US5045468A
(en)
|
1986-12-12 |
1991-09-03 |
Cell Enterprises, Inc. |
Protein-free culture medium which promotes hybridoma growth
|
SU1484094A1
(ru)
*
|
1987-04-03 |
1994-01-15 |
Институт биоорганической химии АН БССР |
Способ очистки антител к тиреоидным гормонам
|
US6048728A
(en)
|
1988-09-23 |
2000-04-11 |
Chiron Corporation |
Cell culture medium for enhanced cell growth, culture longevity, and product expression
|
US5110913A
(en)
|
1990-05-25 |
1992-05-05 |
Miles Inc. |
Antibody purification method
|
US5096816A
(en)
|
1990-06-05 |
1992-03-17 |
Cetus Corporation |
In vitro management of ammonia's effect on glycosylation of cell products through pH control
|
EP0666312A1
(en)
|
1994-02-08 |
1995-08-09 |
Wolfgang A. Renner |
Process for the improvement of mammalian cell growth
|
US5429746A
(en)
*
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
US5853714A
(en)
*
|
1995-03-27 |
1998-12-29 |
Genetics Institute, Inc. |
Method for purification of IL-12
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US5705364A
(en)
|
1995-06-06 |
1998-01-06 |
Genentech, Inc. |
Mammalian cell culture process
|
US6656466B1
(en)
|
1995-06-06 |
2003-12-02 |
Genetech, Inc. |
Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
|
US5721121A
(en)
|
1995-06-06 |
1998-02-24 |
Genentech, Inc. |
Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
|
JP4306813B2
(ja)
|
1995-09-19 |
2009-08-05 |
アスビオファーマ株式会社 |
動物細胞の新規培養方法
|
DE69623109T2
(de)
|
1996-04-19 |
2002-12-12 |
Societe Des Produits Nestle S.A., Vevey |
Menschliche immortalisierte Colon-Epithelialzellen
|
WO1998017786A1
(en)
|
1996-10-23 |
1998-04-30 |
Oravax, Inc. |
Heat inactivation of viruses in antibody preparations
|
AU4959997A
(en)
*
|
1996-11-15 |
1998-06-10 |
Kennedy Institute Of Rheumatology, The |
Suppression of tnf alpha and il-12 in therapy
|
ES2335365T3
(es)
|
1996-11-27 |
2010-03-25 |
Genentech, Inc. |
Purificacion por afinidad de polipeptido en una matriz de proteina a.
|
US6955917B2
(en)
*
|
1997-06-20 |
2005-10-18 |
Bayer Healthcare Llc |
Chromatographic method for high yield purification and viral inactivation of antibodies
|
IL121900A
(en)
|
1997-10-07 |
2001-12-23 |
Omrix Biopharmaceuticals Ltd |
A method for the purification of immunoglobulins
|
US20020045207A1
(en)
|
1997-10-31 |
2002-04-18 |
Lynne A. Krummen |
Glycoprotein production process
|
AU1663599A
(en)
|
1997-12-19 |
1999-07-12 |
Novo Nordisk A/S |
Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents
|
CN103641885A
(zh)
|
1998-05-06 |
2014-03-19 |
基因技术股份有限公司 |
用离子交换层析纯化蛋白质
|
US6528286B1
(en)
|
1998-05-29 |
2003-03-04 |
Genentech, Inc. |
Mammalian cell culture process for producing glycoproteins
|
CA2276216A1
(en)
*
|
1998-06-24 |
1999-12-24 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
An artificial peptide capable of neutralizing the biological activity of interleukin-18
|
US6914128B1
(en)
*
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
EP1650307B1
(en)
|
1999-09-27 |
2010-07-14 |
Genentech, Inc. |
Methods for making recombinant proteins using apoptosis inhibitors
|
WO2001059089A2
(en)
|
2000-02-08 |
2001-08-16 |
