JP2012036158A - 中性脂肪低減剤 - Google Patents
中性脂肪低減剤 Download PDFInfo
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- JP2012036158A JP2012036158A JP2010180294A JP2010180294A JP2012036158A JP 2012036158 A JP2012036158 A JP 2012036158A JP 2010180294 A JP2010180294 A JP 2010180294A JP 2010180294 A JP2010180294 A JP 2010180294A JP 2012036158 A JP2012036158 A JP 2012036158A
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- Prior art keywords
- neutral fat
- reducing agent
- strain
- lactobacillus brevis
- fat reducing
- Prior art date
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Links
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Abstract
【解決手段】ラクトバチラス・ブレビス(Lactobacillus brevis)に属する菌株の菌体又はその処理物を有効成分として含有する中性脂肪低減剤。
【選択図】なし
Description
(中性脂肪低減剤の調製)
ラクトバチラス・ブレビスSBC8803菌株を酵母エキスと液糖を主成分とする培地中、30℃で24時間培養し、遠心分離によって菌体を回収した。回収した菌体の一部を蒸留水に懸濁して100mg/mlの菌体懸濁液を得た。これを「生菌」の中性脂肪低減剤とした。一方、回収した菌体の一部をオートクレーブ処理(121℃、20分)で殺菌した後、凍結乾燥し、これを蒸留水に懸濁して100mg/mLの菌体の処理物の懸濁液を得た。これを「死菌」の中性脂肪低減剤とした。
(マウスへの中性脂肪低減剤の投与試験)
C57BL/6Jマウス(雄性、日本チャールス・リバー)32匹を、試験開始時の体重の平均値及び分散が群間でバラつかないように各群8匹の4群に分けた。なお、マウスは、1週間の馴化飼育を経た後、5週齢の時点で試験に使用した。
試験飼料(食餌)は、表1の組成となるように調製した。表1中、各成分量の単位はgである。また、馴化飼育期間中は、飼料としてAIN93Mを用いた。なお、表1中、中性脂肪低減剤(生菌)の成分量及び中性脂肪低減剤(死菌)の成分量は、菌体の乾燥重量及び菌体の処理物の乾燥重量である。
1週間馴化飼育した後、各群のマウスに所定の試験飼料及び水道水を6週間自由に摂餌・摂水させた。馴化飼育期間及びその後の試験飼料投与期間を通じて、マウスは、飼育装置(温度23±5℃、相対湿度55±10%、EBAC、日本クレア)中で、常時換気、明暗時間12時間(明期:8時〜20時)の条件下で4匹/1ケージで集団飼育した。
飼育開始時、及び飼育期間中1週間おきにマウスの体重を測定した。各群8匹の測定値の平均を各群の体重とした。
試験飼料投与開始から6週間後、各群のマウスについて、エーテル麻酔下、心採血、解剖を行い、血漿中性脂肪濃度、副睾丸周辺脂肪重量、後腹壁脂肪重量、腸間膜脂肪重量を測定した。
(中性脂肪低減剤を添加したヨーグルトの調製)
常法に従って製造したヨーグルトに、実施例1の「生菌」の中性脂肪低減剤をヨーグルト100gあたり菌体量が5mgとなるように添加及び混合し、中性脂肪低減剤を含有するヨーグルトを調製した。
(ヒトへの中性脂肪低減剤の投与試験)
血漿GOT(AST)値が36IU/L以上、血漿GPT(ALT)値が36IU/L以上、又は血漿γGTP値が61IU/L以上のいずれかに該当する(重複して該当する場合も可)成人ヒト被験者に対し、実施例3で調製したヨーグルト100gを1日1回2週間に渡って食すこと以外は通常通りに生活してもらったうえで、試験開始時及び試験開始後2週間目の時点での血漿中性脂肪濃度を測定した。
Claims (7)
- ラクトバチラス・ブレビス(Lactobacillus brevis)に属する菌株の菌体又はその処理物を有効成分として含有する中性脂肪低減剤。
- 前記菌株が、ラクトバチラス・ブレビス亜種ブレビス(Lactobacillus brevis subspecies brevis)に属する菌株である、請求項1に記載の中性脂肪低減剤。
- 前記菌株が、ラクトバチラス・ブレビス(Lactobacillus brevis)SBC8803(受託番号:FERM BP−10632)菌株である、請求項1又は2に記載の中性脂肪低減剤。
- 請求項1〜3のいずれか一項に記載の中性脂肪低減剤を含有する医薬品。
- 請求項1〜3のいずれか一項に記載の中性脂肪低減剤を含有する飲食品。
- 請求項1〜3のいずれか一項に記載の中性脂肪低減剤を含有する飲食品添加物。
- 請求項1〜3のいずれか一項に記載の中性脂肪低減剤を含有する発酵乳。
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