JP2019502743A - 経口投与用の解毒組成物及びその調製方法 - Google Patents
経口投与用の解毒組成物及びその調製方法 Download PDFInfo
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Abstract
Description
より詳細には、本発明は、植物系活性物質を含有する解毒組成物に関する。
また本発明は、前記組成物の調製及び肝臓の体内からの老廃物の除去を促進するためのその使用に関する。
− 緑色の時に摘み取られた新鮮な全果実である緑コショウ;
− 完熟時に収穫された果実である白コショウ。水中に数日間浸漬後、果実から果皮と中果皮の外側部分を取り除き、乾燥させる;
− 最初の果実が赤色に変わるとすぐに穂が収穫された黒コショウ。乾燥後、果実は柄から分離される。
i)コショウ植物の花序茎の収穫、乾燥、任意の粉砕及び任意のふるい分けを行う工程;
ii)コショウ植物の新鮮な及び/又は乾燥した花序茎を、水、アルコール又は水−アルコール混合物等の極性溶媒を用いて抽出し、次いで抽出物を濾過し、抽出物を任意に濃縮し、任意に乾燥状態にする工程。
− 煎出は、極性溶媒中で花序茎を煮沸すること、一定の時間、特に1分〜2時間、特に約20分間の間、この煮沸を維持すること、その後、任意に室温に戻すことを含む。
− 冷浸は、冷却した極性溶媒中に一定の時間コショウ植物の花序茎を浸漬して放置し、可溶性化合物を抽出することから成る。特に冷浸工程は、1時間〜15日間、好ましくは1日間の持続時間を有する。最も具体的には、室温、すなわち10〜25℃でそれは行われる。
− 浸出は、上記のように、好ましくは沸点の極性溶媒をコショウ植物の花序茎の上に注ぐこと、次いで1分〜2時間の期間にわたって浸出するために放置することから成る。
− 温浸は、沸点よりも低い温度の極性溶媒中でコショウ植物の花序茎を加熱することを含む:例えば水の場合は10〜89℃、特に25〜70℃である。
−「浸透(percolation)」又は「溶出(leaching)」は、新鮮な又は予め乾燥した及び粉砕したコショウ植物の花序茎に極性溶媒を通過させることから成る。
− 蒸留は、例えばVMHD(パルス真空マイクロ波水蒸気蒸留)によって実施できる。この抽出工程中、極性溶媒は大気圧より高い圧力とする。特に溶媒が水である場合、水は亜臨界状態であってもよい(すなわち、水の温度が100〜374℃であり、圧力が1〜218バールである)。これらの条件下では、水は液体の形態である。
− 第一に、通常、ピペリンはコショウ植物の果実/種子からアルコール抽出又は超臨界CO2溶媒抽出により抽出されるのに対して、本発明はコショウ植物の花序茎からの活性物質の浸出(すなわち水抽出)に関するものである;
− 第二に、コショウ植物の花序にはピペリンがほとんど含まれていない(乾燥物の1.00重量%)。Institut de Technologie Alimentaire(コン・トー、ベトナム)が実施した分析結果を表1に示す:
結果を乾燥物の重量パーセントとして表す。
− 乾燥と粉砕のいずれかにより、特に「茶」の形態の調製品に使用される粗い粒子を得る;
− 又は、乾燥、粉砕及びふるい分けにより、約300μm〜800μmの、通常は500μmに近い粒径を有する粉末を得る;
− 又は極性溶媒を用いた抽出により、乾燥状態にできる液体抽出物を得る。
上で詳細に述べた浸出プロセスに従って、カンポット原種由来のコショウ植物の乾燥及び粉砕した花序茎の茶を調製する。これはカンポット由来のコショウ植物の乾燥及び粉砕した花序茎のみから成る(乾燥物質2.5g/水100ml)。当該茶は肝臓の解毒剤として、体内からの老廃物の除去を促進するために使用することができる。
カンポット産のコショウ植物の乾燥及び粉砕した花序茎と、消化を助ける効果と強壮効果が知られているレモングラスの根茎から成る茶を調製する(水100ml当たり各々の乾燥物質はそれぞれ2.5gと0.5g)。当該茶は消化剤や抗鼓腸薬として腹部膨満の緩和に使用することができる。