Genentech, Inc. |
Improved galactosylation of recombinant glycoproteins
|
TWI335336B
(ja)
*
|
2000-02-10 |
2011-01-01 |
Abbott Gmbh & Co Kg |
|
US7598055B2
(en)
|
2000-06-28 |
2009-10-06 |
Glycofi, Inc. |
N-acetylglucosaminyltransferase III expression in lower eukaryotes
|
EP1175931A1
(en)
|
2000-07-25 |
2002-01-30 |
Computer Cell Culture Center S.A. |
Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
US6635448B2
(en)
|
2000-08-21 |
2003-10-21 |
Clonexdevelopment, Inc. |
Methods and compositions for increasing protein yield from a cell culture
|
US6693173B2
(en)
|
2000-12-26 |
2004-02-17 |
Alpha Therapeutic Corporation |
Method to remove citrate and aluminum from proteins
|
US20030096414A1
(en)
|
2001-03-27 |
2003-05-22 |
Invitrogen Corporation |
Culture medium for cell growth and transfection
|
DE60231016D1
(de)
|
2001-06-05 |
2009-03-12 |
Genetics Inst Llc |
Verfahren zur Reinigung stark anionischer Proteine
|
EP1423510A4
(en)
|
2001-08-03 |
2005-06-01 |
Glycart Biotechnology Ag |
ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED CELL CYTOTOXICITY DEPENDENT OF ANTIBODIES
|
KR20040039472A
(ko)
|
2001-10-02 |
2004-05-10 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
진핵 세포에서 재조합체 단백질의 제조 방법
|
HUP0600342A3
(en)
|
2001-10-25 |
2011-03-28 |
Genentech Inc |
Glycoprotein compositions
|
WO2004039826A1
(en)
|
2001-11-14 |
2004-05-13 |
Centocor, Inc. |
Anti-il-6 antibodies, compositions, methods and uses
|
HUP0402226A2
(hu)
|
2001-11-28 |
2005-02-28 |
Sandoz Ag. |
Eljárás sejttenyésztésre
|
PL374311A1
(en)
|
2001-12-21 |
2005-10-03 |
Immunex Corporation |
Methods for purifying protein
|
US20030201229A1
(en)
|
2002-02-04 |
2003-10-30 |
Martin Siwak |
Process for prefiltration of a protein solution
|
ATE417858T1
(de)
|
2002-02-05 |
2009-01-15 |
Genentech Inc |
Proteinaufreinigung
|
CA2417689C
(en)
|
2002-03-05 |
2006-05-09 |
F. Hoffmann-La Roche Ag |
Improved methods for growing mammalian cells in vitro
|
US20030190710A1
(en)
|
2002-03-28 |
2003-10-09 |
Devries Ruth L. |
Control of glycoforms in IgG
|
US20040132140A1
(en)
|
2002-04-09 |
2004-07-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Production process for antibody composition
|
EP1543106B1
(en)
|
2002-07-15 |
2007-04-11 |
Immunex Corporation |
Methods and media for controlling sialylation of proteins produced by mammalian cells
|
US7067279B1
(en)
|
2002-08-23 |
2006-06-27 |
Immunex Corporation |
Cell culture performance with betaine
|
US6974681B1
(en)
|
2002-08-23 |
2005-12-13 |
Immunex Corporation |
Cell culture performance with vanadate
|
CN1856324A
(zh)
|
2002-09-17 |
2006-11-01 |
Gtc生物治疗学公司 |
缺乏重链间二硫键的免疫球蛋白分子的分离
|
US7208585B2
(en)
|
2002-09-18 |
2007-04-24 |
Genencor International, Inc. |
Protein purification
|
US20040162414A1
(en)
|
2002-11-22 |
2004-08-19 |
Santora Ling C. |
Method for reducing or preventing modification of a polypeptide in solution
|
CN100402660C
(zh)
|
2002-12-23 |
2008-07-16 |
布里斯托尔-迈尔斯斯奎布公司 |
用于蛋白质生产的哺乳动物细胞培养方法中产物质量提高
|
MXPA05006523A
(es)
|
2002-12-23 |
2005-08-26 |
Squibb Bristol Myers Co |
Procesos de cultivo de celulas de mamiferos para la produccion de proteinas.
