC-UHFFFAOYSA-N 0.000 description 1
- FMXXCKCIVXGUNS-UHFFFAOYSA-N CCC(CC)N(CC1)CCN1c(nc1)ccc1C(N(C)c1ccccc1)=O Chemical compound CCC(CC)N(CC1)CCN1c(nc1)ccc1C(N(C)c1ccccc1)=O FMXXCKCIVXGUNS-UHFFFAOYSA-N 0.000 description 1
- CMNVZVJPAQJIHB-UHFFFAOYSA-N CCC(CC)N(CC1)CCN1c1nc(cccc2)c2c(C(F)(F)F)c1 Chemical compound CCC(CC)N(CC1)CCN1c1nc(cccc2)c2c(C(F)(F)F)c1 CMNVZVJPAQJIHB-UHFFFAOYSA-N 0.000 description 1
- CHCQTZLMIGHHLF-UHFFFAOYSA-N CS(c(cc1)ccc1-c1ccc(NCCNCC2CC2)nn1)(=O)=O Chemical compound CS(c(cc1)ccc1-c1ccc(NCCNCC2CC2)nn1)(=O)=O CHCQTZLMIGHHLF-UHFFFAOYSA-N 0.000 description 1
- SBPZVMHEQOLMGT-UHFFFAOYSA-N Clc(cc1)ccc1-c(cc1)nnc1N(CC1)CCN1C1CCCC1 Chemical compound Clc(cc1)ccc1-c(cc1)nnc1N(CC1)CCN1C1CCCC1 SBPZVMHEQOLMGT-UHFFFAOYSA-N 0.000 description 1
- DMMRSMPUZJDBFI-UHFFFAOYSA-N FC(c1cccc(N(CC2)CCN2C2CCCC2)n1)(F)F Chemical compound FC(c1cccc(N(CC2)CCN2C2CCCC2)n1)(F)F DMMRSMPUZJDBFI-UHFFFAOYSA-N 0.000 description 1
- ITESUNPODOQZSA-UHFFFAOYSA-N Fc1ccc(COc(cc2)cc(cc3)c2nc3N(CC2)CCN2C2CC2)cc1 Chemical compound Fc1ccc(COc(cc2)cc(cc3)c2nc3N(CC2)CCN2C2CC2)cc1 ITESUNPODOQZSA-UHFFFAOYSA-N 0.000 description 1
- REZSROOERNUDJU-UHFFFAOYSA-N O=C(C1CC1)c(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1 Chemical compound O=C(C1CC1)c(cc1)cc(cc2)c1nc2N(CC1)CCN1C1CC1 REZSROOERNUDJU-UHFFFAOYSA-N 0.000 description 1
- CGRYCNPIEPEUCJ-UHFFFAOYSA-N O=C(c(cc1)cnc1N(CC1)CCN1C1CC1)N1CCCC1 Chemical compound O=C(c(cc1)cnc1N(CC1)CCN1C1CC1)N1CCCC1 CGRYCNPIEPEUCJ-UHFFFAOYSA-N 0.000 description 1
- GSHXFMNTSJJDCC-UHFFFAOYSA-N O=C(c1ccc(N(CC2)CCN2C2CCCC2)nc1)N1CCCCC1 Chemical compound O=C(c1ccc(N(CC2)CCN2C2CCCC2)nc1)N1CCCCC1 GSHXFMNTSJJDCC-UHFFFAOYSA-N 0.000 description 1
- CBCBWVTULZRWPE-UHFFFAOYSA-N O=C(c1ccccc1)c(cc1)ccc1N(CC1)CCN1C1CC1 Chemical compound O=C(c1ccccc1)c(cc1)ccc1N(CC1)CCN1C1CC1 CBCBWVTULZRWPE-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200200168 | 2002-02-05 | ||
US35663002P | 2002-02-08 | 2002-02-08 | |
US39930402P | 2002-07-26 | 2002-07-26 | |
DKPA200201142 | 2002-07-26 | ||
PCT/DK2003/000071 WO2003066604A2 (fr) | 2002-02-05 | 2003-02-05 | Nouvelles aryl- et heteroarylpiperazines |
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JP2005533747A JP2005533747A (ja) | 2005-11-10 |
JP4607458B2 true JP4607458B2 (ja) | 2011-01-05 |
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JP2003565978A Expired - Fee Related JP4607458B2 (ja) | 2002-02-05 | 2003-02-05 | 新規なアリールおよびへテロアリールピペラジン |
Country Status (12)
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EP (1) | EP1474401A2 (fr) |
JP (1) | JP4607458B2 (fr) |
CN (1) | CN1628109A (fr) |
AU (2) | AU2003203148A1 (fr) |
BR (1) | BR0307429A (fr) |
CA (1) | CA2474214A1 (fr) |
IL (1) | IL162859A0 (fr) |
MX (1) | MXPA04007612A (fr) |
NO (1) | NO328714B1 (fr) |
PL (1) | PL372390A1 (fr) |
WO (1) | WO2003066604A2 (fr) |
ZA (1) | ZA200405694B (fr) |
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-
2003
- 2003-02-05 IL IL16285903A patent/IL162859A0/xx unknown
- 2003-02-05 BR BR0307429-3A patent/BR0307429A/pt not_active Application Discontinuation
- 2003-02-05 EP EP03701482A patent/EP1474401A2/fr not_active Withdrawn
- 2003-02-05 PL PL03372390A patent/PL372390A1/xx not_active Application Discontinuation
- 2003-02-05 CN CNA038033607A patent/CN1628109A/zh active Pending
- 2003-02-05 JP JP2003565978A patent/JP4607458B2/ja not_active Expired - Fee Related
- 2003-02-05 CA CA002474214A patent/CA2474214A1/fr not_active Abandoned
- 2003-02-05 MX MXPA04007612A patent/MXPA04007612A/es not_active Application Discontinuation
- 2003-02-05 WO PCT/DK2003/000071 patent/WO2003066604A2/fr active Application Filing
- 2003-02-05 AU AU2003203148A patent/AU2003203148A1/en not_active Abandoned
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2004
- 2004-07-16 ZA ZA2004/05694A patent/ZA200405694B/en unknown
- 2004-09-03 NO NO20043709A patent/NO328714B1/no not_active IP Right Cessation
-
2010
- 2010-01-13 AU AU2010200135A patent/AU2010200135A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR0307429A (pt) | 2004-12-28 |
MXPA04007612A (es) | 2004-11-10 |
AU2010200135A1 (en) | 2010-02-04 |
CN1628109A (zh) | 2005-06-15 |
AU2003203148A1 (en) | 2003-09-02 |
NO328714B1 (no) | 2010-05-03 |
WO2003066604A3 (fr) | 2003-12-04 |
NO20043709L (no) | 2004-09-03 |
PL372390A1 (en) | 2005-07-25 |
EP1474401A2 (fr) | 2004-11-10 |
JP2005533747A (ja) | 2005-11-10 |
IL162859A0 (en) | 2005-11-20 |
WO2003066604A2 (fr) | 2003-08-14 |
CA2474214A1 (fr) | 2003-08-14 |
ZA200405694B (en) | 2005-09-28 |
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