カンポット産のコショウ植物の乾燥及び粉砕した花序茎と、ショウガの根茎から成る茶を調製する(各々の乾燥物質2.5g/水100ml)。ショウガは血液循環に対する有益な効果のために推奨され、強壮剤や精力剤として使用することができる。
カンポット産のコショウ植物の乾燥及び粉砕した花序茎と、ジャスミンの花から成る茶を調製する(各々の乾燥物質2.5g/水100ml)。当該ジャスミン風味の茶は、ストレスに対抗し、睡眠を促進するための弛緩薬として使用される。
カンポット産のコショウ植物の乾燥及び粉砕した花序茎と、ネコノヒゲの葉から成る茶を調製する(各々の乾燥物質2.5g/水100ml)。当該ミネラル風味の茶は、痩身を助けるために、そして尿酸の除去のために使用される。
次に、小袋包装体(例えばスティック形状)に詰める粉末形状の補助食品又は強化食品を、表2に示す材料を混合することにより調製する:
表3に示す材料を含有する補助食品又は強化食品を、300ml、1L又は1.5Lの水のボトルにねじ込むことができる栓の中に詰める。
表4の材料を混合し、バイアルに入れ、当業者に公知の技術に従ってオートクレーブ処理をした後、コショウ植物の乾燥した花序茎のエタノール/水のアルコール抽出物(体積比70/30のエタノール/水混合物100ml中2.5g)と、乾燥したネコノヒゲの葉のエタノール/水のアルコール抽出物(体積比70/30のエタノール/水混合物100ml中1g)から成る複合物を得る。該抽出物はバイアルに入れる前に濾過する。
表5に示す材料を混合し、当業者に公知の技術に従って混合物を抽出した後、押出顆粒の形状の補助食品又は強化食品を得る。
表6に示す処方に従ってゲルカプセルを調製する。
以下の表7に示す処方に従って錠剤を調製する。
乾燥した茎を浸透し(水100ml当たり2.5g)、次いで抽出物を乾燥状態まで蒸発乾固することにより、コショウ植物の花序茎の水抽出物を調製する。
乾燥した葉を浸透し、次いで抽出物を乾燥状態まで蒸発乾固することにより、ネコノヒゲの葉の水抽出物(水100ml当たり1g)を調製する。
カンポット産のコショウ植物の花序茎の粉末の浸出液の効果を、アルビノスイスマウスで評価した。動物は、10容量%と20容量%の用量で飲料水に加えられた浸出液(2.5gの乾燥物質/100mlの水)を20日間与えられた。得られた結果は、グルタチオンS−トランスフェラーゼ(GST)及び硫黄と化合した酸(−SH)の体内含有量の有意な用量依存的増加を示す。GSTは、グルタチオンと突然変異原性及び発癌性の求電子性化合物との結合を触媒する。さらに、GSTは様々な毒物と結合することができる。また得られた結果は、第I相の酵素であるシトクロムb5及びシトクロムP450が高レベルであることが統計学的に有意であり、用量依存性であることを示した。脂質過酸化マーカーであるマロンジアルデヒド(MDA)の含有量は、20%の浸出液の群でより低かった。従ってこの一連の結果は、浸出液の形態の本発明の組成物の、第I相及び第II相の解毒系酵素の誘導に対する効果を示唆する。
Claims (10)
- 任意に粉砕し、任意にふるいにかけたコショウ植物の乾燥した花序茎及び/又はコショウ植物の花序茎の液体もしくは乾燥した抽出物を含むことを特徴とする、経口投与用の解毒組成物。
- コショウ植物の花序茎が、コショウ植物Piper nigrum又はPiper longumの花序茎、より具体的にはカンボジアのカンポット地域産のコショウ植物の花序茎から選択されることを特徴とする、請求項1に記載の組成物。
- 抽出物が、極性溶媒を用いた前記花序茎の抽出物であることを特徴とする、請求項1又は2に記載の組成物。
- 花序茎に由来する総ポリフェノールを少なくとも1重量%、好ましくは2重量%〜15重量%、より好ましくは3重量%〜10重量%含有することを特徴とする、請求項1〜3のいずれか一項に記載の組成物。
- 浸出液、煎出液、冷浸液等の飲用可能な形態、香味飲料又は任意の他の飲用可能な形態であることを特徴とする、請求項1〜4のいずれか一項に記載の組成物。
- 請求項1〜5のいずれか一項に記載の組成物を0.1%〜85%、好ましくは3%〜65%、より好ましくは20%〜60%の重量比で含む補助食品又は強化食品又は栄養製品。