|
JPWO2004087761A1
(ja)
*
|
2003-03-31 |
2006-07-27 |
麒麟麦酒株式会社 |
ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
|
PT1623019E
(pt)
|
2003-05-15 |
2010-07-20 |
Wyeth Llc |
ALIMENTAÃO COM GLUCOSE DE MODO LIMITADO PARA CULTURA DE CéLULAS ANIMAIS
|
EP3095793B1
(en)
|
2003-07-28 |
2020-03-25 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
GB2404665B
(en)
|
2003-08-08 |
2005-07-06 |
Cambridge Antibody Tech |
Cell culture
|
EP1673452B1
(en)
|
2003-10-10 |
2015-12-23 |
Novo Nordisk Health Care AG |
Method for large-scale production of a polypeptide in eukaryote cells
|
WO2005044856A2
(en)
|
2003-10-27 |
2005-05-19 |
Wyeth |
Removal of high molecular weight aggregates using hydroxyapatite chromatography
|
US8084032B2
(en)
|
2004-01-21 |
2011-12-27 |
Ajinomoto Co., Inc. |
Purification method which prevents denaturation of an antibody
|
SE0400886D0
(sv)
|
2004-04-02 |
2004-04-02 |
Amersham Biosciences Ab |
Process of purification
|
US20060127950A1
(en)
|
2004-04-15 |
2006-06-15 |
Massachusetts Institute Of Technology |
Methods and products related to the improved analysis of carbohydrates
|
EP1745141B2
(en)
|
2004-05-04 |
2019-09-25 |
Novo Nordisk Health Care AG |
O-linked glycoforms of faktor vii and method to manufacture them
|
US7294484B2
(en)
|
2004-08-27 |
2007-11-13 |
Wyeth Research Ireland Limited |
Production of polypeptides
|
KR101335936B1
(ko)
|
2004-09-30 |
2013-12-03 |
바이엘 헬스케어, 엘엘씨 |
생물학적 분자의 통합된 연속 제조를 위한 장치 및 방법
|
US20060094104A1
(en)
|
2004-10-29 |
2006-05-04 |
Leopold Grillberger |
Animal protein-free media for cultivation of cells
|
JP2006143601A
(ja)
|
2004-11-16 |
2006-06-08 |
Yamato Yakuhin Kk |
血液粘度低下剤
|
US8728828B2
(en)
*
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
ATE541919T1
(de)
|
2005-02-11 |
2012-02-15 |
Novo Nordisk Healthcare Ag |
Herstellung eines proteins in serumfreier zellkultur, die ein proteinhydrolysat aus pflanzen enthält
|
US8067182B2
(en)
|
2005-03-11 |
2011-11-29 |
Wyeth Llc |
Method of weak partitioning chromatography
|
CA2604877A1
(en)
|
2005-04-11 |
2006-10-19 |
J.P. Sercel Associates Inc. |
Protein purification
|
WO2006113743A2
(en)
|
2005-04-18 |
2006-10-26 |
Massachusetts Institute Of Technology |
Compositions and methods for rna interference with sialidase expression and uses thereof
|
US7247457B2
(en)
|
2005-04-26 |
2007-07-24 |
United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Detection and identification of enteroviruses by semi-nested amplification of the enterovirus VP1 protein
|
JP2008541770A
(ja)
|
2005-06-03 |
2008-11-27 |
ジェネンテック・インコーポレーテッド |
改変したフコシル化レベルを有する抗体の産生方法
|
US20080311078A1
(en)
|
2005-06-14 |
2008-12-18 |
Gokarn Yatin R |
Self-Buffering Protein Formulations
|
EP1896504B1
(en)
|
2005-06-17 |
2012-11-21 |
Wyeth LLC |
Methods of purifying fc region containing antibodies
|
WO2007022799A1
(en)
|
2005-08-26 |
2007-03-01 |
Ares Trading S.A. |
Process for the preparation of glycosylated interferon beta
|
AR058140A1
(es)
|
2005-10-24 |
2008-01-23 |
Wyeth Corp |
Metodo de produccion proteica utilizando compuestos anti-senescencia
|
WO2007070315A2
(en)
|
2005-12-08 |
2007-06-21 |
Amgen Inc. |
Improved production of glycoproteins using manganese
|
US20070190057A1
(en)
|
2006-01-23 |
2007-08-16 |
Jian Wu |
Methods for modulating mannose content of recombinant proteins
