JP2022026665A - 対極の改質剤 - Google Patents
対極の改質剤 Download PDFInfo
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- JP2022026665A JP2022026665A JP2020130238A JP2020130238A JP2022026665A JP 2022026665 A JP2022026665 A JP 2022026665A JP 2020130238 A JP2020130238 A JP 2020130238A JP 2020130238 A JP2020130238 A JP 2020130238A JP 2022026665 A JP2022026665 A JP 2022026665A
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- aromatic ring
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Abstract
Description
芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極に対する対極の改質剤であって、金属酸化物を含む改質剤。
項2.
金属酸化物が水及び有機溶媒に不溶な金属酸化物である、項1に記載の改質剤。
項3.
金属酸化物が、Cu2O、CuO、Ag2O、MnO2、BaMnO4、OsO4、及びPbO2からなる群より選択される少なくとも一種である、項1又は2に記載の改質剤。
項4.
芳香環骨格を有する化合物が、チモール、フェノール、ビス(4-ヒドロキシフェニル)スルホン、チロシン二ナトリウム水和物、サリチル酸ナトリウム、トルエン、5-ヒドロキシインドール、アニリン、ロイコキニザリン、カルバクロール、1,5-ナフタレンジオール、4-イソプロピル-3-メチルフェノール、2-イソプロピルフェノール、4-イソプロピルフェノール、1-ナフトール、2-tert-ブチル-5-メチルフェノール、2,4,6-トリメチルフェノール、2,6-ジイソプロピルフェノール、2-tert-ブチル-4-エチルフェノール、6-tert-ブチル-2,4-キシレノール、2-tert-ブチル-4-メチルフェノール、2-tert-ブチル-6-メチルフェノール、2,4-ジ-tert-ブチルフェノール、2,4-ジ-tert-ブチル-5-メチルフェノール、ビス(p-ヒドロキシフェニル)メタン、3-tert-ブチルフェノール、2-イソプロピル-5-メチルアニソール、o-クレゾール、m-クレゾール、及びp-クレゾールからなる群より選択される、項1~3のいずれかに記載の改質剤。
項5.
ナノカーボンがカーボンナノチューブである、項1~4のいずれかに記載の改質剤。
項6.
酵素がフラビン結合型グルコースデヒドロゲナーゼである、項1~5のいずれかに記載の改質剤。
項7.
芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極に対する対極であって、項1~6のいずれかに記載の改質剤を含む対極。
項8.
芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極、及び項7に記載の対極を含むセンサ。
項9.
参照極を含まない、項8に記載のセンサ。
項10.
対極の表面積が作用極の表面積よりも大きい、項8又は9に記載のセンサ。
一実施形態において、対極の改質剤は、芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極に対する対極の改質剤であることが好ましい。当該実施形態において、対極は下記2に記載の対極であることが好ましく、作用極は下記3に記載の作用極であることが好ましい。また、当該実施形態において、対極の改質剤は、金属酸化物を含むことが好ましい。
一実施形態において、対極は、芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極に対する対極であることが好ましい。当該実施形態において、対極は、対極の改質剤を含むことが好ましく、対極の改質剤は、上記1に記載の改質剤であることが好ましい。作用極は、下記3に記載の作用極であることが好ましい。
一実施形態において、センサは、芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極、及び、対極を含むことが好ましい。当該実施形態において、対極は、上記2に記載の対極であることが好ましい。
PET基板に金を蒸着したシートを用いて、2.25mm2の作用極部位を持つ電極チップを作製した(図1)。図1において、「1」はPETフィルムであり、「2」は粘着シートであり、「3」は金蒸着PETフィルムであり、「4」は作用極部位である。この作用極部位に2%(w/v)のコール酸ナトリウム及び0.15%(w/v)の単層カーボンナノチューブ(SuperPureTubes、NanoIntegris社、外径1.1~1.7nm)を含む水分散液を0.6μL滴下し乾燥させた。カーボンナノチューブ分散液の乾燥後、作用極部位に超純水に溶解したFADGDH(配列番号2のアミノ酸配列を有する;8.6U/μL)を0.6μL滴下し乾燥させた。FADGDH液の乾燥後、作用極部位に2%(w/v)チモール溶液(50%(v/v)エタノールに溶解)を0.3μL滴下し乾燥させた。化合物液の乾燥後、作用極部位に3%(w/v)ナフィオン液を0.6μL滴下し、乾燥させ、カーボンナノチューブ、FADGDH、及びチモールを作用極部位に固定化した作用極チップを作製した。
(1)酸化銀
(2)二酸化マンガン
(3)マンガン酸バリウム
実施例の対極チップの作製工程において、化合物(1)~(3)を化合物(4)硫化銀に変更するか、カーボンペーストを化合物(1)~(3)と混合せずに用いるか、カーボンペーストを用いない以外は、実施例と同様にしてクロノアンペログラムを得た。
Claims (10)
- 芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極に対する対極の改質剤であって、金属酸化物を含む改質剤。
- 金属酸化物が水及び有機溶媒に不溶な金属酸化物である、請求項1に記載の改質剤。
- 金属酸化物が、Cu2O、CuO、Ag2O、MnO2、BaMnO4、OsO4、及びPbO2からなる群より選択される少なくとも一種である、請求項1又は2に記載の改質剤。
- 芳香環骨格を有する化合物が、チモール、フェノール、ビス(4-ヒドロキシフェニル)スルホン、チロシン二ナトリウム水和物、サリチル酸ナトリウム、トルエン、5-ヒドロキシインドール、アニリン、ロイコキニザリン、カルバクロール、1,5-ナフタレンジオール、4-イソプロピル-3-メチルフェノール、2-イソプロピルフェノール、4-イソプロピルフェノール、1-ナフトール、2-tert-ブチル-5-メチルフェノール、2,4,6-トリメチルフェノール、2,6-ジイソプロピルフェノール、2-tert-ブチル-4-エチルフェノール、6-tert-ブチル-2,4-キシレノール、2-tert-ブチル-4-メチルフェノール、2-tert-ブチル-6-メチルフェノール、2,4-ジ-tert-ブチルフェノール、2,4-ジ-tert-ブチル-5-メチルフェノール、ビス(p-ヒドロキシフェニル)メタン、3-tert-ブチルフェノール、2-イソプロピル-5-メチルアニソール、o-クレゾール、m-クレゾール、及びp-クレゾールからなる群より選択される、請求項1~3のいずれかに記載の改質剤。
- ナノカーボンがカーボンナノチューブである、請求項1~4のいずれかに記載の改質剤。
- 酵素がフラビン結合型グルコースデヒドロゲナーゼである、請求項1~5のいずれかに記載の改質剤。
- 芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極に対する対極であって、請求項1~6のいずれかに記載の改質剤を含む対極。
- 芳香環骨格を有する化合物が付着又は近接するナノカーボンと酵素とを含む作用極、及び請求項7に記載の対極を含むセンサ。
- 参照極を含まない、請求項8に記載のセンサ。
- 対極の表面積が作用極の表面積よりも大きい、請求項8又は9に記載のセンサ。
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