- さらに、下記から選択される少なくとも1つの活性物質を含むことを特徴とする請求項6に記載の補助食品又は強化食品又は栄養製品:
ビタミンB6もしくはC等のビタミン;ベータカロチンもしくはルテイン等のカロチノイド;マグネシウム、カルシウムもしくは鉄等の無機微量元素;ローズマリー、マリアアザミ、クロハツカダイコン、シモツケソウ、イラクサ、トクサ、ネコノヒゲの葉、レモングラス、ショウガもしくはジャスミンの抽出物;追加のポリフェノール及び/又はアントシアン。 - コーティングされた又はコーティングされていない錠剤;多層錠;発泡錠;糖衣錠;ゲルカプセル;ウエハー・カプセル;粉末;顆粒;スティック;ペレット;ソフトカプセル;ガラス瓶、スティックもしくは飲料、点滴ボトル又はスプレー中の水溶液又は懸濁液の形態であることを特徴とする、請求項6又は7に記載の補助食品又は強化食品又は栄養製品。
- 以下の工程の少なくとも1つを含むことを特徴とする、請求項1〜5のいずれか一項に記載の組成物の調製方法:
i)コショウ植物の花序茎の収穫、乾燥、任意の粉砕及び任意のふるい分けを行う工程;
ii)コショウ植物の新鮮な及び/又は乾燥した花序茎を、水、アルコール又は水−アルコール混合物等の極性溶媒を用いて抽出し、次いで抽出物を濾過し、抽出物を任意に濃縮し、任意に乾燥状態にする工程。 - 体内からの老廃物の除去、特に肝臓経路を介した除去の促進に使用するための、請求項1〜5のいずれか一項に記載の解毒組成物又は請求項6〜8のいずれか一項に記載の補助食品もしくは強化食品もしくは栄養製品。
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FR1650470A FR3046935B1 (fr) | 2016-01-21 | 2016-01-21 | Composition a visee detoxifiante pour administration par voie orale et son procede de preparation |
FR1650470 | 2016-01-21 | ||
PCT/FR2017/050088 WO2017125669A1 (fr) | 2016-01-21 | 2017-01-16 | Composition a visée détoxifiante pour administration par voie orale et son procédé de préparation |
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CN108495644B (zh) | 2021-12-10 |
CA3010241A1 (fr) | 2017-07-27 |
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EP3405207B1 (fr) | 2020-10-07 |
MY187440A (en) | 2021-09-22 |
MA46787A (fr) | 2018-11-28 |
EP3405207A1 (fr) | 2018-11-28 |
CN108495644A (zh) | 2018-09-04 |
DK3405207T3 (da) | 2021-01-11 |
KR20180102658A (ko) | 2018-09-17 |
FR3046935A1 (fr) | 2017-07-28 |
BR112018014187A2 (pt) | 2018-12-11 |
PH12018501437A1 (en) | 2019-03-11 |
MA50263A (fr) | 2018-11-28 |
WO2017125669A1 (fr) | 2017-07-27 |
FR3046935B1 (fr) | 2020-12-25 |
US20190030111A1 (en) | 2019-01-31 |
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