|
KR20140071452A
(ko)
|
2006-04-05 |
2014-06-11 |
애브비 바이오테크놀로지 리미티드 |
항체 정제
|
RU2008150314A
(ru)
|
2006-05-19 |
2010-06-27 |
Гликофи, Инк. (Us) |
Композиции эритропоэтина
|
US20100234577A1
(en)
|
2006-06-14 |
2010-09-16 |
Smithkline Beecham Corporation |
Methods for purifying antibodies using ceramic hydroxyapatite
|
DK3255141T3
(da)
|
2006-07-13 |
2022-01-31 |
Wyeth Llc |
Fremstilling af antistoffer med forbedret glycosyleringsmønster
|
LT2061803T
(lt)
*
|
2006-08-28 |
2019-11-25 |
Ares Trading Sa |
Fc turinčių baltymų gryninimo būdas
|
AU2007292253A1
(en)
|
2006-09-08 |
2008-03-13 |
Wyeth |
Arginine wash in protein purification using affinity chromatography
|
US10982250B2
(en)
|
2006-09-18 |
2021-04-20 |
Genentech, Inc. |
Methods of protein production
|
WO2008055260A2
(en)
|
2006-11-03 |
2008-05-08 |
Wyeth |
Glycolysis-inhibiting substances in cell culture
|
EP2089424B1
(en)
|
2006-12-06 |
2015-07-01 |
JCR PHARMACEUTICALS Co., LTD. |
Method for production of human erythropoietin
|
WO2008079302A2
(en)
*
|
2006-12-21 |
2008-07-03 |
Millipore Corporation |
Purification of proteins
|
PT2115126E
(pt)
|
2007-03-02 |
2015-08-24 |
Wyeth Llc |
Utilização de cobre e glutamato na cultura de células para a produção de polipeptídeos
|
AU2008232902B2
(en)
|
2007-03-30 |
2013-10-03 |
Medlmmune, Llc |
Antibody formulation
|
EP2508614A3
(en)
|
2007-04-03 |
2012-11-28 |
Oxyrane UK Limited |
Glycosylation of molecules
|
WO2008128227A1
(en)
|
2007-04-16 |
2008-10-23 |
Momenta Pharmaceuticals, Inc. |
Defined glycoprotein products and related methods
|
TW200902708A
(en)
|
2007-04-23 |
2009-01-16 |
Wyeth Corp |
Methods of protein production using anti-senescence compounds
|
EP1988101A1
(en)
|
2007-05-04 |
2008-11-05 |
Novo Nordisk A/S |
Improvement of factor VIII polypeptide titers in cell cultures
|
WO2008135498A2
(en)
|
2007-05-04 |
2008-11-13 |
Novo Nordisk A/S |
Prevention of protein degradation in mammalian cell cultures
|
EP2152293B1
(en)
*
|
2007-05-11 |
2016-10-19 |
The Board of Regents of the University of Nebraska |
Compositions for protein delivery and methods of use thereof
|
US8053236B2
(en)
|
2007-05-11 |
2011-11-08 |
Amgen Inc. |
Feed media
|
WO2008154014A2
(en)
|
2007-06-11 |
2008-12-18 |
Amgen Inc. |
A method for culturing mammalian cells to improve recombinant protein production
|
LT3597659T
(lt)
|
2007-07-09 |
2023-05-10 |
Genentech, Inc. |
Disulfidinės jungties redukcijos prevencijos būdas gaminant polipeptidą rekombinantiniu būdu
|
WO2009023562A2
(en)
|
2007-08-09 |
2009-02-19 |
Wyeth |
Use of perfusion to enhance production of fed-batch cell culture in bioreactors
|
WO2009058769A1
(en)
|
2007-10-30 |
2009-05-07 |
Schering Corporation |
Purification of antibodies containing hydrophobic variants
|
SI2215117T2
(en)
|
2007-10-30 |
2018-04-30 |
Genentech, Inc. |
Purification of the antibody by cation exchange chromatography
|
TWI661833B
(zh)
|
2007-11-30 |
2019-06-11 |
百慕達商艾伯維生物技術有限責任公司 |
蛋白質調配物及製造其之方法
|
EP2574676B1
(en)
|
2007-12-27 |
2017-08-30 |
Baxalta GmbH |
Cell culture processes
|
US8093364B2
(en)
|
2008-01-18 |
2012-01-10 |
Bio-Rad Laboratories, Inc. |
Enhanced purification of antibodies and antibody fragments by apatite chromatography
|
AU2009223054A1
(en)
|
2008-03-11 |
2009-09-17 |
Genentech, Inc. |
Antibodies with enhanced ADCC function
|
ES2406029T3
(es)
|
2008-04-15 |
2013-06-05 |
Grifols Therapeutics Inc. |
Ultrafiltración/diafiltración en dos fases
|
AU2009242453B2
(en)
|
2008-05-02 |
2014-12-04 |
Seagen Inc. |
Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
|
WO2010016943A2
(en)
|
2008-08-08 |
2010-02-11 |
Biogen Idec Ma Inc. |
Nutrient monitoring and feedback control for increased bioproduct production
|
LT2848625T
(lt)
|
2008-08-14 |
2019-10-10 |
Genentech, Inc. |
Priemaišų pašalinimo būdai, panaudojant reziduojančio baltymo pakeitimą jonų mainų membraninės chromatografijos pagalba
|
CN102216452B
(zh)
|
2008-09-26 |
2013-08-21 |
尤里卡治疗公司 |
具有变异糖基化方式的细胞系和蛋白质
|
AU2009307728B2
(en)
|
2008-10-20 |
2014-12-11 |
Abbvie Inc. |
Antibodies that bind to IL-18 and methods of purifying the same
|
CN102257004A
(zh)
|
2008-10-20 |
2011-11-23 |
雅培制药有限公司 |
与il-12结合的抗体及其纯化方法
|
KR101722423B1
(ko)
|
2008-10-20 |
2017-04-18 |
애브비 인코포레이티드 |
항체 정제 동안의 바이러스 불활성화
|
EP2921501A1
(en)
|
2008-10-20 |
2015-09-23 |
Abbvie Inc. |
Isolation and purification of antibodies using Protein A affinity chromatography
|
JP5793080B2
(ja)
|
2008-10-31 |
2015-10-14 |
ワイス・エルエルシー |
セラミックヒドロキシアパタイトクロマトグラフィーを使用する酸性タンパク質の精製
|
US20110236391A1
(en)
|
2008-12-09 |
2011-09-29 |
Hanns-Christian Mahler |
Method for obtaining an excipient-free antibody solution
|
AU2009331897A1
(en)
|
2008-12-22 |
2010-07-01 |
F. Hoffmann-La Roche Ag |
Immunoglobulin purification
|
CN102272144B
(zh)
|
2009-01-08 |
2014-09-17 |
通用电气健康护理生物科学股份公司 |
采用单一聚合物相***的分离方法
|
WO2010102114A1
(en)
|
2009-03-05 |
2010-09-10 |
Biogen Idec Ma Inc. |
Purification of immunoglobulins
|
EP2412817B2
(en)
|
2009-03-27 |
2019-06-05 |
Asahi Kasei Medical Co., Ltd. |
Method for removing viruses in high-concentration monoclonal antibody solution
|
TW201041899A
(en)
|
2009-04-13 |
2010-12-01 |
Bristol Myers Squibb Co |
Protein purification by citrate precipitation
|
KR20110139292A
(ko)
|
2009-04-20 |
2011-12-28 |
화이자 인코포레이티드 |
단백질 글리코실화의 제어 및 그와 관련된 조성물 및 방법
|
WO2010136515A1
(en)
|
2009-05-28 |
2010-12-02 |
Boehringer Ingelheim International Gmbh |
Method for a rational cell culturing process
|
AU2010256455A1
(en)
|
2009-06-05 |
2012-01-19 |
Momenta Pharmaceuticals, Inc. |
Methods of modulating fucosylation of glycoproteins
|
US20120329151A1
(en)
|
2009-07-06 |
2012-12-27 |
F. Hoffmann-La Roche Ag |
Method of culturing eukaryotic cells
|
MX2012000841A
(es)
|
2009-07-24 |
2012-02-28 |
Hoffmann La Roche |
Optimizacion de la produccion de anticuerpos.
|
WO2011015926A1
(en)
|
2009-08-03 |
2011-02-10 |
Avesthagen Limited |
A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein
|
CN102712691A
(zh)
|
2009-08-06 |
2012-10-03 |
弗·哈夫曼-拉罗切有限公司 |
蛋白质纯化中提高病毒去除的方法
|
US20110053223A1
(en)
|
2009-08-14 |
2011-03-03 |
Robert Bayer |
Cell culture methods to make antibodies with enhanced adcc function
|
WO2011024025A1
(en)
|
2009-08-28 |
2011-03-03 |
Avesthagen Limited |
An erythropoietin analogue and a method thereof
|
CN108409829A
(zh)
|
2009-09-01 |
2018-08-17 |
弗·哈夫曼-拉罗切有限公司 |
通过改进的a蛋白洗脱增强的蛋白质纯化
|
US9540426B2
(en)
|
2009-10-06 |
2017-01-10 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
MX2012004711A
(es)
|
2009-10-20 |
2012-05-23 |
Abbott Lab |
Aislamiento y purificacion de los anticuerpos anti-il-13 al usar cromatografia de afinidad con proteina a.
|
US20120208986A1
(en)
|
2009-10-20 |
2012-08-16 |
Wenger Marc D |
Use of mixed mode chromatography for the capture and purification of basic antibody products
|
WO2011065940A1
(en)
|
2009-11-24 |
2011-06-03 |
Biogen Idec Ma Inc. |
Method of supplementing culture media to prevent undesirable amino acid substitutions
|
EP2507627A2
(en)
|
2009-12-04 |
2012-10-10 |
Momenta Pharmaceuticals, Inc. |
Antennary fucosylation in glycoproteins from cho cells
|
US8277649B2
(en)
|
2009-12-14 |
2012-10-02 |
General Electric Company |
Membranes and associated methods for purification of antibodies
|
ES2651065T3
(es)
|
2009-12-18 |
2018-01-24 |
Novartis Ag |
Solución de lavado y método para cromatografía de afinidad
|
KR101405463B1
(ko)
|
2010-01-15 |
2014-06-27 |
그래핀스퀘어 주식회사 |
기체 및 수분 차단용 그래핀 보호막, 이의 형성 방법 및 그의 용도
|
JP2013523158A
(ja)
|
2010-04-06 |
2013-06-17 |
ヘリアエ デベロップメント、 エルエルシー |
淡水または塩水藻類からのタンパク質の選択的抽出
|
BR112012025645A2
(pt)
|
2010-04-07 |
2017-12-12 |
Momenta Pharmaceuticals Inc |
glicanos de alta manose.
|
SG185038A1
(en)
|
2010-04-26 |
2012-11-29 |
Novartis Ag |
Improved cell culture medium
|
RU2577972C2
(ru)
|
2010-04-26 |
2016-03-20 |
Новартис Аг |
Способ получения рекомбинантного полипептида
|
MX343604B
(es)
|
2010-05-28 |
2016-11-11 |
Genentech Inc |
Disminuir nivel de lactato e incrementar producción de polipéptidos por regulación a la baja de la expresión de lactato dehidrogenasa y piruvato dehidrogenasa quinasa.
|
WO2012019160A1
(en)
|
2010-08-05 |
2012-02-09 |
Amgen Inc. |
Dipeptides to enhance yield and viability from cell cultures
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
WO2012050175A1
(ja)
|
2010-10-15 |
2012-04-19 |
日本ケミカルリサーチ株式会社 |
糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
|
EP2450375A1
(en)
|
2010-11-09 |
2012-05-09 |
Sandoz Gmbh |
Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor
|
EP2649087A1
(en)
|
2010-12-08 |
2013-10-16 |
Amgen Inc. |
Ion exchange chromatography in the presence of an amino acid
|
MX357821B
(es)
|
2010-12-21 |
2018-07-25 |
Hoffmann La Roche |
Preparación de anticuerpo enriquecida con isoforma y método para obtenerla.
|
EP2683821B1
(en)
|
2011-03-06 |
2018-07-25 |
Merck Serono SA |
Low fucose cell lines and uses thereof
|
TR201810703T4
(tr)
|
2011-03-25 |
2018-08-27 |
Hoffmann La Roche |
Yeni protein saflaştırma yöntemleri.
|
EP2511293A1
(en)
|
2011-04-13 |
2012-10-17 |
LEK Pharmaceuticals d.d. |
A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
|
US9133493B2
(en)
|
2011-04-21 |
2015-09-15 |
Amgen Inc. |
Method for culturing mammalian cells to improve recombinant protein production
|
WO2012147048A2
(en)
|
2011-04-29 |
2012-11-01 |
Biocon Research Limited |
Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
|
US20120283419A1
(en)
|
2011-05-03 |
2012-11-08 |
Avantor Performance Materials, Inc. |
Separation of protein monomers from aggregates by solid weak anion exchange support functionalized with amine moieties
|
DK2707383T3
(en)
|
2011-05-13 |
2018-07-23 |
Biogen Ma Inc |
PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULPHIDE BINDINGS
|
WO2013006461A1
(en)
|
2011-07-01 |
2013-01-10 |
Biogen Idec Ma Inc. |
Cholesterol-based media supplementals for cell culture
|
WO2013006479A2
(en)
|
2011-07-01 |
2013-01-10 |
Amgen Inc. |
Mammalian cell culture
|
CN103717729B
(zh)
|
2011-07-08 |
2017-11-21 |
动量制药公司 |
细胞培养方法
|
WO2013013013A2
(en)
|
2011-07-21 |
2013-01-24 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for producing modified glycoproteins
|
US9994610B2
(en)
|
2011-10-19 |
2018-06-12 |
Roche Glycart Ag |
Separation method for fucosylated antibodies
|